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141. 发明授权

US11382208B2 Device for a vehicle for detecting an activation action in a detection region 有权
公开(公告)号：US11382208B2
公开(公告)日：2022-07-05
申请号：US17101238
申请日：2020-11-23
申请人： Huf Hülsbeck & Fürst GmbH & Co. KG
发明人： Berthold Sieg
IPC分类号： H05K1/02 , H05K1/18 , H05K1/11 , E05B85/10 , E05B81/76 , B60R25/20 , B60R25/01
摘要： The invention relates to a device (10) for a vehicle (1) for detecting an activation action in a detection region (51), and in particular for mounting on a vehicle part (5), in order to activate a function of the vehicle (1) depending on the detection, comprising: a multi-layer printed circuit board (20), at least one electrically conductive sensor element (31) for capacitive sensing in the detection region (51), wherein the sensor element (31) is arranged on the printed circuit board (20), at least two shielding elements (40) for shielding (41) for the sensing.

142. 发明授权

US11377698B2 Method of treating a cancer patient without the need for a tissue biopsy 有权
公开(公告)号：US11377698B2
公开(公告)日：2022-07-05
申请号：US16560504
申请日：2019-09-04
申请人： Inivata Ltd.
发明人： Clive Morris , Vincent Plagnol , Tim Forshew
IPC分类号： C12Q1/6886 , C12Q1/6827
摘要： Provided herein, among other things, is a method of treating a cancer patient without the need for a tissue biopsy. In some embodiments, the method may comprise (a) performing or having performed a sequencing assay on cell-free DNA (cfDNA) from a sample of blood from the patient to determine if the cell-free DNA comprises actionable and/or non-actionable sequence variations in one or more target genes, and (b) treating the patient using the following method: i. administering a therapy that is targeted to an actionable sequence variation if the patient is identified as having the actionable sequence variation, and ii. administering a non-targeted therapy in the absence of any follow-up genetic testing on DNA extracted from a tissue biopsy if one or more non-actionable sequence variations and no actionable sequence variations are identified.

143. 发明授权

US11377478B2 T-cell modulatory multimeric polypeptides and methods of use thereof 有权
公开(公告)号：US11377478B2
公开(公告)日：2022-07-05
申请号：US17578094
申请日：2022-01-18
申请人： Cue Biopharma, Inc.
发明人： Ronald D. Seidel, III , Rodolfo J. Chaparro
IPC分类号： C07K14/55 , A61K35/17 , C07K14/47 , C07K14/74 , A61K9/00 , C07K14/005 , G01N33/50 , A61K38/00 , A61K39/00
摘要： The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.

144. 发明授权

US11373200B2 Current value estimation using machine learning 有权
公开(公告)号：US11373200B2
公开(公告)日：2022-06-28
申请号：US17056381
申请日：2019-06-20
申请人： RITEBAND AB
发明人： Niklas Ahlgren , Linda Portnoff , Pontus Thorsson , Tone Pedersen
IPC分类号： G06Q30/02 , G06N20/00
摘要： There is provided a system, method and computer program product for estimating a current value of an intangible asset, by obtaining a source file representing the intangible asset; analyzing the source file to identify at least one characteristic; classifying the source file to belong to at least one class based on the identified at least one characteristic; obtaining one or more evaluation parameters associated with the creator of the intangible asset from at least one first data source; obtaining any historical values associated with the intangible asset; predicting, using a machine learning model, a future value of the intangible asset based on the selected at least one class; the one or more evaluation parameter; and any obtained historical value; and estimating, by the machine learning model, the current value of the intangible asset based on the predicted future value and a pre-set time period.

145. 发明授权

US11370052B2 Arc welding system and wire feeding device 有权
公开(公告)号：US11370052B2
公开(公告)日：2022-06-28
申请号：US16080251
申请日：2017-03-09
申请人： DAIHEN Corporation
发明人： Masahiro Inoue , Yukiya Morita , Hisao Miyahara , Hirokazu Kawai , Songjie Hou , Hayato Baba , Hideo Shiozaki , Tetsuo Era , Tomoyuki Ueyama
IPC分类号： B23K9/133 , B23K9/10 , B23K9/09 , B23K9/073 , B23K9/12
摘要： An arc welding system of a consumable electrode type comprises: a wire feeding device that feeds welding wire from a wire feeding source to a welding torch; and a power supply device that supplies electric power between the welding wire fed to the welding torch and a base material, the system being configured to weld the base material by arc generated by the supplied electric power. The wire feeding device is provided with: an intermediate wire feeding source that is disposed between the wire feeding source and the welding torch and is configured to temporarily accommodate the welding wire fed from the wire feeding source and to feed the accommodated welding wire to the welding torch; a pull-out feeding part that feeds the welding wire at the wire feeding source to the intermediate wire feeding source; and a push-out feeding part that feeds the welding wire accommodated in the intermediate wire feeding source to the welding torch.

146. 发明授权

US11369963B2 Devices and methods for sample analysis 有权
公开(公告)号：US11369963B2
公开(公告)日：2022-06-28
申请号：US16850711
申请日：2020-04-16
申请人： Abbott Laboratories
发明人： Jeffrey B. Huff , Mark A. Hayden , Graham Davis , Sergey Gershtein
IPC分类号： B01L3/00 , G01N27/447 , G01N33/543 , G01N27/327
摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. Additional analyte detection devices configured to operate an analyte detection chip to prepare a test sample and to detect an analyte related signal from the prepared test sample in the analyte detection chip are disclosed. The analyte detection chip may include a digital microfluidics (DMF) region and an analyte detection region which may overlap or may be spatially separated. The analyte detection device may be configured for detection of analyte by an optical or electrochemical means operably connected with an analyte detection chip inserted into the device.

147. 发明授权

US11365453B2 Cell-free nucleic acids for the analysis of the human microbiome associated with respiratory infection 有权
公开(公告)号：US11365453B2
公开(公告)日：2022-06-21
申请号：US17347138
申请日：2021-06-14
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Iwijn de Vlaminck , Michael Kertesz , Kiran Kaur Khush , Mark Alec Kowarsky , Lance Martin , Stephen R. Quake , Hannah Valantine
IPC分类号： C12Q1/70 , G16B30/00 , C12Q1/6883 , G16B20/00 , G16B30/10 , G16B20/20 , C12Q1/689 , C12Q1/6895
摘要： Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with an therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like.

148. 发明授权

US11365440B2 Method for processing rolling circle amplification products 有权
公开(公告)号：US11365440B2
公开(公告)日：2022-06-21
申请号：US16987283
申请日：2020-08-06
申请人： Vanadis Diagnostics
发明人： Mathias Howell , Ove Öhman , Fredrik Persson , Linus Olausson
IPC分类号： C12Q1/68 , C12Q1/682 , C12Q1/6851 , B01J13/04 , C08L83/04 , G01N33/58
摘要： This disclosure provides, among other things, a method for processing a membrane comprising rolling circle amplification (RCA) products. In some embodiments, this method may comprise: (a) obtaining a porous capillary membrane that comprises fluorescently labeled RCA products that are in or on the membrane; (b) depositing a curable polymer onto the membrane; and (c) curing the curable polymer to encapsulate the RCA products in a solid. In some embodiments, the curable polymer may be a silicone and may be transparent in its solid form. A kit for performing the method and a composition made by the method are also provided.

149. 发明授权

US11360093B2 Colorectal cancer diagnostic composition, and method for detecting diagnostic marker 有权
公开(公告)号：US11360093B2
公开(公告)日：2022-06-14
申请号：US16111087
申请日：2018-08-23
申请人： MEDICINAL BIOCONVERGENCE RESEARCH CENTER
发明人： Sunghoon Kim , Min Chul Park , Peter Charles Goughnour
IPC分类号： G01N31/00 , G01N33/53 , G01N33/574 , C12Q1/68 , C12Q1/6886
摘要： The present invention relates to a colorectal cancer diagnostic composition and method for detecting a diagnostic marker, more specifically to a colorectal cancer diagnostic composition comprising one or more mRNAs selected from the group consisting of lysyl-tRNA synthetase (KRS) and aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) of a preparation for measuring protein expression levels thereof, and a method for detecting a marker form a sample obtained from a test subject in order to provide information necessary for diagnosing colorectal cancer. The colorectal cancer diagnostic marker comprising KRS and AIMP1, according to the present invention, has raised expression levels of same in the serum of a colorectal cancer patient in comparison to a normal control group. Therefore, whether colorectal cancer is present can be accurately and rapidly determined by measuring the expression levels of one or more markers selected from the group consisting of KRS and AIMP1.

150. 发明授权

US11356074B2 Impedance matching device and impedance matching method 有权
公开(公告)号：US11356074B2
公开(公告)日：2022-06-07
申请号：US17328121
申请日：2021-05-24
申请人： DAIHEN Corporation
发明人： Tatsuya Morii
IPC分类号： H03H7/38 , H01J37/32
摘要： An impedance matching device comprises a variable capacitor including multiple capacitance elements and connected in parallel having capacitors and each having one end connected in series to a high-frequency power source and semiconductor switches and connected to the respective capacitors, and a control unit. The control unit derives a reflection coefficient based on the obtained information concerning an impedance viewed from the high-frequency power source toward the load side, updates the states of the respective semiconductor switches and included in the multiple capacitance elements and with a first cycle in the case where the reflection coefficient is equal to or more than a predetermined value, and updates the states of the respective semiconductor switches and included in the plurality of capacitance elements and with a second cycle longer than the first cycle in the case where the reflection coefficient is less than the predetermined value.

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