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121. 发明申请

US20140234220A1 METHOD AND COMPOSITION FOR DISPERSIONS OF GOLD NANOPARTICLES 审中-公开
标题翻译：黄金纳米粒子分布的方法和组成
公开(公告)号：US20140234220A1
公开(公告)日：2014-08-21
申请号：US14183229
申请日：2014-02-18
申请人： Dan V. Goia , John I. Njagi , Calin V. Pop
发明人： Dan V. Goia , John I. Njagi , Calin V. Pop
IPC分类号： A61K41/00 , A61K47/48
CPC分类号： A61K47/6923
摘要： The present disclosure relates to a method for making a gold nanoparticle dispersion. The method includes providing a first solution that has gold ions in a liquid medium, adding NTA molecules to the first solution to form a gold nanoparticle dispersion. When the NTA molecules are added to the first solution, the NTA molecules act as a reducing agent to reduce the gold ions to gold atoms, after which the gold atoms nucleate to form gold nanoparticles. The excess NTA molecules then attach to the surface of the gold nanoparticles to stabilize the dispersion. The present disclosure also relates to a dispersion composition that includes a liquid medium, gold nanoparticles dispersed throughout the liquid medium, and NTA molecules directly coating the gold nanoparticles.
摘要翻译：本公开涉及一种制备金纳米颗粒分散体的方法。该方法包括提供在液体介质中具有金离子的第一溶液，将NTA分子加入到第一溶液中以形成金纳米颗粒分散体。当NTA分子被添加到第一溶液中时，NTA分子用作还原剂以将金离子还原成金原子，之后金原子成核形成金纳米颗粒。然后过量的NTA分子附着到金纳米颗粒的表面以稳定分散体。本公开还涉及包含液体介质，分散在整个液体介质中的金纳米颗粒和直接涂覆金纳米颗粒的NTA分子的分散体组合物。

122. 发明授权

US08790934B2 Nanoparticles 有权
标题翻译：纳米颗粒
公开(公告)号：US08790934B2
公开(公告)日：2014-07-29
申请号：US13306924
申请日：2011-11-29
申请人： Soledad Penades , Javier Rojo , Manuel Martin-Lomas
发明人： Soledad Penades , Javier Rojo , Manuel Martin-Lomas
IPC分类号： G01N33/551 , G01N33/552 , G01N33/553 , G01N33/543
CPC分类号： G01N33/54346 , A61K9/5115 , A61K47/6923 , B82Y5/00 , B82Y10/00 , B82Y15/00 , G01N33/588 , G01N33/80 , Y10T436/24
摘要： Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.
摘要翻译：描述了研究和调节含碳水化合物的部分与其他物质的相互作用的材料和方法，特别是小颗粒，例如，金属或半导体原子的簇，其可以用作固定包含碳水化合物基团的多个配体的底物。然后可以使用这些“纳米颗粒”来研究碳水化合物介导的相互作用。与其他碳水化合物或蛋白质，以及作为治疗和诊断试剂。

123. 发明授权

US08785202B2 Colloidal metal compositions and methods 有权
标题翻译：胶体金属组成和方法
公开(公告)号：US08785202B2
公开(公告)日：2014-07-22
申请号：US12708326
申请日：2010-02-18
申请人： Lawrence Tamarkin , Giulio F. Paciotti
发明人： Lawrence Tamarkin , Giulio F. Paciotti
IPC分类号： A01N55/02 , A61K31/28 , A61K33/24 , G01N33/48 , G01N33/53
CPC分类号： C07K14/525 , A61K38/191 , A61K38/39 , A61K39/39 , A61K47/60 , A61K47/6923 , A61K49/0013 , A61K49/0017 , A61K49/0056 , A61K49/0065 , A61K51/1244 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , C07K16/241
摘要： The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.
摘要翻译：本发明包括用于药物递送系统的组合物和方法，包括治疗化合物，药剂，药物，检测剂，核酸序列和生物因子。通常，这些载体组合物包含胶态金属，衍生化PEG（聚乙二醇）和试剂。本发明还包括制备这种胶体金属组合物和治疗癌症的方法和组合物。

124. 发明申请

US20140199340A1 TOLEROGENIC SYNTHETIC NANOCARRIERS FOR INDUCING REGULATORY B CELLS 有权
标题翻译：用于诱导调节性B细胞的富集合成纳米颗粒
公开(公告)号：US20140199340A1
公开(公告)日：2014-07-17
申请号：US14161660
申请日：2014-01-22
申请人： Selecta Biosciences, Inc.
发明人： Roberto A. Maldonado
IPC分类号： A61K39/00
CPC分类号： A61K39/385 , A61K9/127 , A61K9/14 , A61K9/51 , A61K9/5115 , A61K9/5146 , A61K9/5153 , A61K31/192 , A61K38/13 , A61K38/1816 , A61K38/38 , A61K39/00 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/36 , A61K47/50 , A61K47/52 , A61K47/544 , A61K47/593 , A61K47/643 , A61K47/69 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K2039/5154 , A61K2039/55511 , A61K2039/55555 , A61K2039/577 , B82Y5/00 , B82Y40/00 , G01N33/505 , G01N33/56972 , G01N2333/7051 , G01N2333/70514 , G01N2333/70517 , Y02A50/401 , Y02A50/41 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory B cells.
摘要翻译：公开了合成纳米载体方法和相关组合物，其包含B细胞和/或MHC II类限制性表位和免疫抑制剂，以产生耐受性免疫应答，例如产生抗原特异性调节性B细胞。

125. 发明申请

US20140170201A1 UNIFORM FIELD MAGNETIZATION AND TARGETING OF THERAPEUTIC FORMULATIONS 审中-公开
标题翻译：治疗方案的统一现场磁化和目标
公开(公告)号：US20140170201A1
公开(公告)日：2014-06-19
申请号：US14041646
申请日：2013-09-30
申请人： Drexel University , The Children's Hospital of Philadelphia
发明人： Robert J. Levy , Boris Polyak , Michael Chorny , Ilia Fishbein , Ivan Alferiev , Gennady Friedman , Darryl Williams
IPC分类号： A61K41/00 , A61K35/44 , A61K35/76 , A61K31/713 , A61K31/337 , A61K31/203
CPC分类号： A61K41/00 , A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K31/203 , A61K31/337 , A61K31/713 , A61K35/44 , A61K35/761 , A61K47/42 , A61K47/59 , A61K47/6455 , A61K47/6923 , A61K47/6929 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343 , C12N2710/10345
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.
摘要翻译：提供了用于治疗颗粒的磁性靶向的系统和方法。治疗性颗粒包含一种或多种磁性或可磁化材料和至少一种治疗剂。使用能够磁化可磁化材料的均匀磁场来特异性地靶向治疗颗粒，并且可以将其靶向到身体中的特定位置，或者可以被靶向用于捕获，容纳和移除。还提供了不使用有机溶剂制备的生物可吸收纳米颗粒，以及用于治疗使用这种生物可再吸收纳米颗粒的方法。

126. 发明授权

US08747903B2 Composition for nucleic acid delivery using metal nanoparticles and preparing method thereof 失效
标题翻译：使用金属纳米颗粒的核酸递送的组合物及其制备方法
公开(公告)号：US08747903B2
公开(公告)日：2014-06-10
申请号：US13430882
申请日：2012-03-27
申请人： Sei Kwang Hahn , Min-Young Lee , Kitae Park , Ki Su Kim , Hwiwon Lee
发明人： Sei Kwang Hahn , Min-Young Lee , Kitae Park , Ki Su Kim , Hwiwon Lee
IPC分类号： A61K9/14 , A61K31/7088 , A61K31/713 , C12N5/071 , A61K31/00 , B82Y5/00 , B82Y40/00
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/5115 , A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/7088 , A61K47/59 , A61K47/61 , A61K47/6923 , B82Y40/00
摘要： The present invention relates to a composition for nucleic acid delivery and a method for preparing the same, more particularly to a composition for nucleic acid delivery having excellent stability in the body environment and excellent intracellular delivery efficiency of nucleic acid, and enabling target directed delivery of nucleic acid, and a method for preparing the same.
摘要翻译：本发明涉及用于核酸递送的组合物及其制备方法，更具体地涉及用于核酸递送的组合物，其在体内环境中具有优异的稳定性和优异的核酸的细胞内递送效率，并且能够实现目标定向递送核酸及其制备方法。

127. 发明申请

US20140154325A1 IN VIVO PHOTODYNAMIC THERAPY OF CANCER VIA A NEAR INFRARED AGENT ENCAPSULATED IN CALCIUM PHOSPHATE NANOPARTICLES 审中-公开
标题翻译：通过磷酸钙纳米颗粒中附近的近红外光学剂进行血液光化学治疗
公开(公告)号：US20140154325A1
公开(公告)日：2014-06-05
申请号：US14175600
申请日：2014-02-07
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： James H. Adair , Mark Kester , Peter C. Eklund , Erhan I. Altinoglu , Brian M. Barth , Timothy J. Russin , James M.D. Kaiser , Thomas T. Morgan
IPC分类号： A61K41/00 , A61K9/51
CPC分类号： A61K41/0057 , A61K9/51 , A61K47/6921 , A61K47/6923
摘要： Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.
摘要翻译：描述了纳米包封的光敏剂及其在治疗肿瘤和/或成像中的用途。优选地，将光敏剂包封在磷酸钙纳米颗粒（CPNP）中。将PS封装在CPNP中增加PS的半衰期，增加PS进入靶细胞组织的吸收，增加PS的光稳定性，增加PS的光效，增加PS的体内保留或组合最终使其成为用于光动力疗法，成像靶组织，血管或肿瘤，和/或检测或定位肿瘤的高效药物。

128. 发明申请

US20140128451A1 Compositions and Methods for Delivery of MicroRNA to Cells 审中-公开
标题翻译：将微RNA转运至细胞的组合物和方法
公开(公告)号：US20140128451A1
公开(公告)日：2014-05-08
申请号：US14059027
申请日：2013-10-21
申请人： Preethi H Gunaratne , Lalithya C Singh , Matthew L Anderson
发明人： Preethi H Gunaratne , Lalithya C Singh , Matthew L Anderson
IPC分类号： A61K31/7105 , A61K47/48
CPC分类号： A61K31/7105 , A61K31/282 , A61K31/519 , A61K33/00 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C12N15/111 , C12N2310/141 , C12N2320/32 , Y02A50/395 , A61K2300/00
摘要： Provided herein are gold nanoparticles mediated non-viral delivery of miRNAs, siRNAs, genes and drugs. Nanoparticle platforms and combinatorial drug delivery vehicles comprises gold nanoparticles with a plurality of thilolated hyperbranched dendrons conjugated to the nanoparticle surface. The thiolated hyperbranched dendrons comprise chemically-modifiable surface groups, functionalized interior groups and nano-cavities within the hyperbranched structure to which a variety of payload molecules may be conjugated, optionally via a linker. Payload molecules may comprise nucleic acids, anticancer drugs and small molecule inhibitors, optionally with, non-cytotoxic signaling agents, for example, fluoroscein isothiocyanate. Successful manipulation of the degree of PEGylation and the amount of gold nanoparticles in a polyelectrolyte complex to evaluate the best formulation for highest payload delivery of chemically unmodified miRNA duplexes and stemloops is presented. Also provided are methods for delivering one or more therapeutic agents to a cell or tissue or for treating a pathophysiological condition in a subject by delivering the combinatorial drug delivery vehicles to a cell or tissue associated with the pathophysiological condition to facilitate internalization of the vehicle to effect treatment.
摘要翻译：本文提供金纳米颗粒介导的miRNA，siRNA，基因和药物的非病毒递送。纳米颗粒平台和组合药物递送载体包含金纳米颗粒，其具有与纳米颗粒表面缀合的多个噻唑化的超分支树突。硫醇化的超支化树突包含可超过分支结构的化学修饰的表面基团，官能化的内部基团和纳米空穴，可任选地通过连接体将各种有效载荷分子缀合到其上。有效载荷分子可以包含核酸，抗癌药物和小分子抑制剂，任选地含有非细胞毒性信号传导剂，例如异硫氰酸荧光素。提出了聚乙二醇化程度的成功操作和聚电解质复合物中金纳米颗粒的量，以评估化学未修饰的miRNA双链体和茎突的最高有效载荷的最佳配方。还提供了将一种或多种治疗剂递送至细胞或组织或通过将组合药物递送载体递送至与病理生理条件相关联的细胞或组织来治疗受试者的病理生理状况的方法，以促进载体的内化治疗。

129. 发明申请

US20140107738A1 MAGNETIC PARTICLES 审中-公开
标题翻译：磁性颗粒
公开(公告)号：US20140107738A1
公开(公告)日：2014-04-17
申请号：US14044113
申请日：2013-10-02
申请人： Midatech Limited , Consejo Superior De Investigacione Cientificas
发明人： Soledad Penades , Manual Martin-Lomas , Jesus Martines de la Fuente , Thomas William Rademacher
IPC分类号： A61K47/48 , A61K49/18 , A61K41/00
CPC分类号： A61K47/6923 , A61K9/5094 , A61K47/6929 , A61K49/1845 , A61K49/1881 , B82Y5/00 , Y10T428/2991
摘要： Materials and methods for making small magnetic particles, e.g., clusters of metal atoms, which can be employed as a substrate for immobilizing a plurality of ligands. Also disclosed are uses of these magnetic nanoparticles as therapeutic and diagnostic reagents, and in the study of ligand-mediated interactions.
摘要翻译：用于制造小磁性颗粒的材料和方法，例如金属原子簇，其可以用作固定多个配体的底物。还公开了这些磁性纳米颗粒作为治疗和诊断试剂以及在配体介导的相互作用的研究中的用途。

130. 发明申请

US20140050671A1 THERANOSTIC NANOPARTICLE AND METHODS FOR MAKING AND USING THE NANOPARTICLE 有权
标题翻译：用于制备和使用纳米颗粒的神经酰胺纳米微粒和方法
公开(公告)号：US20140050671A1
公开(公告)日：2014-02-20
申请号：US13969362
申请日：2013-08-16
申请人： University of Washington through its Center for Commercialization
发明人： Miqin Zhang , Chen Fang
IPC分类号： A61K49/18 , A61K49/00 , A61K9/51
CPC分类号： A61K49/1857 , A61K47/6923 , A61K47/6935
摘要： Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided.
摘要翻译：具有聚（β-氨基酯）涂层的纳米粒子。聚（β-氨基酯）涂层包括可由颗粒递送的一种或多种治疗剂和将聚合物偶联到纳米颗粒的核心表面的一个或多个锚定基团。在某些实施方案中，聚（β-氨基酯）包括一个或多个聚环氧烷基团。聚（β-氨基酯）可以进一步包括将纳米颗粒靶向目标位点的靶向剂和允许颗粒成像的诊断剂。还提供了制备和使用纳米颗粒的方法。

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