会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 130. 发明授权
    • Lipid peptide and hydrogel
    • 脂质肽和水凝胶
    • US08916682B2
    • 2014-12-23
    • US12452473
    • 2008-07-04
    • Nobuhide MiyachiTakehisa IwamaMasahiro GotohTatsuo MaruyamaDaisuke Koda
    • Nobuhide MiyachiTakehisa IwamaMasahiro GotohTatsuo MaruyamaDaisuke Koda
    • A61K38/04C07K14/50C07K5/107C07K7/06C07K5/103C07K5/11C07K5/117
    • C07K7/06C07K5/1008C07K5/101C07K5/1016C07K5/1019C07K5/1024
    • There is provided a lipid peptide that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A lipid peptide represented by Formula (1): (where R1 represents an aliphatic group having 9 to 23 carbon atoms; R2, R3, R4 and R5 independently represent a hydrogen atom, an alkyl group having 1 to 7 carbon atom(s) which optionally has a branched chain having 1 to 3 carbon atom(s), a phenylmethyl group, a phenylethyl group or a —(CH2)n—X group, and at least one of R2, R3, R4 and R5 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents an amino group, a guanidine group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which optionally have 1 to 3 nitrogen atom(s); and in represents 1 or 2), and a hydrogel comprising the lipid peptide.
    • 提供了能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶的脂质肽,以及具有高环境适应性,生物相容性和生物降解性的水凝胶。 由式(1)表示的脂质肽:其中,R1表示碳原子数9〜23的脂肪族基; R2,R3,R4,R5分别表示氢原子,碳原子数1〜7的烷基, 任选具有1至3个碳原子的支链,苯基甲基,苯基乙基或 - (CH 2)n -X基团,并且R 2,R 3,R 4和R 5中的至少一个表示 - (CH 2 )n-X基; n表示1〜4的数; X表示氨基,胍基,-CONH 2基或5元环,6元环或稠合杂环,由5 含有1〜3个氮原子的6元环,代表1或2)和包含脂质肽的水凝胶。