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121. 发明申请

US20140080141A1 CLEAR MARGIN DETERMINATION DURING CANCER SURGERY 有权
标题翻译：癌症手术期间清除肿瘤的确定
公开(公告)号：US20140080141A1
公开(公告)日：2014-03-20
申请号：US14119996
申请日：2012-05-25
申请人： PHILADELPHIA HEALTH & EDUCATION CORPORATION , DREXEL UNIVERSITY
发明人： Wei-Heng Shih , Wan Y. Shih , Giang Au , Ari D. Brooks , Vanlila K. Swami
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C07K16/22 , C07K16/30 , G01N33/532 , G01N33/533 , G01N33/574 , G01N33/57484 , G01N33/57492 , G01N33/588 , G01N2333/475 , G01N2333/705 , G01N2400/00 , G01N2458/00 , Y10S977/774 , Y10S977/824 , Y10S977/892 , Y10S977/927
摘要： One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an enhanced detection sensitivity and selectivity and may be formed using a novel and efficient method for conjugating one or more biomarker specific moieties to the quantum dots. The invention is further directed to a method for using the conjugated quantum dots for cancer detection in the margin of excised tissue.
摘要翻译：与一个或多个生物标志物特异性部分缀合的一种或多种水性近红外发射的高产率高度光致发光的稳定的量子点。共轭量子点具有增强的检测灵敏度和选择性，并且可以使用用于将一个或多个生物标记特异性部分缀合到量子点的新颖且有效的方法形成。本发明还涉及一种在切除组织边缘使用共轭量子点进行癌症检测的方法。

122. 发明申请

US20140051989A1 DEVICES ADAPTED FOR ULTRASOUND LOCATION IN PATIENTS AND METHOD OF USE 审中-公开
标题翻译：适用于患者超声位置的装置和使用方法
公开(公告)号：US20140051989A1
公开(公告)日：2014-02-20
申请号：US14008967
申请日：2012-04-19
申请人： Jane E. McGowan , Peter A. Lewin , Christopher Bawiec , Youhan Sunny
发明人： Jane E. McGowan , Peter A. Lewin , Christopher Bawiec , Youhan Sunny
IPC分类号： A61B5/06 , A61M25/00 , A61N5/10 , A61M39/00 , A61B8/00 , A61M16/04
CPC分类号： A61B5/061 , A61B8/00 , A61B8/08 , A61B8/481 , A61M16/04 , A61M16/0488 , A61M25/00 , A61M25/0108 , A61M39/00 , A61M2205/3375 , A61M2240/00 , A61N5/1001
摘要： The present invention relates to devices including a plurality of voids that enhance visualization of the devices in a patient using ultrasound imaging. The sizes of the voids can vary to accommodate ultrasound devices having different ultrasound wave frequencies. The present invention is also directed to a method for using ultrasound imaging technology to detect the location of devices comprising a plurality of voids in a patient. An ultrasound device, such as a wireless, portable ultrasound device, may be used to propagate ultrasound waves towards the patient where the device is inserted. An ultrasound imaging device may then be used to generate an image of the device or a portion thereof from which the location of the device in the patient can be determined.
摘要翻译：本发明涉及包括多个空隙的装置，其利用超声成像增强患者的装置的可视化。空隙的尺寸可以变化以适应具有不同超声波频率的超声装置。本发明还涉及一种使用超声成像技术来检测患者中包括多个空隙的装置的位置的方法。诸如无线便携式超声波装置之类的超声波装置可用于向装置插入的患者传播超声波。然后可以使用超声成像装置来产生装置的图像或其部分，从而可以确定装置在患者体内的位置。

123. 发明授权

US08603403B2 Cyclonic reactor with non-equilibrium gliding discharge and plasma process for reforming of solid hydrocarbons 有权
标题翻译：具有非平衡滑行排放的旋风反应器和固体烃重整的等离子体方法
公开(公告)号：US08603403B2
公开(公告)日：2013-12-10
申请号：US13599198
申请日：2012-08-30
申请人： Alexander F. Gutsol , Alexander Fridman , Anatoliy Polevich , Michael J. Gallagher
发明人： Alexander F. Gutsol , Alexander Fridman , Anatoliy Polevich , Michael J. Gallagher
IPC分类号： B01J19/08
CPC分类号： C01B3/26 , C10J3/18 , C10J3/487 , C10J2300/0916 , C10J2300/092 , C10J2300/093 , C10J2300/0956 , C10J2300/0959 , C10J2300/0973 , C10J2300/1238 , Y02P20/145
摘要： A reactor for reforming a hydrocarbon, and associated processes and systems, are described herein. In one example, a reactor is provided that is configured to use non-equilibrium gliding arc discharge plasma. In another example, the reactor uses a vortex flow pattern. Two stages of reforming are described. In a first stage, the hydrocarbon absorbs heat from the wall of the reactor and combusts to form carbon dioxide, carbon monoxide, and water. In a second stage, a gliding arc discharge is use to form syngas, which is a mixture of hydrogen gas and carbon monoxide. The heat generated by the combustion of the first stage transfers to the wall of the reactor and heated products of the second stage mix with incoming hydrocarbon to provide for partial recuperation of the reaction energy.
摘要翻译：本文描述了用于重整碳氢化合物的反应器以及相关联的方法和系统。在一个示例中，提供了构造成使用非平衡滑动电弧放电等离子体的反应器。在另一个实例中，反应器使用涡流模式。描述了两个阶段的改造。在第一阶段，烃从反应器壁吸收热量并燃烧形成二氧化碳，一氧化碳和水。在第二阶段中，使用滑动电弧放电来形成合成气，其是氢气和一氧化碳的混合物。由第一阶段的燃烧产生的热量转移到反应器的壁和第二阶段的加热产物与进入的烃混合以提供反应能量的部分回收。

124. 发明授权

US08562505B2 Uniform field magnetization and targeting of therapeutic formulations 有权
公开(公告)号：US08562505B2
公开(公告)日：2013-10-22
申请号：US12150864
申请日：2008-05-01
申请人： Robert J. Levy , Boris Polyak , Michael Chorny , Ivan Alferiev , Gennady Friedman , Darryl Williams , Ilia Fishbein
发明人： Robert J. Levy , Boris Polyak , Michael Chorny , Ivan Alferiev , Gennady Friedman , Darryl Williams , Ilia Fishbein
IPC分类号： A61N2/10
CPC分类号： A61K41/00 , A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K31/203 , A61K31/337 , A61K31/713 , A61K35/44 , A61K35/761 , A61K47/42 , A61K47/59 , A61K47/6455 , A61K47/6923 , A61K47/6929 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343 , C12N2710/10345
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.

125. 发明授权

US08534176B2 Method and apparatus for braiding micro strands 有权
标题翻译：用于编织微链的方法和装置
公开(公告)号：US08534176B2
公开(公告)日：2013-09-17
申请号：US13129925
申请日：2009-11-19
申请人： Simon Giszter , Tae Gyo Kim , Arun Ramakrishnan
发明人： Simon Giszter , Tae Gyo Kim , Arun Ramakrishnan
IPC分类号： D04C3/14
CPC分类号： D04C3/42
摘要： A method and apparatus for fabricating microbraided structures is provided. A microbraiding device includes first and second carrier members that are movable with respect to each other. Each carrier includes a plurality of shelters. Spool-less strands of microfiber are retained in shuttles that are movable between the first and second shelters under magnetic forces. The microbraid structure is fabricated as the shuttles move between the first shelters, and as the first carrier member moves relative to the second carrier member.
摘要翻译：提供了一种用于制造微阵列结构的方法和装置。微型装置包括可相对于彼此移动的第一和第二承载构件。每个载体包括多个收容所。无纺布的超细纤维束被保留在可在磁力下在第一和第二收容所之间移动的梭子中。随着梭子在第一遮蔽物之间移动，并且当第一承载构件相对于第二承载构件移动时，制作微框架结构。

126. 发明申请

US20130225953A1 CONCURRENT STIMULATION EFFECT DETECTION 审中-公开
标题翻译：电流刺激效应检测
公开(公告)号：US20130225953A1
公开(公告)日：2013-08-29
申请号：US13581122
申请日：2011-02-25
申请人： Antonio Oliviero , Guglielmo Foffani , Ivan Panyavin , Laura Mordillo-Mateos , Juan De Los Reyes Aguilar Lepe , Anna Merzagora , Kambiz Pourrezaei , Mauricio Rodriguez
发明人： Antonio Oliviero , Guglielmo Foffani , Ivan Panyavin , Laura Mordillo-Mateos , Juan De Los Reyes Aguilar Lepe , Anna Merzagora , Kambiz Pourrezaei , Mauricio Rodriguez
IPC分类号： A61B5/00
CPC分类号： A61B5/4848 , A61B5/0075 , A61B5/14551 , A61B5/4064 , A61B5/7214 , A61M21/00 , A61M2021/0072 , A61M2205/502 , A61M2205/52 , A61M2205/8206 , A61M2230/10 , A61N1/0408 , A61N1/0456 , A61N1/0492 , A61N1/20 , A61N1/36021 , A61N1/36025
摘要： Functional near infrared spectroscopy (fNIRS) imaging is utilized to measure the influence of stimulation in real time. An fNIRS imaging device is integrated into a transcranial direct current stimulation (tDCS) stimulator by embedding fNIRS optodes on the tDCS stimulating electrodes. During tDCS stimulation, blood oxygenation levels are measured. For example, concentrations of oxyhemoglobin and deoxyhemoglobin are measured and compared to the concentrations of a baseline resting state to provide feedback on the efficacy of tDCS. Based on the feedback, a tDCS threshold and a dose-response relation for a particular subject can be quantified, and individualized stimulation parameters can be determined for the particular subject.
摘要翻译：功能近红外光谱（fNIRS）成像用于实时测量刺激的影响。通过在tDCS刺激电极上嵌入fNIRS optodes，将fNIRS成像装置集成到经颅直流刺激（tDCS）刺激器中。在tDCS刺激期间，测量血氧饱和度。例如，测量氧合血红蛋白和脱氧血红蛋白的浓度，并将其与基线静息状态的浓度进行比较，以提供关于tDCS功效的反馈。基于反馈，可以量化特定受试者的tDCS阈值和剂量 - 反应关系，并且可以针对特定受试者确定个体化刺激参数。

127. 发明申请

US20130219362A1 DESIGN RULE HIERARCHY, TASK PARALLELISM, AND DEPENDENCY ANALYSIS IN LOGICAL DECISION MODELS 审中-公开
标题翻译：逻辑决策模型中的设计规则分析，任务并行列表和依赖性分析
公开(公告)号：US20130219362A1
公开(公告)日：2013-08-22
申请号：US13819136
申请日：2011-08-30
申请人： Yuanfang Cai , Sunny Wong
发明人： Yuanfang Cai , Sunny Wong
IPC分类号： G06F9/44
CPC分类号： G06F8/74 , G06N5/00
摘要： A binary augmented constraint network (BACN) allows dependency relationships to be determined without solving constraints. BACN models design decisions as first-class members and expresses how decisions make assumptions upon each other using logical constraints. Pairwise dependency relations (PWDRs) are determined based on the BACN. A design rule hierarchy (DRH) based on assumption relations among design decisions identifies parallelizable tasks within software design. Modules within the same layer of the hierarchy suggest concurrent tasks. Dependencies between layers or within a module suggest possible need for communication. In one configuration, decisions within the top layer of the hierarchy are the most influential design rules, which dominate the rest of the system, and are kept stable. The decisions within subsequent layers assume design decisions in previous layers. The design decisions within each layer are clustered into modules. Modules within the same layer are independent from each other and are candidates for concurrent implementation.
摘要翻译：二进制增强约束网络（BACN）允许在不解决约束的情况下确定依赖关系。 BACN将设计决策设计为一流成员，并表达决策如何利用逻辑约束相互作出假设。成对依赖关系（PWDR）是基于BACN确定的。基于设计决策之间的假设关系的设计规则层次（DRH）可以确定软件设计中的并行化任务。同一层次中的模块建议并发任务。层之间或模块内的依赖关系表明可能需要通信。在一个配置中，层次结构顶层内的决策是最有影响力的设计规则，其主导系统的其余部分，并保持稳定。后续层中的决策假定在以前的层中进行设计决策。每层内的设计决策都集中在模块中。同一层内的模块彼此独立，是并发执行的候选者。

128. 发明授权

US08512947B2 Detection of nucleic acids using a cantilever sensor 有权
公开(公告)号：US08512947B2
公开(公告)日：2013-08-20
申请号：US12141846
申请日：2008-06-18
申请人： Rajakkannu Mutharasan , Kishan Rijal , David R. Maraldo , Gossett Augustus Campbell
发明人： Rajakkannu Mutharasan , Kishan Rijal , David R. Maraldo , Gossett Augustus Campbell
IPC分类号： C12Q1/68 , C12M1/36 , G01N27/00
CPC分类号： C12Q1/6825 , G01N33/54373 , G01N2291/0427
摘要： Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe material is known to bind to the target nucleic acid. The prepared sensor is exposed to the target nucleic acid. The target nucleic acid binds to the probe material. The mass accumulated on the sensor reflects the amount of target nucleic acid bound to the probe material.

129. 发明授权

US08500668B2 Orthosis and method of use for treatment and rehabilitation of dropfoot 有权
标题翻译：矫形术及其用于治疗和康复的方法
公开(公告)号：US08500668B2
公开(公告)日：2013-08-06
申请号：US12305878
申请日：2007-06-29
申请人： Sorin Siegler , Brett W. Hraban , Elizabeth La Montagne , Joshua Meles , Wei Sun
发明人： Sorin Siegler , Brett W. Hraban , Elizabeth La Montagne , Joshua Meles , Wei Sun
IPC分类号： A61F5/00 , A61F5/37 , A61F2/68
CPC分类号： A61F5/0127 , A61B5/1036 , A61B5/4519 , A61B5/4528 , A61H3/00 , A61N1/36003
摘要： A functional electrical stimulation brace responsive to various positions of an intended wearer's foot. The device includes a plurality of sensors positioned at different locations under the intended wearer's foot to detect the current position of the foot. Outputs from the sensors are fed to a controller that uses logic to activate an electrical stimulation unit that stimulates the peroneal muscles of a patient at the appropriate times during the patient's gait. The device may also employ mechanical stabilization of the ankle in addition to the functional electrical stimulation by means of an ankle foot orthosis with a variable resistance hinge. The electrodes are embedded in fixed locations in the brace upper portion so that optimal location of the electrodes relative to the peroneal muscles is maintained every time the device is applied. Also provided is a method for assistance and rehabilitation for a patient by electrical stimulation of the peroneal muscles. In the method, the position of the foot is detected and the peroneal muscles are stimulated responsive to particular positions of the patient's foot in order to activate the muscles at the appropriate times during the patient's gait. The device also provides lateral and torsional stability by means of the ankle-foot orthosis.
摘要翻译：一种功能性电刺激支架，其响应于预期佩戴者的脚的各种位置。该装置包括位于目标佩戴者脚下的不同位置处的多个传感器，以检测脚的当前位置。来自传感器的输出被馈送到控制器，该控制器使用逻辑来激活在患者的步态中适当的时间刺激患者的腓骨肌肉的电刺激单元。除了通过具有可变电阻铰链的踝足矫形器的功能性电刺激之外，该装置还可以采用脚踝的机械稳定。电极被嵌入在支架上部中的固定位置，使得每次施加装置时都保持电极相对于腓骨肌肉的最佳位置。还提供了一种通过电刺激腓骨肌肉来为患者进行辅助和康复的方法。在该方法中，检测脚的位置，并响应于患者脚的特定位置刺激腓骨肌肉，以便在患者的步态中适当的时间激活肌肉。该装置还通过踝足矫形器提供横向和扭转稳定性。

130. 发明授权

US08498097B2 Supercapacitor compositions, devices and related methods 有权
标题翻译：超级电容器组成，器件及相关方法
公开(公告)号：US08498097B2
公开(公告)日：2013-07-30
申请号：US12864774
申请日：2009-01-30
申请人： Yury Gogotsi , Patrice Simon , Celine Largeot , Cristelle Portet , John Chmiola , Pierre-Louis Taberna
发明人： Yury Gogotsi , Patrice Simon , Celine Largeot , Cristelle Portet , John Chmiola , Pierre-Louis Taberna
IPC分类号： H01G9/00 , H01G9/02
CPC分类号： H01G11/24 , H01G11/38 , Y02E60/13 , Y10T29/417
摘要： Disclosed are supercapacitor materials comprising compositions having pores that are optimally sized to maximize capacitance. Also disclosed are related methods for fabricating such supercapacitors.
摘要翻译：公开了超级电容器材料，其包含具有最佳尺寸以使电容最大化的孔的组合物。还公开了用于制造这种超级电容器的相关方法。

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