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121. 发明申请

US20150166991A1 METHODS FOR TREATING MDS1-EVI1 MEDIATED CANCER 审中-公开
标题翻译：用于治疗MDS1-EVI1介导的癌症的方法
公开(公告)号：US20150166991A1
公开(公告)日：2015-06-18
申请号：US14411839
申请日：2013-07-01
申请人： Archibald S. Perkins , Yi Zhang
发明人： Archibald S. Perkins , Yi Zhang
IPC分类号： C12N15/113 , C12N15/11 , A61K45/06 , C07K16/18 , A61K39/395 , A61K31/713
CPC分类号： C12N15/113 , A01K67/0276 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , A01K2267/0381 , A61K31/713 , A61K39/39558 , A61K45/06 , C07K14/4702 , C07K14/82 , C07K16/18 , C12N15/11 , C12N2310/14
摘要： The present invention relates to a method of treating a cancerous condition mediated by the protein MDS1-EVI1 (ME). The method includes administering to a patient an amount of an inhibitor of ME protein activity that is effective to cause cell death of cancer cells that are ME-dependent, thereby treating the cancerous condition. The present invention further relates to a method of causing cell death of a cancer cell that requires MDS1-EVI1 (ME) for survival. The method includes introducing an inhibitor of ME activity into a cancer cell that requires ME for survival, whereby said introducing is effective to cause cancer cell death. Novel agents that can inhibit the activity of ME in vitro or in vivo are also disclosed.
摘要翻译：本发明涉及一种治疗由MDS1-EVI1（ME）蛋白介导的癌症的方法。该方法包括向患者施用一定量的有效引起ME依赖性的癌细胞的细胞死亡的ME蛋白活性抑制剂，从而治疗癌症状况。本发明还涉及使MDS1-EVI1（ME）存活的癌细胞的细胞死亡的方法。该方法包括将ME活性抑制剂引入需要ME用于存活的癌细胞中，由此所述引入有效引起癌细胞死亡。还公开了可以在体外或体内抑制ME的活性的新型药剂。

122. 发明授权

US09057054B2 Antigen-specific long-term memory T-cells 有权
标题翻译：抗原特异性长期记忆T细胞
公开(公告)号：US09057054B2
公开(公告)日：2015-06-16
申请号：US13379075
申请日：2010-06-22
申请人： Yi Zhang
发明人： Yi Zhang
IPC分类号： C12N5/0783 , A61K31/436 , A61K38/20 , A61K45/06 , A61K35/12 , A61K39/00
CPC分类号： C12N5/0636 , A61K31/436 , A61K35/12 , A61K35/17 , A61K38/2013 , A61K38/2086 , A61K45/06 , A61K2039/5158 , A61K2039/57 , C12N2501/04 , A61K2300/00
摘要： The present invention provides compositions, methods, and systems for generating antigen-specific long-term memory T-cells using mTOR pathway inhibitors. The present invention provides compositions, systems, and methods for administering antigen-specific long-term memory T-cells to a subject (e.g., to a subject with cancer in adoptive transfer type of procedures).
摘要翻译：本发明提供了使用mTOR途径抑制剂产生抗原特异性长期记忆性T细胞的组合物，方法和系统。本发明提供了用于向受试者（例如，针对具有过继转移类型的癌症的受试者）给予抗原特异性长期记忆性T细胞的组合物，系统和方法。

123. 发明授权

US09026781B2 System and method for data transmission 有权
标题翻译：数据传输的系统和方法
公开(公告)号：US09026781B2
公开(公告)日：2015-05-05
申请号：US12735247
申请日：2008-12-29
申请人： Yong Liang Liu , Guang Hua Zhou , Yi Zhang
发明人： Yong Liang Liu , Guang Hua Zhou , Yi Zhang
IPC分类号： H04L29/06 , H04L9/08
CPC分类号： H04L9/0827 , H04L2209/60
摘要： A method for transmission data in a system is provided. The system includes a first device, plurality of second devices, and plurality of third devices, the method includes steps of encrypting the data with a first key and encrypting the first key with a second key at the first device, sending the encrypted data from the first device to the second device, decrypting the second key and encrypting the first key with a third key by the second device, sending the encrypted data from the second device to the third device, and decrypting the third key and the first key by the third device.
摘要翻译：提供了一种用于系统中的传输数据的方法。该系统包括第一设备，多个第二设备和多个第三设备，该方法包括以下步骤：利用第一密钥对数据进行加密，并在第一设备处以第二密钥加密第一密钥，从第一设备发送加密数据第一设备到第二设备，用第二设备解密第二密钥并用第三密钥加密第一密钥，将加密数据从第二设备发送到第三设备，并且将第三密钥和第一密钥解密为第三设备设备。

124. 发明授权

US08971068B2 Three-phase rectification module, the system thereof and harmonic suppression method 有权
标题翻译：三相整流模块，其系统和谐波抑制方法
公开(公告)号：US08971068B2
公开(公告)日：2015-03-03
申请号：US13466739
申请日：2012-05-08
申请人： Boyu Pu , Jinping Zhou , Yi Zhang , Wei Chen
发明人： Boyu Pu , Jinping Zhou , Yi Zhang , Wei Chen
IPC分类号： H02M1/12 , H02P27/06 , H02M7/219 , H02M7/487
CPC分类号： H02M1/126 , H02M7/487 , H02M2007/2195 , H02P27/06 , Y02B70/1408 , Y02P80/112
摘要： A three-phase rectification module, the system thereof and harmonic suppression method are provided. The module includes an LCL filter unit, a Vienna rectifier coupled to the LCL filter unit, and a rectifier control unit for controlling the power factor of the three-phase AC power source and the DC output voltage of the Vienna rectifier. A commutation diode is serially connected on the bridge-arm of each set of uni-directional rectification branches which are included in the Vienna rectifier, making it function as current uni-directionally. Herein, the power factor of the three-phase AC power source is matched with the parameters of the LCL filter unit, such that the absolute value of the phase difference between the AC input voltage and the current of the Vienna rectifier is close or equal to zero.
摘要翻译：提供三相整流模块及其系统和谐波抑制方法。该模块包括LCL滤波器单元，耦合到LCL滤波器单元的维也纳整流器，以及用于控制三相AC电源的功率因数和维也纳整流器的DC输出电压的整流器控制单元。在维也纳整流器中包含的每组单向整流分支的桥臂上串联连接一个换向二极管，使其单向电流工作。这里，三相AC电源的功率因数与LCL滤波器单元的参数相匹配，使得AC输入电压与维也纳整流器的电流之间的相位差的绝对值接近或等于零。

125. 发明授权

US08696589B2 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US08696589B2
公开(公告)日：2014-04-15
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
发明人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

126. 发明授权

US08660594B2 Method and data card for shielding short message receiving function 有权
标题翻译：屏蔽短信接收功能的方法和数据卡
公开(公告)号：US08660594B2
公开(公告)日：2014-02-25
申请号：US13520804
申请日：2010-09-25
申请人： Yi Zhang , Gang Xue
发明人： Yi Zhang , Gang Xue
IPC分类号： H04W4/00
CPC分类号： H04W8/183 , H04W4/14 , H04W60/00 , H04W92/08
摘要： The disclosure discloses a method for shielding a short message receiving function. The method includes the following steps of: storing parameters related to short-message-receiving-function-shielding in an Element File (EF) in a Subscriber Identity Model (SIM) card; performing inter-verification by utilizing the EF in the SIM-card and a Non Volatile (NV) random access memory in a data card to determine whether the SIM-card is applied to the data card; and when the SIM-card is determined to be applied to the data card, reporting the parameters related to short-message-receiving-function-shielding to a network during the process of attaching mobile terminal to the network. Compared with the conventional art, the technical solution of the disclosure can shield the short message receiving function without generating short message fee, so as to enhance the stability of the data service to a large extent and increase the flexibility for a subscriber in selecting the service type at the terminal.
摘要翻译：本公开公开了一种用于屏蔽短消息接收功能的方法。该方法包括以下步骤：在用户识别模型（SIM）卡中的元素文件（EF）中存储与短消息接收功能屏蔽有关的参数; 通过利用SIM卡中的EF和数据卡中的非易失性（NV）随机存取存储器来执行相互验证，以确定SIM卡是否被应用于数据卡; 并且当SIM卡被确定为应用于数据卡时，在将移动终端附着到网络的过程中向网络报告与短消息接收功能屏蔽有关的参数。与传统技术相比，本发明的技术方案可以屏蔽短消息接收功能而不产生短消息费用，从而在很大程度上提高数据业务的稳定性，增加用户在选择业务时的灵活性在终端上键入。

127. 发明授权

US08604004B2 Moenomycin analogs, methods of synthesis, and uses thereof 有权
标题翻译：霉酚霉素类似物，合成方法及其用途
公开(公告)号：US08604004B2
公开(公告)日：2013-12-10
申请号：US12681052
申请日：2008-10-03
申请人： Daniel Kahne , Suzanne Walker Kahne , Masaatsu Adachi , Emma Doud , Shinichiro Fuse , Xiaonan Lin , Yi Zhang , Hirokazu Tsukamoto , Bohdan Ostash
发明人： Daniel Kahne , Suzanne Walker Kahne , Masaatsu Adachi , Emma Doud , Shinichiro Fuse , Xiaonan Lin , Yi Zhang , Hirokazu Tsukamoto , Bohdan Ostash
IPC分类号： A61K31/702 , A61K31/715 , A61K31/7016 , A61K31/7028 , C07H5/04 , C07H5/06
CPC分类号： C07H15/10 , C07H11/04
摘要： The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.
摘要翻译：本发明通过向有需要的受试者施用本发明化合物来提供新颖的新霉素类似物及其药物组合物，合成方法和用于治疗感染的方法。门霉素类似物可以合成，生物合成或半合成制备。类似物在治疗或预防革兰氏阳性生物引起的感染中特别有用。某些本发明化合物可具有更广泛的覆盖范围，其包括革兰氏阴性生物体。

128. 发明申请

US20130287305A1 TESTING THE RENDERING OF VISUAL CONTENT 有权
标题翻译：测试视觉内容的渲染
公开(公告)号：US20130287305A1
公开(公告)日：2013-10-31
申请号：US13456826
申请日：2012-04-26
申请人： Sanjeev Dhanda , Yi Zhang
发明人： Sanjeev Dhanda , Yi Zhang
IPC分类号： G06K9/68
CPC分类号： G06F17/3089
摘要： Methods, systems, and apparatus for testing content rendering are described. A method includes receiving input specifying a change to a parameter relating to display of content in a webpage, in response to receiving the input, generating a test image of the webpage including the content, comparing a target image of the content with the generated test image to determine whether the generated test image includes the target image of the content, and selectively providing a failure notification based upon a result of the comparison.
摘要翻译：描述用于测试内容呈现的方法，系统和装置。一种方法包括接收指定对与网页中的内容的显示相关的参数的改变的输入，响应于接收到所述输入，生成包含所述内容的所述网页的测试图像，将所述内容的目标图像与所生成的测试图像进行比较以确定生成的测试图像是否包括内容的目标图像，并且基于比较的结果选择性地提供故障通知。

129. 发明授权

US08571545B2 Short-range wireless relay method and system 有权
标题翻译：短距离无线中继方式及系统
公开(公告)号：US08571545B2
公开(公告)日：2013-10-29
申请号：US13005506
申请日：2011-01-12
申请人： Ning Ge , Yi Zhang , Zhiwei Meng
发明人： Ning Ge , Yi Zhang , Zhiwei Meng
IPC分类号： H04W4/00
CPC分类号： H04W88/04 , H04B7/15557 , H04W60/005 , H04W88/06
摘要： A wireless relay apparatus is provided. The wireless relay apparatus includes a telephone module configured to couple with a public switched telephone network (PSTN) to receive a telephone call, and a wireless module coupled to the telephone module to process the telephone call and configured to wirelessly connect to a mobile terminal such that the telephone call is forwarded to the mobile terminal over a short-range wireless link. Further, the wireless module is configured to operate in one of a transparent mode and a translation mode so as to exchange voice data with the mobile terminal.
摘要翻译：提供一种无线中继装置。该无线中继装置包括电话模块，该电话模块被配置为与公共交换电话网络（PSTN）耦合以接收电话呼叫;以及无线模块，其耦合到所述电话模块以处理所述电话呼叫并且被配置为无线地连接到移动终端通过短距离无线链路将电话呼叫转发到移动终端。此外，无线模块被配置为以透明模式和转换模式之一进行操作，以便与移动终端交换语音数据。

130. 发明申请

US20130281502A1 POST-TREATMENT BREAST CANCER PROGNOSIS 审中-公开
标题翻译：治疗后乳腺癌预后
公开(公告)号：US20130281502A1
公开(公告)日：2013-10-24
申请号：US13914617
申请日：2013-06-10
申请人： Dennis Sgroi , Mark G. Erlander , Yi Zhang , Catherine A. Schnabel
发明人： Dennis Sgroi , Mark G. Erlander , Yi Zhang , Catherine A. Schnabel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to extended treatment and cancer-free survival in a patient. In particular, the disclosure includes the identities of genes that are expressed in correlation with benefit in a switch in endocrine therapy used to treat a patient. The levels of gene expression are disclosed as a molecular index for predicting clinical outcome, and so prognosis, for the patient. The disclosure further includes methods for predicting cancer recurrence, and/or predicting occurrence of metastatic cancer, after initial treatment with an anti-estrogen agent. The disclosure further includes methods for determining or selecting the treatment of a subject based upon the likelihood of life expectancy, cancer recurrence, and/or cancer metastasis.
摘要翻译：该公开内容包括鉴定和使用基因表达谱或模式，其与患者中延长的治疗和无癌生存具有临床相关性。具体地，本公开包括与用于治疗患者的内分泌治疗的转换中的益处相关表达的基因的身份。公开了基因表达水平作为预测临床结果的分子指标，并为患者预后。本发明还包括在用抗雌激素剂初次治疗后预测癌症复发和/或预测转移性癌症的发生的方法。本公开还包括基于预期寿命，癌症复发和/或癌症转移的可能性来确定或选择受试者的治疗的方法。

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