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121. 发明申请

US20110027169A1 PRODUCTION OF HYDROGEN FROM OXYGENATED HYDROCARBONS 有权
标题翻译：从氧化碳氢化合物生产氢
公开(公告)号：US20110027169A1
公开(公告)日：2011-02-03
申请号：US12936729
申请日：2009-04-23
申请人： Jacques Monnier , Yi Zhang , Andrew McFarlan
发明人： Jacques Monnier , Yi Zhang , Andrew McFarlan
IPC分类号： C01B3/02
CPC分类号： C01B3/323 , C01B2203/0233 , C01B2203/0405 , C01B2203/047 , C01B2203/0475 , C01B2203/048 , C01B2203/1047 , C01B2203/1058 , C01B2203/1064 , C01B2203/107 , C01B2203/1082 , C01B2203/1094 , C01B2203/1211 , C01B2203/1217 , C01B2203/1223 , C01B2203/148 , C01B2203/1623 , C01B2203/1638
摘要： The invention provides a process of producing hydrogen that involves aqueous phase reforming of an oxygenated hydrocarbon, preferably one obtained from a renewable source such as biomass. The reaction is carried out in the absence of electrolytes and in the presence of a dispersed particulate heterogeneous catalyst. The reaction is carried out under pressure and relatively low temperature in a stirred tank reactor, preferably a continuous stirred tank reactor.
摘要翻译：本发明提供一种生产氢的方法，其涉及含氧烃的水相重整，优选由可再生来源（例如生物质）获得的那些。反应在不存在电解质的情况下进行，并且在分散的颗粒状非均相催化剂的存在下进行。反应在压力和相对低的温度下在搅拌釜反应器，优选连续搅拌釜反应器中进行。

122. 发明申请

US20100274147A1 DETECTING ISCHEMIA WITH NONLINEAR HEART RATE VARIABILITY MEASURES 审中-公开
标题翻译：用非线性心率变异性测量法检测ISCHEMIA
公开(公告)号：US20100274147A1
公开(公告)日：2010-10-28
申请号：US12761047
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/3418 , G16H50/30
摘要： Systems and methods include accessing a plurality of cardiac indications. A heart rate variability metric is produced by analyzing the plurality of cardiac indications using a measurement from a class of nonlinear measurements. Nonlinear measurements include, but are not limited to, approximate entropy, X-Y scatter from a Poincaré plot, fractal dimension, and detrended fluctuation analysis, in various examples. Based on the heart rate variability metric, a cardiac ischemic state is detected.
摘要翻译：系统和方法包括访问多个心脏指示。通过使用来自一类非线性测量的测量来分析多个心脏指征来产生心率变异性度量。在各种实施例中，非线性测量包括但不限于近似熵，Poincaré图中的X-Y散射，分形维数和去趋势波动分析。基于心率变异性度量，检测到心脏缺血状态。

123. 发明申请

US20100267578A1 PROBE DENSITY SELF-CONSIDERATIONS AND ELONGATION OF COMPLEMENTARY LOOPED PROBES WHERE PROBES ARE ATTACHED TO A SOLID PHASE 有权
标题翻译：探索密度自我考虑和延伸的复杂循环探测器，其中探测器连接到固相
公开(公告)号：US20100267578A1
公开(公告)日：2010-10-21
申请号：US12708362
申请日：2010-02-18
申请人： MICHAEL SEUL , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
发明人： MICHAEL SEUL , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
IPC分类号： C40B30/04
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q1/6827 , C12Q2565/1015 , C12Q2537/143 , C12Q2533/101 , C12Q2535/125 , C12Q2525/301
摘要： In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps:adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.
摘要翻译：在溶液中进行的多重测定方法中，其中溶液含有核酸靶，并且其中使用几个不同类型的寡核苷酸探针，每个类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸目标，所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加有效通过一种或多种以下方法可用于结合探针的靶的浓度：（i）在珠的表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

124. 发明申请

US20100185271A1 DELIVERY APPARATUS FOR A RETRACTABLE SELF EXPANDING NEUROVASCULAR STENT 审中-公开
标题翻译：用于可回收自我扩张神经病变的输送装置
公开(公告)号：US20100185271A1
公开(公告)日：2010-07-22
申请号：US12686988
申请日：2010-01-13
申请人： Yi Zhang
发明人： Yi Zhang
IPC分类号： A61F2/84
CPC分类号： A61F2/915 , A61F2/07 , A61F2/95 , A61F2/966 , A61F2002/91525 , A61F2002/91558 , A61F2002/9505 , A61F2002/9665 , A61F2230/0054 , A61F2250/0018 , A61F2250/0098
摘要： The present invention relates to a delivery apparatus for delivering a self-expanding neurovascular stent that allows for smooth movement of the apparatus along a typically tortuous vascular path, ease of stent deployment, and ease of stent retractability being pushed and pulled through the delivery apparatus. The apparatus includes an outer catheter, and an inner shaft located coaxially within the outer catheter. The stent is mounted on the distal section of the inner shaft and preloaded within the outer catheter distal region. The inner shaft includes at least one stent blocking member disposed in the distal section. The self-expanding stent has proximal, middle and distal ends and is comprised of a plurality of closed cells. The self-expanding stent includes locking members which interlock with the blocking member(s) disposed on the inner shaft so as to lock the stent onto the inner shaft within the outer catheter, and to enable the stent retractable together with the inner shaft being out of and retrieved back to the outer catheter. More specially, the invention may be used in the treatment of blood vessel blockage and aneurysms which occur in the brain.
摘要翻译：本发明涉及一种用于递送自扩张神经血管支架的输送装置，其允许沿着典型曲折的血管路径平滑移动装置，容易地进行支架展开，并且通过推送装置推动和拉动支架缩回容易。该装置包括外导管和同轴地位于外导管内的内轴。支架安装在内轴的远端部分上，并预先装在外导管远端区域内。内轴包括设置在远端部分中的至少一个支架阻挡构件。自扩张支架具有近端，中部和远端，并且由多个闭孔组成。自扩张支架包括与设置在内轴上的阻挡构件互锁的锁定构件，以将支架锁定在外导管内的内轴上，并且使支架能够与内轴一起伸出并返回到外导管。更具体地，本发明可用于治疗发生在脑中的血管阻塞和动脉瘤。

125. 发明授权

US07704215B2 Daytime/nighttime respiration rate monitoring 有权
标题翻译：白天/夜间呼吸率监测
公开(公告)号：US07704215B2
公开(公告)日：2010-04-27
申请号：US12384271
申请日：2009-04-02
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/00
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
摘要翻译：一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。

126. 发明授权

US07619056B2 Thermoset epoxy polymers from renewable resources 有权
标题翻译：可再生资源的热固性环氧聚合物
公开(公告)号：US07619056B2
公开(公告)日：2009-11-17
申请号：US11809034
申请日：2007-05-31
申请人： Anthony East , Michael Jaffe , Yi Zhang , Luiz H Catalani
发明人： Anthony East , Michael Jaffe , Yi Zhang , Luiz H Catalani
IPC分类号： C08G59/50 , C07D493/02
CPC分类号： C08G59/26 , C07D493/04 , C08G59/42 , C08G59/5046 , C08L63/00
摘要： Novel thermoset epoxy polymers using the bisglycidyl ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, are disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. The anhydrosugars are derived from renewable sources and the bisglycidyl ethers are not xenoestrogenic and the thermoset curing agents are likewise derived form renewable resources.
摘要翻译：公开了使用脱水糖的双缩水甘油醚的新型热固性环氧聚合物，例如异山梨醇，异烟肼和异氰酸酯。双缩水甘油醚在制备热固性环氧醚时可用作双酚A的替代物。脱水葡萄糖源自可再生来源，双缩水甘油醚不是异源雌激素，热固性固化剂同样衍生自可再生资源。

127. 发明授权

US07567836B2 ECG signal power vector detection of ischemia or infarction 有权
标题翻译：心电信号功率矢量检测缺血或梗塞
公开(公告)号：US07567836B2
公开(公告)日：2009-07-28
申请号：US11275800
申请日：2006-01-30
申请人： Yi Zhang
发明人： Yi Zhang
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/04011 , A61B5/7207 , A61B5/7285
摘要： A system comprising a processor that includes a cardiac signal vector module and an ischemia detection module. The cardiac signal vector module is configured to measure a first dominant vector corresponding to a direction and magnitude of maximum signal power of a first segment of at least one cardiac cycle of a subject and at least a second dominant vector corresponding to a direction and magnitude of maximum signal power of a second segment of the cardiac cycle from an electrical cardiac signal. The ischemia detection module is configured to measure a change in the first dominant vector, to form a difference by subtracting a measured change in the second dominant vector from a measured change in the first dominant vector, and to declare whether an ischemic event occurred using the difference.
摘要翻译：一种系统，包括包括心脏信号矢量模块和缺血检测模块的处理器。心脏信号矢量模块被配置为测量对应于受试者的至少一个心动周期的第一段的最大信号功率的方向和幅度的第一显性矢量，以及对应于对象的方向和幅度的至少第二显性矢量来自心电信号的心动周期的第二段的最大信号功率。局部缺血检测模块被配置为测量第一显性矢量的变化，以通过从第一显性矢量的测量变化中减去第二显性矢量的测量变化来形成差异，并且声明是否使用区别。

128. 发明申请

US20090155805A1 COPY NUMBER ALTERATIONS THAT PREDICT METASTATIC CAPABILITY OF HUMAN BREAST CANCER 审中-公开
标题翻译：预测人乳腺癌的分类能力的复制编号
公开(公告)号：US20090155805A1
公开(公告)日：2009-06-18
申请号：US12335162
申请日：2008-12-15
申请人： Yi Zhang , Jack X. Yu , Yuqui Jiang , Yixin Wang
发明人： Yi Zhang , Jack X. Yu , Yuqui Jiang , Yixin Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： Disclosed in this specification is a method of defining chromosome regions of prognostic value by summarizing the significance of all SNPs (single nucleotide polymorphism) in a predetermined section of a chromosome to define chromosome regions of prognostic value. Based on the SNPs in specified genes, a more accurate prognosis for breast cancer may be provided.
摘要翻译：在本说明书中公开的是通过总结染色体预定部分中所有SNP（单核苷酸多态性）的意义来定义预后价值的染色体区域来定义预后价值的染色体区域的方法。基于特定基因的SNP，可以提供更准确的乳腺癌预后。

129. 发明授权

US07530956B2 Daytime/nighttime respiration rate monitoring 有权
标题翻译：白天/夜间呼吸率监测
公开(公告)号：US07530956B2
公开(公告)日：2009-05-12
申请号：US11820002
申请日：2007-06-15
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/00
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
摘要翻译：一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。

130. 发明申请

US20090042737A1 Methods and Devices for Correlated, Multi-Parameter Single Cell Measurements and Recovery of Remnant Biological Material 审中-公开
标题翻译：用于相关多参数单细胞测量和残留生物材料回收的方法和装置
公开(公告)号：US20090042737A1
公开(公告)日：2009-02-12
申请号：US12188999
申请日：2008-08-08
申请人： Andrew S. Katz , Haichuan Zhang , Keunho Ahn , Yi Zhang
发明人： Andrew S. Katz , Haichuan Zhang , Keunho Ahn , Yi Zhang
IPC分类号： C40B30/06 , C40B60/12
CPC分类号： B01L3/502761 , B01L7/525 , B01L2200/027 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0663 , B01L2300/087 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , G01N15/1484 , G01N2015/149
摘要： Methods and apparatus are provided for analysis and correlation of phenotypic and genotypic information for a high throughput sample on a cell by cell basis. Cells are isolated and sequentially analyzed for phenotypic information and genotypic information which is then correlated. Methods for correlating the phenotype-genotype information of a sample population can be performed on a continuous flow sample within a microfluidic channel network or alternatively on a sample preloaded into a nano-well array chip. The methods for performing the phenotype-genotype analysis and correlation are scalable for samples numbering in the hundreds of cells to thousands of cells up to the tens and hundreds of thousand cells.
摘要翻译：提供了方法和装置，用于基于细胞的高通量样品的表型和基因型信息的分析和相关性。分离细胞并依次分析表型信息和基因型信息，然后相关。可以在微流体通道网络内的连续流动样品上或者预先加载到纳米阵列芯片中的样品上进行将样品群体的表型 - 基因型信息相关联的方法。用于进行表型 - 基因型分析和相关性的方法可扩展到数百个细胞中的样品编号到数千个细胞直到数十万个细胞。

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