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121. 发明申请

US20110118727A1 SYSTEM AND METHOD FOR ASSESSING THE FORMATION OF A LESION IN TISSUE 有权
标题翻译：用于评估组织中组织形成的系统和方法
公开(公告)号：US20110118727A1
公开(公告)日：2011-05-19
申请号：US12946941
申请日：2010-11-16
申请人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Harry A. Puryear , Saurav Paul
发明人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Harry A. Puryear , Saurav Paul
IPC分类号： A61B18/12 , A61B18/18
CPC分类号： A61B18/1492 , A61B5/0084 , A61B5/01 , A61B5/0402 , A61B5/042 , A61B5/0538 , A61B5/1076 , A61B5/1079 , A61B5/4836 , A61B5/742 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00351 , A61B2018/00714 , A61B2018/00738 , A61B2018/00779 , A61B2018/00875 , A61B2018/0212 , A61B2034/301 , A61B2090/065 , A61B2218/002
摘要： A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU) configured to acquire magnitudes for a component of a complex impedance between an electrode and tissue, and the power applied to the tissue during lesion formation. The ECU is configured to calculate a value responsive to the complex impedance component and the power. The value is indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, or a predicted tissue temperature. The method includes acquiring magnitudes for a component of a complex impedance between an electrode and tissue and the power applied during lesion formation. The method includes calculating a value responsive to the complex impedance component and the power, the value being indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, and/or a predicted tissue temperature.
摘要翻译：提供了一种用于评估组织中病变形成的方法和系统。该系统包括电子控制单元（ECU），其被配置为获取电极和组织之间的复阻抗的分量的大小以及在损伤形成期间施加到组织的功率。 ECU被配置为计算响应于复阻抗分量和功率的值。该值表示预测的病变深度，病变达到预定深度的可能性，或预测的组织温度。该方法包括获取电极和组织之间的复阻抗的分量的大小以及在损伤形成期间施加的功率。该方法包括计算响应于复阻抗分量和功率的值，该值指示预测的病变深度，病变达到预定深度的可能性和/或预测的组织温度。

122. 发明授权

US07879030B2 Multipolar, virtual-electrode catheter with at least one surface electrode and method for ablation 有权
标题翻译：具有至少一个表面电极的多极虚拟电极导管和消融方法
公开(公告)号：US07879030B2
公开(公告)日：2011-02-01
申请号：US11190560
申请日：2005-07-27
申请人： Saurav Paul , Kedar Ravindra Belhe
发明人： Saurav Paul , Kedar Ravindra Belhe
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/1472
摘要： Virtual-electrode catheters and methods for using such virtual-electrode catheters are disclosed. For example, bipolar and multipolar, virtual-electrode catheters having at least one internal electrode and at least one surface electrode, and methods of using these catheters for treatment of cardiac arrhythmias via, for example, radiofrequency (RF) ablation are disclosed. The catheters may comprise a catheter body with an internal lumen extending within it and adapted to flowingly receive a conductive fluid. An exit feature defining a flow path from the internal lumen to the catheter's outer surface may exist through a sidewall of the catheter body. A conductor is mounted within the internal lumen adjacent to the exit feature and is adapted to deliver treatment energy to the tissue via the conductive fluid in the internal lumen. At least one surface electrode is mounted on the outer surface of the catheter body adjacent to the exit feature.
摘要翻译：公开了虚拟电极导管和使用这种虚拟电极导管的方法。例如，公开了具有至少一个内部电极和至少一个表面电极的双极和多极虚拟电极导管，以及通过例如射频（RF）消融来治疗心律失常的这些导管的方法。导管可以包括具有在其内延伸并适于流动地接收导电流体的内腔的导管体。限定从内腔到导管的外表面的流动路径的出口特征可以通过导管主体的侧壁而存在。导体被安装在与出口特征相邻的内腔中，并且适于经由内腔中的导电流体将治疗能量递送至组织。至少一个表面电极安装在导管主体的与出口部件相邻的外表面上。

123. 发明申请

US20100286530A1 Photodynamic-based tissue sensing device and method 审中-公开
标题翻译：基于光动力学的组织感测装置及方法
公开(公告)号：US20100286530A1
公开(公告)日：2010-11-11
申请号：US12744201
申请日：2008-12-18
申请人： Saurav Paul , Israel Byrd
发明人： Saurav Paul , Israel Byrd
IPC分类号： A61B6/00
CPC分类号： A61N5/062 , A61B5/0084 , A61N5/0601
摘要： A system and method for diagnosis or treatment of tissue is provided. One or more optic fibers are disposed within a deformable, tubular body. An electronic control unit activates an electromagnetic radiation source to direct a first set of electromagnetic radiation through a first optic fiber to the tissue. The unit also receives a signal generated by an electromagnetic radiation sensor in response to a second set of electromagnetic radiation received through the first optic or a second fiber. The second set of electromagnetic radiation originates from the tissue in response to the first set of electromagnetic radiation and may be reflected or emitted by a substance contained in the tissue that alters radiation characteristics of the tissue. Finally, the unit is configured to determine a characteristic of the tissue (e.g. the distance from the tissue to the tubular body) responsive to the signal.
摘要翻译：提供了用于诊断或治疗组织的系统和方法。一个或多个光纤设置在可变形的管状体内。电子控制单元激活电磁辐射源以将第一组电磁辐射通过第一光纤引导到组织。该单元还响应于通过第一光学器件或第二光纤接收的第二组电磁辐射，接收由电磁辐射传感器产生的信号。第二组电磁辐射响应于第一组电磁辐射来自组织，并且可以被包含在组织中的物质反射或发射，从而改变组织的辐射特性。最后，单元被配置成响应于该信号来确定组织的特征（例如，从组织到管状体的距离）。

124. 发明申请

US20100191142A1 ANATOMICAL THERMAL SENSING DEVICE AND METHOD 有权
标题翻译：解剖学感测装置及方法
公开(公告)号：US20100191142A1
公开(公告)日：2010-07-29
申请号：US12751946
申请日：2010-03-31
申请人： Saurav Paul , Todd Stangenes , Riki Thao
发明人： Saurav Paul , Todd Stangenes , Riki Thao
IPC分类号： A61B5/01
CPC分类号： A61B18/1402 , A61B5/01 , A61B5/015 , A61B5/053 , A61B5/6852 , A61B5/6885 , A61B2562/0271
摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.
摘要翻译：使用温度感测来识别或评估解剖体或结构的医疗装置包括细长的管状构件，至少一个电极，热传感器和温度响应评估系统或部件。至少一个电极可以连接到细长管状构件的远端部分，并且一个或多个电极可以被配置成向解剖体或结构的一部分提供能量或热量。热传感器可以被配置为测量解剖体或结构部分（例如组织或血液池）的热响应。温度响应评估系统或组件可以耦合到热传感器。在实施例中，该装置可以包括可容纳诸如针的工具的内腔和端口开口。还公开了使用温度感测来识别解剖体或结构的方法。

125. 发明申请

US20090177111A1 System and method for displaying contact between a catheter and tissue 审中-公开
标题翻译：用于显示导管和组织之间的接触的系统和方法
公开(公告)号：US20090177111A1
公开(公告)日：2009-07-09
申请号：US12353897
申请日：2009-01-14
申请人： Stephan P. Miller , Don C. Deno , Lewis C. Hill, II , Yuriy Malinin , Holly Cotner , Suzann R. Mouw , Patrick W. Drigans , Saurav Paul
发明人： Stephan P. Miller , Don C. Deno , Lewis C. Hill, II , Yuriy Malinin , Holly Cotner , Suzann R. Mouw , Patrick W. Drigans , Saurav Paul
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/053 , A61B5/042 , A61B5/6885 , A61B18/02 , A61B18/1206 , A61B18/1492 , A61B2218/002
摘要： A system and method for assessing and displaying a degree of contact between a sensor, an electrode, and tissue in a body is provided. Values for the sensor are read, and a degree of contact is calculated. This degree of contact is displayed to a clinician in a variety of ways to indicate the degree of contact to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了用于评估和显示传感器，电极和身体中的组织之间的接触程度的系统和方法。读取传感器的值，并计算接触程度。这种接触程度以各种方式显示给临床医生，以指示与临床医生的接触程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

126. 发明申请

US20090163862A1 TISSUE ANCHORING CATHETER SYSTEMS AND METHODS 有权
标题翻译：组织锚固导管系统和方法
公开(公告)号：US20090163862A1
公开(公告)日：2009-06-25
申请号：US11962512
申请日：2007-12-21
申请人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
发明人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
IPC分类号： A61M5/46 , A61M25/04
CPC分类号： A61M25/04 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/065 , A61M25/0084 , A61M2025/0089 , A61M2025/0095
摘要： Catheter systems and methods are disclosed for anchoring the catheter system to tissue, e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft connected to a catheter handle. A delivery sheath is provided within the outer catheter shaft, the delivery sheath housing a needle. At least one anchor is operatively associated with the delivery sheath, the at least one anchor operable at the catheter handle to secure the delivery sheath to tissue for conveying biologic or chemical agents, or other therapeutic fluid from the needle to the tissue. The tissue anchoring catheter may further comprise sensing means such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.
摘要翻译：公开了用于将导管系统锚定到组织的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗性流体。示例性组织锚定导管包括连接到导管手柄的外导管轴。输送护套设置在外导管轴内，输送护套容纳针。至少一个锚定件与输送护套可操作地相关联，所述至少一个锚固件可在导管手柄处操作以将输送护套固定到组织，用于将生物或化学试剂或其它治疗流体从针输送到组织。组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声波传感器的感测装置。

127. 发明申请

US20070078457A1 Multipolar, multi-lumen, virtual-electrode catheter with at least one surface electrode and method for ablation 有权
标题翻译：具有至少一个表面电极的多极，多腔虚拟电极导管和消融方法
公开(公告)号：US20070078457A1
公开(公告)日：2007-04-05
申请号：US11209024
申请日：2005-08-22
申请人： Saurav Paul , Kedar Belhe
发明人： Saurav Paul , Kedar Belhe
IPC分类号： A61B18/18 , A61B17/20
CPC分类号： A61B18/1492 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： Multipolar, multi-lumen, virtual-electrode catheters having at least one surface electrode, and methods for treatment (e.g., treatment of cardiac arrhythmias) with such catheters are disclosed. The catheters have at least two internal lumens, and at least one internal, flexible electrode rides in each internal lumen. The flexible electrodes carry treatment energy (e.g., radiofrequency energy). The energy exits the catheters via at least one exit feature (e.g., slots, portholes, or micro-pores). The methods for treatment include operating the catheters in different modes depending upon location and type of treatment to be performed. The treatment energy delivered by one of the internal, flexible electrodes may be directed to the other internal, flexible electrode; or the energy delivered by one or both of the internal, flexible electrodes may be directed to one or more surface electrodes. The delivered energy establishes at least one electric field, and possibly one or more lesions, in the tissue.
摘要翻译：公开了具有至少一个表面电极的多极，多腔虚拟电极导管和用这种导管治疗（例如治疗心律不齐）的方法。导管具有至少两个内部腔，并且每个内腔中至少有一个内部柔性电极。柔性电极携带处理能量（例如，射频能量）。能量经由至少一个出口特征（例如，狭槽，孔口或微孔）离开导管。治疗方法包括根据要进行的治疗的位置和类型以不同的模式操作导管。由内部柔性电极之一传递的处理能量可以被引导到另一个内部柔性电极; 或者由一个或两个内部柔性电极传送的能量可以被引导到一个或多个表面电极。递送的能量在组织中建立至少一个电场，并且可能建立一个或多个病变。

128. 发明授权

US09918787B2 Monitoring, managing and/or protecting system and method for non-targeted tissue 有权
公开(公告)号：US09918787B2
公开(公告)日：2018-03-20
申请号：US13101755
申请日：2011-05-05
申请人： Reed R. Heimbecher , Saurav Paul , John M. Berns , Jeffrey A. Schweitzer
发明人： Reed R. Heimbecher , Saurav Paul , John M. Berns , Jeffrey A. Schweitzer
IPC分类号： A61B18/00 , A61B18/14 , A61B90/00 , A61B18/18 , A61B34/30
CPC分类号： A61B18/1492 , A61B18/18 , A61B34/30 , A61B90/04 , A61B2018/0022 , A61B2018/00285 , A61B2018/00642 , A61B2018/00696 , A61B2018/00714 , A61B2018/00779 , A61B2018/00869 , A61B2018/00875 , A61B2018/00898 , A61B2018/00904 , A61B2034/301
摘要： A monitoring, managing and protecting system is provided that includes a monitoring probe working in conjunction with an ablating device. The probe is configured to be positioned in close proximity to a region of non-targeted tissue proximate an ablation site of targeted tissue and to be operatively connected to an electrical response assessment system or component. The probe includes an elongate shaft having proximal and distal ends, with a handle disposed at the proximal end thereof and a tissue monitoring and protecting apparatus disposed at the distal end thereof. The ablating device includes an elongate shaft having proximal and distal ends, with a handle mounted at the proximal end thereof and an ablation element mounted at the distal end thereof. The monitoring probe measures electrical characteristics of the non-targeted tissue and/or of the tissue between the monitoring electrode and the ablation electrode. The electrical response assessment system determines whether the tissue is being damaged based on the electrical measurements. The monitoring, managing and protecting system can notify a practitioner based on the determination, or modify or stop the ablation procedure.

129. 发明授权

US09694213B2 Acoustic coupling for assessment and ablation procedures 有权
公开(公告)号：US09694213B2
公开(公告)日：2017-07-04
申请号：US12979475
申请日：2010-12-28
申请人： Saurav Paul , Troy T. Tegg , Reed R. Heimbecher
发明人： Saurav Paul , Troy T. Tegg , Reed R. Heimbecher
IPC分类号： A61B8/00 , A61N7/02 , A61B8/08 , A61B8/12 , A61B17/00
CPC分类号： A61N7/022 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/4494 , A61B2017/00106
摘要： Acoustic coupling systems and methods are disclosed as these can be used for assessment and ablation procedures. An exemplary acoustic assessment system for a catheter has a flexible catheter shaft. At least one acoustic transducer is positioned in the flexible catheter shaft. The at least one acoustic transducer emits a generated acoustic signal for reflection by adjacent tissue. The at least one acoustic transducer receives a reflected acoustic signal from the adjacent tissue and generates electrical signals corresponding to one or more property of the tissue. An output device is electrically connected to the at least one acoustic transducer. The output device receives the electrical signals and generate output for a user for assessing the tissue.

130. 发明申请

US20150290476A1 NON-INVASIVE LUNG PACING 审中-公开
标题翻译：非入侵式肺活检
公开(公告)号：US20150290476A1
公开(公告)日：2015-10-15
申请号：US14440857
申请日：2013-11-05
申请人： Jesus Arturo CABRERA , James C. BALLARD , James C. KROCAK , Saurav PAUL , REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： James C. Krocak , Saurav Paul , Jesus Arturo Cabrera , John Robert Ballard
IPC分类号： A61N7/00 , A61H31/00
CPC分类号： A61N7/00 , A61B8/4281 , A61B2018/00839 , A61H31/00 , A61H2031/002 , A61H2230/405 , A61N2007/0026 , A61N2007/0078 , A61N2007/0095
摘要： A system for diaphragmatic pacing includes an ultrasonic transducer and a control module. The ultrasonic transducer has an emitting surface. The emitting surface is configured to couple with a tissue of a patient. The transducer is configured to transdermally emit ultrasonic energy and induce movement in a thoracic diaphragm of the patient in response thereto. The control module is coupled to the transducer and has a processor. The processor is configured to execute an algorithm to control operation of the transducer.
摘要翻译：用于膈肌起搏的系统包括超声换能器和控制模块。超声波换能器具有发射表面。发射表面被配置为与患者的组织联接。换能器被配置为经皮发射超声波能量并且响应于该能量诱导患者的胸膜中的运动。控制模块耦合到换能器并具有处理器。处理器被配置为执行算法来控制换能器的操作。

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