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121. 发明授权

US07590517B2 Methods, systems, and computer program products for computational analysis and design of amphiphilic polymers 有权
标题翻译：用于计算分析和设计两亲性聚合物的方法，系统和计算机程序产品
公开(公告)号：US07590517B2
公开(公告)日：2009-09-15
申请号：US10446171
申请日：2003-05-28
申请人： Robert Doerksen , Bin Chen , William F. DeGrado , Michael L. Klein
发明人： Robert Doerksen , Bin Chen , William F. DeGrado , Michael L. Klein
IPC分类号： G06G7/48
CPC分类号： G06F19/701
摘要： Methods, systems, and computer program products for computational polymer processing including, without limitation, computational amphiphilic polymer design, conformational energy minimization, generation and refinement of torsional parameters for sub-units of potential polymers, generation of modified force field parameters, and prediction of conformational information for potential polymers. A target polymer backbone or portion thereof is identified. Small model compounds that have structural connectivities that are similar to structural connectivities of the target polymer backbone or portion thereof, are identified, whereby the combination of the small model compounds serve as a model of the target polymer or portion thereof. Gradient-corrected density functional theory (“DFT”) torsional potentials are calculated for the small model compounds, wherein energies are calculated at unconstrained and constrained geometries of the selected small model compounds. New torsional parameters are then obtained from the DFT torsional potentials. The new torsional parameters are combined with other terms to form a modified (or new) force field for the target polymer backbone or portion thereof. Molecular dynamics and configurational-biased Monte Carlo (“MD/MC”) simulations are performed using the modified force field, whereby results of the MD/MC simulations serve as predicted conformation properties of the target polymer backbone. The predicted conformation properties for the multiple target polymer backbones are then used to select one or more of the target polymer backbones as candidate amphiphilic polymer backbones for synthesis.
摘要翻译：用于计算聚合物处理的方法，系统和计算机程序产品，包括但不限于计算两亲性聚合物设计，构象能量最小化，潜在聚合物的子单元的扭转参数的产生和细化，生成修改的力场参数以及预测潜在聚合物的构象信息。鉴定目标聚合物主链或其部分。鉴定出具有与目标聚合物主链或其部分的结构连接性相似的结构连接性的小型化合物，由此小型化合物的组合用作目标聚合物或其部分的模型。对于小模型化合物计算梯度校正密度泛函理论（“DFT”）扭转电位，其中在所选择的小模型化合物的无约束和约束几何形状下计算能量。然后从DFT扭转电位获得新的扭转参数。新的扭转参数与其它术语组合以形成目标聚合物主链或其部分的修改（或新）力场。使用修改的力场进行分子动力学和构型偏置蒙特卡罗（“MD / MC”）模拟，由此MD / MC模拟的结果用作目标聚合物主链的预测构象性质。然后使用多目标聚合物骨架的预测构象性质来选择一种或多种靶聚合物主链作为合成的候选两亲性聚合物主链。

122. 发明申请

US20060179940A1 Ultra-small Profile, Low Cost Chip Scale Accelerometers of Two and Three Axes Based on Wafer Level Packaging 审中-公开
标题翻译：基于晶圆级封装的两轴和三轴超小型，低成本芯片尺寸加速度计
公开(公告)号：US20060179940A1
公开(公告)日：2006-08-17
申请号：US10906269
申请日：2005-02-11
申请人： Sheng Liu , Bin Chen , Junjie Chen , Jun Wei , Xiaojun Wang
发明人： Sheng Liu , Bin Chen , Junjie Chen , Jun Wei , Xiaojun Wang
IPC分类号： G01P15/00
CPC分类号： G01P15/18 , G01P15/008
摘要： Several micro-machined, ultra-profile two-axis and three-axis accelerometers are fabricated by CMOS-compatible process, which makes them suitable for volume production. The x, y axis signal is based on natural thermal convection, and z-axis signal may be based on thermal convention or piezoresistive in nature. The bulk MEMS (Micro-Electro-Mechanical-Systems) process is based on Deep Reactive Ion Etching (DRIE). After the front-end fabrication process, the accelerometers are packaged at wafer level by glass frit and/or anodic bonding, which lowers the device cost.
摘要翻译：通过CMOS兼容工艺制造出几个微加工的超型二轴和三轴加速度计，使其适合批量生产。 x，y轴信号基于自然热对流，z轴信号可以基于热惯性或压阻性质。大容量MEMS（微机电系统）工艺基于深反应离子蚀刻（DRIE）。在前端制造过程之后，加速度计通过玻璃料和/或阳极粘合在晶片级封装，这降低了器件成本。

123. 发明申请

US20050032831A1 Histone deacetylase inhibitors and methods of use thereof 失效
标题翻译：组蛋白脱乙酰酶抑制剂及其使用方法
公开(公告)号：US20050032831A1
公开(公告)日：2005-02-10
申请号：US10843229
申请日：2004-05-11
申请人： Alan Kozikowski , Bin Chen
发明人： Alan Kozikowski , Bin Chen
IPC分类号： A01N37/10 , A01N43/40 , A01N43/42 , A61K20060101 , A61K31/19 , C07C259/04 , C07C259/06 , C07C271/02 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07D215/48 , C07D215/54 , A61K31/165 , A61K31/47
CPC分类号： C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要： One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译：本发明的一个方面涉及HDAC抑制剂。还提供了使癌细胞对放射治疗的细胞毒性作用敏感的方法。本发明还提供了治疗癌症的方法和治疗神经疾病的方法。另外，本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。

124. 发明授权

US06362382B1 Uncatalyzed fluorination of 240fa 有权
标题翻译： 240fa的未催化氟化
公开(公告)号：US06362382B1
公开(公告)日：2002-03-26
申请号：US09910375
申请日：2001-07-20
申请人： Bin Chen , Michael S. Bolmer
发明人： Bin Chen , Michael S. Bolmer
IPC分类号： C07C1708
CPC分类号： C07C17/206 , C07C17/00
摘要： An uncatalyzed process is provided for the fluorination of 240 fa in the presence of a solvent.
摘要翻译：提供了一种未溶剂化的方法，用于在溶剂存在下240升氟化

125. 发明授权

US06180344B2 5′ Upstream region sequences of the MyoD1 gene and uses thereof 失效
标题翻译： 5'MyoD1基因的上游区序列及其用途
公开(公告)号：US06180344B2
公开(公告)日：2001-01-30
申请号：US09193792
申请日：1998-11-17
申请人： Bin Chen
发明人： Bin Chen
IPC分类号： C12Q168
CPC分类号： C07K14/475 , C12Q1/683 , C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： MyoD1 expression is found at early stages of embryonic myogenesis and in rhabdomyosarcoma, the most common soft-tissue cancer in children. Hypomethylation of a CpG island in the 5′ upstream region of the human MyoD1 gene occurs in a majority of alveolar rhabdomyosarcomas, and may be responsible for higher levels of the MyoD1 expression in this tumor type. The methylation status of the upstream CpG island may play a key role in regulation of the MyoD1 expression not only in alveolar rhabdomyosarcoma, but also during normal development. This invention provides for the assessment of the methylation status of the MyoD1 upstream CpG sites, which may have valuable implications for differential diagnosis of pediatric cancers and may results in potential therapeutic applications.
摘要翻译： MyoD1表达在胚胎发生的早期阶段发现，在横纹肌肉瘤中是儿童中最常见的软组织癌。在人MyoD1基因的5'上游区域中的CpG岛的低甲基化发生在大多数肺泡横纹肌肉瘤中，并且可能是这种肿瘤类型中更高水平的MyoD1表达的原因。上游CpG岛的甲基化状态可能在调控MyoD1表达中不仅在肺泡横纹肌肉瘤中，而且在正常发育过程中也起关键作用。本发明提供了对MyoD1上游CpG位点的甲基化状态的评估，这可能对儿科癌症的鉴别诊断具有宝贵的意义，并且可能导致潜在的治疗应用。

126. 发明授权

US6074985A Fluorination catalysts 有权
标题翻译：氟化催化剂
公开(公告)号：US6074985A
公开(公告)日：2000-06-13
申请号：US369307
申请日：1999-08-03
申请人： Maher Y. Elsheikh , Bin Chen
发明人： Maher Y. Elsheikh , Bin Chen
IPC分类号： B01J27/12 , B01J37/26 , C07B39/00 , C07B61/00 , C07C17/20 , C07C19/08 , B01J21/18 , B01J23/00 , B01J27/06 , C07C17/00 , C07C17/08
CPC分类号： C07B39/00 , B01J27/12 , B01J37/26 , C07C17/206
摘要： A supported Lewis acid catalyst such as antimony V on a fluorine-treated moisture-free activated carbon support is provided, as are fluorination processes using such a catalyst.
摘要翻译：提供了在氟处理的无水活性炭载体上的负载的路易斯酸催化剂如锑V，以及使用这种催化剂的氟化方法。

127. 发明授权

US5730188A Flexible conduit 失效
标题翻译：柔性导管
公开(公告)号：US5730188A
公开(公告)日：1998-03-24
申请号：US728957
申请日：1996-10-11
申请人： Mark D. Kalman , Bin Chen
发明人： Mark D. Kalman , Bin Chen
IPC分类号： F16L9/16 , F16L11/16 , F16L11/24 , F16L11/04
CPC分类号： F16L11/16 , F16L11/083 , F16L9/16
摘要： A flexible conduit formed by a helically wound band of metal that resists burst pressure. The band has a leading edge hook and a trailing edge hook that engage and interlock. The cross-section of the band has a radially asymmetrical Z-shaped profile. When the band is helically wound, the downstream hook of one turn of the band is received in the upstream valley of the previous turn of the band so that the downstream and upstream hooks form an interlock holding the windings together. In the wound configuration, the thickness of the profile between the upstream valley and the internal surface of the tube is greater than the thickness of the profile between the downstream valley and the external surface of the tube to provide greater material thickness to reduce contact stress at the hook and valley interface and to reduce alternating stresses in the valley corners. The outer surface of the profile tapers towards the center of the tube to direct externally applied radial compression forces toward the thickest section of the profile. A multilayer conduit employing the band may include a central, helically wound collapse-resistant layer disposed within a flexible fluid barrier that in turn is disposed within the tube formed by the band. The conduit may be wrapped with one or more tensile strength layers, anti-wear layers, and additional fluid barriers.
摘要翻译：由螺旋缠绕的金属带形成的柔性导管，其抵抗爆破压力。该带具有接合和互锁的前缘钩和后缘钩。带的横截面具有径向不对称的Z形轮廓。当带被螺旋缠绕时，带的一圈的下游钩被容纳在带的前一圈的上游谷中，使得下游和上游钩形成将绕组保持在一起的联锁。在卷绕结构中，上游谷和管内表面之间的轮廓厚度大于下游谷和管的外表面之间的轮廓厚度，以提供更大的材料厚度，以减小接触应力钩和谷界面，并减少谷角中的交替应力。轮廓的外表面朝向管的中心变细，以将外部施加的径向压缩力引向轮廓的最厚部分。采用带的多层导管可以包括设置在柔性流体屏障内的中心的，螺旋缠绕的防塌陷层，该柔性流体屏障又被布置在由带形成的管内。导管可以用一个或多个拉伸强度层，抗磨层和另外的流体屏障包裹。

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