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121. 发明授权

US07053186B2 Antibodies immunospecific for STEAP1 有权
标题翻译：针对STEAP1免疫特异性的抗体
公开(公告)号：US07053186B2
公开(公告)日：2006-05-30
申请号：US10011095
申请日：2001-12-06
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” (serpentine transmembrane antigens of the prostate). Four particular human STEAPs are described and characterized herein. The human STREPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STREP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要在前列腺以及前列腺癌中表达，因此该家族的成员被称为“STRAP”（前列腺的蛇纹状跨膜抗原）。本文描述和表征了四种特定的人STEAP。人类STREP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。前列腺癌各阶段的STREP-1蛋白表达维持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

122. 发明授权

US07008779B1 PHELIX: a testis-specific protein expressed in cancer 失效
标题翻译： PHELIX：在癌症中表达的睾丸特异性蛋白
公开(公告)号：US07008779B1
公开(公告)日：2006-03-07
申请号：US09389000
申请日：1999-08-31
申请人： Daniel E. Afar , Rene S. Hubert , Arthur B. Raitano
发明人： Daniel E. Afar , Rene S. Hubert , Arthur B. Raitano
IPC分类号： C12H15/00
CPC分类号： C07K14/4748 , A01K2217/05 , A61K38/00 , A61K39/00
摘要： Described is a novel gene and its encoded basic Helix Loop Helix protein, termed PHELIX, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express PHELIX, particularly including prostate cancer, bladder cancer, ovarian cancer and testicular cancer. In human normal tissues, PHELIX is only expressed in testis tissue. However, PHELIX is expressed at high levels in prostate cancer cells and in other cancer cells. The structure of PHELIX suggests that it may function as a transcription factor that normally exhibits a testis-specific expression pattern but is turned on in prostate cancer as well as in other cancers.
摘要翻译：描述了一种新型基因及其编码的基本的Helix Loop Helix蛋白，称为PHELIX，以及用于治疗表达PHELIX的各种癌症的诊断和治疗方法和组合物，特别包括前列腺癌，膀胱癌，卵巢癌和睾丸癌。在人正常组织中，PHELIX仅在睾丸组织中表达。然而，PHELIX在前列腺癌细胞和其他癌细胞中以高水平表达。 PHELIX的结构表明它可能作为转录因子起作用，其通常表现出睾丸特异性表达模式，但在前列腺癌以及其他癌症中开启。

123. 发明授权

US06566078B1 36P6D5: secreted tumor antigen 失效
标题翻译：分泌蛋白质称为36P6D5肿瘤特征
公开(公告)号：US06566078B1
公开(公告)日：2003-05-20
申请号：US09702114
申请日：2000-10-30
申请人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
IPC分类号： G01N3353
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary and pancreas.
摘要翻译：描述了一种基因及其编码的分泌型肿瘤抗原，称为36P6D5，以及用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾脏，前列腺，乳腺，结肠，卵巢和胰腺。

124. 发明授权

US06329503B1 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US06329503B1
公开(公告)日：2001-12-11
申请号：US09323873
申请日：1999-06-01
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： C07K100
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。本文描述和表征了四种特定的人STEAP。人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

125. 发明授权

US08647826B2 Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer 失效
标题翻译：核酸和相应的蛋白质125P5C8可用于治疗和检测癌症
公开(公告)号：US08647826B2
公开(公告)日：2014-02-11
申请号：US13052002
申请日：2011-03-18
申请人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
IPC分类号： G01N33/53
CPC分类号： C07K14/4748 , A61K31/7088 , A61K38/1764 , C12Q1/6886 , C12Q2600/158 , G01N33/574 , G01N33/57434
摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后，癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。

126. 发明授权

US08414898B2 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US08414898B2
公开(公告)日：2013-04-09
申请号：US13134650
申请日：2011-06-13
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： A61K39/395
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两个蛋白质完全或主要地在前列腺以及前列腺癌中表达，因此该家族的成员被称为STEAP（前列腺的六个跨膜上皮原体抗原）。本文描述和表征了四种特定的人STEAP。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明其以蛇纹石的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

127. 发明授权

US08173132B2 Nucleic acid and corresponding protein entitled 213P1F11 useful in treatment and detection of cancer 失效
标题翻译：核酸和相应的蛋白质213P1F11可用于治疗和检测癌症
公开(公告)号：US08173132B2
公开(公告)日：2012-05-08
申请号：US12357253
申请日：2009-01-21
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/00
CPC分类号： C07K14/82 , A01K2217/05 , A01K2267/0331
摘要： A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 213P1F11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 213P1F11 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（称为213P1F11）及其编码的蛋白及其变体，其中213P1F11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，213P1F11提供诊断，预后，癌症的预防和/或治疗靶标。 213P1F11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与213P1F11反应的抗体或T细胞可用于主动或被动免疫。

128. 发明申请

US20110318371A1 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的新型蛇纹石跨膜抗原及其用途
公开(公告)号：US20110318371A1
公开(公告)日：2011-12-29
申请号：US13134650
申请日：2011-06-13
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： A61K39/395 , C12N13/00 , A61P35/00 , C12N5/09
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。本文描述和表征了四种特定的人STEAP。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

129. 发明授权

US08003758B2 BPC-1: a secreted brain-specific protein expressed and secreted by prostate and bladder cancer cells 失效
标题翻译： BPC-1：由前列腺和膀胱癌细胞表达和分泌的分泌的脑特异性蛋白
公开(公告)号：US08003758B2
公开(公告)日：2011-08-23
申请号：US12718821
申请日：2010-03-05
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Aya Jakobovits
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Aya Jakobovits
IPC分类号： C07K5/10
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , C07K2317/24 , C07K2319/02 , C12N2799/026 , C12N2799/027
摘要： Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In human normal tissues, BPC-1 is only expressed in certain tissues of the brain. However, BPC-1 is expressed at high levels in prostate cancer cells and is also expressed in bladder cancer cells. The structure of BPC-1 includes a signal sequence and a CUB domain. BPC-1 protein is secreted. Preliminary experimental evidence suggests that BPC-1 is directly involved in oncogenesis or maintenance of the transformed phenotype of cancer cells expressing BPC-1. BPC-1 also appears to bind specifically to a cellular protein expressed in prostate cancer cells and other cells.
摘要翻译：描述了一种新型基因及其编码的分泌的肿瘤抗原，称为BPC-1，以及用于治疗表达BPC-1的各种癌症的诊断和治疗方法和组合物，特别包括前列腺癌和膀胱癌。在人正常组织中，BPC-1仅在脑的某些组织中表达。然而，BPC-1在前列腺癌细胞中以高水平表达，并且也在膀胱癌细胞中表达。 BPC-1的结构包括信号序列和CUB域。分泌BPC-1蛋白。初步实验证据表明，BPC-1直接参与肿瘤发生或维持表达BPC-1的癌细胞的转化表型。 BPC-1也似乎特异性结合前列腺癌细胞和其他细胞中表达的细胞蛋白。

130. 发明授权

US07968307B2 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
公开(公告)号：US07968307B2
公开(公告)日：2011-06-28
申请号：US12575164
申请日：2009-10-07
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： G01N33/574
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

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