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111. 发明申请

US20130216519A1 PROTEASES PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：US20130216519A1
公开(公告)日：2013-08-22
申请号：US13757222
申请日：2013-02-01
申请人： DANISCO US INC.
发明人： David A. Estell , Fiona A. Harding
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.

112. 发明申请

US20130029402A1 BACILLUS STRAIN FOR INCREASED PROTEIN PRODUCTION 有权
标题翻译：用于增加蛋白质生产的微生物菌株
公开(公告)号：US20130029402A1
公开(公告)日：2013-01-31
申请号：US13622968
申请日：2012-09-19
申请人： Danisco US Inc.
发明人： Cristina Bongiorni , Eugenio Ferrari
IPC分类号： C12N9/54 , C12N9/56 , C12N1/21
CPC分类号： C12N9/16 , C07K14/32 , C12N9/1205
摘要： The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified Bacillus sp. Host cells that have at least one inactivated phr gene. The enhanced production of proteins of interest by the modified Bacillus sp. Host cells is further increased in modified Bacillus sp. Host cells that overexpress YmaH. Methods for producing proteins of interest in the modified host cells are also provided
摘要翻译：本发明提供已被遗传操作以具有增强的产生感兴趣蛋白质的能力的宿主细胞。特别地，本发明涉及改良的芽孢杆菌属具有至少一个失活的phr基因的宿主细胞。通过改良的芽孢杆菌菌种增强生产的目的蛋白质宿主细胞在改良的芽孢杆菌中进一步增加。宿主细胞过度表达YmaH。还提供了在修饰的宿主细胞中产生目标蛋白质的方法

113. 发明申请

US20120142076A1 BACILLUS STRAIN FOR INCREASED PROTEIN PRODUCTION 有权
标题翻译：用于增加蛋白质生产的微生物菌株
公开(公告)号：US20120142076A1
公开(公告)日：2012-06-07
申请号：US13377529
申请日：2010-06-02
申请人： Cristina Bongiorni , Eugenio Ferrari
发明人： Cristina Bongiorni , Eugenio Ferrari
IPC分类号： C12N9/54 , C12N9/56 , C12N1/21
CPC分类号： C12N9/16 , C07K14/32 , C12N9/1205
摘要： The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified Bacillus sp. Host cells that have at least one inactivated phr gene. The enhanced production of proteins of interest by the modified Bacillus sp. Host cells is further increased in modified Bacillus sp. Host cells that overexpress YmaH. Methods for producing proteins of interest in the modified host cells are also provided
摘要翻译：本发明提供已被遗传操作以具有增强的产生感兴趣蛋白质的能力的宿主细胞。特别地，本发明涉及改良的芽孢杆菌属具有至少一个失活的phr基因的宿主细胞。通过改良的芽孢杆菌菌种增强生产的目的蛋白质宿主细胞在改良的芽孢杆菌中进一步增加。宿主细胞过度表达YmaH。还提供了在修饰的宿主细胞中产生目标蛋白质的方法

114. 发明申请

US20120009651A1 Production of Thermolysin and Variants Thereof and Use In Liquid Detergents 失效
标题翻译：生产溶血素及其变体并用于液体洗涤剂
公开(公告)号：US20120009651A1
公开(公告)日：2012-01-12
申请号：US12740782
申请日：2008-10-28
申请人： David A. Estell , Ronaldus W.J. Hommes , Amy D. Liu , Andrew Shaw
发明人： David A. Estell , Ronaldus W.J. Hommes , Amy D. Liu , Andrew Shaw
IPC分类号： C12N9/52 , C12N9/54 , D06L1/16 , C12N1/21 , C11D3/60 , C12N9/56 , C12S9/00
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38618 , C11D3/38636 , C12Y304/24027
摘要： The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.
摘要翻译：本发明提供包含至少一种具有改善的储存稳定性和/或催化活性的嗜热菌蛋白酶样中性蛋白酶的方法和组合物。在一些实施方案中，嗜热菌蛋白酶用于清洁和其它包含洗涤剂的应用。在一些特别优选的实施方案中，本发明提供包含热溶菌素的方法和组合物，其配制和/或工程化以抵抗洗涤剂诱导的失活。

115. 发明申请

US20110251073A1 Compositions And Methods Comprising Variant Microbial Proteases 审中-公开
标题翻译：包含变异微生物蛋白酶的组成和方法
公开(公告)号：US20110251073A1
公开(公告)日：2011-10-13
申请号：US12996538
申请日：2009-06-03
申请人： Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, JR.
发明人： Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, JR.
IPC分类号： C12N9/54 , C12N1/21 , C12N15/57 , C12Q1/37 , C12S11/00 , C12S9/00 , C12N15/75 , C40B20/00
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12N9/52 , C12Y304/21062
摘要： The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more properties of a protein. The present invention also provides variant subtilisins suitable for various uses.
摘要翻译：本发明提供蛋白质工程方法。具体地说，本发明提供了使用位点评估库来设计优化蛋白质的两个或多个性质的文库的方法。本发明还提供适用于各种用途的变体枯草杆菌蛋白酶。

116. 发明授权

US07901918B2 Proteases and variants thereof 有权
标题翻译：蛋白酶及其变体
公开(公告)号：US07901918B2
公开(公告)日：2011-03-08
申请号：US12351454
申请日：2009-01-09
申请人： Mads Norregaard-Madsen , Peter Rahbek Ostergaard , Claus Bo Voge Christensen , Soren Flensted Lassen
发明人： Mads Norregaard-Madsen , Peter Rahbek Ostergaard , Claus Bo Voge Christensen , Soren Flensted Lassen
IPC分类号： C12N9/54 , C11D3/386 , C12N15/57 , C12N15/74 , C12N15/75
CPC分类号： C12N9/54 , A61K38/00 , C11D3/386 , Y02A50/473
摘要： The present invention relates to isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and vectors coding for the expression of said proteases and variants, host cells capable of expressing the proteases and variants from the DNA constructs, as well as a method of producing them by cultivating said host cells. The proteases may advantageously be used as constituents in detergent compositions and additives, optionally in combination with other enzymes such as proteases, lipases, cellulases, amylases, peroxidases or oxidases.
摘要翻译：本发明涉及RP-II型分离的蛋白酶和与亲本RP-II蛋白酶相比表现出改进性质的RP-II蛋白酶的变体，DNA构建体和编码所述蛋白酶和变体的表达的载体，具有宿主细胞能力从DNA构建体表达蛋白酶和变体，以及通过培养所述宿主细胞产生它们的方法。蛋白酶可以有利地用作洗涤剂组合物和添加剂中的组分，任选地与其它酶如蛋白酶，脂肪酶，纤维素酶，淀粉酶，过氧化物酶或氧化酶组合使用。

117. 发明授权

US07897728B2 Process for making a low molecular weight gelatine hydrolysate 有权
标题翻译：制备低分子量明胶水解产物的方法
公开(公告)号：US07897728B2
公开(公告)日：2011-03-01
申请号：US11908503
申请日：2006-05-31
申请人： John M. Dolphin , Jason D. Russell
发明人： John M. Dolphin , Jason D. Russell
IPC分类号： C09H3/00 , A61K38/17 , A61K9/48 , C12N9/50 , C12N9/54 , C12N9/62
CPC分类号： C08L89/06 , C08H1/06
摘要： The present invention provides a process to make a gelatine hydrolysate, a gelatine hydrolysate, and gelatine compositions including gelatine hydrolysates. More specifically, the invention provides gelatine compositions having a reduced tendency to cross-link and improved dissolution properties.
摘要翻译：本发明提供一种制备明胶水解产物，明胶水解产物和明胶水解产物的明胶组合物的方法。更具体地，本发明提供具有降低的交联倾向和改善的溶解性质的明胶组合物。

118. 发明授权

US07875445B2 Subtilases 失效
标题翻译：分散液
公开(公告)号：US07875445B2
公开(公告)日：2011-01-25
申请号：US12710502
申请日：2010-02-23
申请人： Preben Nielsen , Poul Erik Pedersen , Helle Outtrup
发明人： Preben Nielsen , Poul Erik Pedersen , Helle Outtrup
IPC分类号： C12N9/54 , C11D3/386 , C12N15/57 , C12N15/74 , C12N15/75
CPC分类号： C12N15/62 , C12N9/54 , C12N15/52
摘要： The present invention relates to novel JP170 like subtilases from wild-type bacteria, hybrids thereof and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as a laundry or an automatic dishwashing detergent.
摘要翻译：本发明涉及来自野生型细菌的新型JP170类枯草芽孢杆菌，其杂种，以及构建和生产这些蛋白酶的方法。此外，本发明涉及所要求的残留物在洗涤剂如衣物或自动餐具洗涤剂中的用途。

119. 发明授权

US07858354B2 Subtilases 有权
标题翻译：分散液
公开(公告)号：US07858354B2
公开(公告)日：2010-12-28
申请号：US12363309
申请日：2009-01-30
申请人： Preben Nielsen , Martin Borchert
发明人： Preben Nielsen , Martin Borchert
IPC分类号： C12N9/54 , C11D3/386 , C12N15/57 , C12N15/74 , C12N15/75
CPC分类号： C11D3/386
摘要： The present invention relates to novel subtilases from wild-type strains of Bacillus, especially the Bacillus strains ZI344, EP655, P203, EP63, ZI120, ZI130, ZI1342 and ZI140, and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as a laundry detergent or an automatic dishwashing detergent.
摘要翻译：本发明涉及来自芽孢杆菌属的野生型菌株，特别是芽孢杆菌菌株ZI344，EP655，P203，EP63，ZI120，ZI130，ZI1342和ZI140的新型枯草芽孢杆菌，以及这些蛋白酶的构建和生产方法。此外，本发明涉及所要求的残留物在洗涤剂中的用途，例如洗衣洗涤剂或自动餐具洗涤剂。

120. 发明授权

US07846231B2 Method of treating organic waste, agent for treating organic waste and microorganisms to be used therein 有权
标题翻译：处理有机废物的方法，用于处理有机废物的试剂和其中使用的微生物
公开(公告)号：US07846231B2
公开(公告)日：2010-12-07
申请号：US10543900
申请日：2004-01-29
申请人： Hiroshi Miyazaki , Kiyoshi Maruta , Tomohiro Hamaoka
发明人： Hiroshi Miyazaki , Kiyoshi Maruta , Tomohiro Hamaoka
IPC分类号： C05F11/08 , C05F11/00 , C05F3/00 , C05F9/00 , C05F1/00 , C05F7/00 , C05D9/02 , C12N9/52 , C12N9/54 , C12N9/56 , A62D3/30
CPC分类号： C12R1/07 , C02F3/34
摘要： There are provided a method of treating organic waste, which is excellent in the smooth temperature elevation in the early stage of the treatment and satisfactory in temperature-maintenance in a high temperature range, and by which the stable treatment of organic waste is achieved and the evaporation of moisture is promoted, thereby a stable effect of treating organic waste and an increased treatment scale being achieved; an agent for treating organic waste; and microorganisms to be used therein. The method is characterized by the use of a mesophilic bacterium showing its activity at 15 to 50° C. and a thermophilic bacterium showing its activity at 50 to 70° C. in the organic waste. As the mesophilic bacteria, bacteria which have an exothermic action and form spores under a temperature of 50° C. or higher are preferable and Bacillus subtilis is more preferable. Among these bacteria, a C-3102 strain (FERM BP-1096) is especially preferable. As the thermophilic bacteria, Bacillus pallidus is preferable and, among these bacteria, a TK6004 strain (FERM BP-08597) is more preferable.
摘要翻译：提供了一种处理有机废弃物的方法，其在处理的早期阶段的平稳的温度上升是优异的，并且在高温范围内的温度维持是令人满意的，并且通过其有机废物的稳定处理和促进水分蒸发，从而达到治疗有机废物的稳定效果，提高处理规模; 一种处理有机废物的药剂; 和其中使用的微生物。该方法的特征在于使用在15至50℃下显示其活性的嗜温细菌，以及在有机废物中在50至70℃显示出其活性的嗜热细菌。作为嗜温菌，优选在50℃以上的温度下具有放热作用并形成孢子的细菌，更优选枯草芽孢杆菌。在这些细菌中，特别优选C-3102菌株（FERM BP-1096）。作为嗜热菌，优选芽孢杆菌，其中更优选TK6004菌株（FERM BP-08597）。

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