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111. 发明授权

US09096631B2 Epimerisation of saccharides 有权
标题翻译：糖的差向异构化
公开(公告)号：US09096631B2
公开(公告)日：2015-08-04
申请号：US13578520
申请日：2011-02-07
申请人： Bruno Frederic Stengel
发明人： Bruno Frederic Stengel
IPC分类号： C07H3/02 , C07H3/04 , C07H1/00 , B01J19/00
CPC分类号： C07H3/06 , A23K20/163 , B01J19/0093 , B01J23/28 , B01J27/24 , B01J2219/00822 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00851 , B01J2219/0086 , B01J2219/00869 , C07H1/00 , C07H3/02
摘要： The present invention relates to a process for an epimerization of a saccharide in a microdevice consisting of a network of micron-sized channels in presence of molybdenum containing catalyst. It further relates to the use of a microdevice consisting of a network of micron-sized channels for the epimerization reaction of saccharides and the oligomerization of the thus obtained epimerized saccharide, preferably into manno-oligosaccharides.
摘要翻译：本发明涉及一种在含钼催化剂存在下由微米级通道网络组成的微型装置中的糖的差向异构化方法。它还涉及由微米级通道网络组成的微装置用于糖类差向异构化反应和由此得到的差向异构化糖的低聚，优选用于低聚半乳糖。

112. 发明授权

US08999374B2 Method of inhibiting salmonella in livestock and poultry 有权
标题翻译：抑制家畜禽类沙门氏菌的方法
公开(公告)号：US08999374B2
公开(公告)日：2015-04-07
申请号：US10536488
申请日：2003-11-26
申请人： Toshimichi Morikoshi , Futoshi Yokomizo
发明人： Toshimichi Morikoshi , Futoshi Yokomizo
IPC分类号： A23K1/17 , A23K1/18 , A23K1/165 , A61K47/00 , A61K36/899 , A01N65/00 , A23K1/16 , A23L1/0528 , A61K31/7016 , C07H3/04 , C12P19/12 , C12P19/14
CPC分类号： A23K1/1826 , A23K20/163 , A23K50/75 , A23L29/244 , A61K31/7016 , C07H3/04 , C12P19/12 , C12P19/14 , Y10S424/823 , Y10S424/826
摘要： The present invention is to provide a β-1,4-mannobiose-containing composition which can inhibit colonization of salmonella in animal body and effectively excrete salmonella outside the body and the method for producing thereof, a feed additive containing the β-1,4-mannobiose-containing composition, and a feed blended with the β-1,4-mannobiose-containing composition. The present invention is intended to provide a method for producing the β-1,4-mannobiose-containing composition wherein a mannan degrading enzyme is functioned to a mannan-containing natural material for producing at least 10% by weight of β-1,4-mannobiose based on the mannan before the degradation, the β-1,4-mannobiose-containing composition prepared through the function of a mannan degrading enzyme to a mannan-containing natural material, which contains at least 10% by weight of β-1,4-mannobiose in terms of dry matter, a feed additive containing the β-1,4-mannobiose-containing composition, and a feed blended with the β-1,4-mannobiose-containing composition.
摘要翻译：本发明提供一种含有-1,4-甘露二糖的组合物，其可以抑制动物体内沙门氏菌的定植，并有效排出身体外的沙门氏菌及其制备方法，含有β- ，含有D-甘露糖的组合物和与含有-1.4-含有甘露糖的组合物混合的饲料。本发明旨在提供一种用于生产含有-1,4-mannobiose的组合物的方法，其中甘露聚糖降解酶对含有甘露聚糖的天然材料起作用，以产生至少10重量％的＆bgr -1 ，基于降解前的甘露聚糖的4-甘露糖苷，通过甘露聚糖降解酶对含有甘露聚糖的天然材料的功能制备的含有-1,4-甘露糖的组合物，其含有至少10重量％以干物质为基础的-1,4-甘露糖苷，含有含有-1.4-含有甘露糖的组合物的饲料添加剂，以及与含有-1.4-含有甘露糖的组合物混合的饲料。

113. 发明申请

US20150079227A1 ROLLING COMPOUND POWDERS FOR APPLYING ON THE SURFACE OF CHEWING GUM CORE MATERIALS 审中-公开
标题翻译：轧制复合粉末涂布在表面上的石墨材料
公开(公告)号：US20150079227A1
公开(公告)日：2015-03-19
申请号：US14387057
申请日：2013-03-07
申请人： SÜDZUCKER AKTIENGESELLSCHAFT MANNHEIM/OCHSENFURT
发明人： Tillmann Dörr , Jörg Bernard
IPC分类号： A23G4/20 , C07H3/04 , A23L1/09
摘要： The present invention relates to rolling compound powders comprising hydrogenated or non-hydrogenated isomaltulose for applying to the surface of chewing gum core materials, chewing gum products comprising such rolling compound powders, processes for reducing the stickiness of compositions of chewing gum core materials by using hydrogenated or non-hydrogenated isomaltulose-containing rolling compound powders in chewing gum preparation processes as well as the use of hydrogenated or non-hydrogenated isomaltulose in rolling compound powders for applying to the surface of chewing gum core materials.
摘要翻译：本发明涉及包含氢化或非氢化异麦芽酮糖的滚动化合物粉末，用于施加到口香糖核心材料的表面，包含这种滚动化合物粉末的口香糖产品，通过使用氢化来降低口香糖核心材料的组合物的粘性的方法或非氢化异麦芽酮糖的滚动化合物粉末，以及在滚动化合物粉末中使用氢化或非氢化异麦芽酮糖作为口香糖核心材料的表面。

114. 发明申请

US20140336369A1 PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF 审中-公开
标题翻译：制备丙氨酸的方法及其合成有用的中间体
公开(公告)号：US20140336369A1
公开(公告)日：2014-11-13
申请号：US14338927
申请日：2014-07-23
申请人： Apicore US LLC
发明人： Ravishanker Kovi , Ashish Naik , Brijesh Patel , Muralikrishna Madala
IPC分类号： C07H11/00 , C07H3/02 , C07H3/04 , C07H1/00 , C07H1/06 , C07H19/01
CPC分类号： C07H11/00 , C07H1/00 , C07H1/06 , C07H3/02 , C07H3/04 , C07H15/04 , C07H15/18 , C07H19/01
摘要： Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.
摘要翻译：公开了用于合成因子Xa抗凝血剂磺达肝素和相关化合物的方法。提供了受保护的五糖中间体，并且通过经脱保护和磺化反应的顺序转化受保护的五糖中间体，可以有效且可扩展地生产磺达肝素钠的方法。

115. 发明申请

US20140235849A1 Method for Increasing the Yield in Lactose Production (III) 有权
标题翻译：增加乳糖产量的方法（三）
公开(公告)号：US20140235849A1
公开(公告)日：2014-08-21
申请号：US14177837
申请日：2014-02-11
申请人： DMK Deutsches Milchkontor GmbH
发明人： Sven-Rainer Döring
IPC分类号： C07H3/04
CPC分类号： C07H3/04 , C13K5/00
摘要： Suggested is a method for improving the yield during the production of crystalline alpha lactose, wherein (a) an aqueous lactose solution is adjusted to a temperature of between about 62 and 67° C., (b) the solution is cooled down to between about 20 and 30° C., (c) the solution is held at this temperature for 0 to 5 h, (d) subsequently, the solution is re-heated to between about 30 and 35° C., (e) the solution is held at this temperature for 0 to 5 h, (f) then the solution is cooled down to about 10° C. and (g) subsequently, the precipitated alpha lactose crystals are separated from the second mother liquor, (h) an amount of a carbohydrate compound is added to the second mother liquor such that the solubility product of the residual amount of lactose that is still soluble is exceeded, (i) the second amount of precipitated alpha lactose crystals is separated from the mother liquor, dried, and (j) both amounts of alpha lactose crystals are combined.
摘要翻译：建议在结晶α乳糖生产期间提高产量的方法，其中（a）将乳糖水溶液调节至约62至67℃之间的温度，（b）将溶液冷却至约 20℃和30℃，（c）溶液在该温度下保持0至5小时，（d）随后将溶液再加热至约30至35℃，（e）溶液为在该温度下保持0至5小时，（f）然后将溶液冷却至约10℃，（g）随后将沉淀的α乳糖晶体与第二母液分离，（h）将碳水化合物化合物加入到第二母液中，使得超过仍然溶解的乳糖残留量的溶解度积，（i）将第二量的沉淀的α乳糖晶体与母液分离，干燥，和 j）将两种量的α乳糖晶体组合。

116. 发明授权

US08470311B2 Therapeutic agent for anaerobic diseases 有权
标题翻译：厌氧性疾病治疗剂
公开(公告)号：US08470311B2
公开(公告)日：2013-06-25
申请号：US12988181
申请日：2009-04-17
申请人： Takayuki Sasaki , Hitomi Shimizu , Yuko Shimatani-Shibata , Hiromi Yonekura
发明人： Takayuki Sasaki , Hitomi Shimizu , Yuko Shimatani-Shibata , Hiromi Yonekura
IPC分类号： A61K35/74 , C07H3/04 , C07H3/06 , C12N1/38 , A61P35/00 , A61P9/10
CPC分类号： C12N15/74 , C12N15/746
摘要： The present invention provides a therapeutic agent for anaerobic diseases such as solid tumor, comprising in combination a pharmaceutical composition for the treatment of an anaerobic disease containing the transformed anaerobic microorganism as an active component and a pharmaceutical composition containing as an active component an anaerobic microorganism colonization and growth enhancer for enhancing the specific colonization and proliferation of the anaerobic microorganism at an anaerobic disease site. Furthermore, the present invention provides to an anaerobic microorganism colonization and growth enhancer for enhancing colonization and growth of the transformed anaerobic microorganism at a disease site that is in an anaerobic environment.
摘要翻译：本发明提供了一种用于厌氧性疾病如固体肿瘤的治疗剂，其组合包含用于治疗含有作为活性成分的转化的厌氧微生物的厌氧性疾病的药物组合物和含有作为活性成分的厌氧微生物定植的药物组合物以及用于在厌氧性疾病部位增强厌氧微生物的特异性定殖和增殖的生长增强剂。此外，本发明提供了一种用于在处于厌氧环境的疾病部位增强转化的厌氧微生物的定植和生长的厌氧微生物定植和生长增强剂。

117. 发明申请

US20130096295A1 Maltoside and Phosphocholine Derivatives, Uses thereof and Methods of Preparing Artificial Lipid Structures Thereof 有权
标题翻译：麦芽糖苷和磷酸胆碱衍生物，其用途及其制备人造脂质结构的方法
公开(公告)号：US20130096295A1
公开(公告)日：2013-04-18
申请号：US13272090
申请日：2011-10-12
申请人： Benjamin R. Travis , Ritesh Mittal , Lijun Huang , Liang Tang
发明人： Benjamin R. Travis , Ritesh Mittal , Lijun Huang , Liang Tang
IPC分类号： C07D249/04 , C07H3/04 , C07F9/10 , C07H5/04
CPC分类号： C07F9/6518 , C07F9/103 , C07H15/26
摘要： Disclosed are saccharide and phosphocholine derivatives. The derivatives include azide and alkyne derivatives which form one end of a variable length carbon chain. The opposite end of the variable length carbon chain is covalently linked to the saccharide or phosphocholine. The saccharide may be, for instance, a maltoside. The alkyne and azide derivatives of the saccharides and phosphocholine may be reacted together to form amphiphilic molecules useful in cellular membrane studies and applications. By adjusting the length of the carbon chain, the biochemical and biophysical properties of the resultant 1,4-disubstituted 1,2,3-triazole compounds may be custom tailored for the intended application. Resultant molecules may form micelles, bicelle, lipid bilayers and other like structures useful in the isolation and purification of membrane bound or membrane associated proteins and biochemical components. The saccharides and phosphocholine molecules may be alternatively substituted as desired to provide additional flexibility in designing the desired end product.
摘要翻译：公开了糖和磷酸胆碱衍生物。衍生物包括形成可变长度碳链的一端的叠氮化物和炔衍生物。可变长度碳链的相对端与糖或磷酸胆碱共价连接。糖可以是例如麦芽糖苷。糖和磷酸胆碱的炔和叠氮衍生物可以一起反应以形成用于细胞膜研究和应用的两亲分子。通过调整碳链的长度，所得的1,4-二取代的1,2,3-三唑化合物的生物化学和生物物理性质可以根据预期的应用定制。所产生的分子可以形成胶束，双胞胎，脂质双层和其他类似的结构，可用于分离和纯化膜结合或膜相关蛋白和生物化学成分。糖和磷酸胆碱分子可以根据需要被替代地替代，以在设计期望的最终产物时提供额外的灵活性。

118. 发明申请

US20120289692A1 PROCESS FOR PURIFYING LIGNOCELLULOSIC FEEDSTOCKS 有权
标题翻译：净化线粒体饲料的方法
公开(公告)号：US20120289692A1
公开(公告)日：2012-11-15
申请号：US13469906
申请日：2012-05-11
申请人： Matthew Gray , Megan Matthes , Thomas Nelson , Andrew Held
发明人： Matthew Gray , Megan Matthes , Thomas Nelson , Andrew Held
IPC分类号： C07H1/08 , C07H3/04 , C07C37/82 , C07C29/76 , C08B15/00 , C07C31/20 , C07C31/22 , C07C39/04 , C07H3/02 , C08B37/00 , C07C31/02
CPC分类号： C10G17/02 , C10G3/00 , C10G2300/1014 , C10G2300/20 , C10G2300/201 , C12P2201/00 , C13K1/02 , C13K1/06 , C13K13/002 , C13K13/007 , Y02E50/16 , Y02P30/20
摘要： The present invention includes methods for removing contaminants, such as mineral salts, mineral acids, terpenoids, stilbenes, flavonoids, proteinaceous materials, metal impurities, ash and other organic products, from a lignocellulosic feedstock stream containing oxygenated hydrocarbons.
摘要翻译：本发明包括从含有氧化烃的木质纤维素原料流中除去诸如矿物盐，矿物酸，萜类，茋，类黄酮，蛋白质物质，金属杂质，灰分和其它有机产物的污染物的方法。

119. 发明申请

US20120263649A1 DETECTION OF MYCOBACTERIA 审中-公开
标题翻译：检测MYCOBACTERIA
公开(公告)号：US20120263649A1
公开(公告)日：2012-10-18
申请号：US13395382
申请日：2010-09-10
申请人： Keriann Marie Backus , Benjamin Davis , Clifton B. Barry, III , Helena Boshoff
发明人： Keriann Marie Backus , Benjamin Davis , Clifton B. Barry, III , Helena Boshoff
IPC分类号： C07H5/06 , A61K49/00 , G01N24/08 , C07H3/04 , C12Q1/04 , G01N21/64
CPC分类号： A61K49/0067 , A61K49/0043 , C07H3/04 , C07H5/02 , C07H11/04 , C07H13/06
摘要： A method for determining the presence of mycobacteria species in an organism or biological sample, the method comprising adding to the organism or biological sample a probe molecule comprising a substrate and a label, which probe molecule can be incorporated into mycobacteria, the presence of mycobacteria being determined by a detector responsive to the presence of the label, optionally after applying a stimulus; suitable probe molecules include compounds comprising a label and a substrate, which label is can be detected by a detector responsive to the presence of the label, optionally after applying a stimulus, characterised by compound being able to engage with the active site of Antigen 85B (Ag85B) such that it can form simultaneous hydrogen bonds with two or more amino acids in the active site selected from Arg 43, Trp 264, Ser126, His 262 and Leu 42, or the corresponding amino acids in Antigen 85A (Ag85A) or Antigen 85C (Ag85C), at least one of which is with Ser126.
摘要翻译：一种用于确定生物体或生物样品中分枝杆菌物种存在的方法，所述方法包括向生物体或生物样品添加包含底物和标记的探针分子，所述探针分子可以并入分枝杆菌中，分枝杆菌的存在是由响应于标签存在的检测器确定，任选地在施加刺激之后; 合适的探针分子包括包含标记物和底物的化合物，所述标记物可以通过检测器检测，所述检测器响应于标记物的存在，任选地在施用刺激之后，其特征在于化合物能够与抗原85B的活性位点 Ag85B），使得其可以在选自Arg 43，Trp 264，Ser126，His 262和Leu 42的活性位点或抗原85A（Ag85A）或抗原85C中的相应氨基酸形成与两个或更多个氨基酸的同时氢键（Ag85C），其中至少一个是Ser126。

120. 发明申请

US20120135475A1 LIQUEFIED BIOMASS 有权
标题翻译：液化生物量
公开(公告)号：US20120135475A1
公开(公告)日：2012-05-31
申请号：US13322395
申请日：2010-05-21
申请人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
发明人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
IPC分类号： C12P19/14 , C07H3/04 , C07H3/02 , C12P1/04 , C12P1/02
CPC分类号： C12P19/02 , C12P19/14 , Y02E50/17
摘要： The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.
摘要翻译：本发明涉及液化甜菜和/或甘蔗生物质材料及其生产方法和用途。液化生物质储存稳定，可用于生产发酵产物。

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