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111. 发明授权

US09254311B2 Modified polynucleotides for the production of proteins 有权
标题翻译：用于生产蛋白质的修饰多核苷酸
公开(公告)号：US09254311B2
公开(公告)日：2016-02-09
申请号：US14390100
申请日：2013-03-09
申请人： Moderna Therapeutics, Inc.
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C07K14/47 , A61K38/17 , A61K31/7115 , A61K9/127 , A61K48/00 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译：本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。

113. 发明授权

US09221891B2 In vivo production of proteins 有权
标题翻译：体内产生蛋白质
公开(公告)号：US09221891B2
公开(公告)日：2015-12-29
申请号：US14390106
申请日：2013-03-15
申请人： Moderna Therapeutics, Inc.
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C12N15/85 , C07K14/47 , A61K31/7115 , A61K9/127 , A61K48/00 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译：本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。

114. 发明申请

US20150342883A1 Hyaluronidase and a Low Density Second PEG Layer on the Surface of Therapeutic-Encapsulated Nanoparticles to Enhance Nanoparticle Diffusion and Circulation 审中-公开
标题翻译：透明质酸酶和治疗性包封纳米颗粒表面上的低密度第二PEG层以增强纳米颗粒扩散和循环
公开(公告)号：US20150342883A1
公开(公告)日：2015-12-03
申请号：US14726770
申请日：2015-06-01
申请人： Drexel University
发明人： Hao Cheng , Hao Zhou
IPC分类号： A61K9/127 , A61K9/50 , A61K31/704
CPC分类号： A61K31/704 , A61K9/5153 , A61K47/6911 , Y10T428/2982
摘要： A delivery system comprising an organic nanoparticle, a hyaluronidase anchored or conjugated to the organic nanoparticle. The organic nanoparticle may be selected from a polymer-based nanoparticle, a lipid-based nanoparticle and nanoparticle formed by lipid-like molecules. In some embodiments, the hyaluronidase is covalently bound to a linker or spacer which, in turn, is anchored or covalently bound to the organic nanoparticle. The delivery system may also comprise an active pharmaceutical agent, a diagnostic agent, and/or a cellular membrane. The organic nanoparticle may further have a low density poly(ethylene glycol) layer on the surface. Methods for using the delivery system including for treating or diagnosing a disease are also provided. The organic nanoparticle provides enhanced diffusion/penetration through the extracellular matrix found in tumors, as well as increased circulation time in a human or animal body.
摘要翻译：包含有机纳米颗粒，锚定或与有机纳米颗粒缀合的透明质酸酶的递送系统。有机纳米颗粒可以选自基于聚合物的纳米颗粒，基于脂质的纳米颗粒和由类脂分子形成的纳米颗粒。在一些实施方案中，透明质酸酶共价结合到接头或间隔物上，接头或间隔物又被锚定或共价结合到有机纳米颗粒上。递送系统还可以包含活性药剂，诊断剂和/或细胞膜。有机纳米颗粒在表面上还可以具有低密度聚（乙二醇）层。还提供了包括用于治疗或诊断疾病的递送系统的使用方法。有机纳米粒子通过在肿瘤中发现的细胞外基质提供增强的扩散/穿透，以及增加人或动物体内的循环时间。

115. 发明授权

US09173890B2 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US09173890B2
公开(公告)日：2015-11-03
申请号：US11946028
申请日：2007-11-27
申请人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
发明人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
IPC分类号： A61K38/00 , A61K31/661 , A61K9/14 , A61K38/10 , A61K38/17 , A61P3/00 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51
CPC分类号： A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

116. 发明授权

US09168225B2 Nano-hybrid delivery system for sequential utilization of passive and active targeting 有权
标题翻译：用于连续使用被动和主动瞄准的纳米混合输送系统
公开(公告)号：US09168225B2
公开(公告)日：2015-10-27
申请号：US13642868
申请日：2011-04-20
申请人： Seungpyo Hong , Ying Liu
发明人： Seungpyo Hong , Ying Liu
IPC分类号： A61K9/127 , A61K9/51 , A61K9/14
CPC分类号： A61K9/127 , A61K9/1273 , A61K9/14 , A61K9/146 , A61K9/5153
摘要： The present invention features nanohybrid drug delivery composition which combines both passive and active targeting for the prevention and treatment of disease. The composition is shell-encapsulated multivalent polymeric scaffold with a therapeutic agent and targeting agent attached thereto.
摘要翻译：本发明的特征在于纳米杂交药物递送组合物，其组合用于预防和治疗疾病的被动和主动靶向。该组合物是具有与其连接的治疗剂和靶向剂的壳包封的多价聚合物支架。

117. 发明申请

US20150283095A1 NANOPARTICLES WITH BIODEGRADABLE AND BIOCOMPATIBLE POLYMER PLGA, LOADED WITH THE DRUG FOR HUMAN USE PENTOXIFYLLINE 审中-公开
标题翻译：具有可生物降解和生物聚合的聚合物PLGA的纳米颗粒，用于用于人类使用的戊二醛的药物
公开(公告)号：US20150283095A1
公开(公告)日：2015-10-08
申请号：US14443260
申请日：2013-11-15
申请人： UNIVERSIDAD DE SANTIAGO DE CHILE
发明人： Luis Ernerto Constandil Córdova , Paula Soledad Ibarra Durán , Cristian Andres Vilos Ortiz , Luis Velásquez Cumplido , Teresa Pelissier Serrano , Claudio Aurelio Laurido Fuenzalida , Alejandro Hernández Kunstmann
IPC分类号： A61K9/51 , A61K9/00 , A61K9/50 , A61K31/522
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/5089 , A61K9/5192 , A61K31/522
摘要： The invention relates to a novel pharmaceutical formulation comprising polymer nanoparticles of the biodegradable and biocompatible polymer poly(lactic-glycolic) acid (PLGA), loaded with the drug pentoxifylline, the method for the synthesis of the PLGA nanoparticles loaded with pentoxifylline, and to the use thereof in the effective treatment for the relief of chronic pain and for the prevention of chronic pain via the administration of a single dose.
摘要翻译：本发明涉及一种新型药物制剂，其包含负载药物己酮可可碱的可生物降解和生物相容性聚合物聚（乳酸 - 乙醇酸）酸（PLGA）的聚合物纳米颗粒，用于合成负载己酮可可碱的PLGA纳米颗粒的方法，以及其用于缓解慢性疼痛和通过施用单一剂量来预防慢性疼痛的有效治疗。

118. 发明申请

US20150283093A1 NANOENCAPSULATION OF CURCUMINOID METABOLITES - PROCESS, COMPOSITION AND APPLICATIONS THEREOF 审中-公开
标题翻译： CURCUMINOID代谢物的纳米抗体 - 其制备方法，组合物及其应用
公开(公告)号：US20150283093A1
公开(公告)日：2015-10-08
申请号：US14680076
申请日：2015-04-07
申请人： Muhammed Majeed , Kalyanam Nagabhushanam
发明人： Muhammed Majeed , Kalyanam Nagabhushanam
IPC分类号： A61K9/51 , A61K31/12
CPC分类号： A61K9/5192 , A61K9/5153 , A61K31/12
摘要： Disclosed is a process wherein nano-sized particles containing curcumin metabolites are prepared by the rapid expansion of subcritical solutions of curcumin metabolites and a polymeric substance into liquid solvents precipitating the nano-sized particles.
摘要翻译：公开了一种方法，其中通过将姜黄素代谢物和聚合物质的亚临界溶液快速膨胀到沉淀纳米尺寸颗粒的液体溶剂中来制备含有姜黄色素代谢物的纳米尺寸颗粒。

119. 发明申请

US20150283079A1 METHODS FOR FABRICATING ISOLATED MICRO- OR NANO-STRUCTURES USING SOFT OR IMPRINT LITHOGRAPHY 有权
标题翻译：使用软件或印刷图形制作分离的微米或纳米结构的方法
公开(公告)号：US20150283079A1
公开(公告)日：2015-10-08
申请号：US14658386
申请日：2015-03-16
申请人： The University of North Carolina at Chapel Hill
发明人： Joseph M. DeSimone , Jason P. Rolland , Benjamin W. Maynor , Larken E. Euliss , Ginger Denison Rothrock , Ansley E. Dennis , Edward T. Samulski , R. Jude Samulski
IPC分类号： A61K9/14 , A61K47/34
CPC分类号： A61K9/14 , A61K9/0097 , A61K9/5138 , A61K9/5153 , A61K9/5192 , A61K47/34 , B81C99/0085 , B82Y10/00 , B82Y40/00 , G03F7/0002 , H01L51/0004 , H01L51/0021 , Y10T428/24273 , Y10T428/24479 , Y10T428/3154
摘要： The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.
摘要翻译：目前公开的主题描述了基于氟化弹性体的材料，特别是基于全氟聚醚（PFPE）的材料在高分辨率软或压印光刻应用中的应用，例如微米和纳米级复制成型，以及第一纳米接触使用弹性体模具成型有机材料以产生高保真特征。因此，目前公开的主题描述了使用软或压印光刻技术生产任何形状的独立的，分离的纳米结构的方法。

120. 发明申请

US20150265716A1 Nanoparticles For Targeted Delivery of Multiple Therapeutic Agents and Methods of Use 有权
标题翻译：用于靶向递送多种治疗剂的纳米颗粒和使用方法
公开(公告)号：US20150265716A1
公开(公告)日：2015-09-24
申请号：US14434300
申请日：2013-10-09
申请人： The Brigham and Women's Hospital, Inc. , Massachusetts Institute of Technology
发明人： Pedro M. Valencia , Eric M. Pridgen , Suresh Gadde , Rohit Karnik , Robert S. Langer , Stephen J. Lippard , Omid C. Farokhzad
IPC分类号： A61K47/48 , A61K31/4745 , A61K47/34 , A61K9/14 , A61K45/06 , A61K33/24 , A61K9/51
CPC分类号： A61K47/6937 , A61K9/14 , A61K9/51 , A61K9/5146 , A61K9/5153 , A61K31/4745 , A61K31/555 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/593 , A61K47/6869 , B82Y5/00 , A61K2300/00
摘要： Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.
摘要翻译：本文提供了含有含有多种聚合物的纳米颗粒的组合物，其中至少一部分聚合物包含疏水性聚合物，拓扑异构酶抑制剂和含Pt化学治疗剂，其中聚合物在水性液体中自组装成形成纳米颗粒，并且其中含Pt化学治疗剂和拓扑异构酶抑制剂以约24:1至约1:24的比例存在于纳米颗粒的疏水核心内。还提供了减少癌细胞增殖的方法和在包括使用这些组合物的受试者中治疗癌症的方法。还提供了制备这些纳米颗粒的方法。

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