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111. 发明授权

US6140339A Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof 失效
标题翻译：单体和二聚芳基异喹啉生物碱及其衍生物
公开(公告)号：US6140339A
公开(公告)日：2000-10-31
申请号：US1801
申请日：1997-12-31
申请人： Gerhard Bringmann , Michael R. Boyd , Matthias Wenzel
发明人： Gerhard Bringmann , Michael R. Boyd , Matthias Wenzel
IPC分类号： A61K31/47 , A61K31/4725 , A61P33/06 , C07D217/02 , C07D217/04 , C07D217/24 , C07D401/04 , C07D401/10 , C07D491/04 , A61K31/472 , C07D217/06
CPC分类号： C07D491/04 , A61K31/47 , C07D217/02 , C07D217/04 , C07D217/24
摘要： The present invention provides new monomeric derivatives of the C-8'-7 linked naphthylisoquinoline alkaloid dioncophylline D. The invention also provides new C-4 substituted monomeric arylisoquinoline alkaloid derivatives. The present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers, wherein either or both of said monomer(s) is (are) monomeric compound(s) of the present invention. Monomeric and dimeric compounds of the present invention have medically useful properties, such as antimicrobial properties, more specifically such as antimalarial and antiviral properties. Monomeric compounds of the present invention are also useful as building blocks or intermediates for synthesis of novel dimeric arylisoquinoline alkaloids. Monomeric and dimeric compounds of the present invention may be obtained in substantially pure form by total synthesis, partial synthesis, or derivatization from known synthetic or naturally occurring compounds, and by isolation and purification from plants of the Dioncophyllaceae and Ancistrocladaceae families.
摘要翻译：本发明提供了C-8'-7连接的萘基异喹啉生物碱二萜类植物D的新单体衍生物。本发明还提供新的C-4取代的单体芳基异喹啉生物碱衍生物。本发明还提供由偶联的第一和第二芳基异喹啉单体组成的新型二聚芳基异喹啉生物碱，其中所述单体中的一种或两种是本发明的单体化合物。本发明的单体和二聚体化合物具有医学上有用的性质，例如抗微生物性质，更具体地，例如抗疟疾和抗病毒性质。本发明的单体化合物也可用作合成新型二聚芳基异喹啉生物碱的结构单元或中间体。本发明的单体和二聚体化合物可以通过从合成或天然存在的化合物的全部合成，部分合成或衍生化，以及通过从Dioncophyllaceae和Ancistrocladaceae家族的植物中分离和纯化而以基本上纯的形式获得。

112. 发明授权

US6136992A 2-alkoxy estradiols and derivatives thereof 失效
标题翻译： 2-烷氧基雌二醇及其衍生物
公开(公告)号：US6136992A
公开(公告)日：2000-10-24
申请号：US41212
申请日：1998-03-12
申请人： Siya Ram , Ravi Varma , Yesh Sachdeva
发明人： Siya Ram , Ravi Varma , Yesh Sachdeva
IPC分类号： C07J1/00 , C07J41/00
CPC分类号： C07J1/00 , C07J41/00
摘要： Compounds represented by the following structural formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification. The compounds are disclosed as useful in the treatment of various forms of cancer.
摘要翻译：由以下结构式表示的化合物：其中R1，R2和R3如说明书中所定义。该化合物被公开用于治疗各种形式的癌症。

113. 发明授权

US6114397A Gossypol for the treatment of cancer 失效
标题翻译：棉酚用于治疗癌症
公开(公告)号：US6114397A
公开(公告)日：2000-09-05
申请号：US379872
申请日：1995-01-27
申请人： Mary R. Flack , Richard Knazek , Marcus Reidenberg
发明人： Mary R. Flack , Richard Knazek , Marcus Reidenberg
IPC分类号： A61K31/11 , A61K31/22 , A61K31/12
CPC分类号： A61K31/11 , A61K31/22
摘要： A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts thereof. Also included is a method for treating cancer in a human which comprises administering to the human subject an anti-cancer effective amount of any of the compounds listed above in combination with an anti-cancer effective amount of other conventional chemotherapeutic agents. Finally, the invention also encompasses a pharmaceutical composition comprising an anti-cancer effective amount of gossypol, gossypol acetic acid, or gossypolone, and an anti-cancer effective amount of a conventional chemotherapeutic agent, or combinations of the latter.
摘要翻译：一种治疗人体癌症的方法，其包括向人类受试者施用抗癌有效量的选自棉酚，棉酚乙酸，棉酚，其代谢物或其生理学上可接受的盐的化合物。还包括用于治疗人类癌症的方法，其包括向人类受试者施用抗癌有效量的任何上述化合物与抗癌有效量的其它常规化学治疗剂的组合。最后，本发明还包括药物组合物，其包含抗癌有效量的棉酚，棉酚乙酸或棉酚，以及抗癌有效量的常规化学治疗剂或后者的组合。

114. 发明授权

US6110465A Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines 失效
标题翻译：丙型肝炎病毒分离株的包膜2基因的高变区1的核苷酸和推导的氨基酸序列，以及在诊断方法和疫苗中使用从这些高变序列得到的试剂
公开(公告)号：US6110465A
公开(公告)日：2000-08-29
申请号：US484322
申请日：1995-06-07
申请人： Jens Bukh , Roger H. Miller , Robert H. Purcell
发明人： Jens Bukh , Roger H. Miller , Robert H. Purcell
IPC分类号： A61K39/00 , C07K14/18 , A61K39/29
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222
摘要： The nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of 49 isolates of hepatitis C are disclosed. The invention relates to the use of these sequences to design proteins and nucleic acid sequences useful in diagnostic methods and vaccines.
摘要翻译：公布了49株丙型肝炎分离株的包膜2基因的高变区1的核苷酸和推定的氨基酸序列。本发明涉及这些序列用于设计可用于诊断方法和疫苗的蛋白质和核酸序列的用途。

115. 发明授权

US6094780A Ergonomic handle for terminal insertion tool 失效
标题翻译：端子插入工具的人体工程学手柄
公开(公告)号：US6094780A
公开(公告)日：2000-08-01
申请号：US11248
申请日：1998-01-27
申请人： James D. McGlothlin , Ova E. Johnston , Cheryl Fairfield Estill
发明人： James D. McGlothlin , Ova E. Johnston , Cheryl Fairfield Estill
IPC分类号： B25G1/00 , B25B27/14 , B25G1/10 , H01R43/22 , B25B23/16
CPC分类号： H01R43/22 , B25G1/102 , B25G1/105 , Y10T16/469 , Y10T16/476 , Y10T29/53222
摘要： An ergonomic tool handle (21) which is useful for a terminal insertion hand tool, gardening hand tools, knives, box cutters, screwdrivers and other pushing or pulling type hand tools. The tool handle (21) of the present invention is contoured to promote neutral posture between the hand and wrist as well as complementing the shape of the closed hand to distribute longitudinal tool forces evenly throughout the hand and arm of the user. The tool handle (21) accomplishes this neutral posture and contoured fit by featuring a humplike crown (28) which fits snugly into the pocket of the palm, a relatively flat underside (29) around which the user's finger tips (55-57) are wrapped and two sides (51, 52) with convex regions (30, 31) in diagonally offset relation. By moving one's hand up or down the tool handle (21), one size of tool handle (21) can ergonomically fit approximately 95% of male and female hand sizes.
摘要翻译： PCT No.PCT / US96 / 12339 Sec。 371日期：1998年1月27日 102（e）1998年1月27日PCT PCT 1996年7月25日PCT公布。出版物WO97 / 04927 日期1997年2月13日符合人体工程学的工具手柄（21），适用于终端插入手工工具，园艺手工具，刀具，盒式切割机，螺丝刀等推拉式手动工具。本发明的工具手柄（21）具有轮廓，以促进手和手腕之间的中立姿势，以及补充闭合的手的形状，以将纵向工具力均匀地分布在使用者的手臂中。工具手柄（21）通过将适合贴合在手掌口袋中的凹凸表冠（28），使用者的手指尖（55-57）周围的相对平坦的下侧（29）缠绕和具有对角偏移关系的凸区域（30,31）的两侧（51,52）。通过向上或向下移动工具把手（21），一个尺寸的工具把手（21）可以符合人体工程学，适合大约95％的男性和女性手的尺寸。

116. 发明授权

US6046228A Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof 有权
标题翻译：含有饱和1,2-二硫杂环化合物的抗病毒药物组合物及其应用
公开(公告)号：US6046228A
公开(公告)日：2000-04-04
申请号：US214331
申请日：1999-01-04
申请人： William G. Rice , Robert R. Schultz , David C. Baker , Louis E. Henderson
发明人： William G. Rice , Robert R. Schultz , David C. Baker , Louis E. Henderson
IPC分类号： A61K31/385 , A61K45/06 , C07D339/04 , C07D339/08 , C07D339/02 , C07D409/00
CPC分类号： C07D339/04 , A61K31/385 , A61K45/06 , C07D339/08
摘要： The present invention is directed to pharmaceutical compositions including a saturated 1,2-dithiaheterocyclic compound having antiviral activity. The present invention also provides a kit containing the pharmaceutical composition and methods of treating or preventing viral disease using the composition, as well as methods for inactivating retrovirus in a body fluid.
摘要翻译： PCT No.PCT / US97 / 10870 Sec。 371日期1999年1月4日 102（e）1999年1月4日PCT PCT 1997年7月3日PCT公布。第WO98 / 01440号公报日本1998年1月15日本发明涉及包含具有抗病毒活性的饱和1,2-二硫杂环化合物的药物组合物。本发明还提供了包含药物组合物和使用该组合物治疗或预防病毒性疾病的方法的试剂盒，以及用于灭活体液中的逆转录病毒的方法。

117. 发明授权

US6033905A Gibbon ape leukemia virus-based retroviral vectors 失效
标题翻译：长臂猿基于白血病病毒的逆转录病毒载体
公开(公告)号：US6033905A
公开(公告)日：2000-03-07
申请号：US716351
申请日：1997-02-24
申请人： Maribeth V. Eiden , Carolyn A. Wilson , Nicholas J. Deacon , David J. Hooker
发明人： Maribeth V. Eiden , Carolyn A. Wilson , Nicholas J. Deacon , David J. Hooker
IPC分类号： C12N15/09 , A61K31/70 , A61K35/76 , A61K48/00 , C07H21/04 , C07K14/15 , C12N5/10 , C12N7/00 , C12N7/01 , C12N15/48 , C12N15/867 , C12N15/00 , C12N5/00
CPC分类号： C12N15/86 , C07K14/005 , A61K48/00 , C12N2740/13022 , C12N2740/13043 , C12N2840/203
摘要： The present invention provides replication-defective hybrid retroviral vectors comprising GaLV components and methods for preparing and using such vectors. The vectors comprise a envelope component, a core component and a defective genome, at least one of which is derived from GaLV. The vectors can comprise the minimal cis acting sequences from GaLV that allow packaging of the defective genome in a hybrid virion.
摘要翻译： PCT No.PCT / US94 / 03784 Sec。 371日期1997年2月24日 102（e）1997年2月24日PCT PCT 1994年4月6日PCT公布。出版物WO94 / 23048 日期：1994年10月13日本发明提供了包含GaLV组分的复制缺陷型复合逆转录病毒载体和用于制备和使用这些载体的方法。载体包含包膜组分，核心组分和缺陷基因组，其中至少一种衍生自GaLV。载体可以包含来自GaLV的最小顺式作用序列，其允许将缺陷基因组包装在杂交病毒粒子中。

118. 发明授权

US6027516A Highly elastic, adjustable helical coil stent 失效
标题翻译：高弹性，可调螺旋线圈支架
公开(公告)号：US6027516A
公开(公告)日：2000-02-22
申请号：US434822
申请日：1995-05-04
申请人： Theodor Kolobow , Jeffrey Y. Wang
发明人： Theodor Kolobow , Jeffrey Y. Wang
IPC分类号： A61F2/06 , A61F2/84 , A61F2/88 , A61M29/00
CPC分类号： A61F2/88 , A61F2/95 , A61F2/958 , A61F2002/9505
摘要： A highly elastic, adjustable helical coil stent (10) has a helical coil (20) which can be contracted around a small diameter catheter (12) for percutaneous insertion into a human body and then can be remotely expanded back to its original shape when positioned at the desired location within the human body. The helical coil is preferably formed of a metal alloy (25) with high elasticity, such as superelastic Nitinol, encased within an elastomer (26). The helical coil is affixed at its distal end to a catheter and affixed at its proximal end to a control tube (30). By rotating the control tube in one direction relative to the catheter (e.g., clockwise), the helical coil contracts and by rotating the control tube in the opposite direction (e.g., counterclockwise), the helical coil expands. The adjustable helical coil stent of the present invention is particularly useful for total or partial heart assist during heart bypass procedures. It can also be used, for example, as a stent for damaged blood vessels or other body conduits in either humans or animals.
摘要翻译：高度弹性的，可调节的螺旋线圈支架（10）具有螺旋线圈（20），该螺旋线圈（20）可以围绕小直径的导管（12）收缩，用于经皮插入人体内，然后可以在定位时远程扩展回其原始形状在人体内的所需位置。螺旋线圈优选地由包含在弹性体（26）内的具有高弹性的金属合金（25）形成，例如超弹性镍钛诺。螺旋线圈在其远端处固定到导管，并在其近端处固定到控制管（30）。通过相对于导管（例如，顺时针）在一个方向旋转控制管，螺旋线圈收缩并且通过使控制管沿相反方向（例如逆时针方向）旋转，螺旋线圈膨胀。本发明的可调螺旋线圈支架对于心脏旁路手术期间的全部或部分心脏辅助是特别有用的。它也可以用作例如人或动物中损伤的血管或其它体导管的支架。

119. 再颁专利

USRE36529E Spectroscopic imaging device employing imaging quality spectral filters 失效
标题翻译：使用成像质量光谱滤光片的光谱成像装置
公开(公告)号：USRE36529E
公开(公告)日：2000-01-25
申请号：US996497
申请日：1997-12-23
申请人： Edgar N. Lewis , Ira W. Levin , Patrick J. Treado
发明人： Edgar N. Lewis , Ira W. Levin , Patrick J. Treado
IPC分类号： G01J3/28 , G02B21/33 , G01B9/02 , G01J3/44 , G01N21/35 , G01N21/64
CPC分类号： G02B21/33 , G01J3/2823
摘要： Techniques for providing spectroscopic imaging integrates an acousto-optic tunable filter (AOTF), or an interferometer, and a focal plane array detector. In operation, wavelength selectivity is provided by the AOTF or the interferometer. A focal plane array detector is used as the imaging detector in both cases. Operation within the ultraviolet, visible, near-infrared (NIR) spectral regions, and into the infrared spectral region, is achieved. The techniques can be used in absorption spectroscopy and emission spectroscopy. Spectroscopic images with a spectral resolution of a few nanometers and a spatial resolution of about a micron, are collected rapidly using the AOTF. Higher spectral resolution images are recorded at lower speeds using the interferometer. The AOTF technique uses entirely solid-state components and requires no moving parts. Alternatively, the interferometer technique employs either a step-scan interferometer or a continuously modulated interferometer.
摘要翻译：用于提供光谱成像的技术集成了声光可调谐滤波器（AOTF）或干涉仪，以及焦平面阵列检测器。在操作中，波长选择性由AOTF或干涉仪提供。在这两种情况下，使用焦平面阵列检测器作为成像检测器。实现了紫外线，可见光，近红外（NIR）光谱区域和红外光谱区域内的操作。该技术可用于吸收光谱和发射光谱学。使用AOTF快速收集具有几纳米的光谱分辨率和约一微米的空间分辨率的光谱图像。使用干涉仪以更低的速度记录较高的光谱分辨率图像。 AOTF技术使用完全固态组件，不需要移动部件。或者，干涉仪技术采用步进扫描干涉仪或连续调制干涉仪。

120. 发明授权

US6017957A Partial agonists of the strychnine insensitive glycine modulatory site of the N-methyl-D-aspartate receptor complex as neuropsychopharmacological agents 失效
标题翻译： N-甲基-D-天冬氨酸受体复合物的士的宁不敏感的甘氨酸调节位点的部分激动剂作为神经精神药理学试剂
公开(公告)号：US6017957A
公开(公告)日：2000-01-25
申请号：US390745
申请日：1989-08-08
申请人： Phil Skolnick , Anita Lewin , Juan-Carlos Marvizon , James Monn , Kenner Rice
发明人： Phil Skolnick , Anita Lewin , Juan-Carlos Marvizon , James Monn , Kenner Rice
IPC分类号： A61K31/195 , A61K31/215 , A61K45/00 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/28
CPC分类号： A61K31/195 , A61K31/215
摘要： A method is disclosed for the treatment of neuropsychopharmacological disorders which are associated with or result from excessive activation of the N-methyl-D-aspartate receptor complex, which method comprises administering an effective neuropsychopharmacological disorder-treating amount of a compound possessing partial agonist properties for the strychnine insensitive glycine modulatory sites of N-methyl-D-aspartate receptors. Exemplary of partial agonists which are useful in the method of the invention are 1-aminocyclopropanecarboxylic acid, and associated derivates thereof. Novel injectable pharmaceutical compositions are also disclosed.
摘要翻译：公开了用于治疗与N-甲基-D-天冬氨酸受体复合物的过量活化相关或由其引起的神经精神药理学障碍的方法，该方法包括给予有效的神经精神药理学障碍治疗量的具有部分激动剂性质的化合物 N-甲基-D-天冬氨酸受体的士的宁不敏感的甘氨酸调节位点。可用于本发明方法的部分激动剂的实例是1-氨基环丙烷羧酸及其相关衍生物。还公开了新的可注射药物组合物。

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