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111. 发明授权

US09260683B2 Molecularly imprinted polymer for wine, method of preparing, and use of same 有权
标题翻译：葡萄酒的分子印迹聚合物，制备方法和使用方法
公开(公告)号：US09260683B2
公开(公告)日：2016-02-16
申请号：US14351814
申请日：2012-10-15
申请人： The Trustees of Dartmouth College , Constellation Brands U.S. Operations, Inc.
发明人： Joseph J. Belbruno , Mark Kelm
IPC分类号： C12H1/056 , G01N33/14 , C08L33/12 , C08L75/04 , C12G1/00 , C08F220/14
CPC分类号： C12H1/0424 , C08F220/14 , C08L33/12 , C08L75/04 , C12G1/00 , G01N33/146
摘要： Shown herein are compositions of, and methods of use for, molecularly imprinted polymers useful for extracting and/or detecting target molecule compounds of wine.
摘要翻译：本文所示为用于提取和/或检测葡萄酒的目标分子化合物的分子印迹聚合物的组合物和使用方法。

112. 发明授权

US09255901B2 System and method for post-exposure dosimetry using electron paramagnetic resonance spectroscopy 有权
标题翻译：使用电子顺磁共振光谱法进行后曝光剂量测定的系统和方法
公开(公告)号：US09255901B2
公开(公告)日：2016-02-09
申请号：US13061423
申请日：2009-08-28
申请人： Harold M. Swartz , Jiang Gui , Xiaoming He , Piotr Leniewski , Roberto J. Nicolalde Flores , Benjamin B. Williams , Dean E. Wilcox
发明人： Harold M. Swartz , Jiang Gui , Xiaoming He , Piotr Leniewski , Roberto J. Nicolalde Flores , Benjamin B. Williams , Dean E. Wilcox
IPC分类号： A61B1/24 , G01R33/30 , A61B10/00 , A61B5/055 , A61B6/00 , G01N24/10 , G01R33/60
CPC分类号： G01N24/10 , G01R33/60
摘要： An apparatus and method for triaging patients according to radiation exposure measures electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. In vivo, radiation induced spectra are obtained from intact fingernails, toenails, or teeth placed within a magnet and with pickup coils over nails between the cut edge at the end of the fingernail and proximal skin or placed adjacent to at least one tooth. The system may also operate in vitro with fingernail clippings. At least three spectra are obtained with one after a delay at above twenty degrees Celsius, and at least one at power levels different from the others. The spectra are used to determine and remove a mechanically induced signal from EPR spectra to determine radiation-induced spectra. The radiation induced spectra are used to determine radiation dose, the dose is compared to triage limits, and a radiological triage tag is printed for the patients.
摘要翻译：根据放射线照射患者的装置和方法测量指甲，脚趾甲和/或牙齿的电子顺磁共振谱。在体内，辐射诱导的光谱是从完整的指甲，脚趾甲或放置在磁体内的牙齿获得的，并且在指甲末端处的切割边缘和近端皮肤之间的钉子上具有拾取线圈，或者放置在与至少一个牙齿相邻的位置。该系统还可以在体外用指甲剪来操作。在二十摄氏度以上的延迟之后至少有三个光谱获得，至少有一个在功率水平不同于其他光谱。光谱用于确定和去除EPR光谱中的机械感应信号，以确定辐射诱导光谱。辐射诱导光谱用于确定辐射剂量，将剂量与分类限值进行比较，并为患者印刷放射性分类标签。

113. 发明申请

US20150374308A1 Method And Apparatus For Medical Imaging Using Differencing Of Multiple Fluorophores 审中-公开
标题翻译：使用多个荧光团差异的医学成像方法和装置
公开(公告)号：US20150374308A1
公开(公告)日：2015-12-31
申请号：US14767836
申请日：2014-02-13
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE
发明人： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
IPC分类号： A61B5/00 , A61K49/00
摘要： A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
摘要翻译：产生受试者组织中靶向荧光团浓度的校正荧光数据的方法包括向受试者施用第一和第二荧光造影剂，靶向目的组织的第一造影剂，第二剂未被靶向。用第一刺激波长的光照射组织，并以适当的发射波长获取第一数据; 在第二刺激波长照射组织，并且以与第二试剂相关联的第二发射波长获取第二数据，第一和第二发射波长不同。通过从第一数据中减去第二数据来产生差分数据。系统提供多个波长的刺激和捕获，具有图像存储和减法代码，以执行该方法。校正的数据可以形成荧光图像，或用于产生荧光断层图像。

114. 发明授权

US09205113B2 Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression 有权
标题翻译：合成三萜类化合物和调节干/祖细胞基因表达的方法
公开(公告)号：US09205113B2
公开(公告)日：2015-12-08
申请号：US14395157
申请日：2013-05-07
申请人： Trustees of Dartmouth College
发明人： Gordon W. Gribble , Liangfeng Fu , Michael B. Sporn , Karen T. Liby
IPC分类号： A61K31/56 , A61K35/44 , C07C61/29 , C07J63/00 , C07C62/38 , C07C229/50 , C07C235/78 , C07C255/47 , C07C291/10 , C07C317/44 , C07C323/55 , A61K35/12 , C07C62/32
CPC分类号： A61K35/44 , A61K31/56 , A61K35/12 , C07C61/29 , C07C62/32 , C07C62/38 , C07C229/50 , C07C235/78 , C07C255/47 , C07C291/10 , C07C317/44 , C07C323/55 , C07C2603/52 , C07J63/008 , C07J71/0005
摘要： Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided. Furthermore, the present invention provides methods for producing a cell, such as a stem or progenitor cell, with induced gene expression by contacting a stem or progenitor cell with an effective amount of a synthetic triterpenoid to induce the expression of one or more of SOX9 (Sex determining region Y-box 9), COL2A1 (Type II Collagen (alpha1)), TGF-βI, TGF-p2, TGF-33, BMP2, BMP4, BMPRII (Bone Morphogenic Protein Receptor II), SMAD (Small Mothers Against Decapentaplegic) 3, SMAD4, SMAD6, SMAD7, TIMP (Tissue Inhibitor of Metalloproteinase)-1 or TIMP-2 in the stem or progenitor cell, wherein the stem or progenitor cell is not a mesenchymal stem cell, periosteium cell or osteoprogenitor cell. In one embodiment, the stem or progenitor cell is multipotent.
摘要翻译：提供合成三萜类化合物及其使用方法诱导干细胞或祖细胞的基因表达和分化。此外，本发明提供了通过使干细胞或祖细胞与有效量的合成三萜化合物接触以诱导一种或多种SOX9的表达来生产具有诱导的基因表达的细胞例如干细胞或祖细胞的方法（性别确定区域Y盒9），COL2A1（II型胶原（α1）），TGF-和bgr I，TGF-p2，TGF-β3，BMP2，BMP4，BMPRII（骨形态发生蛋白受体II），SMAD 针对剔除性皮炎）3，SMAD4，SMAD6，SMAD7，TIMP（金属蛋白酶组织抑制剂）-1或TIMP-2在茎或祖细胞中，其中干细胞或祖细胞不是间充质干细胞，骨膜细胞或骨祖细胞。在一个实施方案中，干细胞或祖细胞是多能的。

115. 发明授权

US09179888B2 System and method for providing patient registration without fiducials 有权
标题翻译：提供无基准患者登记的系统和方法
公开(公告)号：US09179888B2
公开(公告)日：2015-11-10
申请号：US13392173
申请日：2010-08-27
申请人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
发明人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
IPC分类号： A61B5/05 , A61B8/00 , A61B5/06 , A61B8/08 , A61B19/00 , G06T7/00 , A61B6/00 , A61B17/00
CPC分类号： A61B8/00 , A61B5/064 , A61B6/501 , A61B6/5247 , A61B8/0816 , A61B8/4245 , A61B8/5238 , A61B34/20 , A61B2017/00725 , A61B2034/2055 , A61B2090/364 , A61B2090/374 , A61B2090/378 , G06T7/30
摘要： A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preoperative image; creating an independent registration corresponding to each different starting positions, by optimizing a spatial transformation between the preoperative image and the ultrasound image to provide a first batch of registrations; executing a second registration to fine-tune the alignment between the preoperative image and the ultrasound image; and concatenating the spatial transformation to obtain spatial transformation between the patient in an operating room and a corresponding preoperative image.
摘要翻译：一种用于提供无基准的患者登记的方法包括以下步骤：将患者的超声图像随机地相对于术前图像在不同的起始位置空间放置; 通过优化术前图像和超声图像之间的空间变换来提供第一批注册，从而产生对应于每个不同起始位置的独立登记; 执行第二注册以微调术前图像与超声图像之间的对准; 并且连接空间变换以获得手术室中的患者与相应的术前图像之间的空间变换。

116. 发明授权

US09028812B2 T cell receptor-deficient T cell compositions 有权
公开(公告)号：US09028812B2
公开(公告)日：2015-05-12
申请号：US13502978
申请日：2010-10-29
申请人： Charles L. Sentman
发明人： Charles L. Sentman
IPC分类号： C12N5/10 , C12N5/0783 , A61K39/00
摘要： The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.

117. 发明申请

US20150110760A1 NKP30 RECEPTOR TARGETED THERAPEUTICS 有权
标题翻译： NKP30受体靶向治疗
公开(公告)号：US20150110760A1
公开(公告)日：2015-04-23
申请号：US14342060
申请日：2012-08-31
申请人： Tong Zhang , Charles L. Sentman
发明人： Tong Zhang , Charles L. Sentman
IPC分类号： A61K35/17 , C12N5/0783 , C07K14/705
CPC分类号： A61K35/17 , A61K38/00 , C07K14/70503 , C07K14/70521 , C07K14/70575 , C07K14/70578 , C07K14/70596 , C07K2319/00 , C07K2319/03 , C12N5/0636 , C12N2800/22
摘要： The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using these chimeric NKp30 T cells, isolated populations thereof, and compositions comprising the same. In another aspect, said chimeric NKp30 T cells are further designed to express a functional non-TCR receptor. The disclosure also pertains to methods of making said chimeric NKp30 T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said chimeric NKp30 T cells, populations thereof, or compositions comprising the same.
摘要翻译：本发明涉及表达嵌合NK-p30受体（“嵌合NKp30T细胞”）的T细胞和其他细胞，制备和使用嵌合NKp30 T细胞的方法，以及使用这些嵌合NKp30T细胞，其分离群体的方法，和包含它们的组合物。在另一方面，进一步设计所述嵌合NKp30T细胞以表达功能性非TCR受体。本公开还涉及制备所述嵌合NKp30T细胞的方法，以及使用所述嵌合NKp30T细胞，其群体或包含其的组合物来减少或改善或预防或治疗疾病和病症的方法。

118. 发明授权

US08975274B2 Compositions and methods for treating cancer 有权
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US08975274B2
公开(公告)日：2015-03-10
申请号：US14345728
申请日：2012-09-18
申请人： Trustees of Dartmouth College
发明人： Gordon W. Gribble , Justin M. Lopchuk
IPC分类号： A61K31/473 , A61K31/4709 , C07D401/12 , C07D219/10 , C12N5/09
CPC分类号： C07D401/12 , A61K31/473 , C07D219/10 , C12N5/0693
摘要： The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the antitumor compound.
摘要翻译：本发明是具有改进的双（4-氨基苯基）醚系链的双吖啶或双喹啉嵌入剂，以改善抗肿瘤化合物的活性，选择性，溶解性和生物利用度。

119. 发明申请

US20150057326A1 Method for Synthesizing Cycloalkanyl[b]indoles, Cycloalkanyl[b]benzofurans, Cycloalkanyl[b]benzothiophenes, Compounds and Methods of Use 有权
标题翻译：合成环烷基[b]吲哚，环烷基[b]苯并呋喃，环烷基[b]苯并噻吩的方法，化合物和使用方法
公开(公告)号：US20150057326A1
公开(公告)日：2015-02-26
申请号：US14537154
申请日：2014-11-10
申请人： Trustees of Dartmouth College
发明人： Jimmy Wu
IPC分类号： C07D209/94 , C07D491/08 , C07D209/96 , C07D491/18 , C07D405/04 , C07D409/04
CPC分类号： C07D209/94 , C07D209/70 , C07D209/96 , C07D405/04 , C07D409/04 , C07D491/08 , C07D491/18
摘要： A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a Ga(III) or In(III) salt. Compositions and methods of using these compounds to stimulate secretion and/or production of glucagon-like peptide-1 or inhibit the activity of Calcitonin Gene-Related Peptide receptor are also provided.
摘要翻译：提供了合成环烷基[b]吲哚以及相关环烷基[b]苯并呋喃和环烷基[b]苯并噻吩的方法。该方法是单一的多组分反应，其结合（1）吲哚，苯并呋喃或苯并硫代，（2）醛，酮或缩酮，和（3）二烯在酸存在下，特别是Ga III）或In（III）盐。还提供了使用这些化合物刺激胰高血糖素样肽-1的分泌和/或产生或抑制降钙素基因相关肽受体活性的组合物和方法。

120. 发明授权

US08948849B2 System and method for optode and electrode positioning cap for electroencephalography, diffuse optical imaging, and functional neuroimaging 有权
标题翻译：用于脑电图，漫射光学成像和功能神经成像的光电和电极定位帽的系统和方法
公开(公告)号：US08948849B2
公开(公告)日：2015-02-03
申请号：US13863183
申请日：2013-04-15
申请人： The Trustees of Dartmouth College
发明人： Solomon G. Diamond , Paolo Giacometti
IPC分类号： A61B6/00 , A61B5/0478 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/0478 , A61B5/0077 , A61B5/14553
摘要： An electroencephalographic electrode and optode positioning device has the form of a cap suitable for placement on a subject's head. The cap has semirigid telescopic structures that stiffen it to provide accurate electrode and optode spacing, and stability during subject activity. The cap is intended for use in functional neuroimaging and, although its materials are compatible with fMRI, is usable without fMRI to permit study of physically as well as mentally active subjects.
摘要翻译：脑电图电极和光电极定位装置具有适于放置在受试者头部上的帽子的形式。帽具有半刚性伸缩结构，使其硬化以提供精确的电极和光栅间距，以及受试者活动期间的稳定性。该帽旨在用于功能性神经成像，尽管其材料与fMRI兼容，但在没有fMRI的情况下可以使用，以允许对身体和精神活动的受试者进行研究。

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