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111. 发明申请

US20110144657A1 SYSTEMS AND METHODS FOR DETERMINING THE LIKELIHOOD OF ENDOCARDIAL BAROTRAUMA IN TISSUE DURING ABLATION 有权
标题翻译：系统和方法，用于确定髋关节置换术中组织内BAROTRAUMA
公开(公告)号：US20110144657A1
公开(公告)日：2011-06-16
申请号：US12964956
申请日：2010-12-10
申请人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Rohan Lathia , Harry A. Puryear , Valtino X. Afonso , Saurav Paul
发明人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Rohan Lathia , Harry A. Puryear , Valtino X. Afonso , Saurav Paul
IPC分类号： A61B19/00 , A61B5/053
CPC分类号： A61B18/1492 , A61B5/036 , A61B5/0538 , A61B2017/00026 , A61B2017/00119 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/301 , A61B2090/372
摘要： A method and system for determining a likelihood of barotrauma occurring in tissue during the formation of a lesion therein is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire at least one value of at least one component of a complex impedance between an electrode and the tissue. The ECU is further configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue. The method comprises acquiring at least one value of at least one component of a complex impedance between an electrode and the tissue. The method further comprises calculating an index responsive to the at least one value of the at least one complex impedance component. The calculating index is indicative of a likelihood of barotrauma occurring in the tissue.
摘要翻译：提供了一种用于确定在其中形成病变期间在组织中发生的气压伤的可能性的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取电极和组织之间的复阻抗的至少一个分量的至少一个值。 ECU还被配置为响应于至少一个复阻抗分量的至少一个值来计算索引。该指数表示在组织中发生气压伤的可能性。该方法包括获取电极和组织之间的复阻抗的至少一个分量的至少一个值。该方法还包括响应于至少一个复阻抗分量的至少一个值来计算索引。计算指标表示在组织中发生气压伤的可能性。

112. 发明申请

US20110028837A1 Photodynamic-based myocardial mapping device and method 审中-公开
标题翻译：基于光动力学的心肌贴壁装置及方法
公开(公告)号：US20110028837A1
公开(公告)日：2011-02-03
申请号：US12934601
申请日：2009-04-02
申请人： Israel A. Byrd , Saurav Paul , Dale E. Just , Jamie Skoglund , Paul McDowall
发明人： Israel A. Byrd , Saurav Paul , Dale E. Just , Jamie Skoglund , Paul McDowall
IPC分类号： A61B6/00 , A61B1/07 , A61B1/04
CPC分类号： A61B5/6859 , A61B1/07 , A61B5/0044 , A61B5/0071 , A61B5/0084 , A61B5/4839 , A61B5/6858 , A61B5/7278 , A61B2562/0233 , A61B2562/046 , A61B2576/023 , A61M5/007 , A61M25/007 , A61M25/0147
摘要： A photodynamic mapping device includes a shaft with a proximal end and a distal end, at least one optical electrode at the distal end of the shaft, and at least one optical fiber positioned inside the shaft. In embodiments, the at least one optical fiber extends from the distal end of the shaft and is coupled to the at least one optical electrode provided at or about an outer surface of the device. In an embodiment, at least one optical fiber is coupled, at or about the proximal end of the shaft, to a light source coupled and an optical sensor. An analyzer can be coupled to the optical sensor. Embodiments of such devices can be configured to deliver substances, such as photodynamic therapeutic substances.
摘要翻译：光动力测绘装置包括具有近端和远端的轴，在轴的远端处的至少一个光电极和位于轴内部的至少一个光纤。在实施例中，至少一个光纤从轴的远端延伸并且耦合到设置在设备的外表面处或周围的至少一个光电极。在一个实施例中，至少一个光纤在轴的近端处或周围耦合到耦合的光源和光学传感器。分析仪可以耦合到光学传感器。这种装置的实施例可以被配置为递送物质，例如光动力学治疗物质。

113. 发明申请

US20090171331A1 SYSTEMS AND METHODS OF PHOTODYNAMIC-BASED CARDIAC ABLATION VIA THE ESOPHAGUS 失效
标题翻译：以ESOPHAGUS为基础的基于光化学的心脏病患者的系统和方法
公开(公告)号：US20090171331A1
公开(公告)日：2009-07-02
申请号：US12345569
申请日：2008-12-29
申请人： Saurav Paul , Isreal A. Byrd
发明人： Saurav Paul , Isreal A. Byrd
IPC分类号： A61B18/18
CPC分类号： A61B18/24 , A61B90/39 , A61B2017/00084 , A61B2018/2272 , A61B2090/065 , A61B2090/3954 , A61N5/0601 , A61N5/062
摘要： Systems and methods for photodynamic ablation of cardiac tissue via an esophagus are disclosed. An exemplary system includes an ablation catheter having an expandable distal end for securing the ablation catheter in the esophagus. The distal end of the ablation catheter contains at least one light source operable to activate a photodynamic substance delivered to the target area of the cardiac tissue to be ablated and form a lesion. The system also includes at least one feedback device contained in the distal end of the ablation catheter. The at least one feedback device provides feedback for at least one of: positioning a distal end of an ablation catheter in a desired position in the esophagus adjacent a target area of the cardiac tissue to be ablated, forming an adequate lesion, and assessing lesion formation.
摘要翻译：公开了通过食道对心脏组织的光动力消融的系统和方法。示例性系统包括具有用于将消融导管固定在食道中的可扩展远端的消融导管。消融导管的远端包含至少一个光源，其可操作以激活被输送到待烧蚀的心脏组织的靶区域并形成病变的光动力物质。该系统还包括包含在消融导管的远端中的至少一个反馈装置。所述至少一个反馈装置为以下中的至少一个提供反馈：将消融导管的远端定位在邻近被切除的心脏组织的靶区域的食道中的期望位置，形成足够的损伤，以及评估损伤形成。

114. 发明申请

US20080161786A1 Pressure-sensitive conductive composite contact sensor and method for contact sensing 有权
标题翻译：压敏导电复合接触传感器和接触感应方法
公开(公告)号：US20080161786A1
公开(公告)日：2008-07-03
申请号：US11647314
申请日：2006-12-29
申请人： Kedar Ravindra Belhe , Saurav Paul
发明人： Kedar Ravindra Belhe , Saurav Paul
IPC分类号： A61B18/08
CPC分类号： A61B18/1492 , A61B5/6885 , A61B2018/00083 , A61B2018/00577 , A61B2018/00875 , A61B2018/00988 , A61B2090/064 , A61B2090/065 , A61B2562/0209 , A61M25/00 , A61M2025/0002 , G01L1/20
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

115. 发明授权

US09289606B2 System for electroporation therapy 有权
标题翻译：电穿孔治疗系统
公开(公告)号：US09289606B2
公开(公告)日：2016-03-22
申请号：US12874788
申请日：2010-09-02
申请人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
发明人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
IPC分类号： A61B18/18 , A61N1/32 , A61B18/14 , A61B18/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2018/0016
摘要： Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
摘要翻译：导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件，电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗，包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。光纤温度感测电极导管包括具有腔体的尖端电极，其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。光纤/检测器装置监测热致变色或热致变色材料，获取光信号并产生指示光信号光谱的输出信号。分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。

116. 发明授权

US09095349B2 Systems and methods for determining the likelihood of endocardial barotrauma in tissue during ablation 有权
标题翻译：用于确定消融期间组织中心内膜气压伤的可能性的系统和方法
公开(公告)号：US09095349B2
公开(公告)日：2015-08-04
申请号：US12964956
申请日：2010-12-10
申请人： Jeffrey M. Fish , Israel A. Byrd , Lynn Gilmour , Jeremy D. Dando , Christopher J. Geurkink , Rohan Lathia , Harry A. Puryear , Valtino X. Afonso , Saurav Paul
发明人： Jeffrey M. Fish , Israel A. Byrd , Lynn Gilmour , Jeremy D. Dando , Christopher J. Geurkink , Rohan Lathia , Harry A. Puryear , Valtino X. Afonso , Saurav Paul
IPC分类号： A61B5/053 , A61B18/14 , A61B17/00 , A61B18/00 , A61B19/00 , A61B5/03
CPC分类号： A61B18/1492 , A61B5/036 , A61B5/0538 , A61B2017/00026 , A61B2017/00119 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/301 , A61B2090/372
摘要： A method and system for determining a likelihood of barotrauma occurring in tissue during formation of a lesion therein is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire at least one value of at least one component of a complex impedance between an electrode and the tissue. The ECU is configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue. The method comprises acquiring at least one value of at least one component of a complex impedance between an electrode and the tissue. The method comprises calculating an index responsive to the at least one value of the at least one complex impedance component. The calculated index is indicative of a likelihood of barotrauma occurring in the tissue.
摘要翻译：提供了一种用于在其中形成病变期间确定在组织中发生的气压破坏的可能性的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取电极和组织之间的复阻抗的至少一个分量的至少一个值。 ECU被配置为响应于至少一个复阻抗分量的至少一个值来计算索引。该指数表示在组织中发生气压伤的可能性。该方法包括获取电极和组织之间的复阻抗的至少一个分量的至少一个值。该方法包括响应于至少一个复阻抗分量的至少一个值计算索引。计算的指数表示在组织中发生气压伤的可能性。

117. 发明授权

US08603084B2 System and method for assessing the formation of a lesion in tissue 有权
标题翻译：用于评估组织中病变形成的系统和方法
公开(公告)号：US08603084B2
公开(公告)日：2013-12-10
申请号：US12946941
申请日：2010-11-16
申请人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Harry A. Puryear , Saurav Paul
发明人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Harry A. Puryear , Saurav Paul
IPC分类号： A61B18/10
CPC分类号： A61B18/1492 , A61B5/0084 , A61B5/01 , A61B5/0402 , A61B5/042 , A61B5/0538 , A61B5/1076 , A61B5/1079 , A61B5/4836 , A61B5/742 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00351 , A61B2018/00714 , A61B2018/00738 , A61B2018/00779 , A61B2018/00875 , A61B2018/0212 , A61B2034/301 , A61B2090/065 , A61B2218/002
摘要： A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU) configured to acquire magnitudes for a component of a complex impedance between an electrode and tissue, and the power applied to the tissue during lesion formation. The ECU is configured to calculate a value responsive to the complex impedance component and the power. The value is indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, or a predicted tissue temperature. The method includes acquiring magnitudes for a component of a complex impedance between an electrode and tissue and the power applied during lesion formation. The method includes calculating a value responsive to the complex impedance component and the power, the value being indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, and/or a predicted tissue temperature.
摘要翻译：提供了一种用于评估组织中病变形成的方法和系统。该系统包括电子控制单元（ECU），其被配置为获取电极和组织之间的复阻抗的分量的大小以及在损伤形成期间施加到组织的功率。 ECU被配置为计算响应于复阻抗分量和功率的值。该值表示预测的病变深度，病变达到预定深度的可能性，或预测的组织温度。该方法包括获取电极和组织之间的复阻抗的分量的大小以及在损伤形成期间施加的功率。该方法包括计算响应于复阻抗分量和功率的值，该值指示预测的病变深度，病变达到预定深度的可能性和/或预测的组织温度。

118. 发明授权

US08577447B2 Optic-based contact sensing assembly and system 有权
标题翻译：基于光学的接触感测组件和系统
公开(公告)号：US08577447B2
公开(公告)日：2013-11-05
申请号：US11941073
申请日：2007-11-15
申请人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
发明人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
IPC分类号： A61B18/14
CPC分类号： A61B5/6885 , A61B5/0084 , A61B5/6852 , A61B5/6886 , A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00084 , A61B2090/065 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M2025/0002
摘要： The invention relates to an optic-based sensing assembly and a system incorporating the assembly and related use of the assembly. In particular, the invention relates to an optic-based catheter assembly and related system used to determine contact between a catheter and surrounding proximate environment, such as tissue. An embodiment of such a system may, for example, be used for visualization, mapping, ablation, or other methods of diagnosis and treatment of tissue and/or surrounding areas.
摘要翻译：本发明涉及一种基于光学的感测组件以及结合该组件的组件和该组件的相关使用的系统。特别地，本发明涉及一种基于光学的导管组件和相关系统，其用于确定导管和周围的近处环境（例如组织）之间的接触。这种系统的实施例可以例如用于组织和/或周围区域的可视化，映射，消融或其它诊断和治疗方法。

119. 发明授权

US08500731B2 Adjustable length flexible polymer electrode catheter and method for ablation 有权
标题翻译：可调长度柔性聚合物电极导管和消融方法
公开(公告)号：US08500731B2
公开(公告)日：2013-08-06
申请号：US12347097
申请日：2008-12-31
申请人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
发明人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/1815
摘要： An ablation catheter includes a flexible elongated shaft having a flexible electrode at its distal end. The flexible electrode includes an inner, flexible, electrically-conductive element and an outer, flexible, electrically-conductive polymer layer in electrical contact with the inner, flexible, electrically-conductive element. The catheter further includes an electrically insulative sheath surrounding at least a portion of the flexible electrode and a linear displacement mechanism capable of adjusting at least one of the electrically insulative sheath and the flexible electrode to vary a length of the flexible electrode exposed at the distal end of the shaft. Also disclosed is an adjustable length ablation electrode and methods of ablating tissue.
摘要翻译：消融导管包括在其远端具有柔性电极的柔性细长轴。柔性电极包括内部柔性导电元件和与内部柔性导电元件电接触的外部柔性导电聚合物层。所述导管还包括围绕所述柔性电极的至少一部分的电绝缘护套和能够调节所述电绝缘护套和所述柔性电极中的至少一个的线性位移机构，以改变在所述远端暴露的所述柔性电极的长度的轴。还公开了可调节长度的消融电极和消融组织的方法。

120. 发明授权

US07996078B2 Systems and methods of photodynamic-based cardiac ablation via the esophagus 失效
标题翻译：通过食道的基于光动力的心脏消融的系统和方法
公开(公告)号：US07996078B2
公开(公告)日：2011-08-09
申请号：US12345569
申请日：2008-12-29
申请人： Saurav Paul , Israel A. Byrd
发明人： Saurav Paul , Israel A. Byrd
IPC分类号： A61N1/30
CPC分类号： A61B18/24 , A61B90/39 , A61B2017/00084 , A61B2018/2272 , A61B2090/065 , A61B2090/3954 , A61N5/0601 , A61N5/062
摘要： Systems and methods for photodynamic ablation of cardiac tissue via an esophagus are disclosed. An exemplary system includes an ablation catheter having an expandable distal end for securing the ablation catheter in the esophagus. The distal end of the ablation catheter contains at least one light source operable to activate a photodynamic substance delivered to the target area of the cardiac tissue to be ablated and form a lesion. The system also includes at least one feedback device contained in the distal end of the ablation catheter. The at least one feedback device provides feedback for at least one of: positioning a distal end of an ablation catheter in a desired position in the esophagus adjacent a target area of the cardiac tissue to be ablated, forming an adequate lesion, and assessing lesion formation.
摘要翻译：公开了通过食道对心脏组织的光动力消融的系统和方法。示例性系统包括具有用于将消融导管固定在食道中的可扩展远端的消融导管。消融导管的远端包含至少一个光源，其可操作以激活被输送到待烧蚀的心脏组织的靶区域并形成病变的光动力物质。该系统还包括包含在消融导管的远端中的至少一个反馈装置。所述至少一个反馈装置为以下中的至少一个提供反馈：将消融导管的远端定位在邻近被切除的心脏组织的靶区域的食道中的期望位置，形成足够的损伤，以及评估损伤形成。

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