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    • 111. 发明授权
    • Method of providing fast relief to a user of a nicotine chewing gum
    • 向尼古丁口香糖使用者提供快速释放的方法
    • US08524196B2
    • 2013-09-03
    • US11791945
    • 2004-11-30
    • Carsten Andersen
    • Carsten Andersen
    • A61K9/58
    • A61K31/465A61K9/0058
    • The invention relates to a method of relieving nicotine craving comprising the steps of providing at least one chewing gum comprising tobacco alkaloid to a user, providing relief of nicotine craving to said user by transferring of tobacco alkaloid from the chewing gum to the human body of said user by chewing of said chewing gum, said chewing of said chewing gum comprising a chewing process involving a transfer of tobacco alkaloid from said chewing gum above a threshold transfer rate in the period of about ½ minute to about 2½ minutes from initiation of said chewing process.
    • 本发明涉及一种减轻尼古丁渴望的方法,包括以下步骤:向使用者提供包含烟草生物碱的至少一种口香糖,通过将烟草生物碱从口香糖转移到所述口腔内的人体,使所述使用者缓解尼古丁渴望 所述咀嚼口咀嚼所述口香糖,所述咀嚼口香糖包括咀嚼方法,所述咀嚼方法涉及在所述咀嚼过程开始之后约1/2分钟至约2.5分钟的时间内从所述口香糖转移烟草生物碱高于阈值转移速率 。
    • 115. 发明申请
    • Alpha-Amylase Variants
    • α-淀粉酶变体
    • US20120252095A1
    • 2012-10-04
    • US13478512
    • 2012-05-23
    • Allan SvendsenSóeren KjaerulffHenrik Bisgaard-FrantzenCarsten Andersen
    • Allan SvendsenSóeren KjaerulffHenrik Bisgaard-FrantzenCarsten Andersen
    • C12N9/28
    • C12N9/2414C07H21/04C11D3/38609C11D3/38618C12N9/2417
    • The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an alpha-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an alpha-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an alpha-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like alpha-amylase, which variant exhibits increased.
    • 本发明涉及亲本的类戊酰样α-淀粉酶的变体,其包含2,3,4,5或6个/位置的突变。 这些变体在高温下(相对于亲本)具有增加的稳定性。 本发明还涉及包含编码本发明的α-淀粉酶变体的DNA序列的DNA构建体,携带本发明的DNA构建体的重组表达载体,用本发明的DNA构建体转化的细胞,使用 本发明的α-淀粉酶变体用于洗涤和/或餐具洗涤,纺织品退浆,淀粉液化,包含本发明的α-淀粉酶变体的洗涤剂添加剂,手动或自动洗碗洗涤剂组合物,其包含α-淀粉酶变体 本发明提供一种产生母体类戊酰样α-淀粉酶的变体的方法,该变体表现出增加。