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111. 发明授权

US07488290B1 System and method for assessing cardiac performance through transcardiac impedance monitoring 有权
标题翻译：通过心跳阻抗监测评估心脏性能的系统和方法
公开(公告)号：US07488290B1
公开(公告)日：2009-02-10
申请号：US10782642
申请日：2004-02-19
申请人： Jeffrey E. Stahmann , Donald L. Hopper , Veerichetty Kadhiresan , John D. Hatlestad
发明人： Jeffrey E. Stahmann , Donald L. Hopper , Veerichetty Kadhiresan , John D. Hatlestad
IPC分类号： A61B5/00
CPC分类号： A61B7/00 , A61B5/021
摘要： A system and method for assessing cardiac performance through transcardiac impedance monitoring is described. Intracardiac impedance measures are directly collected through an implantable medical device. The intracardiac impedance measures are correlated to cardiac dimensional measures relative to performance of an intrathoracic pressure maneuver. The cardiac dimensional measures are grouped into at least one measures set corresponding to a temporal phase of the intrathoracic pressure maneuver. The at least one cardiac dimensional measures set is evaluated against a cardiac dimensional trend for the corresponding intrathoracic pressure maneuver temporal phase to represent cardiac performance.
摘要翻译：描述了通过心跳阻抗监测来评估心脏性能的系统和方法。通过植入式医疗设备直接收集心内阻塞措施。心内阻抗测量与胸腔内压力操作性能相关的心脏尺寸测量值相关。心脏尺寸测量被分组为对应于胸内压力操纵的时间相位的至少一个测量组。针对相应的胸内压力机动时间阶段的心脏尺寸趋势来评估至少一个心脏尺寸测量集合以表示心脏性能。

112. 发明授权

US07983745B2 Advanced patient management with environmental data 有权
标题翻译：高级患者管理与环境数据
公开(公告)号：US07983745B2
公开(公告)日：2011-07-19
申请号：US12350875
申请日：2009-01-08
申请人： John D. Hatlestad , Jeffrey E. Stahmann , Qingsheng Zhu
发明人： John D. Hatlestad , Jeffrey E. Stahmann , Qingsheng Zhu
IPC分类号： A61N1/00
CPC分类号： A61B5/0031 , A61B5/0022 , A61B5/0205 , A61B5/0537 , A61B5/0816 , A61B5/091 , A61B5/1118 , A61B7/04 , A61B2560/0247 , A61B2560/0252 , A61B2560/0257 , A61N1/37252 , A61N1/37282 , G06F19/00 , G06F19/3418 , G16H40/63 , G16H50/30
摘要： Systems, devices and methods for using environmental data to manage health care are disclosed. One aspect is an advanced patient management system. In various embodiments, the system includes at least one implantable medical device (IMD) to acquire at least one IMD parameter indicative of patient wellness, means to acquire at least one environmental parameter from at least one external source, and means to correlate the at least one parameter indicative of patient wellness and the at least one environmental parameter to assist with patient health care decisions. Other aspects and embodiments are provided herein.
摘要翻译：公开了使用环境数据来管理医疗保健的系统，设备和方法。一个方面是先进的患者管理系统。在各种实施例中，系统包括至少一个可植入医疗装置（IMD），以获取指示患者健康的至少一个IMD参数，从至少一个外部源获取至少一个环境参数的手段，以及至少将指示患者健康的一个参数和用于协助患者医疗保健决定的至少一个环境参数。本文提供了其它方面和实施例。

113. 发明授权

US07881781B2 Thoracic impedance detection with blood resistivity compensation 有权
标题翻译：胸部阻抗检测与血液电阻率补偿
公开(公告)号：US07881781B2
公开(公告)日：2011-02-01
申请号：US12628384
申请日：2009-12-01
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Boyce Moon
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Boyce Moon
IPC分类号： A61B5/00
CPC分类号： A61B5/053 , A61N1/3627 , A61N1/36521
摘要： This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.
摘要翻译：本文件尤其涉及一种使用胸部阻抗来确定胸部存在多少液体的心律管理装置或其他可植入医疗装置，例如用于检测或预测充血性心力衰竭，肺水肿，胸腔积液，低血压，等等。根据胸部阻抗确定的胸腔液量补偿血液电阻率的变化，这可能是血细胞比容水平的变化或其他因素引起的。血液电阻补偿的胸腔液量可以存储在设备中或者传输到外部设备进行存储或显示。血液电阻补偿的胸液量也可用于调整心脏起搏，心脏再同步或其他心律控制或对患者的其他治疗。本文件还讨论了用于预测或指示贫血的装置和方法的应用。

114. 发明授权

US07819804B2 Detection of congestion from monitoring patient response to a recumbent position 有权
标题翻译：通过监测患者对卧位的反应来检测拥塞
公开(公告)号：US07819804B2
公开(公告)日：2010-10-26
申请号：US12204152
申请日：2008-09-04
申请人： John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann
发明人： John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann
IPC分类号： A61B5/00
CPC分类号： A61B5/0809 , A61B5/0816 , A61B5/1071 , A61B5/1116 , A61B5/1135 , A61B5/4806 , A61B5/6831 , A61B5/6846 , A61B5/686 , A61N1/36542
摘要： Systems and methods obtain information that allows detection of whether a patient suffers from congestion by monitoring a response of the patient to a recumbent position of the patient's body. The patient may be monitored to determine a respiration pattern for a non-recumbent position such as standing and a respiration pattern for a recumbent position such as lying down. The two patterns may be compared, either by a processing device or a physician, to determine a difference in the two respiration patterns. Furthermore, the congestion may be inferred from detecting an amount of time that the patient spends in a recumbent position or from detecting the recumbent angle that the patient obtains, either of which is presumed to indicate whether a recumbent position presents discomfort to the patient due to the presence of congestion.
摘要翻译：系统和方法获得允许通过监视患者对患者身体的卧位的反应来检测患者是否患有拥塞的信息。可以监测患者以确定用于躺卧位置的无卧位的呼吸模式，例如躺卧和躺卧位置的呼吸模式。可以通过处理装置或医师来比较两种模式，以确定两种呼吸模式的差异。此外，可以通过检测患者在躺卧位置中花费的时间量或从检测患者获得的躺卧角度来推断拥塞，其中任何一个被推定为指示躺卧位置是否由于患者的不适而给患者带来不适拥堵的存在。

115. 发明授权

US07672718B2 Thoracic impedance detection with blood resistivity compensation 有权
标题翻译：胸部阻抗检测与血液电阻率补偿
公开(公告)号：US07672718B2
公开(公告)日：2010-03-02
申请号：US12139948
申请日：2008-06-16
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Boyce Moon
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Boyce Moon
IPC分类号： A61B5/00
CPC分类号： A61B5/053 , A61N1/3627 , A61N1/36521
摘要： This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.
摘要翻译：本文件尤其涉及一种使用胸部阻抗来确定胸部存在多少液体的心律管理装置或其他可植入医疗装置，例如用于检测或预测充血性心力衰竭，肺水肿，胸腔积液，低血压，等等。根据胸部阻抗确定的胸腔液量补偿血液电阻率的变化，这可能是血细胞比容水平的变化或其他因素引起的。血液电阻补偿的胸腔液量可以存储在设备中或者传输到外部设备进行存储或显示。血液电阻补偿的胸液量也可用于调整心脏起搏，心脏再同步或其他心律控制或对患者的其他治疗。本文件还讨论了用于预测或指示贫血的装置和方法的应用。

116. 发明授权

US09943234B2 Using respiration distress manifestations for heart failure detection 有权
公开(公告)号：US09943234B2
公开(公告)日：2018-04-17
申请号：US11736058
申请日：2007-04-17
申请人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
发明人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
IPC分类号： A61B5/08 , A61B5/0205 , A61B5/11 , A61B5/00 , A61N1/362
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.

117. 发明授权

US08738119B2 Multi-sensor strategy for heart failure patient management 有权
标题翻译：心脏病患者管理的多传感器策略
公开(公告)号：US08738119B2
公开(公告)日：2014-05-27
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译：一种装置包括多个传感器和一个处理器。每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化状态根据第一和第二规则发生。

118. 发明授权

US07744542B2 Implanted air passage sensors 有权
标题翻译：植入式通风传感器
公开(公告)号：US07744542B2
公开(公告)日：2010-06-29
申请号：US11379396
申请日：2006-04-20
申请人： Thomas Piaget , Paul Huelskamp , Jeffrey E. Stahmann , John D. Hatlestad
发明人： Thomas Piaget , Paul Huelskamp , Jeffrey E. Stahmann , John D. Hatlestad
IPC分类号： A61B5/0205
CPC分类号： A61B5/0031 , A61B5/036 , A61B5/08 , A61B5/0833 , A61B5/0836 , A61B5/1459 , A61B5/4818 , A61B5/68 , A61B7/003 , A61B2560/0242
摘要： A physiological sensor is located within the airway of the subject's body, such as for measuring barometric pressure and communicating this value to a blood pressure or other monitoring device, which can derive gauge pressure using the barometric pressure and a measured absolute pressure within the body. The physiological sensor may also detect one or more other physiological parameters such as air flow, sound, or a chemical property. It may be anchored within the airway with the ability to communicate wirelessly to one or more other medical devices, such as an implanted cardiac function management device. Methods of use are also described.
摘要翻译：生理传感器位于受试者身体的气道内，例如用于测量大气压力并将该值传递到血压或其他监测装置，其可以使用大气压力和体内测量的绝对压力来导出表压。生理传感器还可以检测一个或多个其它生理参数，例如气流，声音或化学性质。它可以锚定在气道内，具有与一个或多个其它医疗装置（例如植入式心脏功能管理装置）无线通信的能力。还描述了使用方法。

119. 发明申请

US20100010378A1 Apparatus and Method for Detecting Lung Sounds Using an Implanted Device 有权
标题翻译：使用植入装置检测肺声的装置和方法
公开(公告)号：US20100010378A1
公开(公告)日：2010-01-14
申请号：US12545652
申请日：2009-08-21
申请人： John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann
发明人： John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann
IPC分类号： A61B7/00
CPC分类号： A61B7/003 , A61N1/36514 , A61N1/36535
摘要： Adventitious lung sounds indicative of lung congestion are detected using an implantable sensor. The sensor is adapted to be positioned adjacent to a pulmonary system and to output signals indicative of lung sounds in response to pulmonary system activity. A controller receives the signals and processes the signals to detect the presence of adventitious lung sounds. A respiratory cycle sensor operating in conjunction with the lung-sound sensor enables classification of an adventitious lung sound according to its time occurrence within the respiratory cycle. Posture sensing in conjunction with lung-sound sensing provides valuable additional information as to the severity of the lung congestion.
摘要翻译：使用植入式传感器检测到指示肺充血的不定肺声。传感器适于邻近肺部系统定位，并响应于肺部系统活动而输出指示肺部声音的信号。控制器接收信号并处理信号以检测不定肺声的存在。与肺声传感器一起操作的呼吸循环传感器可以根据呼吸周期内的时间发生分类不定肺声。结合肺部感觉的姿势感知提供了关于肺充血严重程度的有价值的附加信息。

120. 发明授权

US08301252B2 Advanced patient management with composite parameter indices 有权
标题翻译：高级患者管理与复合参数指标
公开(公告)号：US08301252B2
公开(公告)日：2012-10-30
申请号：US13162311
申请日：2011-06-16
申请人： John D. Hatlestad , Jeffrey E. Stahmann , Qingsheng Zhu
发明人： John D. Hatlestad , Jeffrey E. Stahmann , Qingsheng Zhu
IPC分类号： A61N1/18
CPC分类号： A61B5/7475 , A61B5/0031 , A61B5/024 , A61B5/02405 , A61B5/0816 , A61B5/091 , A61B5/743 , A61B2560/0271 , G06F19/00 , G06F19/3475 , G06F19/3481 , G16H40/63 , G16H50/30
摘要： Systems, devices and methods for defining, identifying and utilizing composite parameter indices from health-related parameters are disclosed. One aspect is a programmable device having machine executable instructions for performing a method to assist with managing a patient's health. In various embodiments, a first set of at least two health-related parameters is acquired. A first composite parameter is generated using the first set of at least two health-related parameters. Other aspects and embodiments are provided herein.
摘要翻译：公开了用于定义，识别和利用来自健康相关参数的复合参数索引的系统，设备和方法。一个方面是具有用于执行帮助管理患者健康的方法的机器可执行指令的可编程设备。在各种实施例中，获取至少两个健康相关参数的第一组。使用第一组至少两个健康相关参数生成第一个复合参数。本文提供了其它方面和实施例。

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