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111. 发明授权

US08361095B2 Loop thrombectomy device 有权
标题翻译：环路血栓切除装置
公开(公告)号：US08361095B2
公开(公告)日：2013-01-29
申请号：US12372352
申请日：2009-02-17
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B17/22
CPC分类号： A61B17/320725 , A61B17/320708 , A61B2017/320716 , A61B2017/320733
摘要： A thrombectomy device may include an elongate torsion member having a proximal end and a distal end, and a plurality of helically arranged engagement members disposed at a distal portion of the elongate torsion member. Preferably, at least a portion of the engagement members has a rounded, atraumatic shape. The engagement members have a collapsed state where the engagement members are compressed toward the elongate torsion member, and an expanded state where the engagement members are expanded radially outward. Preferably, the engagement members are attached to and extends radially outward from the elongate torsion member at a different longitudinal point such that the engagement members are spaced longitudinally and circumferentially from each other when in the expanded state. When the thrombectomy device is deployed in a body lumen or cavity, the engagement members expands out to contact a wall of the body lumen or cavity.
摘要翻译：血栓切除装置可以包括具有近端和远端的细长扭转构件，以及设置在细长扭转构件的远侧部分处的多个螺旋布置的接合构件。优选地，至少一部分接合构件具有圆形的无创伤形状。接合构件具有接合构件朝向细长扭转构件被压缩的折叠状态，以及接合构件径向向外延伸的展开状态。优选地，接合构件在不同的纵向点处从细长扭转构件附接并径向向外延伸，使得接合构件在处于膨胀状态时彼此纵向和周向间隔开。当血栓切除装置部署在体腔或空腔中时，接合构件膨胀以接触体腔或空腔的壁。

112. 发明授权

US08343204B2 Composite stent graft 有权
标题翻译：复合支架移植
公开(公告)号：US08343204B2
公开(公告)日：2013-01-01
申请号：US12092120
申请日：2006-10-31
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/826 , A61F2002/828 , A61F2220/0075 , A61F2230/0054 , A61F2250/0056
摘要： A composite prosthesis (19, 99, 199) and method are disclosed herein. This endoluminal prosthesis is constructed by separately deploying a first prosthesis (9, 201) and a second prosthesis (14, 208), wherein the first prosthesis is deployed and secured to the interior surface of a body lumen (260). In a subsequent step, the second prosthesis is deployed substantially within and secured to the first prosthesis. Although additional prostheses may be deployed within the second prosthesis, in a preferred configuration the first and second prostheses combine to provide all of the necessary attributes associated with a functioning endoluminal prosthesis. Thus, one of the first and second prostheses is permeable to blood and exerts sufficient radial force to cause the composite prosthesis to securely engage an interior surface of the body lumen at one or both of the composite prosthesis's proximal and distal ends, while the other of the first and second prostheses is impermeable to blood flow.
摘要翻译：本文公开了一种复合假体（19,99,199）和方法。该腔内假体通过分开展开第一假体（9,201）和第二假体（14,208）来构造，其中第一假体展开并固定到体腔（260）的内表面。在随后的步骤中，第二假体基本上部署在第一假体内并固定到第一假体。虽然附加的假体可以部署在第二假体内，但是在优选的构造中，第一和第二假体组合以提供与功能性腔内假体相关联的所有必要属性。因此，第一和第二假体中的一个可渗透血液并施加足够的径向力，以使得复合假体在复合假体的近端和远端中的一个或两个处牢固地接合体腔的内表面，而另一个第一和第二假体是不透血的。

113. 发明授权

US08313521B2 Method of delivering an implantable medical device with a bioabsorbable coating 有权
标题翻译：用生物可吸收涂层递送可植入医疗器械的方法
公开(公告)号：US08313521B2
公开(公告)日：2012-11-20
申请号：US11599859
申请日：2006-11-15
申请人： Patrick H. Ruane , Waleska Perez-Segarra , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Brian L. Bates , Thomas A. Osborne
发明人： Patrick H. Ruane , Waleska Perez-Segarra , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Brian L. Bates , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/146 , A61L31/16 , A61L33/022 , A61L2300/602 , A61L2300/608 , A61L2420/08 , A61N5/1002
摘要： Methods of delivering a bioactive material to a body vessel are disclosed. The method steps can include providing an expandable medical device with a coating having a bioactive layer, and providing a second layer of a biodegradable polymer positioned over the bioactive layer. The second layer provides for controlled release of the bioactive material from the bioactive layer. The medical device is inserted into a body vessel using a catheter such that the medical device contacts the body vessel.
摘要翻译：公开了将生物活性物质输送到身体血管的方法。方法步骤可以包括提供具有生物活性层的涂层的可扩张医疗装置，以及提供位于生物活性层上方的生物可降解聚合物的第二层。第二层提供生物活性物质从生物活性层的受控释放。使用导管将医疗装置插入身体容器中，使得医疗装置接触身体容器。

114. 发明授权

US08123769B2 Thrombus removal device 有权
标题翻译：血栓清除装置
公开(公告)号：US08123769B2
公开(公告)日：2012-02-28
申请号：US11502659
申请日：2006-08-11
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B17/22
CPC分类号： A61B17/22 , A61B17/221 , A61B2017/00685 , A61B2017/22001 , A61B2017/2212 , A61B2017/320733 , A61B2017/320741
摘要： A thrombi removal device includes a shaft with a distal end and a proximal end and a helical coil attached at one end to the distal end of the shaft and extending in the distal direction from the shaft. The coil has a plurality of body portions with turns or winding spaced apart longitudinally and laterally to facilitate screwing the coil into the thrombus and to provide a sufficient open area into which the thrombus can be captured. The distal end of the coil is provided with a loop. The angle of the loop relative to a longitudinal axis extending through the helical coil is about the same as the angle of at least one body portion.
摘要翻译：血栓去除装置包括具有远端和近端的轴和螺旋线圈，该螺旋线圈在一端附接到轴的远端并且在远端方向上从轴延伸。线圈具有多个主体部分，其具有匝或绕组，其纵向和横向间隔开，以便于将线圈拧入血栓并提供足够的开放区域，血栓可被捕获到其中。线圈的远端设有一个回路。环路相对于延伸穿过螺旋线圈的纵向轴线的角度与至少一个主体部分的角度大致相同。

115. 发明授权

US08105349B2 Removable vena cava filter having primary struts for enhanced retrieval and delivery 有权
标题翻译：可移动的腔静脉过滤器具有主支架，用于增强检索和传送
公开(公告)号：US08105349B2
公开(公告)日：2012-01-31
申请号：US11108254
申请日：2005-04-18
申请人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
发明人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/005 , A61F2230/008
摘要： A removable filter having a collapsed state and an expanded state for capturing thrombi in a blood vessel is disclosed. The filter comprises a plurality of primary struts and a plurality of secondary struts. Each primary strut in the expanded state extends from a primary strut first end to an anchoring hook. Each primary strut extends arcuately along a longitudinal axis and linearly radially. The plurality of primary strut first ends are attached together along the longitudinal axis. Each secondary strut in the expanded state extends from a secondary strut first end to a free end. Each secondary strut extends arcuately along the longitudinal axis and linearly radially. The plurality of secondary struts are attached together along the longitudinal axis. The plurality of secondary struts centralize the filter in the expanded state in the blood vessel.
摘要翻译：公开了一种具有收缩状态和用于在血管中捕获血栓的膨胀状态的可移除过滤器。过滤器包括多个主支柱和多个辅助支柱。处于膨胀状态的每个主支柱从主支柱第一端延伸到锚钩。每个主支柱沿着纵向轴线弧线延伸并且线性地径向延伸。多个主支柱第一端沿着纵向轴线连接在一起。处于膨胀状态的每个辅助支柱从辅助支柱第一端延伸到自由端。每个辅助支柱沿着纵向轴线弧线延伸并且线性地径向延伸。多个辅助支柱沿着纵向轴线连接在一起。多个次级支柱将血管中处于膨胀状态的过滤器集中。

116. 发明授权

US08043232B2 High performance wire guide 有权
标题翻译：高性能导线
公开(公告)号：US08043232B2
公开(公告)日：2011-10-25
申请号：US11496882
申请日：2006-07-31
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09166
摘要： A high performance wire guide is disclosed, having a core wire and an outer member disposed about the core wire for enhanced torque transmission along a longitudinal length of the core wire. The outer member may be an outer coil wrapped around the core wire in an interference fit.
摘要翻译：公开了一种高性能线引导件，其具有芯线和围绕芯线设置的外部构件，用于沿着芯线的纵向长度增强扭矩传递。外部构件可以是以过盈配合缠绕在芯线上的外部线圈。

117. 发明授权

US07896888B2 Multiple wire guide introducer system 有权
标题翻译：多导线导引系统
公开(公告)号：US07896888B2
公开(公告)日：2011-03-01
申请号：US11971364
申请日：2008-01-09
申请人： Thomas A. Osborne , Brian L. Bates
发明人： Thomas A. Osborne , Brian L. Bates
IPC分类号： A61F11/00
CPC分类号： A61M25/0662 , A61M25/0172
摘要： An introducer system for introducing a plurality of wire guides into a vessel of a patient includes first and second wire guides, and a catheter. The first wire guide has a curved proximal end, and a distal end sufficiently flexible for passage through the vessel to a target site for the procedure. The catheter has proximal and distal open ends, and a lumen extending therebetween. At least the distal end of the catheter has sufficient flexibility for passage over the first wire guide to the target site, and has an inwardly curved portion between the proximal and distal open ends. The catheter further has a side port proximally positioned along the inwardly curved portion. The side port is sized and arranged such that the curve of the first wire guide proximal end is passable therethrough when the catheter is passed over the first wire guide. The second wire guide is sized for passage through the lumen when the first wire guide is positioned in the lumen. The second wire guide has a stiffness greater than the stiffness of the first wire guide.
摘要翻译：用于将多个线导引器引入患者的容器中的导引器系统包括第一和第二线引导件和导管。第一线引导件具有弯曲的近端，并且远端具有足够的柔性，用于通过血管到达该过程的目标部位。导管具有近端和远端开口端，以及在其间延伸的腔。至少导管的远端具有足够的柔性，用于在第一线导向件上通过到目标部位，并且在近端和远端开口端之间具有向内弯曲的部分。导管还具有沿着向内弯曲的部分向近侧定位的侧端口。侧端口的尺寸和布置使得当导管穿过第一导线器时，第一导线器近端的曲线可以穿过其中。当第一线引导件定位在内腔中时，第二线引导件的尺寸适于通过内腔。第二导线器的刚度大于第一导线器的刚度。

118. 发明授权

US07828839B2 Flexible barb for anchoring a prosthesis 有权
标题翻译：用于锚定假体的柔性倒钩
公开(公告)号：US07828839B2
公开(公告)日：2010-11-09
申请号：US11849858
申请日：2007-09-04
申请人： William A. Cook , Michael P. DeBruyne , Mark R. Frye , Benjamin Nickless , Thomas A. Osborne , Ronan T. Young
发明人： William A. Cook , Michael P. DeBruyne , Mark R. Frye , Benjamin Nickless , Thomas A. Osborne , Ronan T. Young
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61B2017/0412 , A61B2017/0437 , A61F2002/8483 , A61F2220/0016
摘要： A system for anchoring an endoluminal prosthesis comprises a barb. The barb comprises a base, a retractable body extending distally from the base towards a distal anchor, and a hinge disposed between the base and the anchor and spaced apart from the base. The anchor pivots about the hinge between a retracted configuration and an extended configuration. Additional devices, systems, and methods are disclosed.
摘要翻译：用于锚定内腔假体的系统包括倒钩。倒钩包括基部，从基部朝向远侧锚定件向远侧延伸的可伸缩体，以及设置在基部和锚固件之间并与基部间隔开的铰链。锚固件在缩回配置和延伸配置之间绕铰链枢转。公开了附加设备，系统和方法。

119. 发明申请

US20100160956A1 REMOVABLE VENA CAVA FILTER FOR REDUCED TRAUMA IN COLLAPSED CONFIGURATION 有权
标题翻译：可拆卸VENA CAVA过滤器，用于减少配置中的TRAUMA
公开(公告)号：US20100160956A1
公开(公告)日：2010-06-24
申请号：US12717637
申请日：2010-03-04
申请人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
发明人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8483 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： The present invention provides a method of capturing thrombi in a blood vessel, which includes delivering a removable filter in a collapsed state within the blood vessel and deploying the filter to an expanded state within the blood vessel. The filter includes a plurality of primary struts and a plurality of secondary struts emanating from a hub and extending arcuately along a longitudinal axis and linearly radially. Each primary strut has an arcuate segment including first and second curved portions. Each secondary strut includes first and second arcs. The primary struts terminate with an anchoring hook. Each primary strut crosses another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter and the anchoring hooks occupy a second diameter, the first diameter being greater than the second diameter for filter retrieval or delivery. In the expanded state, the secondary struts centralize the filter in the blood vessel and the anchoring hooks engage with the blood vessel.
摘要翻译：本发明提供了一种在血管中捕获血栓的方法，其包括在血管内以折叠状态递送可移除的过滤器，并将该过滤器展开至血管内的扩张状态。过滤器包括多个主支柱和从轮毂发出并沿着纵向轴线弧形延伸并且线性地径向延伸的多个辅助支柱。每个主支柱具有包括第一和第二弯曲部分的弓形段。每个辅助支柱包括第一和第二弧。主支柱终止于锚钩。每个主支柱在塌缩状态下沿着纵向轴线跨越另一个主支柱，使得弓形段占据第一直径，并且锚定钩占据第二直径，第一直径大于用于过滤器取出或输送的第二直径。在扩张状态下，副支柱将过滤器集中在血管中，并且锚钩与血管接合。

120. 发明授权

US07722795B2 Medical device including unitary, continuous portion of varying durometer 有权
标题翻译：医疗设备包括单位，连续部分变化的硬度
公开(公告)号：US07722795B2
公开(公告)日：2010-05-25
申请号：US10813415
申请日：2004-03-30
申请人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
IPC分类号： B29C35/08
CPC分类号： A61M25/0009 , A61L29/06 , B29C35/08 , B29K2077/00 , B29L2031/7542 , C08F283/04 , C08G69/48 , Y10T29/4998 , C08L77/00 , C08F218/16
摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.
摘要翻译：一种医疗装置（110），包括导管轴（111）和具有变化的硬度的整体连续形成部分（108），并且可选地包括可膨胀气囊（18,118）。整体和连续形成的部分（108）和球囊（18,118）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

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