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111. 发明授权

US5795303A Systems and methods for making time-sequential measurements of biopotentials sensed in myocardial tissue 失效
标题翻译：用于对心肌组织中感测到的生物电位进行时间顺序测量的系统和方法
公开(公告)号：US5795303A
公开(公告)日：1998-08-18
申请号：US921878
申请日：1997-09-02
申请人： David K. Swanson , Dorin Panescu
发明人： David K. Swanson , Dorin Panescu
IPC分类号： A61B5/0428 , A61B5/00 , A61B5/042 , A61B5/0452 , A61N1/05 , A61N1/37 , A61N1/40 , A61B5/0402
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/04525 , A61B5/6858 , A61N1/056 , A61N1/3702 , A61N1/403 , A61B2562/0209 , A61B2562/043
摘要： Analog or digital systems and methods generate a composite signal derived from a biological event in a time-sequential fashion. The systems and methods input a first set of signals derived from a biological event using a first group of sensors during a first time interval. The systems and methods input a second set of signals derived from the biological event during a second time interval sequentially after the first time interval using a second group of sensors. The second group of sensors has at least one common sensor that is part of the first group and other sensors that are not part of the first group. The systems and methods time align the first and second sets of signals using the signals sensed by the at least one common sensor, thereby generating the composite signal. The systems and methods time align by shifting the first and second sets of signals either with or without computing a time difference between them.
摘要翻译：模拟或数字系统和方法以时间顺序的方式产生从生物事件导出的复合信号。系统和方法在第一时间间隔期间使用第一组传感器输入从生物事件导出的第一组信号。系统和方法使用第二组传感器在第一时间间隔之后，在第二时间间隔期间输入从生物事件导出的第二组信号。第二组传感器具有至少一个共同的传感器，其是第一组的一部分和不是第一组的一部分的其它传感器。系统和方法使用由至少一个公共传感器感测的信号来对准第一和第二组信号，由此产生复合信号。系统和方法通过移动第一组信号和第二组信号，或者在计算或不计算它们之间的时间差的情况下对准时间。

112. 发明授权

US5755715A Tissue heating and ablation systems and methods using time-variable set point temperature curves for monitoring and control 失效
标题翻译：组织加热和消融系统和方法使用时变设定点温度曲线进行监测和控制
公开(公告)号：US5755715A
公开(公告)日：1998-05-26
申请号：US656756
申请日：1996-06-03
申请人： Roger A. Stern , Dorin Panescu , David K. Swanson
发明人： Roger A. Stern , Dorin Panescu , David K. Swanson
IPC分类号： A61B17/00 , A61B18/00 , A61B18/10 , A61B18/12 , A61B18/14 , A61B19/00 , A61B17/39
CPC分类号： A61B18/00 , A61B18/1206 , A61B18/1492 , A61B18/14 , A61B2017/00017 , A61B2017/00084 , A61B2017/00101 , A61B2017/00292 , A61B2017/003 , A61B2017/00482 , A61B2018/00083 , A61B2018/00095 , A61B2018/00101 , A61B2018/00178 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00815 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00892 , A61B2018/00916 , A61B2018/00988 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2090/0803 , A61B2562/08 , A61M2205/273 , A61M2205/6018 , A61M2205/6027 , A61M2205/70 , A61M2230/50
摘要： Systems and methods employ an energy emitting electrode to heat tissue. The systems and methods follow a prescribed temperature set curve, in which a setpoint temperature changes over time, to control the application of energy to the electrode.
摘要翻译：系统和方法采用能量发射电极来加热组织。系统和方法遵循规定的温度设定曲线，其中设定点温度随时间而变化，以控制向电极施加能量。

113. 发明授权

US5702386A Non-linear control systems and methods for heating and ablating body tissue 失效
标题翻译：用于加热和消融身体组织的非线性控制系统和方法
公开(公告)号：US5702386A
公开(公告)日：1997-12-30
申请号：US670985
申请日：1996-06-28
申请人： Roger A. Stern , Dorin Panescu , David K. Swanson
发明人： Roger A. Stern , Dorin Panescu , David K. Swanson
IPC分类号： A61B17/00 , A61B18/00 , A61B18/10 , A61B18/12 , A61B18/14 , A61B19/00 , A61B17/36
CPC分类号： A61B18/00 , A61B18/1206 , A61B18/1492 , A61B18/14 , A61B2017/00017 , A61B2017/00084 , A61B2017/00101 , A61B2017/00292 , A61B2017/003 , A61B2017/00482 , A61B2018/00083 , A61B2018/00095 , A61B2018/00101 , A61B2018/00178 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00815 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00892 , A61B2018/00916 , A61B2018/00988 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2090/0803 , A61B2562/08 , A61M2205/273 , A61M2205/6018 , A61M2205/6027 , A61M2205/70 , A61M2230/50
摘要： Systems and methods employ an energy emitting electrode to heat tissue. The systems and methods control the application of energy to the electrode using adjustments that take into account, in a non-linear fashion, changes in monitored operating conditions.
摘要翻译：系统和方法采用能量发射电极来加热组织。这些系统和方法通过使用非线性方式考虑监视的操作条件的变化的调整来控制对电极的能量的应用。

114. 发明授权

US5935079A Systems and methods for positioning multiple electrode structures in electrical contact with the myocardium 失效
标题翻译：用于定位多个电极结构与心肌电接触的系统和方法
公开(公告)号：US5935079A
公开(公告)日：1999-08-10
申请号：US925196
申请日：1997-09-08
申请人： David K. Swanson , Dorin Panescu
发明人： David K. Swanson , Dorin Panescu
IPC分类号： A61B5/042 , A61B5/0424 , A61B5/0428 , A61B18/14 , A61B5/04
CPC分类号： A61B5/6885 , A61B5/0422 , A61B5/0424 , A61B5/6858 , A61B18/1492 , A61B2018/1465 , A61B2090/065 , A61B2562/0209 , A61B2562/043 , A61B5/04288
摘要： Systems and methods evaluate electrical contact between the myocardium and one or more electrodes inside the heart. The systems and methods electrically sense electrical contact between the myocardium and electrodes and generate unitary contact-indicating outputs indicating the presence or absence of electrical contact between the myocardium and each particular electrode. The systems and methods also correlate the electrode-specific unitary outputs to generate a compound contact-indicating output. The compound output represents the aggregate of the electrical contact between the myocardium and multiple electrodes on a multiple electrode array.
摘要翻译：系统和方法评估心肌与心脏内的一个或多个电极之间的电接触。系统和方法电感地感知心肌和电极之间的电接触，并产生指示心肌和每个特定电极之间电接触存在或不存在的单位接触指示输出。系统和方法还将电极特有的单一输出相关联以产生复合接触指示输出。复合输出表示多个电极阵列上的心肌和多个电极之间的电接触的聚集体。

115. 发明授权

US5598848A Systems and methods for positioning multiple electrode structures in electrical contact with the myocardium 失效
标题翻译：用于定位多个电极结构与心肌电接触的系统和方法
公开(公告)号：US5598848A
公开(公告)日：1997-02-04
申请号：US221347
申请日：1994-03-31
申请人： David K. Swanson , Dorin Panescu
发明人： David K. Swanson , Dorin Panescu
IPC分类号： A61B5/042 , A61B5/0424 , A61B5/0428 , A61B18/14 , A61B5/04
CPC分类号： A61B5/6885 , A61B5/0422 , A61B5/0424 , A61B5/6858 , A61B18/1492 , A61B2018/1465 , A61B2090/065 , A61B2562/0209 , A61B2562/043 , A61B5/04288
摘要： Systems and methods evaluate electrical contact between the myocardium and one or more electrodes inside the heart. The systems and methods electrically sense electrical contact between the myocardium and electrodes and generate unitary contact-indicating outputs indicating the presence or absence of electrical contact between the myocardium and each particular electrode. The systems and methods also correlate the electrode-specific unitary outputs to generate a compound contact-indicating output. The compound output represents the aggregate of the electrical contact between the myocardium and multiple electrodes on a multiple electrode array.
摘要翻译：系统和方法评估心肌与心脏内的一个或多个电极之间的电接触。系统和方法电感地感知心肌和电极之间的电接触，并产生指示心肌和每个特定电极之间电接触存在或不存在的单位接触指示输出。系统和方法还将电极特有的单一输出相关联以产生复合接触指示输出。复合输出表示多个电极阵列上的心肌和多个电极之间的电接触的聚集体。

116. 发明授权

US5494042A Systems and methods for deriving electrical characteristics of cardiac tissue for output in iso-characteristic displays 失效
标题翻译：用于导出等离子体显示器输出的心脏组织电特征的系统和方法
公开(公告)号：US5494042A
公开(公告)日：1996-02-27
申请号：US188316
申请日：1994-01-28
申请人： Dorin Panescu , David K. Swanson
发明人： Dorin Panescu , David K. Swanson
IPC分类号： A61B5/042 , A61B5/05 , A61B5/053 , A61B18/00 , A61N1/05 , A61B5/04
CPC分类号： A61N1/056 , A61B5/0422 , A61B5/044 , A61B5/053 , A61B5/0538 , A61B5/6855 , A61B5/6858 , A61N1/36185 , A61N1/3686 , A61B18/00 , A61B2562/0209 , A61B2562/043
摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods arrange the derived tissue electrical characteristics into groups of equal electrical characteristics. The systems and methods display the groups of equal electrical characteristics in spatial relation to the location of the examined tissue regions. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
摘要翻译：系统和方法使用三个或更多个间隔开的电极检查心脏组织形态，其中至少两个电极位于心脏内与心内膜组织接触。所述系统和方法将电流透过位于所选择的电极对之间的心脏组织的区域，每对电极中的至少一个位于心脏内。系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。系统和方法将衍生的组织电特征组织成具有相等电特性的组。系统和方法显示与检查的组织区域的位置具有空间关系的等电特性的组。系统和方法使得可以使用多个心内膜电极进行心脏组织的电特征的多次测量。可以使用多路复用来促进数据处理。系统和方法还可以识别低相对电特征的区域，指示梗死组织，无侵入性手术技术。

117. 发明授权

US07364546B2 Multi-functional medical catheter and methods of use 有权
标题翻译：多功能医用导管及使用方法
公开(公告)号：US07364546B2
公开(公告)日：2008-04-29
申请号：US11687832
申请日：2007-03-19
申请人： Dorin Panescu , David K. Swanson
发明人： Dorin Panescu , David K. Swanson
IPC分类号： A61B18/00 , A18B18/14
CPC分类号： A61B5/0422 , A61B5/0538 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/4472 , A61B18/1492 , A61B2017/00106 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/124 , A61B2018/1467 , A61B2090/065 , A61B2090/3782 , A61B2090/3784 , A61B2090/3929 , A61B2090/3958 , A61B2090/3975 , A61M25/0133 , A61M2025/0161 , A61N1/056 , A61N1/08 , A61N7/02 , A61N2007/0078
摘要： The present invention provides multi-functional medical catheters, systems and methods for their use. In one particular embodiment, a medical catheter (100) includes a flexible elongate body (105) having a proximal end (110) and a distal end (120). A plurality of spaced apart electrodes (130-136) are operably attached to the flexible body near the distal end. At least some of the electrodes are adapted for mapping a tissue and, in some embodiments, at least one of the electrodes is adapted for ablating a desired portion of the tissue. The catheter includes a plurality of tissue orientation detectors (140-146) disposed between at least some of the electrodes. In this manner, the medical catheter is capable of tissue mapping, tissue imaging, tissue orientation, and/or tissue treatment functions.
摘要翻译：本发明提供了多功能医用导管，其使用的系统和方法。在一个具体实施例中，医疗导管（100）包括具有近端（110）和远端（120）的柔性细长主体（105）。多个间隔开的电极（130-136）在远端附近可操作地附接到柔性体。至少一些电极适于映射组织，并且在一些实施例中，电极中的至少一个适于消融组织的期望部分。导管包括设置在至少一些电极之间的多个组织取向检测器（140-146）。以这种方式，医用导管能够进行组织测绘，组织成像，组织取向和/或组织处理功能。

118. 发明授权

US06895267B2 Systems and methods for guiding and locating functional elements on medical devices positioned in a body 有权
标题翻译：用于在定位在身体中的医疗装置上引导和定位功能元件的系统和方法
公开(公告)号：US06895267B2
公开(公告)日：2005-05-17
申请号：US10147179
申请日：2001-10-24
申请人： Dorin Panescu , David W. Arnett , David K. Swanson
发明人： Dorin Panescu , David W. Arnett , David K. Swanson
IPC分类号： A61B5/04 , A61B5/042 , A61B5/055 , A61B5/06 , A61B8/08 , A61B17/00 , A61B18/14 , A61B19/00 , A61B5/05
CPC分类号： A61B8/4254 , A61B5/04011 , A61B5/0422 , A61B5/055 , A61B5/06 , A61B5/063 , A61B5/6856 , A61B5/6858 , A61B8/0833 , A61B8/4472 , A61B18/1492 , A61B34/20 , A61B2017/00053 , A61B2018/00214 , A61B2018/00839 , A61B2034/2051 , A61B2034/2063 , A61B2090/3782
摘要： A system for performing an invasive diagnostic or therapeutic medical procedure includes a first probe having a distal portion carrying a plurality of functional elements and a second probe having a distal portion carrying a functional element and a location sensor. The system includes a proximity processing subsystem in communication with the functional elements carried by each of the first and second probes and configured to determine a proximity of the functional element carried by the second probe relative to a first functional element carried by the first probe. The systems further includes a location processing subsystem configured to determine an absolute position and orientation of the location sensor carried by the second probe with respect to a three-dimensional reference coordinate system that can be internal or external to the three-dimensional space in which the first and second probes are positioned.
摘要翻译：用于执行侵入式诊断或治疗医疗程序的系统包括具有承载多个功能元件的远侧部分的第一探针和具有承载功能元件的远侧部分和位置传感器的第二探针。该系统包括与由第一和第二探针中的每一个承载的功能元件通信的邻近处理子系统，并被配置为确定由第二探针承载的功能元件相对于由第一探针承载的第一功能元件的接近程度。所述系统还包括位置处理子系统，该位置处理子系统被配置为确定第二探针承载的位置传感器相对于三维参考坐标系的绝对位置和取向，所述三维参考坐标系可以在三维空间内部或外部，定位第一和第二探针。

119. 发明授权

US5546940A System and method for matching electrical characteristics and propagation velocities in cardiac tissue to locate potential ablation sites 失效
标题翻译：用于匹配心脏组织中的电特性和传播速度以定位潜在消融部位的系统和方法
公开(公告)号：US5546940A
公开(公告)日：1996-08-20
申请号：US524115
申请日：1995-08-22
申请人： Dorin Panescu , David K. Swanson
发明人： Dorin Panescu , David K. Swanson
IPC分类号： A61B5/042 , A61B5/05 , A61B5/053 , A61B18/00 , A61B18/14 , A61B5/04 , A61N1/18
CPC分类号： A61B18/00 , A61B5/0422 , A61B5/053 , A61B5/0538 , A61B5/6855 , A61B5/6858 , A61B18/14 , A61B2562/0209 , A61B2562/043
摘要： Systems and methods examine heart tissue morphology for the purpose of locating a potential ablation site. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods also sense the timing of local depolarization events in the tissue in which impedance is sensed and derive therefrom the propagation velocities of the sensed depolarization events. The systems and methods match the derived tissue electrical characteristics with the derived propagation velocities in spatial relation to the electrodes to characterize the morphology of the contacted heart tissue to identify a potential ablation site.
摘要翻译：系统和方法检查心脏组织形态，以定位潜在的消融部位。系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。系统和方法还感测组织中局部去极化事件的定时，其中阻抗被感测并从其导出感测的去极化事件的传播速度。系统和方法将衍生的组织电特征与衍生的与电极空间关系的传播速度相匹配，以表征所接触的心脏组织的形态以鉴定潜在的消融部位。

120. 发明授权

US08868165B1 Use of cardiogenic impedance waveform morphology to analyze cardiac conditions and to adjust treatment therapy 有权
标题翻译：使用心源阻抗波形形态分析心脏状况并调整治疗疗法
公开(公告)号：US08868165B1
公开(公告)日：2014-10-21
申请号：US11863516
申请日：2007-09-28
申请人： Yelena Nabutovsky , Dorin Panescu , Weiqun Yang , Mihir Naware
发明人： Yelena Nabutovsky , Dorin Panescu , Weiqun Yang , Mihir Naware
IPC分类号： A61B5/053 , A61B5/04
CPC分类号： A61B5/053 , A61B5/0205 , A61B5/04 , A61B5/042 , A61B5/04525 , A61B5/0538 , A61B5/7246 , A61N1/3627 , A61N1/36521
摘要： In specific embodiments, one or more cardiogenic impedance signal template is stored, where each template has a corresponding morphology. Additionally, one or more cardiogenic impedance signal is obtained using electrodes implanted within a patient, where each signal has a corresponding morphology. The morphology of one or more obtained cardiogenic impedance signal is compared to the morphology of one or more stored template, to determine one or more metric indicative of similarity between the compared morphologies. The one or more metric indicative of similarity is used to analyze the patient's cardiac condition, to discriminate among arrhythmias and/or to adjust a cardiac pacing parameter.
摘要翻译：在具体实施例中，存储一个或多个心源阻抗信号模板，其中每个模板具有对应的形态。另外，使用植入患者体内的电极获得一个或多个心源性阻抗信号，其中每个信号具有相应的形态。将一个或多个获得的心源阻抗信号的形态与一个或多个存储的模板的形态进行比较，以确定指示比较形态之间的相似性的一个或多个度量。使用指示相似性的一个或多个度量来分析患者的心脏状况，区分心律失常和/或调整心脏起搏参数。

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