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111. 发明授权

US07332501B2 Indol-3-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists 有权
标题翻译：吲哚-3-基 - 羰基 - 螺 - 哌啶衍生物作为V1a受体拮抗剂
公开(公告)号：US07332501B2
公开(公告)日：2008-02-19
申请号：US11483462
申请日：2006-07-10
申请人： Caterina Bissantz , Christophe Grundschober , Hasane Ratni , Mark Rogers-Evans , Patrick Schnider
发明人： Caterina Bissantz , Christophe Grundschober , Hasane Ratni , Mark Rogers-Evans , Patrick Schnider
IPC分类号： A61K31/438 , C07D401/14 , C07D405/14
CPC分类号： C07D471/10 , C07D401/06 , C07D491/10
摘要： The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, methods for preparing the compounds and pharmaceutical compositions, and their use in the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.
摘要翻译：本发明涉及作为V1a受体拮抗剂并由式I表示的吲哚-3-基 - 羰基 - 螺 - 哌啶衍生物：其中螺哌啶头基A和残基R 1， R 2和R 3如本文所定义。本发明还涉及含有这些化合物的药物组合物，制备化合物和药物组合物的方法及其用于治疗痛经，高血压，慢性心力衰竭，不适当的血管加压素分泌，肝硬化，肾病综合征，强迫症，焦虑和抑郁症。

112. 发明授权

US07011960B2 Substituted 2-amino-3-(2-amino-phenylsulfanyl)-propionic acids 有权
标题翻译：取代的2-氨基-3-（2-氨基 - 苯硫基） - 丙酸
公开(公告)号：US07011960B2
公开(公告)日：2006-03-14
申请号：US10252971
申请日：2002-09-23
申请人： Konrad Bleicher , Scott Borthwick , Hans Iding , Mark Rogers-Evans , Stefan Schmid , Han Min Tong , Beat Wirz
发明人： Konrad Bleicher , Scott Borthwick , Hans Iding , Mark Rogers-Evans , Stefan Schmid , Han Min Tong , Beat Wirz
IPC分类号： C12P13/04 , A61K38/17 , A01N43/10 , C07D291/06 , C07C323/02
CPC分类号： C12P13/04 , C07C323/59 , C07C323/63 , C07D285/36 , C12P11/00 , C12P41/005
摘要： The present invention relates to a new process for the preparation compounds of formula I wherein R1, R2, R3 and n are as described in the description which process comprises reacting compounds of formula II wherein R1, R2, R3, n and R4 are as described in the description, with a protease in an aqueous system containing an organic co-solvent. The compound of formula I are useful for the preparation of 1,5-benzothiazepines which are useful as enzyme inhibitors, such as protease, interleukin-1β-converting enzyme, elastase or angiotensin converting enzyme, GPCR antagonists (cholecystokinin, angiotensin II receptor).
摘要翻译：本发明涉及制备式I化合物的新方法，其中R 1，R 2，R 3和n如上所述在描述中，该方法包括使式II化合物其中R 1，R 2，R 3，R 3，R 4和R 4， / SUP>如描述中所述，在含有有机共溶剂的水性体系中具有蛋白酶。式I化合物可用于制备可用作酶抑制剂的1,5-苯并硫氮杂，如蛋白酶，白细胞介素-1β转换酶，弹性蛋白酶或血管紧张素转换酶，GPCR拮抗剂（缩胆囊素，血管紧张素II受体）。

113. 发明申请

US20060053267A1 Scaling address space utilization in a multi-threaded, multi-processor computer 失效
公开(公告)号：US20060053267A1
公开(公告)日：2006-03-09
申请号：US10920910
申请日：2004-08-18
申请人： Christopher McDonald , Bruce Mealey , Mark Rogers
发明人： Christopher McDonald , Bruce Mealey , Mark Rogers
IPC分类号： G06F12/10
CPC分类号： G06F12/1072 , G06F12/1036 , G06F12/109 , G06F2212/682
摘要： Scaling address space utilization in a multi-threaded, multi-processor computer, including attaching to process memory of an exporting process a region of virtual memory specified in a cross-memory descriptor; requesting, by an importing thread of an importing process having process memory, a lightweight attachment of the region of virtual memory to the process memory of the importing process for exclusive use by the importing thread; and lightweight attaching, by an operating system to the process memory of the importing process, the region of virtual memory for exclusive use by the importing thread.

114. 发明申请

US20050070722A1 1'-Benzyl-3-bromo-[1,3']bipyrrolidinyl-2-one 有权
标题翻译： 1'-苄基-3-溴 - [1,3']联吡咯烷-2-酮
公开(公告)号：US20050070722A1
公开(公告)日：2005-03-31
申请号：US10916954
申请日：2004-08-12
申请人： Mark Rogers-Evans
发明人： Mark Rogers-Evans
IPC分类号： C07B61/00 , C07D207/14 , C07D207/26 , C07D207/273 , C07D207/40 , C07D207/416 , C07D501/00 , C07D501/24 , C07F9/572 , C07F9/6558 , C07F9/547
CPC分类号： C07D207/273 , C07D207/14 , C07D207/416 , C07D501/00 , C07F9/572 , C07F9/65583
摘要： The compound (R)-(1′-benzyl-3-bromo-[1,3′]bipyrrolidinyl-2-one) which is an intermediate for antibacterial vinylpyrrolidinone-cephalosporin derivatives.
摘要翻译：作为抗菌乙烯基吡咯烷酮 - 头孢菌素衍生物的中间体的化合物（R） - （1'-苄基-3-溴 - [1,3']联吡咯烷-2-酮）。

115. 发明申请

US20050067952A1 Flexible, molded EL lamp 审中-公开
标题翻译：柔性模制EL灯
公开(公告)号：US20050067952A1
公开(公告)日：2005-03-31
申请号：US10674275
申请日：2003-09-29
申请人： Ramona Fechter , Mark Rogers
发明人： Ramona Fechter , Mark Rogers
IPC分类号： H01J1/62 , H01J63/04 , H05B20060101 , H05B33/14 , H05B33/26
CPC分类号： H05B33/145 , H05B33/26
摘要： A flexible EL lamp is made by depositing successive layers onto a release layer. The lamp is molded into a substantially stiffer article, leaving the lamp as a portion of a surface of the article. In one embodiment of the invention, the lamp emits light through the article. In another embodiment, the lamp emits light from the exposed portion of the surface. The EL lamp, as molded, can be substantially flat or have a three dimensional shape. The lamp is molded with or without the release layer.
摘要翻译：柔性EL灯通过将相继的层沉积到释放层上而制成。灯被模制成基本更硬的制品，将灯留作制品表面的一部分。在本发明的一个实施例中，灯通过物品发光。在另一个实施例中，灯从表面的暴露部分发射光。成型的EL灯可以是基本平坦的或具有三维形状。该灯被模制有或没有释放层。

116. 发明授权

US06693702B2 Laser range estimation aid 有权
标题翻译：激光距离估计辅助
公开(公告)号：US06693702B2
公开(公告)日：2004-02-17
申请号：US09953583
申请日：2001-09-11
申请人： Mark Rogers
发明人： Mark Rogers
IPC分类号： G01C300
CPC分类号： G01C3/10
摘要： In order to judge range with the laser range estimation aid the lasers (1, 2 and 3) should be activated via the switch (8) and directed at the target of range desired. The lasers (1, 2 and 3) should produce a triangle pattern of dots. If there is an upright triangle (10, 11), then the target is below or closer that the zero range. If there is a single dot, then target is substantially at the zero range (12). If there is an inverted triangle (13, 14), then the target is above or further away from the zero range. Also, the size of the pattern produced can be found relative to the terrain which allows for further range calculation.
摘要翻译：为了通过激光距离估计辅助来判断范围，激光器（1,2和3）应该通过开关（8）被激活并且指向所需范围的目标。激光器（1,2和3）应该产生一个点的三角形图案。如果有一个直立的三角形（10,11），则目标在零范围之下或更近。如果有一个点，则目标基本上在零范围（12）。如果存在倒三角形（13,14），则目标在零范围之上或更远。此外，可以相对于允许进一步范围计算的地形找到所生成的图案的尺寸。

117. 发明授权

US06321525B1 Overspeed detection techniques for gas turbine engine 有权
标题翻译：燃气轮机超速检测技术
公开(公告)号：US06321525B1
公开(公告)日：2001-11-27
申请号：US09497558
申请日：2000-02-03
申请人： David Mark Rogers
发明人： David Mark Rogers
IPC分类号： F02C928
CPC分类号： F02C9/28 , F01D17/06 , F05D2270/02 , F05D2270/021 , F05D2270/042 , G05B23/0235
摘要： Unique systems and methods are disclosed to detect and remediate an overspeed condition of a gas turbine engine. Such techniques include sensing rotational speed of a rotating member of a gas turbine engine and providing a first speed threshold that varies with rotational acceleration of this member over a predefined range. An overspeed condition of the gas turbine engine is detected if the rotational speed exceeds this first speed threshold and a second speed threshold. This second speed threshold is greater than or equal to the first speed threshold when the overspeed condition is detected. In response to the overspeed detection, a fuel valve may be actuated to adjust fuel flow to the engine. In one embodiment, an analog circuit compares the first and second speed thresholds to the rotational speed and controls current flow through an actuator for an overspeed fuel valve associated with the engine.
摘要翻译：公开了独特的系统和方法来检测和修复燃气涡轮发动机的超速状况。这样的技术包括感测燃气涡轮发动机的旋转构件的旋转速度，并且提供随着该构件在预定范围内的旋转加速度而变化的第一速度阈值。如果转速超过该第一速度阈值和第二速度阈值，则检测燃气涡轮发动机的超速状况。当检测到超速状况时，该第二速度阈值大于或等于第一速度阈值。响应于超速检测，可以启动燃料阀以调节到发动机的燃料流量。在一个实施例中，模拟电路将第一和第二速度阈值与转速进行比较，并且控制通过用于与发动机相关联的超速燃料阀的致动器的电流。

118. 发明授权

US06303790B1 Process for the preparation of pyridine derivatives 有权
标题翻译：吡啶衍生物的制备方法
公开(公告)号：US06303790B1
公开(公告)日：2001-10-16
申请号：US09716538
申请日：2000-11-20
申请人： Hans Hilpert , Fabienne Hoffmann-Emery , Goesta Rimmler , Mark Rogers-Evans , Helmut Werner Stahr , Pius Waldmeier
发明人： Hans Hilpert , Fabienne Hoffmann-Emery , Goesta Rimmler , Mark Rogers-Evans , Helmut Werner Stahr , Pius Waldmeier
IPC分类号： C07D21375
CPC分类号： C07D213/75 , C07D213/82
摘要： A process is described for preparing certain 4-alkyl- or 4-aryl-pyridine derivatives.
摘要翻译：描述了制备某些4-烷基 - 或4-芳基 - 吡啶衍生物的方法

119. 发明授权

US5398961A Flexible strap attachment method and apparatus for passenger air bag module cover 失效
标题翻译：用于乘客安全气囊模块盖的柔性表带安装方法和装置
公开(公告)号：US5398961A
公开(公告)日：1995-03-21
申请号：US261526
申请日：1994-06-17
申请人： Mark Rogers , Daniel W. Anderson , Melinda M. Newhouse
发明人： Mark Rogers , Daniel W. Anderson , Melinda M. Newhouse
IPC分类号： B60R21/215 , B60R21/216 , B60R21/16
CPC分类号： B60R21/215 , B60R21/216
摘要： A fastening method and apparatus for attaching an automotive vehicle instrument panel air bag deployment door, an air bag module cover, to a passenger air bag module reaction canister. The apparatus provides a reliable cover release mechanism during an air bag deployment while allowing relative flexibility between the cover and reaction canister. The flexibility feature eliminates tolerance stack up problems by allowing the cover to locate off the instrument panel where it is intended to fit.
摘要翻译：一种用于将机动车辆仪表板气囊展开门（气囊模块盖）附接到乘客安全气囊模块反应罐的紧固方法和装置。该设备在气囊展开期间提供可靠的盖释放机构，同时允许盖和反应罐之间的相对灵活性。灵活性功能通过允许盖板将仪表板放置在适合的位置，消除了容错堆叠问题。

120. 发明授权

US09767552B2 Systems and methods for detecting the presence of anomalous material within tissue 有权
公开(公告)号：US09767552B2
公开(公告)日：2017-09-19
申请号：US14342976
申请日：2012-09-06
申请人： Jon Paul Dobson , Mark Rogers Davidson , Yunmei Chen , Keith David White
发明人： Jon Paul Dobson , Mark Rogers Davidson , Yunmei Chen , Keith David White
IPC分类号： G06T7/00 , G01R33/50 , G01R33/56 , A61B5/00
CPC分类号： G06T7/0012 , A61B5/4088 , G01R33/50 , G01R33/5608 , G06T2200/04 , G06T2207/10088 , G06T2207/20076 , G06T2207/30016
摘要： In one embodiment, the presence of anomalous material within tissue is detected by scanning a patient using magnetic resonance imaging (MRI) to obtain MRI data, identifying individual voxels of the MRI data, identifying multiple parameters of each voxel, and determining as to each voxel based upon the identified parameters the likelihood of tissue represented by the voxel containing anomalous material.

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