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101. 发明授权

US06979307B2 Systems and methods for preparing autologous fibrin glue 失效
标题翻译：制备自体纤维蛋白胶的系统和方法
公开(公告)号：US06979307B2
公开(公告)日：2005-12-27
申请号：US10053247
申请日：2002-01-15
申请人： Roberto Beretta , Nicholas A. Grippi
发明人： Roberto Beretta , Nicholas A. Grippi
IPC分类号： A61L27/00 , A61L24/10 , A61L31/00 , A61M37/00 , A61B19/00 , A61K35/16 , A61M5/00 , B01D33/15
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , A61C5/64 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2065 , A61J1/2086 , A61J1/2089 , A61L24/00 , B01D21/262 , B01D33/15
摘要： The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium separates red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container blocks flow through the cannula upon entering therein.
摘要翻译：本发明提供了一种用于制备适于再生生物体中的组织的自体固体纤维蛋白网的系统。该系统包括含有分离介质和低密度高粘度液体的密封的初级容器。当容器含有血液并离心时，分离介质将红细胞与血浆分离，并且初级容器具有第一压力。该系统还包括含有钙凝固活化剂的密封的次级容器。次级容器具有小于第一压力的第二压力。该系统还包括包括具有第一端和第二端的插管的转移装置。第一和第二端刺穿密封的初级和次级容器，以便在第一和第二容器之间提供流体连通。主容器块的低密度高粘度液体在进入其中时流过套管。

102. 发明申请

US20050252867A1 Methods of applying a biological composition to an individual 有权
公开(公告)号：US20050252867A1
公开(公告)日：2005-11-17
申请号：US11159482
申请日：2005-06-23
申请人： Robert Baugh , Lisa Lim , Julie Johnston , John Rivera
发明人： Robert Baugh , Lisa Lim , Julie Johnston , John Rivera
IPC分类号： A61L24/00 , A61L24/10 , A61L26/00 , A61M1/36 , B01D33/27 , C12N5/08 , A61K35/16 , B01D33/15 , B01D37/00 , B04B3/00 , C02F1/00 , C02F1/38
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： Provided are methods of applying biological compositions, that is, autologous bioadhesive sealant compositions containing one or more biological agents, to an individual, wherein all the blood components used in preparing the composition are derived from the patient who is to receive the biological composition. In one embodiment, the method comprises obtaining a whole blood sample from an individual; forming an inactive platelet rich plasma from the whole blood sample; mixing a biological agent into the inactive platelet rich plasma; obtaining thrombin from the whole blood sample; mixing the thrombin into the inactive platelet rich plasma to form a biological composition; and applying the biological composition to the individual.

103. 发明申请

US20050059921A1 Extracorporeal pathogen reduction system 失效
公开(公告)号：US20050059921A1
公开(公告)日：2005-03-17
申请号：US10720811
申请日：2003-11-24
申请人： Hosheng Tu , Hun-Chi Lin , Yu-An Chang
发明人： Hosheng Tu , Hun-Chi Lin , Yu-An Chang
IPC分类号： A61K20060101 , A61M1/00 , A61M1/26 , A61M1/34 , A61M5/00 , A61M37/00 , B01D24/28 , B01D33/00 , B01D33/01 , B01D33/15 , B01D61/00 , B01D61/20 , B01D63/16
CPC分类号： A61M1/3496 , A61M1/26 , A61M1/262 , A61M2202/20 , B01D63/16
摘要： The invention relates to an apparatus system and methods for treatment of virus-infected or pathogen-loaded human blood components separated from normal components comprising a separation apparatus and treatment apparatus system that inactivate pathogens in an extracorporeal body fluid system.

104. 发明授权

US6361700B2 Method and partitioning blood using polyesters 有权
标题翻译：使用聚酯的方法和分配血液
公开(公告)号：US6361700B2
公开(公告)日：2002-03-26
申请号：US78896701
申请日：2001-02-20
申请人： COGNIS CORP
发明人： GATES JEFFREY A , SHARP MICHAEL S
IPC分类号： B01L3/14 , C08G63/21 , C08G63/48 , C08G63/52 , G01N33/49 , B01D33/15 , C08F20/00 , C08G63/54
CPC分类号： B01L3/5021 , C08G63/21 , C08G63/48 , C08G63/52 , G01N33/491
摘要： A polyester is provided which facilitates the separation of blood into light and heavy phases via centrifugation in a blood collection vessel. The polyester is useful as a component of a partitioning composition formulated to have appropriate specific gravity to be positioned intermediate the light and heavy blood phases during centrifugation. The polyester composition can be prepared with relative ease compared to prior art polyesters useful in blood partitioning compositions. The polyesters of this invention comprise a dicarboxylic acid member, a polymeric fatty acid, a diol member and a moiety having at least one polymerizable carbon-carbon double bond and at least one functional group capable of reacting with the ends of the polyester chain. The polyesters have a lower viscosity when synthesized and are later cured to increase their viscosity to the desired level.
摘要翻译：提供了一种聚酯，其有助于通过在采血容器中离心将血液分离成轻质和重质相。聚酯可用作分配组合物的组分，其配制成在离心过程中具有适当的比重位于轻和重的血液相之间。与可用于血液分配组合物的现有技术聚酯相比，可以相对容易地制备聚酯组合物。本发明的聚酯包括二羧酸构件，聚合脂肪酸，二醇构件和具有至少一个可聚合碳 - 碳双键的部分和至少一个能够与聚酯链端部反应的官能团。聚合物在合成时具有较低的粘度，并且随后固化以将其粘度增加到所需的水平。

105. 发明授权

US5928214A High concentration white cells, a method for agglomeration of the high concentration and a bag set for use in conjunction therewith 有权
标题翻译：高浓度白细胞，高浓度聚集方法和与之结合使用的袋装
公开(公告)号：US5928214A
公开(公告)日：1999-07-27
申请号：US128208
申请日：1998-08-03
申请人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
发明人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
IPC分类号： A01N1/02 , A61K35/14 , A61M1/02 , A61B19/00 , B01D33/15
CPC分类号： A01N1/0263 , A01N1/02 , A01N1/0221 , A61B5/150038 , A61B5/150229 , A61B5/150366 , A61B5/150755 , A61M1/0236 , A61M2202/0439 , A61M2202/0462 , Y10S206/828
摘要： A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
摘要翻译：由具有高细胞存活能力的高浓度白细胞形成的治疗产品。通过将血液置于容器中并防止血液凝结，将血液分离成两部分，其中一种是通过使用试剂和离心，隔离白细胞浓度，并冷冻白细胞。

106. 发明授权

US5855799A Rotary disk filter with backwash 失效
标题翻译：旋转盘式过滤器带反冲洗
公开(公告)号：US5855799A
公开(公告)日：1999-01-05
申请号：US770232
申请日：1996-12-19
申请人： Karl-Heinz Herrmann
发明人： Karl-Heinz Herrmann
IPC分类号： B01D17/04 , B01D29/15 , B01D29/41 , B01D33/21 , B01D33/23 , B01D63/06 , B01D63/16 , B01D65/02 , C02F3/10 , B01D37/00 , B01D33/15
CPC分类号： C02F3/101 , B01D17/045 , B01D29/15 , B01D29/413 , B01D33/21 , B01D33/23 , B01D63/065 , B01D63/16 , B01D65/02 , B01D2201/082 , B01D2201/34 , B01D2321/04 , Y02W10/15
摘要： A high capacity filter apparatus for removing solids from fluids includes a opposing filter elements defining an internal volume. Fluid to be filtered passes through the filter elements into the internal volume and through an outlet. The filter element is continuously cleaned by backwashing along the outer surface of the elements.
摘要翻译：用于从流体中除去固体的高容量过滤装置包括限定内部体积的相对的过滤器元件。要过滤的流体通过过滤元件进入内部容积并通过出口。过滤元件通过沿着元件的外表面的反冲洗连续清洁。

107. 发明授权

US5252228A Cytocentrifugation device, apparatus, and method 失效
标题翻译：细胞离心装置，装置和方法
公开(公告)号：US5252228A
公开(公告)日：1993-10-12
申请号：US788310
申请日：1991-11-05
申请人： Barry O. Stokes , Carmelo G. Quirante
发明人： Barry O. Stokes , Carmelo G. Quirante
IPC分类号： B04B5/02 , B04B7/16 , G01N1/28 , G01N33/48 , G01N33/483 , B01D33/15
CPC分类号： G01N1/2813 , G01N2001/2846 , Y10T428/24273 , Y10T428/24488
摘要： Cytocentrifugation apparatus is improved by providing centrifuging devices with a plurality of liquid-receiving chambers arranged serially along and opening into an elongate conduit leading to and terminating within a filter-pad-holder so that a filter-pad-prewetting liquid can be passed along such conduit and into a liquid-flow opening of a filter pad held by such holder in advance of passage along said conduit and through such liquid-flow opening in the filter pad of a cell-carrying liquid sample during a centrifugation run of the apparatus. Retention of prewetting liquid in the filter pad around the sample liquid flow helps to prevent loss of cells to the filter pad. Various other structural modifications of the cytocentrifugation device and filter pads used therewith also help to prevent loss of cells to the filter pad.
摘要翻译：细胞离心装置通过提供离心装置来提高，该离心装置具有多个液体接收室，该多个液体容纳室沿着并且开口延伸到细长的管道中，该细长导管通向并终止于过滤垫保持器内，使得过滤垫预润湿液体可以沿着这样的方式通过并且在装置的离心运行期间，通过这种保持器保持的过滤垫的液体流入开口，并且沿着所述导管通过并通过细胞携带液体样品的过滤垫中的这种液体流动开口。过滤垫周围的预润湿液体保留在样品液体流动下有助于防止细胞向滤板的损失。细胞离心装置和其中使用的滤垫的各种其它结构修饰也有助于防止细胞向滤片的损失。

108. 发明授权

US5087358A Filtering machine for fibrous substances having revolving cone-shaded filters 失效
标题翻译：具有旋转锥形过滤器的纤维物质过滤机
公开(公告)号：US5087358A
公开(公告)日：1992-02-11
申请号：US564182
申请日：1990-08-08
申请人： Donato Massignani
发明人： Donato Massignani
IPC分类号： B01D33/15
CPC分类号： B01D33/15 , B01D2201/48 , Y10T137/85954 , Y10T137/86187
摘要： The invention discloses a machine for the filtering of solid, in particular fibrous, particles suspended in liquids, including a delivery chamber (2) collecting the liquid to be treated, a raceway (3) leading the liquid to be treated into a treatment chamber (4) having a cylindrical bottom (5), wherein there is at least one pair of revolving filters (6, 7), an overflow chamber (16) connected with a recycling tank and an area (21) for the discharge of the recovered solid particles. In the machine each filter (12) has a surface in the shape of a truncated cone and its horizontal axis is essentially perpendicular to the flow direction of the liquid to be treated, the two filters are coaxial with each other and face each other, so as to form a concave space (20) therebetween. The taper of the filters causes the double effect of increasing the filtering performance of the machine and of avoiding its standstill when the delivery of liquid to be treated increases.
摘要翻译：本发明公开了一种用于过滤悬浮在液体中的固体，特别是纤维状颗粒的机器，包括收集待处理液体的输送室（2），将待处理液体引导到处理室中的滚道（3） 4）具有圆柱形底部（5），其中存在至少一对旋转过滤器（6,7），与回收罐连接的溢流室（16）和用于排出回收固体的区域（21）粒子。在机器中，每个过滤器（12）具有截头圆锥形状的表面，其水平轴线基本上垂直于待处理液体的流动方向，两个过滤器彼此同轴并相互面对，因此以在其间形成凹形空间（20）。过滤器的锥度引起增加机器的过滤性能和避免在待处理液体的输送增加时停止的双重作用。

109. 发明授权

US5032270A Thickener 失效
标题翻译：增稠剂
公开(公告)号：US5032270A
公开(公告)日：1991-07-16
申请号：US411538
申请日：1989-10-03
申请人： Harry Nilsson , Bjarne Nilsson
发明人： Harry Nilsson , Bjarne Nilsson
IPC分类号： B01D24/38 , B01D33/15 , B01D33/21 , B01D33/70
CPC分类号： B01D33/215 , B01D2201/282
摘要： A filter for thickening fiber suspensions or other liquids containing solid material includes a plurality of rotatable filter disks (3) mutually spaced in axial direction and adapted to be partially submerged in a liquid (5) to be filtered. Each filter disk includes a plurality of filter sectors (4) communicating with axial filtrate discharge ducts (2) at the outer peripheries of the filter disks (3) for removal of filtrate. The axial filtrate discharge ducts (2) are open to atmosphere at at least one end (2') thereof for the purpose of conducting air through these ducts into the interior of the filter sections to replace filtrate flowing out. Advantageously, there is communication between all axial filtrate discharge ducts through annular filter disk holders (1) carrying the filter sectors (4) of the filter disks.
摘要翻译： PCT No.PCT / SE89 / 00042 Sec。 371日期：1989年10月3日 102（e）日期1989年10月3日PCT 1989年2月3日PCT PCT。公开号WO89 / 07003 日本1989年8月10日。用于增稠纤维悬浮液或含有固体材料的其它液体的过滤器包括沿轴向互相间隔并适于部分浸没在待过滤的液体（5）中的多个可旋转过滤盘（3）。每个过滤盘包括在过滤盘（3）的外周处与轴向滤液排出管（2）连通的多个过滤器区段（4），用于除去滤液。轴向滤液排放管道（2）在其至少一个端部（2'）处对大气开放，目的是将空气通过这些管道进入过滤器部分的内部，以代替流出的滤液。有利地，通过承载过滤盘的过滤器扇区（4）的环形过滤器盘保持器（1）在所有轴向滤液排出管之间存在连通。

110. 发明授权

US4999104A Disk-type decker 失效
标题翻译：盘式甲板
公开(公告)号：US4999104A
公开(公告)日：1991-03-12
申请号：US244708
申请日：1988-09-15
申请人： Uwe Krieger
发明人： Uwe Krieger
IPC分类号： B01D33/15
CPC分类号： B01D33/15
摘要： In a disk-type decker that is employed to drain suspensions and that has axially distributed suspension chambers and filtrate chambers that are separated by rotating screen disks and open into a stationary tub, the filtrate chambers are evacuated to increase the throughput of the decker and improve and accelerate drainage. The filtrate chambers are for this purpose divided by radial and axial transverse partitions into individual filtrate-chamber sections distributed along the circumference and sealed off from one another. When the screen disks and hence the filtrate-chamber sections rotate and the sections enter into flow engagement with filtrate outlets at the bottom of the decker, they are simultaneously evacuated, accelerating drainage through the disks. The results are a higher throughput, a lower material density in the filtrate, and lower specific investment costs at the same throughput or material density in the filtrate. The filtrates can be separated because the filtrate outlets are divided along the circumference.
摘要翻译：在用于排出悬架的盘式甲板中，并且具有轴向分布的悬浮室和通过旋转筛盘分离并打开到固定桶中的滤液室，滤液室被抽空以增加甲板的生产量并改善并加速排水。滤液室为此目的除以径向和轴向的横向隔板，分成沿着圆周分布的各个滤液室部分，并彼此密封。当筛盘和因此的滤液室部分旋转并且部分与甲板底部的滤液出口进入流动接合时，它们被同时排空，加速通过盘的排出。结果是更高的产量，滤液中的较低的材料密度，以及在滤液中相同的生产量或材料密度下的较低的特定投资成本。滤液可以分离，因为滤液出口沿圆周分开。

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