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101. 发明申请

US20010037083A1 Method and apparatus to control drug therapy dosages in an implantable pump 有权
标题翻译：在可植入泵中控制药物治疗剂量的方法和装置
公开(公告)号：US20010037083A1
公开(公告)日：2001-11-01
申请号：US09804136
申请日：2001-03-12
发明人： Jerome T. Hartlaub , Duane L. Bourget
IPC分类号： A61M031/00 , A61K009/22
CPC分类号： G05B19/106 , A61M5/14276 , A61M2005/1405 , A61M2005/14208 , A61M2205/3523 , A61M2205/52 , G06F19/00 , G06F19/3468
摘要： An implantable drug infusion pump for delivering drug therapy to a patient and which also permits a patient to deliver or self-administer an additional bolus, reduces the likelihood of over dosage or under dosage by drug dosage characteristic limitations programmed into a microprocessor memory. The dose limits define the maximum and minimum amount of drug to be delivered per unit time or otherwise, reducing the likelihood that a patient may inadvertently or deliberately interfere with a treatment regimen.
摘要翻译：用于向患者递送药物治疗并且还允许患者递送或自我施用另外的推注的可植入药物输注泵减少了编程到微处理器存储器中的药物剂量特征限制的过度剂量或剂量的可能性。剂量限度定义每单位时间或其他方式递送的药物的最大和最小量，减少患者可能无意或故意干扰治疗方案的可能性。

102. 发明申请

US20010025157A1 Implantable dispensing device for controllably dispensing medicinal fluid 审中-公开
标题翻译：用于可控地分配药液的植入式分配装置
公开(公告)号：US20010025157A1
公开(公告)日：2001-09-27
申请号：US09760128
申请日：2001-01-12
发明人： Marshall S. Kriesell
IPC分类号： A61M037/00 , A61K009/22
CPC分类号： A61M5/1452 , A61M5/14276 , A61M2205/36 , A61M2205/3613
摘要： A compact, small-volume, very low flow rate fluid dispensing device for precisely dispensing medicinal fluids into a patient at a very low, controlled flow rate over long periods of time. The dispensing device is readily implantable into the patient's body and includes a novel heat stimulatable polymer gel material which uniquely functions as an internal energy source for controllably expelling the medicinal fluids from the device.
摘要翻译：紧凑，小体积，非常低流速的流体分配装置，用于在长时间段内以非常低的，受控制的流速精确地将医用流体分配到患者体内。分配装置易于植入患者的身体，并且包括新颖的可热刺激的聚合物凝胶材料，其独特地用作用于可控地将药液从装置排出的内部能量源。

103. 发明申请

US20010024657A1 Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity 审中-公开
公开(公告)号：US20010024657A1
公开(公告)日：2001-09-27
申请号：US09774054
申请日：2001-01-31
发明人： E. Itzhak Lerner , Vered Rosenberger , Moshe Flashner
IPC分类号： A61F013/02 , A61K009/70 , A61K009/22
CPC分类号： A61K9/006 , A61K9/0063
摘要： The invention is directed to a controlled-release solid composition for the oral cavity or nullpharmaceutical oral patchnull that adheres to hard dental surfaces, such as teeth and dentures, and releases an active pharmaceutical agent into the oral cavity. Release of the agent is for a predetermined period of time and at a predetermined sustained concentration. The site of action of the agent is local or systemic.

104. 发明申请

US20010014353A1 Directly compressible high load acetaminophen formulations 失效
标题翻译：直接可压缩的高负荷对乙酰氨基酚制剂
公开(公告)号：US20010014353A1
公开(公告)日：2001-08-16
申请号：US09798755
申请日：2001-03-02
发明人： Edward A. Hunter , Bob E. Sherwood , Joseph A. Zeleznik
IPC分类号： A61K009/20 , A61K009/22 , A61K009/14
CPC分类号： A61K9/2095 , A61K9/2009 , A61K9/2054 , A61K31/167
摘要： Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e., up to 80% or greater) amounts of acetaminophen based on the weight of the total tablet.
摘要翻译：直接压缩固体药物剂型，其含有：a）约40至约95重量％的对乙酰氨基酚; b）约1至约60重量％的包含微晶纤维素的直接压缩载体; 和c）约0.01至约4.0重量％的药学上可接受的润滑剂。对乙酰氨基酚和直接压缩载体在高剪切条件下组合，足以将对乙酰氨基酚和直接压缩载体转化成均匀的颗粒而不降解。在本发明的优选方面，润滑剂还在高剪切条件下与对乙酰氨基酚和直接压缩载体组合。还公开了制备直接压片的固体药物剂型的方法和剂型的治疗方法。该方法特别适用于制备基于总片剂重量的含有高负荷量（即高达80％或更多）量的对乙酰氨基酚的直接压缩剂型。

105. 发明申请

US20010006784A1 APOLIPOPROTEIN E POLYMORPHISM AND TREATMENT OF ALZHEIMER'S DISEASE 有权
标题翻译：阿奇霉素多糖和阿尔茨海默病的治疗
公开(公告)号：US20010006784A1
公开(公告)日：2001-07-05
申请号：US09342993
申请日：1999-06-29
发明人： JUDES POIRIER
IPC分类号： C12Q001/68 , A61K009/22 , A61K031/44 , A01N043/42 , C07H021/04
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Disclosed herein are methods for identifying a patient for the treatment of cognitive impairments.
摘要翻译：本文公开了用于鉴定用于治疗认知障碍的患者的方法。

106. 发明申请

US20040247692A1 Method for fabricating aspherical lens 审中-公开
标题翻译：制造非球面透镜的方法
公开(公告)号：US20040247692A1
公开(公告)日：2004-12-09
申请号：US10861020
申请日：2004-06-03
发明人： Ga-lane Chen
IPC分类号： B29D011/00 , A61K009/22 , A61K009/50 , G02B027/10
CPC分类号： G02B27/4216 , G02B5/1814 , G03F7/0005
摘要： A method for fabricating an aspherical lens includes the steps of: providing an aspherical lens (10, 10null) having an aspherical surface (101, 101null) and an opposite flat surface (102, 102null); and defining a multiple-step grating in the flat surface by a photolithographic method. The aspherical lens has a reduced chromatic aberration effect, and can thus provide a clear image. Furthermore, an effect of the aspherical lens having the grating is equivalent to that of a conventional aspherical lens unit. Thus when the aspherical lens is used in an optical system, it can reduce a bulk and a weight of the optical system.
摘要翻译：一种制造非球面透镜的方法包括以下步骤：提供具有非球面（101,101'）和相对的平坦表面（102,102'）的非球面透镜（10,10'）; 并通过光刻法在平坦表面中限定多步光栅。非球面透镜具有减小的色差效应，因此可以提供清晰的图像。此外，具有光栅的非球面透镜的效果与常规非球面透镜单元的效果相当。因此，当非球面透镜用于光学系统时，其可以减小光学系统的体积和重量。

107. 发明申请

US20040247672A1 Injectable sustained release compositions 审中-公开
标题翻译：可注射的持续释放组合物
公开(公告)号：US20040247672A1
公开(公告)日：2004-12-09
申请号：US10843872
申请日：2004-05-12
申请人： Alkermes Controlled Therapeutics, Inc.
发明人： Mark A. Tracy , Chiem V. Pham , Firouz Asgarzadeh , J. Don Wang
IPC分类号： A61K009/22
CPC分类号： A61K9/0024 , A61K9/0019 , A61K47/34
摘要： The present invention relates to a polymer paste and a sustained release composition comprising the paste and a biologically active agent. The polymer paste comprises a biocompatible, biodegradable polymer having an inherent viscosity of about 0.12 dL/g or less and a viscosity reducing agent, wherein the biocompatible, biodegradable polymer is present in the polymer paste in at least 60% by weight and the viscosity of the paste is about 400 cP or less. The sustained release composition comprises a biologically active agent and a polymer paste comprising a biocompatible, biodegradable polymer having an inherent viscosity of about 0.12 dL/g or less and a viscosity reducing agent, wherein the biocompatible, biodegradable polymer is present in the polymer paste in at least 60% by weight and the viscosity of the sustained release composition is about 400 cP or less. In a particular embodiment, the sustained release composition is injectable.
摘要翻译：本发明涉及聚合物糊剂和包含该糊剂和生物活性剂的缓释组合物。聚合物浆料包含特性粘度为约0.12dL / g或更低的生物相容的可生物降解的聚合物和粘度降低剂，其中生物相容的可生物降解的聚合物以至少60重量％的量存在于聚合物浆料中，糊剂约为400cP以下。持续释放组合物包含生物活性剂和聚合物糊剂，其包含特性粘度为约0.12dL / g或更低的生物相容的可生物降解的聚合物和粘度降低剂，其中所述生物相容的可生物降解的聚合物存在于聚合物糊料中至少60重量％，持续释放组合物的粘度为约400cP以下。在一个具体实施方案中，持续释放组合物是可注射的。

108. 发明申请

US20040247669A1 Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth 有权
公开(公告)号：US20040247669A1
公开(公告)日：2004-12-09
申请号：US10772781
申请日：2004-02-04
发明人： Jerry B. Gin , Benjamin F. Ross
IPC分类号： A61K009/22
CPC分类号： A23G3/368 , A23G3/362 , A23G3/54 , A23L27/72 , A23L33/165 , A23V2002/00 , A61K9/0056 , Y10S514/959 , A23V2200/224 , A23V2250/51088 , A23V2250/264 , A23V2250/1642
摘要： Flavored dosage forms, e.g., lozenges and gums, are provided for sustained release of a flavoring agent in the mouth. The dosage forms provide sustained release by virtue of a wet matrix formed by admixture of a biocompatible, hydrophilic, water-insoluble polymer such as ethylcellulose and a flavoring agent, particularly an essential oil or a constituent thereof, e.g., a terpene or sesquiterpene. The dosage forms may also include a second beneficial agent in addition to the flavoring agent. Exemplary such beneficial agents include ionizable zinc compounds and other cold remedies, local anesthetic and anti-infective agents, diet aids, fluoride-releasing compounds, and nicotine. The dosage forms, when formulated as lozenges, may be somewhat adhesive or substantially nontacky, depending primarily on the molecular weight of the hydrophilic polymer. Adhesive lozenges can serve as dosage forms that adhere to the teeth or gums for delivery of a beneficial agent thereto. Methods for using the dosage forms to provide sustained release of a flavoring agent and optionally deliver a second beneficial agent are also provided, as are methods for treating the common cold, treating a sore throat, facilitating weight loss, and assisting in smoking cessation.

109. 发明申请

US20040247668A1 Controlled release composite 有权
标题翻译：控释复合材料
公开(公告)号：US20040247668A1
公开(公告)日：2004-12-09
申请号：US10771622
申请日：2004-02-05
申请人： Wright Medical Technology, Inc. a Delaware corporation
发明人： Warren Oliver Haggard , Michael Earl Kaufman , Jack Eldon Parr , Linda Morris
IPC分类号： A61K038/14 , A61K031/704 , A61K031/65 , A61K031/525 , A61K031/545 , A61K009/22 , A61K033/24
CPC分类号： A61K9/167 , A61K9/1611 , A61K9/501
摘要： A composite is disclosed having a controlled rate of dissolution. The composite includes (a) a first region that includes a first composition that includes calcium sulfate, the first region exhibiting a first rate of dissolution; and (b) a second region that includes a second composition that includes calcium sulfate, the second region exhibiting a second rate of dissolution, the first rate of dissolution being different from the second rate of dissolution.
摘要翻译：公开了具有受控的溶解速率的复合材料。所述复合物包括（a）第一区域，其包括第一组合物，所述第一组合物包括硫酸钙，所述第一区域呈现出第一溶解速率; 和（b）第二区域，其包括包含硫酸钙的第二组合物，所述第二区域呈现第二溶解速率，所述第一溶解速率与所述第二溶解速率不同。

110. 发明申请

US20040243106A1 Osmotic delivery device with membrane plug retention mechanism 审中-公开
标题翻译：渗透输送装置具有膜塞保持机构
公开(公告)号：US20040243106A1
公开(公告)日：2004-12-02
申请号：US10885828
申请日：2004-07-07
发明人： Rupal Ayer
IPC分类号： A61K009/22
CPC分类号： A61K9/0004
摘要： An osmotic delivery device includes a delivery device body having a first end with a beneficial agent delivery orifice and a second open end. An expandable, semipermeable membrane plug is secured in an open end of the delivery device body by a plurality of holes formed in the delivery device body around the open end of the delivery device body.
摘要翻译：渗透输送装置包括具有第一端和有益药剂输送口和第二开口端的输送装置本体。可膨胀的半透膜膜塞通过形成在输送装置主体中的多个孔固定在输送装置主体的开口端中，该多个孔围绕输送装置主体的开口端。

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