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101. 发明申请

US20160377629A1 Methods and Apparatus for Detection of Gluten Sensitivity, and its Differentiation from Celiac Disease 审中-公开
标题翻译：检测麸质敏感性及其与乳糜泻分化的方法和装置
公开(公告)号：US20160377629A1
公开(公告)日：2016-12-29
申请号：US15258949
申请日：2016-09-07
申请人： CYREX LABORATORIES, LLC
发明人： Aristo Vojdani
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N2800/065 , G01N2800/24
摘要： Antibodies are used as biomarkers to assist in distinguishing gluten immune reactivity and sensitivity, silent celiac disease, Crohn's disease and other gut-related pathologies from classical celiac disease. In one class of embodiments, sera, saliva or other samples from a human or other animal are tested for antibodies to (a) a wheat antigen; (b) a gliadin antigen; and (c) one or more of a wheat germ agglutinin, a gluteomorphin, a glutenin, a deamidated glutenin, a prodynorphin, and a dynorphin. Test results are considered particularly interesting where the wheat antigen and the gliadin antigen are both selected from the group consisting of native and deamidated forms of α-gliadin 33-mer, α-gliadin-17-mer, γ-gliadin-15-mer, ω-gliadin-17-mer, and glutenin 21-mer. Test plates and kits can advantageously test for antibodies to at least three, five, seven or all of mixed wheat antigens, α-gliadin, γ-gliadin, ω-gliadin, glutenin, α-glutenin, wheat germ agglutinin, gluteomorphin, prodynorphins, transglutaminase-2, transglutaminase-3, transglutaminase-6, and gliadin-bound transglutaminase.
摘要翻译：抗体用作生物标志物，以帮助区分麸质免疫反应性和敏感性，沉默性乳糜泻，克罗恩病和其他与经典乳糜泻相关的肠道相关病理学。在一类实施方案中，测试来自人或其他动物的血清，唾液或其它样品的抗体（a）小麦抗原; （b）麦醇溶蛋白抗原; 和（c）一种或多种小麦胚凝集蛋白，糠醛，麦谷蛋白，脱酰氨基蛋白，雌激素和强啡肽中的一种或多种。小麦抗原和麦醇溶蛋白抗原均选自天然和脱氨基形式的α-麦醇溶蛋白33聚体，α-麦醇溶蛋白-17聚体，γ-麦醇溶蛋白-15聚体， ω-麦醇溶蛋白-17聚体，和麦谷蛋白21聚体。测试板和试剂盒可以有利地测试至少三种，五种，七种或全部混合小麦抗原，α-麦醇溶蛋白，γ-麦醇溶蛋白，ω-麦醇溶蛋白，麦谷蛋白，α-麦谷蛋白，小麦胚芽凝集素，gl ute素，转谷氨酰胺酶-2，转谷氨酰胺酶-3，转谷氨酰胺酶-6和谷氨酸结合转谷氨酰胺酶。

102. 发明申请

US20160376361A1 IL-18 binding molecules 审中-公开
标题翻译： IL-18结合分子
公开(公告)号：US20160376361A1
公开(公告)日：2016-12-29
申请号：US15164508
申请日：2016-05-25
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
IPC分类号： C07K16/24 , G01N33/68 , C12P21/00
CPC分类号： C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要： IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译： IL-18参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白（IL18BP）（天然存在和高度特异性抑制剂）的负调控。该可溶性蛋白质与游离IL-18形成复合物，防止其与IL-18受体的相互作用，从而中和并抑制其生物学活性。本发明公开了结合IL-18并且不结合IL-18BP（IL-18 / IL-18BP复合物）的IL-18的结合分子，特别是抗体或其片段。除了其生理作用外，IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子，或作为用于表征，检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。

103. 发明授权

US09528998B2 Methods and reagents for diagnosing rheumatoid arthrtis 有权
标题翻译：用于诊断类风湿关节炎的方法和试剂
公开(公告)号：US09528998B2
公开(公告)日：2016-12-27
申请号：US13086528
申请日：2011-04-14
申请人： Toru Yoshimura , Ryotaro Chiba
发明人： Toru Yoshimura , Ryotaro Chiba
IPC分类号： G01N33/68
CPC分类号： G01N33/6863 , G01N33/6803 , G01N33/6854 , G01N2800/102
摘要： Methods for diagnosing rheumatoid arthritis (RA) are disclosed, using measurement of the CCL8 protein level in a test sample from a subject. Testing for CCL8 as an indicator of RA can be combined with testing for other indicators of RA, including clinical assessments, imaging or other RA markers such as Rheumatoid factor (RF). CCL8 testing can be used for discriminating RA from other diseases or conditions, evaluating the severity of RA. Related diagnostic reagents, kits, pharmaceutical compositions, and methods for identifying a candidate substance as a therapeutic agent for treating rheumatoid arthritis are also described.
摘要翻译：公开了用于诊断受试者的测试样品中CCL8蛋白质水平的方法来诊断类风湿性关节炎（RA）。测试CCL8作为RA的指标可以与RA的其他指标的测试结合，包括临床评估，成像或其他RA标志物，如类风湿因子（RF）。 CCL8检测可用于区分RA与其他疾病或病症，评估RA的严重程度。还描述了用于鉴定作为治疗类风湿性关节炎的治疗剂的候选物质的相关诊断试剂，试剂盒，药物组合物和方法。

104. 发明申请

US20160370380A1 COMBINATORIAL ANTIBODY DIAGNOSTIC 审中-公开
标题翻译：组合抗体诊断
公开(公告)号：US20160370380A1
公开(公告)日：2016-12-22
申请号：US15184630
申请日：2016-06-16
申请人： PharmaSeq, Inc.
发明人： Wlodek Mandecki , Ji Li , Maryann Gruda
IPC分类号： G01N33/68 , G06F19/16 , G06F19/18 , G01N33/574 , G01N33/564
CPC分类号： G01N33/6845 , C07K17/14 , G01N33/564 , G01N33/574 , G01N33/6854 , G01N33/6893 , G01N2800/26 , G16B15/00 , G16B20/00
摘要： Provided among other things is an indexed library on one or more solid phase supports of a substantial representation of all theoretical peptide combinations having a certain length of 3 to 5 amino acids, or a combination thereof, and being formed with a certain collection of amino acids that numbers as follows: # of amino acids Lengthin collection 36 to 18 44 to 18 54 to 18 the peptides spaced apart from the supports sufficiently such that one or more of the peptides binds an antibody composition substantially more strongly than others

105. 发明授权

US09518082B2 Antibody purification and purity monitoring 有权
标题翻译：抗体纯化和纯度监测
公开(公告)号：US09518082B2
公开(公告)日：2016-12-13
申请号：US14215370
申请日：2014-03-17
申请人： ALDERBIO HOLDINGS LLC
发明人： Daniel S. Allison , Steven D. Davin , Hoa Binh Do , Leon F. Garcia-Martinez , Geoffrey F. Lee , Ethan W. Ojala , Mark Young , John A. Latham
IPC分类号： C07K1/22 , C07K16/06 , C07K19/00 , C07K16/18 , G01N33/68
CPC分类号： C07K16/18 , B01D15/327 , B01D15/3809 , B01D15/424 , C07K1/165 , C07K1/20 , C07K1/22 , C07K1/34 , C07K1/36 , C07K16/065 , C07K2317/14 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/55 , G01N33/68 , G01N33/6854
摘要： Processes for producing and purifying recombinant proteins are disclosed. In particular, the present disclosure provides processes of producing and purifying multi-subunit proteins expressed in yeast or filamentous fungal cells. The production and/or purification of such proteins are monitored for impurities, preferably using lectin binding assays, such that one or more process parameters may be adjusted to maximize the amount of desired recombinant protein and minimize the amount of glycosylated impurities. The processes can also be monitored for other undesired product-associated impurities, such as aggregates and nucleic acids. In exemplary embodiments, the recombinant proteins are multi-subunit proteins, such as antibodies, the host cell is a yeast, such as Pichia pastoris, and the glycosylated impurity is a glycovariant of the desired recombinant polypeptide, such as an N-linked and/or O-linked glycovariant.
摘要翻译：公开了生产和纯化重组蛋白的方法。特别地，本公开内容提供了生产和纯化在酵母或丝状真菌细胞中表达的多亚基蛋白的方法。监测这些蛋白质的产生和/或纯化杂质，优选使用凝集素结合测定法，使得可调整一个或多个工艺参数以最大化所需重组蛋白质的量并使糖化杂质的量最小化。还可以监测其它不期望的产物相关杂质如聚集体和核酸的过程。在示例性实施方案中，重组蛋白是多亚基蛋白，例如抗体，宿主细胞是酵母，如巴斯德毕赤酵母，糖基化杂质是所需重组多肽的糖变体，例如N-连接和/ 或O-连接的糖变体。

106. 发明申请

US20160356783A1 MULTI-DIMENSIONAL CHROMATOGRAPHIC METHODS FOR SEPARATING N-GLYCANS 有权
公开(公告)号：US20160356783A1
公开(公告)日：2016-12-08
申请号：US15241717
申请日：2016-08-19
申请人： Momenta Pharmaceuticals, Inc.
发明人： Ian Christopher Parsons , Ting Zheng , Nur Sibel Gunay , Carlos J. Bosques
IPC分类号： G01N33/68 , B01D15/18 , B01D15/42 , B01D15/32 , B01D15/16 , G01N30/46 , B01D15/36
CPC分类号： G01N33/6803 , B01D15/166 , B01D15/1864 , B01D15/1878 , B01D15/325 , B01D15/363 , B01D15/426 , C07K1/36 , G01N1/34 , G01N30/463 , G01N33/6854 , G01N2400/00 , G01N2440/38 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , Y10T436/145555
摘要： A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.

107. 发明申请

US20160334413A1 THERAPEUTIC AND DIAGNOSTIC METHODS FOR AUTISM SPECTRUM DISORDERS AND OTHER CONDITIONS 审中-公开
标题翻译：传染病和其他病症的治疗和诊断方法
公开(公告)号：US20160334413A1
公开(公告)日：2016-11-17
申请号：US15136021
申请日：2016-04-22
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： Avindra Nath , Tongguang Wang , Christina Michelle Morris-Berry , Harvey Singer
IPC分类号： G01N33/68 , A61K31/4525 , A61K31/4184
CPC分类号： G01N33/6854 , A61K31/4184 , A61K31/4525 , A61K31/7105 , A61K39/3955 , C07K16/2869 , C07K2317/10 , C07K2317/21 , C07K2317/73 , C07K2317/75 , G01N33/6893 , G01N2333/705 , G01N2333/726 , G01N2800/30 , G01N2800/50
摘要： The present invention relates to the field of autism. More specifically, the present invention provides methods for treating individuals with autism spectrum disorders. The present invention also provides methods for predicting a likelihood of ASD. In one embodiment, a method for treating a female patient having a high risk factor of having children with ASD comprises the steps of (a) identifying in a sample taken from the female patient the presence of AT-1 antibodies; and (b) administering an effective amount of an AT-1 inhibitor or inhibitor of AT-1 antibodies to the female patient.
摘要翻译：本发明涉及自闭症领域。更具体地，本发明提供了治疗患有自闭症谱系障碍的个体的方法。本发明还提供了用于预测ASD可能性的方法。在一个实施方案中，用于治疗患有ASD儿童的高危险因素的女性患者的方法包括以下步骤：（a）在从女性患者取得的样品中鉴定出AT-1抗体的存在; 和（b）向女性患者施用有效量的AT-1抑制剂或AT-1抗体抑制剂。

108. 发明申请

US20160333409A1 METHOD FOR IDENTIFYING DISEASE-ASSOCIATED CDR3 PATTERNS IN AN IMMUNE REPERTOIRE 审中-公开
标题翻译：用于识别免疫球蛋白相关CDR3模式的方法
公开(公告)号：US20160333409A1
公开(公告)日：2016-11-17
申请号：US15064338
申请日：2016-03-08
申请人： CB BIOTECHNOLOGIES, INC.
发明人： JIAN HAN
IPC分类号： C12Q1/68 , G06F19/18
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q2600/156 , C12Q2600/172 , G01N33/6854 , G16B20/00
摘要： The present disclosure generally pertains to a method for developing diagnostic tests that are based on the immune response and the resulting immune repertoire. The presently disclosed method increases the signal and reduces the background to allow the identification of shared CDR3s that can be used to produce a disease signature. The presently disclosed method may be used to develop a diagnostic test for different diseases including, but not limited to, cancer, autoimmune disease, inflammatory disease and infectious disease.
摘要翻译：本公开通常涉及用于开发基于免疫应答和所得免疫谱的诊断测试的方法。目前公开的方法增加了信号并减少了背景以允许识别可用于产生疾病特征的共享CDR3。本公开的方法可用于开发不同疾病的诊断测试，包括但不限于癌症，自身免疫性疾病，炎性疾病和感染性疾病。

109. 发明申请

US20160327569A1 Immunogenicity Assay 审中-公开
公开(公告)号：US20160327569A1
公开(公告)日：2016-11-10
申请号：US15143576
申请日：2016-04-30
申请人： ANP Technologies, Inc.
发明人： Ray Yin , Jing Pan , Yli Remo Vallejo , Thomas Small , Dujie Qin , De Chen
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/6854 , G01N33/54306 , G01N33/558
摘要： Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.

110. 发明申请

US20160326237A1 METHODS OF TREATMENT FOR GUILLAIN-BARRE SYNDROME 审中-公开
标题翻译：治疗谷朊病毒综合征的方法
公开(公告)号：US20160326237A1
公开(公告)日：2016-11-10
申请号：US14939706
申请日：2015-11-12
申请人： ANNEXON, INC. , THE UNIVERSITY OF GLASGOW
发明人： Arnon Rosenthal , Michael Leviten , Hugh J. Willison , Rhona McGonigal
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/6854
摘要： This invention relates generally to methods of treatment for Guillain-Barre' Syndrome (GBS) and, more specifically, to methods involving the inhibition of the classical pathway of complement activation.
摘要翻译：本发明一般涉及吉兰巴利综合征（GBS）的治疗方法，更具体地涉及涉及抑制补体活化的经典途径的方法。

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