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101. 发明申请

US20090209918A1 METHOD AND DEVICE FOR DIALYSIS 审中-公开
标题翻译：用于透析的方法和装置
公开(公告)号：US20090209918A1
公开(公告)日：2009-08-20
申请号：US12206674
申请日：2008-09-08
申请人： Rick Berglund
发明人： Rick Berglund
IPC分类号： A61M5/32 , A61M25/00
CPC分类号： A61M1/3655 , A61F2/06 , A61F2/064 , A61M39/0247 , A61M2039/0258 , A61M2039/0273
摘要： A method and system are provided for performing dialysis. The system provides needleless vascular access which reduces the repeated traumas of conventional dialysis by providing a vascular graft and port combination which interfaces with a specially-designed catheter system. The installed implant is low profile, small and stable, and saddles the vessel to secure the protruding surface tissue above. The stability of the port is maintained by features that encompass the vessel and the surrounding tissue. These features are enhanced by the catheter attachment, which also provides reduced trauma and provides convenient access to the implant for performance of dialysis functions.
摘要翻译：提供了一种执行透析的方法和系统。该系统提供无针管血管通路，通过提供与专门设计的导管系统相连接的血管移植物和端口组合，减少常规透析的重复创伤。所安装的植入物具有薄型，小型和稳定的特征，并且将该容器鞍形以固定上方的突出表面组织。端口的稳定性由包含容器和周围组织的特征保持。通过导管附件增强了这些特征，这也提供了减少的创伤，并提供了便于进入植入物以进行透析功能。

102. 发明申请

US20090156978A1 Arterio-venous shunt devices 有权
标题翻译：动脉静脉分流装置
公开(公告)号：US20090156978A1
公开(公告)日：2009-06-18
申请号：US12378438
申请日：2009-02-12
申请人： John L. Faul , Toshihiko Nishimura , Peter N. Kao , Ronald G. Pearl
发明人： John L. Faul , Toshihiko Nishimura , Peter N. Kao , Ronald G. Pearl
IPC分类号： A61B5/021 , A61M1/00 , A61B5/026
CPC分类号： A61B17/11 , A61B5/026 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61M1/3653 , A61M1/3655 , A61M5/14276 , A61M5/1723 , A61M2230/06 , A61M2230/202 , A61M2230/205 , A61M2230/30
摘要： A long-term implantable arterio-venous shunt device is provided that can be used as a therapeutic method. The shunt device is implanted between an artery and a vein, preferably between the aorta and the inferior vena cava. The shunt device decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. The blood flow rate could be controlled either via an open loop or a closed loop control means. The shunt device could also be a self-adjustable shunt device to self-adjust its structure to control the blood flow rate through its lumen. Based on the effects of the shunt device to the respiratory, cardiac and circulatory system, the implantable shunt device could be beneficial as a therapy to patients with problems or conditions related to these systems.
摘要翻译：提供了可用作治疗方法的长期可植入动静脉分流装置。分流装置植入动脉和静脉之间，优选在主动脉和下腔静脉之间。分流装置降低全身血管阻力，并允许植入后通过分流装置的血流速度至少为5ml / min。可以通过开环或闭环控制装置来控制血液流量。分流装置也可以是自调节分流装置，以自我调节其结构以控制通过其管腔的血液流速。基于分流装置对呼吸，心脏和循环系统的影响，可植入分流装置可作为对与这些系统相关的问题或病症的患者的治疗有益。

103. 发明申请

US20090076435A1 Catheter Assembly 有权
标题翻译：导管大会
公开(公告)号：US20090076435A1
公开(公告)日：2009-03-19
申请号：US11857060
申请日：2007-09-18
申请人： Jeffry S. Melsheimer , Arman H. Valaie
发明人： Jeffry S. Melsheimer , Arman H. Valaie
IPC分类号： A61M37/00
CPC分类号： A61M25/0606 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0032 , A61M25/0631 , A61M2025/0031
摘要： A catheter assembly is provided with a flexible tubular body having two lumens. A solid slidable member with a sharp distal end is disposed within one of the lumens. The slidable member is capable of sliding within the lumen of the tubular body between an exposed position in which the sharp distal end of the slidable member protrudes from the distal end of the tubular body and a shielded position in which the distal end of the slidable member is within the tubular body. One advantage is that the sharp distal end of the slidable member may be withdrawn into the tubular body in order to shield a patient from unintentional cutting or irritation from the sharp distal end of the slidable member.
摘要翻译：导管组件设置有具有两个流明的柔性管状体。具有尖锐远端的固体可滑动构件设置在一个管腔内。可滑动构件能够在管状体的内腔内滑动在可滑动构件的尖锐远端从管状体的远端突出的暴露位置和可滑动构件的远端之间的屏蔽位置在管状体内。一个优点是，可滑动构件的尖锐远端可以被抽出到管状体中，以便屏蔽患者免受来自可滑动构件的尖锐远端的意外切割或刺激。

104. 发明申请

US20080275290A1 Implantable heart assist system and method of applying same 审中-公开
公开(公告)号：US20080275290A1
公开(公告)日：2008-11-06
申请号：US11417917
申请日：2006-05-03
申请人： Anthony Viole , Laksen Sirimanne , Steven F. Bolling , Shawn O'Leary , Robert Pecor , Ryan Kelly , Wolfgang Werner , Masoud Beizai
发明人： Anthony Viole , Laksen Sirimanne , Steven F. Bolling , Shawn O'Leary , Robert Pecor , Ryan Kelly , Wolfgang Werner , Masoud Beizai
IPC分类号： A61M1/10
CPC分类号： A61M1/3621 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/101 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/122 , A61M1/125 , A61M1/3655 , A61M25/0026 , A61M25/007
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment of the intravascular extracardiac system comprises a pump with inflow and outflow conduits that are sized and configured to be implantable intravascularly through a non-primary vessel, whereby it may positioned where desired within the patient's vasculature. The system comprises a subcardiac pump that may be driven directly or electromagnetically from within or without the patient. The pump is configured to be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart. In another embodiment, the system is positioned extracorporeally, with the inflow conduit and outflow conduit applied percutaneously to a non-primary vessel for circulating blood to and from the non-primary vessel or between the non-primary vessel and another blood vessel within the patient's vasculature.

105. 发明授权

US07331921B2 Implantable heart assist system and method of applying same 有权
标题翻译：植入式心脏辅助系统及其应用方法
公开(公告)号：US07331921B2
公开(公告)日：2008-02-19
申请号：US10878592
申请日：2004-06-28
申请人： Anthony Viole , Laksen Sirimanne , Steven F. Bolling , Shawn O'Leary , Robert Pecor , Ryan Kelly , Wolfgang Werner , Masoud Beizai
发明人： Anthony Viole , Laksen Sirimanne , Steven F. Bolling , Shawn O'Leary , Robert Pecor , Ryan Kelly , Wolfgang Werner , Masoud Beizai
IPC分类号： A61M1/12
CPC分类号： A61M1/3621 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/101 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/122 , A61M1/125 , A61M1/3655 , A61M25/0026 , A61M25/007
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment of the intravascular extracardiac system comprises a pump with inflow and outflow conduits that are sized and configured to be implantable intravascularly through a non-primary vessel, whereby it may positioned where desired within the patient's vasculature. The system comprises a subcardiac pump that may be driven directly or electromagnetically from within or without the patient. The pump is configured to be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart. In another embodiment, the system is positioned extracorporeally, with the inflow conduit and outflow conduit applied percutaneously to a non-primary vessel for circulating blood to and from the non-primary vessel or between the non-primary vessel and another blood vessel within the patient's vasculature.
摘要翻译：用于补充患者的血液循环（包括心输出量）的心外泵送，而不将其任何组分连接到患者的心脏，以及使用它们的方法。血管内心外系统的一个实施例包括具有流入和流出导管的泵，其尺寸和构造可通过非主血管血管内植入，由此可将其定位在患者的脉管系统内所需的位置。该系统包括可以从患者内部或不具有直接驱动或电磁驱动的亚心脏泵。泵被配置为与患者的心脏同步地连续地或以脉动方式操作，从而潜在地减少心脏的后负荷。在另一个实施例中，系统被定位在体外，流入管道和流出管道经皮施加到非主血管，用于使血液循环到非主血管或非主血管之间或非主血管与患者的另一血管之间循环脉管系统

106. 发明申请

US20070269489A1 EXTRACORPOREAL CELL-BASED THERAPEUTIC DEVICE AND DELIVERY SYSTEM 有权
标题翻译：基于细胞的细胞治疗设备和递送系统
公开(公告)号：US20070269489A1
公开(公告)日：2007-11-22
申请号：US11670123
申请日：2007-02-01
申请人： H. Humes
发明人： H. Humes
IPC分类号： A61F6/06 , A61K39/00 , A61P43/00 , C12M1/00
CPC分类号： A61M5/14 , A61M1/3655 , A61M1/3687 , A61M1/3689 , A61M2202/09
摘要： Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. Exemplary designs are disclosed. In a first exemplary embodiment the device includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. In another exemplary embodiment the device includes a wafer or a series of wafers forms a substrate onto which cells are grown. The wafer(s) are then inserted into a device. The devices are intended to be extracorporeal. Disclosed is a device for delivering a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation. The device may also deliver a member of different cell products. The device comprises an anchoring element that can be anchored to an inner wall of an extracorporeal tube for blood. The device also comprises a capsule that is held in place within the extracorporeal tube for blood or fluid by an anchor. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid passing the capsule. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
摘要翻译：公开了基于体外细胞的治疗装置和递送系统，其提供了响应于动态生理环境而由活细胞产生的生物活性分子的治疗递送的方法。公开了示例性设计。在第一示例性实施例中，该装置包括长的中空纤维，其中细胞层在管腔内体积内生长或在双重中空填充的腔室内生长。在另一个示例性实施例中，该装置包括晶片或一系列晶片形成其上生长细胞的基底。然后将晶片插入设备中。这些设备旨在体外。公开了用于将预先选择的分子例如激素递送到哺乳动物的全身循环中的装置。该装置还可以递送不同细胞产品的成员。该装置包括锚定元件，该锚定元件可以锚定到用于血液的体外管的内壁。该装置还包括一个胶囊，其通过锚固件保持在用于血液或流体的体外管内的适当位置。该装置适于将产生和分泌预先选择的分子的活细胞固定到通过胶囊的血液或液体中。本发明还提供了一种用于经皮引入本发明的装置的预选血管或体腔的微创方法。

107. 发明申请

US20070179422A1 Diaphragm pressure pod for medical fluids 有权
标题翻译：医用液体隔膜压力舱
公开(公告)号：US20070179422A1
公开(公告)日：2007-08-02
申请号：US11270080
申请日：2005-11-09
申请人： William Schnell , David Bell , Karen Wilson , David Utterberg
发明人： William Schnell , David Bell , Karen Wilson , David Utterberg
IPC分类号： A61M37/00
CPC分类号： A61M1/3641 , A61M1/16 , A61M1/3627 , A61M1/3639 , A61M1/3655 , A61M39/00 , F16L29/005 , Y10T137/85978
摘要： A tubular medical fluid flow set comprises a pressure sensing chamber connected in flow-through relation to fluid flow tubing of the set. The pressure sensing chamber defines a movable, flexible, impermeable diaphragm dividing the chamber into two separate compartments. The fluid flow tubing communicates with one of the compartments and is isolated from the other of the compartments. A port is carried on the chamber, the port having a seal therein, and communicating with the other of the compartments. Thus, the other of the compartments is hermetically sealed until the port is opened for connection with a pressure measuring device, to keep the flexible diaphragm in a desired, initial position prior to opening of the seal.
摘要翻译：管状医疗流体流动装置包括与组件的流体流管连通的压力感测室。压力传感室限定了一个可移动的，柔性的，不可渗透的隔膜，将隔室分隔成两个独立的隔间。流体流动管道与隔室中的一个连通，并且与隔室中的另一个隔离。端口被承载在腔室上，该端口在其中具有密封，并且与另一个隔间连通。因此，隔室中的另一个被气密地密封，直到端口打开以与压力测量装置连接，以便在打开密封件之前将柔性隔膜保持在期望的初始位置。

108. 发明授权

US07172570B2 Apparatus and method for monitoring a vascular access of a patient subjected to an extracorporeal blood treatment 有权
标题翻译：用于监测经受体外血液处理的患者的血管通路的装置和方法
公开(公告)号：US07172570B2
公开(公告)日：2007-02-06
申请号：US10765149
申请日：2004-01-28
申请人： Silvio Cavalcanti , Carlo Alberto Lodi , Massimo Fava
发明人： Silvio Cavalcanti , Carlo Alberto Lodi , Massimo Fava
IPC分类号： A61M37/00 , A61M1/36 , C02F1/44
CPC分类号： A61M1/3621 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3663
摘要： In the apparatus and method for monitoring a vascular access (6) of an extracorporeal circuit (5; 10) of a patient, a control and calculation unit (17) varies a flow rate of a blood pump (9) predisposed to cause blood to circulate in the extracorporeal circuit. The control and calculation unit receives the pressure values in the blood withdrawal line (5) and the blood return line (10) from two pressure sensors (8, 12); the pressure values are a series of different values of the blood flow rate. The control and calculation unit processes the data gathered by means of a mathematical model which describes the variation of pressure in the vascular access as a function of the flow rate, in order to determine the blood flow rate in the vascular access. The invention detects the presence and location of a stenosis at the vascular access of a patient subjected to a hemodialysis treatment.
摘要翻译：在用于监测患者的体外循环（5; 10）的血管通路（6）的装置和方法中，控制和计算单元（17）改变预先使血液引起的血液泵（9）的流速在体外循环。控制和计算单元从两个压力传感器（8,12）接收抽血管线（5）和血液回流管线（10）中的压力值; 压力值是一系列不同的血液流量值。控制和计算单元通过数学模型处理收集的数据，该数学模型描述作为流速的函数的血管通路中的压力变化，以便确定血管通路中的血流量。本发明检测经血液透析治疗的患者的血管通路的狭窄的存在和位置。

109. 发明申请

US20060281962A1 Implantable heart assist system and method of applying same 审中-公开
公开(公告)号：US20060281962A1
公开(公告)日：2006-12-14
申请号：US11418393
申请日：2006-05-03
申请人： Steven Bolling , Anthony Viole , Shawn O'Leary
发明人： Steven Bolling , Anthony Viole , Shawn O'Leary
IPC分类号： A61M1/10
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2230/04
摘要： An extracardiac pumping system and method for using it supplement the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart. A battery powered pump may be implanted subcutaneously and attached to an inflow conduit fluidly coupled to a patient's femoral artery via a subcutaneous anastomosis connection. The pump draws blood from the inflow conduit and discharges it through an outflow conduit fluidly coupled to a second peripheral artery via another subcutaneous anastomosis connection. The battery may be charged extracorporeally and the pump may be operated in either a continuous or pulsatile fashion in synchronization with the patient's heart. The conduits can be housed in a multi-lumen catheter and a reservoir may be provided which fluidly communicates with the inflow conduits. An additional feature may keep blood traveling extracorporeally within the system at or near body temperature. The system is capable of adjusting outflow from the pump to optimize the mixing of red blood cells in the aorta and thereby enhance oxygen delivery to tissues by minimizing blood cell concentration in the center of the aorta.

110. 发明申请

US20060270963A1 Cannulae having a redirecting tip 审中-公开
公开(公告)号：US20060270963A1
公开(公告)日：2006-11-30
申请号：US11417528
申请日：2006-05-03
申请人： Steven Bolling , Shawn O'Leary , Robert Pecor , Brad Sharp , Anthony Viole , Wolfgang Werner
发明人： Steven Bolling , Shawn O'Leary , Robert Pecor , Brad Sharp , Anthony Viole , Wolfgang Werner
IPC分类号： A61M5/00
CPC分类号： A61M25/0068 , A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/1034 , A61M1/1096 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M5/14244 , A61M25/001 , A61M25/003 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M25/04 , A61M2025/0031 , A61M2025/0037 , A61M2025/1047
摘要： A percutaneous cannula is provided that directs blood into a vessel of a patient. The cannula includes a main cannula portion and a tip portion. The tip portion directs blood-flow in a direction generally counter to the direction of flow through the lumen. The cannula is configured to prevent blood-flow exiting the distal end from immediately discharging against a wall of the vessel.

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