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101. 发明申请

US20130224212A1 METHODS AND PRODUCTS RELATING TO GSK3SS REGULATION 审中-公开
标题翻译：与GSK3SS相关的方法和产品规范
公开(公告)号：US20130224212A1
公开(公告)日：2013-08-29
申请号：US13887679
申请日：2013-05-06
申请人： Mercedes Rincon , Tina M. Thornton
发明人： Mercedes Rincon , Tina M. Thornton
IPC分类号： C12N9/96 , C07K16/40
CPC分类号： A61K38/45 , A61K45/06 , C07K16/40 , C12N9/12 , C12N9/1205 , C12N9/96 , C12Q1/485 , C12Y207/11026 , G01N2333/91205 , G01N2333/9121 , G01N2440/14 , G01N2500/04 , G01N2500/20
摘要： The invention relates to methods and compositions for regulation of GSK3β activity. The invention provides phosphorylated GSK3β polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3β activity.
摘要翻译：本发明涉及用于调节GSK3β活性的方法和组合物。本发明提供了磷酸化的GSK3beta多肽和识别这种多肽的抗体。本发明还包括用于治疗与升高或降低的GSK3β活性相关的疾病的方法。

102. 发明申请

US20130075385A1 Thermal Eraser For Tactile Drawings 有权
标题翻译：用于触觉图的热敏橡皮擦
公开(公告)号：US20130075385A1
公开(公告)日：2013-03-28
申请号：US13685002
申请日：2012-11-26
申请人： University of Vermont and State Agricultural Colle
发明人： Michael Rosen , Michael Coleman , Joshua Coffee , William David Banks , Kristin Leigh Funabashi , Rebecca Risko , Akie Hashimoto , Keegan Jennings Brown , Katherine Accomando
IPC分类号： B43L19/00
CPC分类号： B43L19/00 , B43L19/0043
摘要： A thermal eraser for erasing tactile drawing features from a tactile drawing medium, along with methods of erasing tactile drawing features formed on a tactile drawing medium, are disclosed. The thermal eraser has a heated tip that can be heated to a temperature sufficient to cause the tactile drawing feature to flow back into the surface of the tactile drawing medium. The heated tip has a tip temperature that can be controlled by a temperature-regulating circuit. A set-point temperature can be used to set the tip temperature and maintain the tip temperature. The thermal eraser can be controlled by hand or by an electro-mechanical device such as a tactile printer.
摘要翻译：公开了一种用于从触觉绘图介质擦除触觉绘图特征的热擦除器，以及消除在触觉绘图介质上形成的触觉绘图特征的方法。热擦除器具有加热的尖端，其可以被加热到足以使触觉拉伸特征流回到触摸绘图介质的表面的温度。加热的尖端具有可由温度调节电路控制的尖端温度。设定点温度可用于设置尖端温度并保持尖端温度。热擦除器可以手动或电动机械装置如触觉式打印机进行控制。

103. 发明授权

US08244655B2 Force-sensing orthotic electric device controller 失效
标题翻译：力传感矫正装置控制器
公开(公告)号：US08244655B2
公开(公告)日：2012-08-14
申请号：US12250156
申请日：2008-10-13
申请人： Sandra L. Hubbard , Michael Rosen
发明人： Sandra L. Hubbard , Michael Rosen
IPC分类号： G06F17/00 , G06N5/00
CPC分类号： G05G1/42 , A61G5/04
摘要： Control devices and kits of components of control devices are provided. The subject invention also provides systems for designing control devices and/or kits of components of control devices. A system user can provide data about an end user to an expert system via a user interface, and the expert system can use the data and a method for selecting appropriate components to design a control device and/or kit. The control device can be a self-referenced control device and can include a controller and a wearable interface.
摘要翻译：提供控制装置和控制装置的部件组件。本发明还提供了用于设计控制装置和/或控制装置的组件套件的系统。系统用户可以经由用户界面向专家系统提供关于最终用户的数据，并且专家系统可以使用数据和用于选择适当组件以设计控制设备和/或套件的方法。控制装置可以是自引用的控制装置，并且可以包括控制器和可佩戴的接口。

104. 发明申请

US20120058950A1 DETECTION OF NEUROPEPTIDES ASSOCIATED WITH PELVIC PAIN DISORDERS AND USES THEREOF 审中-公开
标题翻译：与皮肤疼痛相关的神经病变的检测及其用途
公开(公告)号：US20120058950A1
公开(公告)日：2012-03-08
申请号：US13295036
申请日：2011-11-11
申请人： Ronald W. Wood , Jay Reeder , Edward M. Schwarz , Edward M. Messing , Susan R. Schoen , Margaret A. Vizzard , Ian Dickerson
发明人： Ronald W. Wood , Jay Reeder , Edward M. Schwarz , Edward M. Messing , Susan R. Schoen , Margaret A. Vizzard , Ian Dickerson
IPC分类号： A61K38/02 , A61P29/00 , A61K31/517 , G01N33/566 , A61K31/426
CPC分类号： G01N33/74 , C07K14/57527 , C07K14/57563 , G01N2333/5753 , G01N2800/34
摘要： Diagnostic assessment and therapeutic treatment of pelvic pain disorders, including bladder disorders, bowel disorders, and/or reproductive tissue or organ disorders that are characterized by increased expression of the neuropeptides CGRP and/or PACAP. Additionally, applicants have developed a transgenic non-human model for pelvic pain disorders, where the transgenic animal expresses in bladder sensory neurons a recombinant neuropeptide implicated in the pelvic pain disorder.
摘要翻译：诊断评估和治疗治疗骨盆疼痛疾病，包括膀胱疾病，肠病和/或生殖组织或器官功能障碍，其特征在于神经肽CGRP和/或PACAP的表达增加。此外，申请人已经开发了用于骨盆疼痛疾病的转基因非人类模型，其中转基因动物在膀胱感觉神经元中表达涉及盆腔疼痛障碍的重组神经肽。

105. 发明授权

US08080920B2 Piezoelectric vibrational energy harvesting systems incorporating parametric bending mode energy harvesting 有权
标题翻译：包含参数弯曲模式能量收集的压电振动能量采集系统
公开(公告)号：US08080920B2
公开(公告)日：2011-12-20
申请号：US12532322
申请日：2008-03-21
申请人： Robert G. Andosca , Junru Wu
发明人： Robert G. Andosca , Junru Wu
IPC分类号： H01L41/113
CPC分类号： H01L41/1136 , H02N2/188
摘要： Vibrational energy harvesting (VEH) structures that include resonant beams each having a fundamental resonance frequency and a parametric mode frequency and including at least one piezoelectric layer for generating electrical charge in response to each of fundamental-resonance excitation and parametric-mode excitation of that beam. Circuitry is provided for harvesting the electrical charge from the resonant beam. In some embodiments, the parametric mode frequency of the beam is tuned to be close to its fundamental resonance frequency so as to increase the effective bandwidth of a VEH structure. The effective bandwidth of a VEH structure can be further increased by tuning ones of multiple parametric-mode-enabled resonant beams to slightly different fundamental resonance frequencies and parametric mode frequencies.
摘要翻译：振动能量收集（VEH）结构，其包括每个具有基本共振频率和参数模式频率的谐振光束，并且包括至少一个用于响应于该光束的基本共振激发和参数模式激励中的每一个产生电荷的压电层。提供电路用于从谐振光束收集电荷。在一些实施例中，波束的参数模式频率被调谐为接近其基本共振频率，以便增加VEH结构的有效带宽。通过将多个参数模式启用的谐振光束中的一个调谐到略微不同的基本共振频率和参数模式频率，可以进一步提高VEH结构的有效带宽。

106. 发明申请

US20100209048A1 Optical Fiber Microscopy Launch System and Method 有权
标题翻译：光纤显微镜发射系统及方法
公开(公告)号：US20100209048A1
公开(公告)日：2010-08-19
申请号：US12772311
申请日：2010-05-03
申请人： Guy G. Kennedy , David M. Warshaw
发明人： Guy G. Kennedy , David M. Warshaw
IPC分类号： G02B6/30 , G02B21/06 , G02B21/34
CPC分类号： G02B6/3624 , G02B6/0028 , G02B6/262 , G02B6/34 , G02B6/3644 , G02B6/3696 , G02B21/06 , G02B21/34 , Y10S385/901
摘要： A sample slide, launch system, and method for microscopy having two optical fibers positioned proximate a sample slide with optical fiber mounting elements to deliver EMR to a surface of the sample slide at a critical angle for total internal reflection microscopy. In one exemplary embodiment, the EMR from the first optical fiber and the EMR from the second optical fiber may have different polarization states and/or wavelengths.
摘要翻译：用于显微镜的样品载玻片，发射系统和方法，其具有用光纤安装元件定位在样品载玻片附近的两根光纤，用于以完全内反射显微镜的临界角将EMR递送到样品载玻片的表面。在一个示例性实施例中，来自第一光纤的EMR和来自第二光纤的EMR可以具有不同的偏振状态和/或波长。

107. 发明申请

US20100143899A1 METHODS AND PRODUCTS FOR DIAGNOSING CANCER 审中-公开
标题翻译：用于诊断癌症的方法和产品
公开(公告)号：US20100143899A1
公开(公告)日：2010-06-10
申请号：US12312807
申请日：2007-11-29
申请人： Marcus Bosenberg , Viswanathan Muthusamy , Sekhar Duraisamy
发明人： Marcus Bosenberg , Viswanathan Muthusamy , Sekhar Duraisamy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to methods and kits for the detection and diagnosis of cancer or precancerous conditions. Methylation of specific genes has been identified as indicative of cancer and methods of the invention, in part, relate to the detection of methylation levels in cells as a determination of cancer or a precancerous condition in the cell.
摘要翻译：本发明涉及用于检测和诊断癌症或癌前病症的方法和试剂盒。特定基因的甲基化已经被鉴定为癌症的指示，本发明的方法部分地涉及检测细胞中的甲基化水平，作为细胞中癌症或癌前病症的确定。

108. 发明授权

US07711225B2 Optical fiber microscopy launch system and method 有权
标题翻译：光纤显微镜发射系统及方法
公开(公告)号：US07711225B2
公开(公告)日：2010-05-04
申请号：US12480345
申请日：2009-06-08
申请人： Guy G. Kennedy , David M. Warshaw
发明人： Guy G. Kennedy , David M. Warshaw
IPC分类号： G02B6/00 , G02B6/04 , G02B21/06
CPC分类号： G02B6/3624 , G02B6/0028 , G02B6/262 , G02B6/34 , G02B6/3644 , G02B6/3696 , G02B21/06 , G02B21/34 , Y10S385/901
摘要： A sample slide, launch system, and method for microscopy having a fiber insertion portal terminating within the sample slide and having a fiber insertion axis such that when an optical fiber is inserted within the fiber insertion portal the optical fiber is positioned so to deliver an EMR to a surface of the sample slide at a desired angle.
摘要翻译：用于显微镜的样品载玻片，发射系统和方法，其具有端接在样品载玻片内的纤维插入入口并且具有光纤插入轴线，使得当光纤插入光纤插入入口内时，光纤被定位成递送EMR 到样品的表面以期望的角度滑动。

109. 发明申请

US20080275366A1 Systems For And Methods Of Assessing Lower Urinary Tract Function Via Sound Analysis 失效
标题翻译：通过声音分析评估下尿路功能的系统和方法
公开(公告)号：US20080275366A1
公开(公告)日：2008-11-06
申请号：US12123145
申请日：2008-05-19
申请人： John Brohan , Peter Zvara , Katarina Zvarova
发明人： John Brohan , Peter Zvara , Katarina Zvarova
IPC分类号： A61B5/20
CPC分类号： A61B5/202 , A61B5/208 , A61B2562/0204
摘要： Systems for and methods of assessing lower urinary tract function from urinary flow data via sound analysis and user-provided information regarding the lower urinary tract symptoms (LUTS) of frequency, urgency and urge incontinence. Embodiments of the LUTS assessment systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The LUTS assessment systems may include sound analysis software for analyzing the strength and duration of each urination event and may include a web-based software application for viewing the results via the Internet or other network. The database stores information from multiple urination events, and combined with information regarding the lower urinary tract symptoms, serves as an objective tool to assess bladder function and monitor progression of disease or therapy effectiveness.
摘要翻译：通过声音分析和用户提供的关于频率，紧急和急迫性尿失禁的下尿路症状（LUTS）的用户提供的信息来评估尿流量功能的系统和方法。 LUTS评估系统的实施例包括计算机和电话或数字记录机构，用于捕获作为音频文件存储在数据库中的一个或多个排尿事件的声音。 LUTS评估系统可以包括用于分析每次排尿事件的强度和持续时间的声音分析软件，并且可以包括用于经由因特网或其他网络观看结果的基于web的软件应用。数据库存储来自多个排尿事件的信息，并结合有关下尿路症状的信息，作为评估膀胱功能和监测疾病进展或治疗有效性的客观工具。

110. 发明授权

US07229755B1 Method for detection of alterations in the DNA mismatch repair pathway 失效
标题翻译：检测DNA错配修复途径改变的方法
公开(公告)号：US07229755B1
公开(公告)日：2007-06-12
申请号：US08448444
申请日：1994-11-01
申请人： Richard D. Kolodner , Robert A. G. Reenan , Richard Fishel
发明人： Richard D. Kolodner , Robert A. G. Reenan , Richard Fishel
IPC分类号： C12Q1/68 , A61K49/00 , G01N33/566 , C07K1/00 , C07H21/04 , C12N15/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/16
摘要： We have now discovered that eukaryotes, including mammals, have a DNA mismatch repair pathway analogous to the pathway that exists in bacteria. Defects or alterations in this mismatch repair pathway in a mammal, such as a human, will result in the accumulation of unstable repeated DNA sequences. Such a phenotype has a high correlation to disease state in a number of cancers, such as hereditary colon cancers. Accordingly, discovering a defect or alteration in the pathway can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.
摘要翻译：我们现在已经发现，真核生物，包括哺乳动物，具有与细菌中存在的途径类似的DNA错配修复途径。哺乳动物（例如人）中错配修复途径的缺陷或改变将导致不稳定的重复DNA序列的积累。这种表型与许多癌症如遗传性结肠癌的疾病状态高度相关。因此，发现途径中的缺陷或改变可以诊断癌症的易感性，并且可以诊断特定癌症。

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