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101. 发明授权

US09395353B2 Nanopore-facilitated single molecule detection of nucleic acid 有权
标题翻译：纳米孔促进核酸分子检测
公开(公告)号：US09395353B2
公开(公告)日：2016-07-19
申请号：US13810105
申请日：2011-07-14
申请人： Li-Qun Gu , Yong Wang , Kai Tian
发明人： Li-Qun Gu , Yong Wang , Kai Tian
IPC分类号： G01N27/327 , G01N33/487 , C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6886 , C12Q2600/178 , G01N33/48721 , C12Q2523/307 , C12Q2525/161 , C12Q2525/207 , C12Q2565/631
摘要： The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patient's blood sample.
摘要翻译：本发明提供了一种新的和改进的基于纳米孔技术的寡核苷酸检测方法，其中探针含有靶寡核苷酸的互补序列，探针的3'末端，5'末端或两个末端具有末端延伸。具有探针的改进的纳米孔传感器能够灵敏，选择性和直接检测，分化和定量靶寡核苷酸，如miRNA。本发明的检测方法也可以用作基于患者血液样品中的miRNA水平的用于癌症检测的非侵入性和成本有效的诊断方法。

102. 发明申请

US20160166459A1 INSTRUMENT-ASSISTED SOFT TISSUE MOBILIZATION TOOL 审中-公开
标题翻译：仪器辅助软组织移动工具
公开(公告)号：US20160166459A1
公开(公告)日：2016-06-16
申请号：US14969862
申请日：2015-12-15
申请人： Jaya Ghosh , Ellie Koehly , Yaw Sarpong , Roger de la Torre , Jonathon Buehler , Brett Hayes , Teresa Graff , Katherina Chen
发明人： Jaya Ghosh , Ellie Koehly , Yaw Sarpong , Roger de la Torre , Jonathon Buehler , Brett Hayes , Teresa Graff , Katherina Chen
IPC分类号： A61H1/00
CPC分类号： A61H7/001 , A61H2201/0153 , A61H2201/1695
摘要： A tool for use in assisting soft tissue mobilization and bodily tissue amelioration, such as stimulation of superficial tissue, deep tissue mobilization, breaking up scar tissue, and soft tissue massaging, are described. The tool comprises a device for application to bodily tissue that includes a body having a substantially teardrop shape in a vertical section. In a longitudinal aspect, the body includes a first and a second portion. The first portion of the device corresponds at least in part to a substantially bulbous handle part of the teardrop shape of the vertical section and is adapted for ease of grasping and manipulation at the first end. The second portion of the device corresponds at least in part to a substantially tapered converging double-beveled linear edge of the teardrop shape of the vertical section and is adapted for facilitated application of the device to bodily tissue at the second end.
摘要翻译：描述了用于辅助软组织动员和身体组织改善的工具，例如刺激表面组织，深层组织移动，分解瘢痕组织和软组织按摩。该工具包括用于应用于身体组织的装置，其包括在垂直部分中具有基本上泪滴形状的主体。在纵向方面，主体包括第一和第二部分。该装置的第一部分至少部分地对应于垂直部分的泪滴形状的大致球形手柄部分，并且适于在第一端容易抓握和操纵。装置的第二部分至少部分地对应于垂直部分的泪滴形状的基本上锥形的收敛双斜面线性边缘，并且适于便于将装置应用于第二端的身体组织。

103. 发明授权

US09351966B2 Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same 有权
标题翻译：包含奥美拉唑和兰索拉唑组合的组合物和缓冲剂及其使用方法
公开(公告)号：US09351966B2
公开(公告)日：2016-05-31
申请号：US14490531
申请日：2014-09-18
申请人： The Curators of the University of Missouri
发明人： Jeffrey O. Phillips
IPC分类号： A61K31/4439 , A61K9/20 , A61K31/415 , A61K31/44
CPC分类号： A61K31/4439 , A61K9/2009 , A61K9/2054 , A61K9/2059 , A61K31/415 , A61K31/44 , A61K2300/00
摘要： The present disclosure relates to pharmaceutical compositions comprising omeprazole, lansoprazole and sodium bicarbonate. Methods of using such compositions are also provided.
摘要翻译：本公开涉及包含奥美拉唑，兰索拉唑和碳酸氢钠的药物组合物。还提供了使用这些组合物的方法。

104. 发明授权

US09329223B2 Deep level transient spectrometer 有权
标题翻译：深层瞬态光谱仪
公开(公告)号：US09329223B2
公开(公告)日：2016-05-03
申请号：US13540151
申请日：2012-07-02
申请人： Daniel E. Montenegro , Jason B. Rothenberger , Mark A. Prelas , Robert V Tompson, Jr. , Annie Tipton
发明人： Daniel E. Montenegro , Jason B. Rothenberger , Mark A. Prelas , Robert V Tompson, Jr. , Annie Tipton
IPC分类号： G01R31/00 , G01R31/26
CPC分类号： G01R31/2648
摘要： A method for detecting surface and bulk deep states in semiconductor materials is provided. In various embodiments, the method comprises configuring a detection circuit of charge based deep level transient spectrometer in one of a parallel mode and a series mode by controlling the configuration of a switching circuit of the detection circuit. The method additionally comprises generating digitized voltage charge outputs of a device under test utilizing the detection circuit as controlled via execution of an analog-to-digital conversion and timing program by a control system of the charge based deep level transient spectrometer. Furthermore, the method comprises obtaining desired information about deep level transients of the device under test based on the digitized voltage charge outputs via execution of a control system operable to execute a Q-DLTS data analysis program by the control system.
摘要翻译：提供了一种用于检测半导体材料中的表面和体积深度状态的方法。在各种实施例中，该方法包括通过控制检测电路的开关电路的配置来配置基于并联模式和串联模式之一的基于电荷的深度级瞬态光谱仪的检测电路。该方法还包括通过由基于电荷的深度级瞬态光谱仪的控制系统执行模数转换和定时程序来控制的检测电路产生被测器件的数字化电压电荷输出。此外，该方法包括通过执行可控制系统执行Q-DLTS数据分析程序的控制系统，通过基于数字化的电压电荷输出来获得关于被测设备的深电平瞬变的期望信息。

105. 发明授权

US09198365B2 Method to develop high oleic acid soybeans using conventional soybean breeding techniques 有权
公开(公告)号：US09198365B2
公开(公告)日：2015-12-01
申请号：US13351757
申请日：2012-01-17
申请人： Kristin D. Bilyeu , James Grover Shannon , Jeong-Dong Lee , Anh Tung Pham
发明人： Kristin D. Bilyeu , James Grover Shannon , Jeong-Dong Lee , Anh Tung Pham
IPC分类号： A01H5/10
CPC分类号： C12N15/8247 , A01H1/00 , A01H5/10
摘要： The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid.

106. 发明授权

US09176281B2 Capillary wall coupled whispering gallery mode microresonator 有权
标题翻译：毛细管壁耦合语音库模式微谐振器
公开(公告)号：US09176281B2
公开(公告)日：2015-11-03
申请号：US13867748
申请日：2013-04-22
申请人： The Curators of the University of Missouri
发明人： Hai Xiao , Hanzheng Wang
IPC分类号： G02B6/26 , G02B6/42 , G02B6/293
CPC分类号： G02B6/29341 , Y10T29/49815 , Y10T29/49826
摘要： A microresonator structure comprises a waveguide and a microsphere. The waveguide is of elongated cylindrical shape and includes a first section of optical transmission material and a cavity section axially aligned with the first section. The cavity section includes a first cavity and a second cavity. The first cavity is adjacent to the first section and includes a first sidewall of optical transmission material with an inner surface that tapers inward to an apex positioned adjacent to the first section. The second cavity is positioned adjacent to the first cavity of hollow cylindrical shape and includes a circumferential second sidewall of optical transmission material that abuts the first sidewall. The microsphere has a spherical outer surface and is positioned within the cavity section such that the outer surface contacts a portion of the first sidewall and a portion of the second sidewall.
摘要翻译：微谐振器结构包括波导和微球。该波导具有细长的圆柱形形状并且包括光学传输材料的第一部分和与第一部分轴向对齐的空腔部分。空腔部分包括第一腔和第二腔。第一空腔与第一部分相邻并且包括光学透射材料的第一侧壁，内表面向内逐渐变细到邻近第一部分定位的顶点。第二腔被定位成与中空圆柱形的第一空腔相邻，并且包括邻近第一侧壁的光学透射材料的周向第二侧壁。微球具有球形外表面并且位于空腔部分内，使得外表面接触第一侧壁的一部分和第二侧壁的一部分。

107. 发明授权

US09173693B2 Apparatus and method for sternal closure 有权
标题翻译：用于胸骨闭合的装置和方法
公开(公告)号：US09173693B2
公开(公告)日：2015-11-03
申请号：US14031670
申请日：2013-09-19
申请人： Wayne C. McDaniel , Joseph T. Walls , Janet L. Rettenmaier
发明人： Wayne C. McDaniel , Joseph T. Walls , Janet L. Rettenmaier
IPC分类号： A61B17/86 , A61B17/88 , A61B17/70 , A61B17/84 , A61B17/72 , F16B12/24 , A61B17/80 , A61B17/82
CPC分类号： A61B17/8685 , A61B17/7098 , A61B17/7225 , A61B17/8076 , A61B17/823 , A61B17/842 , A61B17/844 , A61B17/846 , A61B17/8635 , A61B17/864 , A61B17/8811 , F16B12/24
摘要： The present disclosure provides a sternal closure fixation device. The fixation device includes a first sternum implant disposable within an interior cavity of a first half of a severed sternum such that the first implant contacts opposing anterior and posterior faces of the cavity. The fixation device additionally includes, a second sternum implant disposable within an interior cavity of a second half of a severed sternum such that the second implant contacts opposing anterior and posterior faces of the cavity. Furthermore, the fixation device includes a rigid fixation pin sized and structured to be disposed within an internal bore of the first implant and within an internal bore of the second implant, whereby when the first and second halves of the severed sternum are joined together, the first and second halves of the sternum are prevented from shear movement in any direction relative to each other.
摘要翻译：本公开提供了一种胸骨闭合固定装置。固定装置包括第一胸骨植入物，该第一胸骨植入物可在切割的胸骨的前半部分的内腔内部一次性地使得第一植入件接触空腔的相对的前表面和后表面。固定装置另外包括第二胸骨植入物，其一次性位于切断的胸骨的第二半部的内腔内，使得第二植入物接触腔的相对的前后面。此外，固定装置包括刚性固定销，其尺寸和结构设置成设置在第一植入物的内孔内并在第二植入物的内孔内，由此当切断的胸骨的第一和第二半部连接在一起时，防止胸骨的第一和第二半部相对于彼此在任何方向上的剪切运动。

108. 发明申请

US20150266983A1 FLEXIBLE TO RIGID NANOPOROUS POLYURETHANE-ACRYLATE (PUAC) TYPE MATERIALS FOR STRUCTURAL AND THERMAL INSULATION APPLICATIONS 有权
标题翻译：柔性尼龙聚氨酯（PUAC）类型材料，用于结构和热绝缘应用
公开(公告)号：US20150266983A1
公开(公告)日：2015-09-24
申请号：US14208892
申请日：2014-03-13
申请人： The Curators of the University of Missouri
发明人： Nicholas Leventis , Chariklia Sotiriou-Leventis , Abhishek Bang
IPC分类号： C08F122/10 , B01J31/22 , C07C269/00 , C08F222/10 , C07C269/04
CPC分类号： C07C271/28 , B01J31/2208 , B01J2531/42 , C07C67/30 , C07C69/74 , C07C69/753 , C07C69/757 , C07C269/02 , C07C2602/42 , C08F122/10 , C08F122/26 , C08F222/10 , C08F222/1006 , C08F222/26 , C08F2222/1066 , C08G2101/0091 , C08J9/28 , C08J2205/026 , C08J2335/02
摘要： Novel urethane-acrylate (UAC) Star monomers and polyurethane-acrylate (PUAC) aerogel polymers derived therefrom are described herein, along with other novel, related monomers and polymers. Also described herein are processes for preparing the UAC Star monomers, the PUAC aerogel polymers, and the other related monomers and polymers. The PUAC and related polymers herein are useful in various applications including in structural and thermal insulation.
摘要翻译：本文描述了衍生自其的新型聚氨酯 - 丙烯酸酯（UAC）星形单体和聚氨酯 - 丙烯酸酯（PUAC）气凝胶聚合物，以及其它新颖的相关单体和聚合物。本文还描述了制备UAC Star单体，PUAC气凝胶聚合物和其它相关单体和聚合物的方法。本文中的PUAC和相关聚合物可用于各种应用，包括结构和绝热。

109. 发明申请

US20150077138A1 WAVEGUIDE PROBE FOR NONDESTRUCTIVE MATERIAL CHARACTERIZATION 有权
标题翻译：用于非结构材料表征的波导探测器
公开(公告)号：US20150077138A1
公开(公告)日：2015-03-19
申请号：US14026754
申请日：2013-09-13
申请人： The Curators of the University of Missouri
发明人： Mohammad Tayeb Ghasr , Matthew Kempin , Reza Zoughi
IPC分类号： G01N22/00
CPC分类号： G01N22/00 , G01N22/02 , H01Q13/065
摘要： An open-ended waveguide probe including a finite flange extending outwardly and functioning as an infinite flange. A signal source provides a microwave signal to the waveguide, which in turn transmits microwave electromagnetic energy incident upon an object to be tested. The finite flange at the waveguide's aperture is shaped to reduce scattering of the electromagnetic field reflected from the object and received by the aperture. The probe is adapted for coupling to a receiver for sampling the reflected electromagnetic field received by the aperture and the receiver is adapted for coupling to a processor for determining at least one material characteristic of the object based on sampled electromagnetic field reflected from the object.
摘要翻译：一种开放式波导探头，包括向外延伸的有限凸缘，起到无限凸缘的作用。信号源向波导提供微波信号，波导又传输入射到待测物体上的微波电磁能。波导孔径处的有限法兰被成形为减少从物体反射并被孔径接收的电磁场的散射。探头适于耦合到接收器，用于对由孔径接收的反射电磁场进行采样，并且接收器适于耦合到处理器，用于基于从对象反射的采样电磁场确定对象的至少一种材料特性。

110. 发明授权

US08926932B2 High surface area carbon and process for its production 有权
标题翻译：高表面积碳及其生产工艺
公开(公告)号：US08926932B2
公开(公告)日：2015-01-06
申请号：US11937150
申请日：2007-11-08
申请人： Peter Pfeifer , Galen J. Suppes , Parag Shah , Jacob W. Burress
发明人： Peter Pfeifer , Galen J. Suppes , Parag Shah , Jacob W. Burress
IPC分类号： C01B21/02 , C01B21/00 , D01F9/12 , C09C1/56 , H01B1/04 , C01B31/08 , B01J31/00 , B01J20/00 , B01J20/20 , B01J20/30 , B01J20/28 , B01J21/18 , B82Y30/00 , C01B3/00 , C01B31/12 , C04B38/00 , C10L3/10 , F17C11/00 , H01G11/34 , H01M4/92 , H01G11/24 , C04B111/00 , H01M8/04
CPC分类号： B01J20/3064 , B01J20/00 , B01J20/20 , B01J20/28057 , B01J20/28083 , B01J20/28085 , B01J21/18 , B82Y30/00 , C01B3/0021 , C01B32/30 , C01B32/342 , C04B38/0022 , C04B2111/00853 , C04B2111/00948 , C10L3/10 , F17C11/005 , F17C11/007 , H01G11/24 , H01G11/34 , H01M4/926 , H01M8/04216 , Y02E60/13 , Y02E60/321 , Y02E60/325 , Y02E60/327 , Y02P20/145 , Y02P70/56 , Y02T10/7022 , C04B35/52 , C04B38/0054
摘要： The present invention provides a high surface area porous carbon material and a process for making this material. In particular, the carbon material is derived from biomass and has large mesopore and micropore surfaces that promote improved adsorption of materials and gas storage capabilities.
摘要翻译：本发明提供高表面积的多孔碳材料及其制造方法。特别地，碳材料来源于生物质，并且具有大的中孔和微孔表面，其促进材料的吸附和气体储存能力的改善。

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