专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

101. 发明授权

US09790186B2 Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection 有权
公开(公告)号：US09790186B2
公开(公告)日：2017-10-17
申请号：US14837139
申请日：2015-08-27
申请人： Trustees of Dartmouth College
发明人： F. Jon Kull , Ronald K. Taylor , Gordon W. Gribble , Evans O. Onyango , Anne R. Kelley
IPC分类号： C07D217/12 , C07D209/12 , C07D215/14 , A23L33/10
CPC分类号： C07D217/12 , A23L33/10 , C07D209/12 , C07D215/14
摘要： Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.

102. 发明授权

US09758587B2 Methods of immune therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties 有权
公开(公告)号：US09758587B2
公开(公告)日：2017-09-12
申请号：US14681905
申请日：2015-04-08
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE
发明人： Randolph J. Noelle
IPC分类号： A61K39/395 , C07K16/28 , C07K16/18 , A61K39/00
CPC分类号： C07K16/2875 , A61K39/395 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/71 , C07K2317/732
摘要： Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation and allergic disorders is disclosed herein.

103. 发明申请

US20170238849A1 MOVEMENT MONITORING SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20170238849A1
公开(公告)日：2017-08-24
申请号：US15436577
申请日：2017-02-17
申请人： Trustees of Dartmouth College
发明人： Ryan Chapman , Douglas Wayne Van Citters , Wayne Edward Moschetti , John-Erik Bell
IPC分类号： A61B5/11 , A61B5/00
CPC分类号： A61B5/1121 , A61B5/0022 , A61B5/0024 , A61B5/1071 , A61B5/1118 , A61B5/112 , A61B5/4528 , A61B5/4566 , A61B5/4571 , A61B5/4576 , A61B5/4585 , A61B5/486 , A61B5/6804 , A61B5/6823 , A61B5/6824 , A61B5/6828 , A61B5/6831 , A61B5/7275 , A61B5/7475 , A61B2505/07 , A61B2505/09 , A61B2560/0209 , A61B2560/0214 , A61B2562/0219 , A61B2562/04
摘要： Systems and methods for monitoring a range of motion of a joint are described. For example, in one embodiment, a first set of sensors may sense accelerations of a first body portion located on a first side of the joint and a second set of sensors may sense accelerations of the second body portion located on a second opposing side of the joint. The acceleration data may then be used to compute the relative motion of the first and second body portions to determine movement of the joint. This joint movement may then be used to determine one or more range of motion movement metrics which are output for viewing by a subject or medical practitioner.

104. 发明授权

US09728565B2 Low full-well capacity image sensor with high sensitivity 有权
公开(公告)号：US09728565B2
公开(公告)日：2017-08-08
申请号：US14898088
申请日：2014-06-11
申请人： TRUSTEES OF DARTMOUTH COLLEGE
发明人： Eric R. Fossum , Jiaju Ma , Donald Hondongwa
IPC分类号： H01L27/146 , H01L31/075 , H01L27/144
CPC分类号： H01L27/14607 , H01L27/1443 , H01L27/1461 , H01L27/14612 , H01L27/14621 , H01L27/14627 , H01L27/1463 , H01L27/1464 , H01L27/14641 , H01L27/14645 , H01L27/14681 , H01L31/075
摘要： Image sensor pixels having low full-well capacity and high sensitivity for applications such as DIS, qDIS, single/multi bit QIS. Some embodiments provide an image sensor pixel architecture, comprises a transfer gate, a floating diffusion region both formed on a first surface of a semiconductor substrate and a buried-well vertically pinned photodiode having a charge accumulation/storage region disposed substantially or entirely beneath the transfer gate. Image sensor may also comprise an array of pixels, wherein each pixel comprises: a vertical bipolar structure including an emitter, base, collector configured for storing photocarriers in the base; and a reset transistor coupled to the base, configured to be completely reset of all free carriers using the reset transistor. The emitter may be configured as a pinning layer to facilitate full depletion of the base. Such image sensor pixels may have a full well capacity less than that giving good signal-to-noise ratio (SNR).

105. 发明授权

US09659706B2 Methods for making radially anisotropic thin-film magnetic torroidal cores 有权
公开(公告)号：US09659706B2
公开(公告)日：2017-05-23
申请号：US14346659
申请日：2012-09-24
申请人： The Trustees of Dartmouth College
发明人： Jizheng Qiu , Charles R. Sullivan
IPC分类号： H01F41/02 , H01F7/02 , G11C11/08 , G11C19/08 , H01F41/18 , H01F3/02 , C23C16/458
CPC分类号： H01F41/02 , C23C16/458 , C23C16/4583 , C23C16/4584 , G11C19/08 , G11C19/0808 , G11C19/0816 , H01F3/02 , H01F7/02 , H01F7/0273 , H01F41/18 , Y10T29/49075 , Y10T29/49076 , Y10T29/49078
摘要： A method of forming a radially anisotropic toroidal magnetic core includes providing apparatus having a first magnet for providing a radial magnetic field extending across a cavity from an axial spindle to a surrounding second magnetic element, placing a substrate in the cavity, the substrate having a hole fitting around the head of the spindle; and sputter-depositing a film of ferromagnetic material onto the substrate. In an embodiment, the spindle is magnetically coupled to a first pole of the first magnet, the second magnetic element is coupled to a second pole of the first magnet, and a thermally conductive, nonmagnetic, insert separates the spindle and the second magnetic element.

106. 发明授权

US09655545B2 Apparatus for measuring in-vivo mechanical properties of biological tissues 有权
公开(公告)号：US09655545B2
公开(公告)日：2017-05-23
申请号：US14345029
申请日：2012-09-17
申请人： The Trustees of Dartmouth College
发明人： Songbai Ji , David W. Roberts , Keith D. Paulsen
IPC分类号： A61B5/107 , A61B5/00 , G02B21/00 , G02B21/36 , A61B90/20 , G06T7/33 , A61B19/00 , G06T7/00 , A61B90/00
CPC分类号： A61B5/1079 , A61B5/0053 , A61B5/0077 , A61B90/20 , A61B2090/364 , A61B2090/371 , G02B21/0012 , G02B21/367 , G06T7/344 , G06T2200/04 , G06T2207/10012 , G06T2207/10056 , G06T2207/30016
摘要： An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired images obtained from the digital cameras form stereo pairs, and a digital image processing system adapted to determine surface topography of tissue from the stereo pairs of images and a resulting surface displacement map as a result from indentation. The apparatus has an one indenter; and mechanical modeling routines stored in memory of the image processing system, the mechanical modeling routines capable of constructing computer models of mechanical properties of tissue, and fitting parameters of the computer model to observed surface displacement maps generated by coregistering surface topography of tissue with and without the indenter positioned on the tissue. In an embodiment, fitted parameters of the computer model are displayed and used to adjust a surgical plan. An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired images obtained from the digital cameras form stereo pairs, and a digital image processing system adapted to determine surface topography of tissue from the stereo pairs of images and a resulting surface displacement map as a result from indentation. The apparatus has an one indenter; and mechanical modeling routines stored in memory of the image processing system, the mechanical modeling routines capable of constructing computer models of mechanical properties of tissue, and fitting parameters of the computer model to observed surface displacement maps generated by coregistering surface topography of tissue with and without the indenter positioned on the tissue. In an embodiment, fitted parameters of the computer model are displayed and used to adjust a surgical plan.

107. 发明授权

US09395425B2 Method and apparatus for magnetic susceptibility tomography, magnetoencephalography, and taggant or contrast agent detection 有权
标题翻译：用于磁化率层析成像，脑磁图和标记剂或造影剂检测的方法和装置
公开(公告)号：US09395425B2
公开(公告)日：2016-07-19
申请号：US14420828
申请日：2013-08-23
申请人： The Trustees of Dartmouth College
发明人： Solomon G. Diamond , Broc A. Burke , Bradley W. Ficko
IPC分类号： G01R33/16 , G01R33/48 , A61B5/04 , A61B5/05 , G01N27/72 , A61B5/00
CPC分类号： G01R33/16 , A61B5/0042 , A61B5/04008 , A61B5/0522 , A61B2562/0223 , G01N27/72
摘要： A magnetic susceptibility tomographic device has sensitive magnetic sensors about a measurement volume and AC bias coils for providing magnetic fields within the volume. Sensing circuitry reads the sensors, and a processor executes magnetic susceptibility tomography (MST) routines from memory to divide the measurement volume into voxels, to determine differences between applied and measured field strengths of magnetic fields at each voxel and thereby determines magnetic susceptibility of each voxel, and to construct tomographic images representative of magnetic susceptibility as MST images. Embodiments with SQUID and fluxgate sensors are described. Applications to direct measurement of tissue magnetic susceptibility, and to locating and quantifying tagged magnetic nanoparticles are disclosed, including antibody-tagged nanoparticles for use in cancer diagnosis and treatments, and the retrieval of taggant identification codes from an object.
摘要翻译：磁化物断层摄影装置具有关于测量体积的敏感磁传感器和用于在体积内提供磁场的AC偏置线圈。感测电路读取传感器，并且处理器执行来自存储器的磁化率层析成像（MST）程序，以将测量体积划分为体素，以确定每个体素上的磁场的施加和测量场强之间的差异，从而确定每个体素的磁化率并构建代表磁化率的断层图像作为MST图像。描述具有SQUID和磁通门传感器的实施例。公开了用于直接测量组织磁化率的应用，以及定位和定量标记的磁性纳米颗粒，包括用于癌症诊断和治疗的抗体标记的纳米颗粒，以及从对象检索标记物识别码。

108. 发明授权

US09382588B2 Markers for identifying breast cancer treatment modalities 有权
标题翻译：识别乳腺癌治疗方式的标志物
公开(公告)号：US09382588B2
公开(公告)日：2016-07-05
申请号：US13985470
申请日：2012-02-15
申请人： Mathieu Lupien , Luca Magnani
发明人： Mathieu Lupien , Luca Magnani
IPC分类号： C12Q1/68 , C07K16/30 , G01N33/574
CPC分类号： C12Q1/6886 , C07K16/3015 , G01N33/57496
摘要： The present invention includes methods for identifying patients who will be resistant to endocrine therapy during breast cancer treatment and determining patient outcome. The methods are based on identifying increased expression of PBX1, or the cistrome signature associated therewith, in breast tissue samples.
摘要翻译：本发明包括用于鉴定在乳腺癌治疗期间对内分泌治疗具有抗性并确定患者结果的患者的方法。所述方法基于在乳腺组织样品中鉴定增加的PBX1表达或与其相关的结肠标志。

109. 发明授权

US09381244B2 VISTA modulators for diagnosis and treatment of cancer 有权
标题翻译：用于诊断和治疗癌症的VISTA调节剂
公开(公告)号：US09381244B2
公开(公告)日：2016-07-05
申请号：US14021353
申请日：2013-09-09
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE
发明人： Randolph Noelle
IPC分类号： A61K39/395 , C07K16/28 , A61K35/00 , A61K45/06 , A61K35/17 , C12N15/113 , A61K39/39 , A61K39/00
CPC分类号： A61K39/39566 , A61K35/17 , A61K39/0011 , A61K39/39 , A61K39/3955 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61K2039/507 , A61K2039/5152 , A61K2039/5256 , A61K2039/55516 , C07K16/2827 , C07K16/2878 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2710/10034 , C12N2710/10043 , Y02A50/386 , Y02A50/41 , Y02A50/412 , A61K31/00
摘要： The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and compositions are able to antagonize the activity of VISTA, a naturally occurring “checkpoint” protein which contributes to immune tolerance, optionally in combination with an antagonist of a second checkpoint pathway such as PD-1. For example, such methods and compositions may be suitable for preventing and treating colon cancer or another cancer. An exemplary VISTA antagonist, specifically, an anti-VISTA antibody, is demonstrated herein to activate an immune response against cancer cells in vitro and in vivo, thereby conferring protective anti-tumor immunity which decreased tumor burden. Additionally, an additive benefit was observed when a VISTA antagonist was used in combination with a second checkpoint protein antagonist, specifically, an antibody against PD-1 ligand (PD-L1).
摘要翻译：本公开涉及用于在有需要的患者中激活免疫应答的组合物和治疗方法。在优选的实施方案中，本发明的方法和组合物能够拮抗VISTA的活性，VISTA是有助于免疫耐受的天然存在的“检查点”蛋白质，任选地与第二检查点途径的拮抗剂如PD-1组合。例如，这些方法和组合物可适用于预防和治疗结肠癌或其它癌症。在本文中证明了一种示例性的VISTA拮抗剂，特别是抗-VISTA抗体，以在体外和体内激活针对癌细胞的免疫应答，由此赋予降低肿瘤负荷的保护性抗肿瘤免疫。另外，当将VISTA拮抗剂与第二检查点蛋白拮抗剂，特别是抗PD-1配体（PD-L1）的抗体组合使用时，观察到附加益处。

110. 发明授权

US09356171B2 Method of forming single-crystal semiconductor layers and photovaltaic cell thereon 有权
标题翻译：在其上形成单晶半导体层和光电池的方法
公开(公告)号：US09356171B2
公开(公告)日：2016-05-31
申请号：US13401206
申请日：2012-02-21
申请人： Jifeng Liu , Xiaoxin Wang
发明人： Jifeng Liu , Xiaoxin Wang
IPC分类号： H01L31/0368 , C30B1/02 , C30B29/06 , H01L31/076 , H01L31/18
CPC分类号： H01L31/0368 , C30B1/02 , C30B1/023 , C30B29/06 , H01L31/03682 , H01L31/076 , H01L31/1872 , Y02E10/546 , Y02E10/548 , Y02P70/521
摘要： A method for forming single crystal or large-crystal-grain thin-film layers deposits a thin-film amorphous, nanocrystalline, microcrystalline, or polycrystalline layer, and laser-heats a seed spot having size on the order of a critical nucleation size of the thin-film layer. The single-crystal seed spot is extended into a single-crystal seed line by laser-heating one or more crystallization zones adjacent to the seed spot and drawing the zone across the thin-film layer. The single-crystal seed line is extended across the thin-film material layer into a single-crystal layer by laser-heating an adjacent linear crystallization zone and drawing the crystallization zone across the thin-film layer. Photovoltaic cells may be formed in or on the single-crystal layer. Tandem photovoltaic devices may be formed using one or several iterations of the method. The method may also be used to form single-crystal semiconductor thin-film transistors, such as for display devices, or to form single-crystal superconductor layers.
摘要翻译：用于形成单晶或大晶粒薄膜层的方法沉积薄膜非晶，纳米晶体，微晶或多晶层，并且激光加热具有临界成核尺寸级别的大小的晶种点薄膜层。通过激光加热与种子斑点相邻的一个或多个结晶区域并将该区域横穿薄膜层，将单晶种子斑点延伸到单晶种子线中。单晶种子线通过激光加热相邻的线性结晶区并在薄膜层上拉伸结晶区，在薄膜材料层上延伸成单晶层。光电池可以形成在单晶层中或单晶层上。可以使用该方法的一个或多个迭代来形成串联光伏器件。该方法也可用于形成诸如显示器件的单晶半导体薄膜晶体管，或者形成单晶超导体层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式