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101. 发明授权

US5124311A Structure of ceramic superconductive wiring and process of fabrication thereof 失效
标题翻译：陶瓷超导布线结构及其制造工艺
公开(公告)号：US5124311A
公开(公告)日：1992-06-23
申请号：US362466
申请日：1989-05-30
申请人： Satoru Mori , Hideaki Yoshida , Takuo Takeshita , Yoshio Kanda
发明人： Satoru Mori , Hideaki Yoshida , Takuo Takeshita , Yoshio Kanda
IPC分类号： H01L23/498 , H01L39/24
CPC分类号： H01L39/247 , H01L23/49888 , H01L2924/0002 , Y10S428/901 , Y10S428/93 , Y10S505/701 , Y10S505/702 , Y10S505/703 , Y10S505/704 , Y10T428/24917 , Y10T428/31678 , Y10T428/31692
摘要： There is disclosed the structure of a superconductive wiring fabricated on an insulating substrate comprising a conductive pattern having at least one wiring strip of a superconductive ceramic formed on the insulating substrate and a protective film covering the wiring pattern and formed of a basic oxide, the basic oxide hardly reacts with the superconductive ceramic because of the fact that most of the superconductive ceramics are bases, then the wiring strip is allowed to stay in the superconductive state for a prolonged period of time.

102. 发明授权

US5123880A Metallic V-belt 失效
标题翻译：金属V型皮带
公开(公告)号：US5123880A
公开(公告)日：1992-06-23
申请号：US614781
申请日：1990-11-14
申请人： Noboru Sekine , Takashi Aoki , Shigeru Kanehara , Keiichi Hanyu , Hideaki Yoshida
发明人： Noboru Sekine , Takashi Aoki , Shigeru Kanehara , Keiichi Hanyu , Hideaki Yoshida
IPC分类号： F16G5/16 , F16H9/24
CPC分类号： F16H9/24 , F16G5/16
摘要： A metallic V belt for use in a V-belt-type continuously variable transmission has an endless metallic belt strap and a plurality of metallic blocks each having a strap insertion slot defined therein and opening outwardly of the V belt at one side of the metallic block, the metallic blocks being mounted on that belt strap with the belt strap positioned in the strap insertion slots in the metallic blocks. A retaining belt strap or retainer is disposed in engagement with portions of the metallic blocks in covering relation to the endless belt strap in the strap insertion slots for retaining the metallic blocks against dislodgment from the belt strap. The retainer is in the form of an endless web having a flat transverse cross section and having at least one hole defined in the endless web. The hole in the endless web may be a slot, a narrow slit, or an elliptical hole.
摘要翻译：用于V形带式无级变速器的金属V带具有环形金属带带和多个金属块，每个金属块具有限定在其中的带插入槽，并且在金属块的一侧向外开放V带金属块被安装在带束带上，带束带位于金属块中的带插入槽中。保持带束带或保持器设置成与金属块的部分接合，以与带状物插入槽中的环形带束带相对地覆盖，用于保持金属块抵抗带束带脱离。保持器是具有平坦横截面的环形腹板的形式，并且具有限定在环形腹板中的至少一个孔。环形腹板中的孔可以是槽，窄缝或椭圆孔。

103. 发明授权

US4717436A Wire for bonding a semiconductor device 失效
标题翻译：用于接合半导体器件的线
公开(公告)号：US4717436A
公开(公告)日：1988-01-05
申请号：US36249
申请日：1987-04-09
申请人： Naoyuki Hosoda , Masaki Morikawa , Naoki Uchiyama , Hideaki Yoshida , Toshiaki Ono
发明人： Naoyuki Hosoda , Masaki Morikawa , Naoki Uchiyama , Hideaki Yoshida , Toshiaki Ono
IPC分类号： C22C9/00 , C30B13/00 , H01B1/02 , H01L21/48 , H01L23/49
CPC分类号： H01L24/43 , C22C9/00 , C30B13/00 , C30B29/02 , H01B1/026 , H01L24/45 , H01L2224/05624 , H01L2224/43 , H01L2224/45015 , H01L2224/45144 , H01L2224/45147 , H01L2224/48624 , H01L2924/00011 , H01L2924/01005 , H01L2924/0101 , H01L2924/01011 , H01L2924/01012 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01019 , H01L2924/0102 , H01L2924/01021 , H01L2924/01022 , H01L2924/01023 , H01L2924/01025 , H01L2924/01027 , H01L2924/01028 , H01L2924/01029 , H01L2924/0103 , H01L2924/01032 , H01L2924/01033 , H01L2924/01037 , H01L2924/01039 , H01L2924/0104 , H01L2924/01041 , H01L2924/01047 , H01L2924/0105 , H01L2924/01052 , H01L2924/01055 , H01L2924/01057 , H01L2924/01058 , H01L2924/01059 , H01L2924/0106 , H01L2924/01063 , H01L2924/01064 , H01L2924/01065 , H01L2924/01066 , H01L2924/01067 , H01L2924/01068 , H01L2924/0107 , H01L2924/01072 , H01L2924/01074 , H01L2924/01075 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/01088 , H01L2924/01105 , H01L2924/014 , H01L2924/10253 , H01L2924/14 , H01L2924/181 , H01L2924/20752 , Y10T428/12431
摘要： The present invention eliminates the problems associated with the use of oxygen-free copper and other high-purity copper materials as bonding wires. In accordance with one aspect of the present invention, at least one rare earth element, or at least one element selected from the group consisting of Mg, Ca, Ti, Zr, Hf, Li, Na, K, Rb and Cs, or the combination of at least one rare earth element and at least one elemented selected from the above-specified group is incorporated in high-purity copper as a refining component in an amount of 0.1-100 ppm on a weight basis, and the high-purity copper is subsequently refined by zone melting. The very fine wire drawn from the so refined high-purity copper has the advantage that it can be employed in high-speed ball bonding of a semiconductor chip with a minimum chance of damaging the bonding pad on the chip by the ball forming at the tip of the wire.In accordance with another aspect of the present invention, 0.5-3 ppm of a rare earth element and/or Y is further incorporated as an alloying component in the zone-refined high-purity copper.
摘要翻译：本发明消除了与使用无氧铜和其它高纯度铜材料作为接合线相关的问题。根据本发明的一个方面，至少一种稀土元素或选自Mg，Ca，Ti，Zr，Hf，Li，Na，K，Rb和Cs中的至少一种元素，或将至少一种稀土元素和至少一种选自上述特定基团的元素的组合作为精制组分以重量计以0.1-100ppm的量加入到高纯度铜中，并且将高纯度铜随后通过区域熔化进行精制。从精细化的高纯度铜制成的极细金属丝具有以下优点：可以将半导体芯片的高速球焊接在最小的可能性上，通过在尖端处的球形成损坏芯片上的焊盘的电线。根据本发明的另一方面，在区域精制的高纯度铜中进一步掺入0.5-3ppm的稀土元素和/或Y作为合金成分。

104. 发明授权

US09072436B2 Device for measuring information regarding blood pressure 有权
标题翻译：用于测量血压信息的装置
公开(公告)号：US09072436B2
公开(公告)日：2015-07-07
申请号：US13044231
申请日：2011-03-09
申请人： Tatsuya Kobayashi , Hideaki Yoshida
发明人： Tatsuya Kobayashi , Hideaki Yoshida
IPC分类号： A61B5/02 , A61B5/0225 , A61B5/021 , A61B8/04
CPC分类号： A61B5/0225 , A61B5/02 , A61B5/021 , A61B5/02141 , A61B8/04
摘要： A measurement device includes an air bag on a peripheral side, an air bag on a central side, and an air bag positioned therebetween. During blood pressure measurement, the air bags integrally behave, and the blood pressure is measured from the change in inner pressure thereof. During pulse wave measurement, the inner pressure of the air bag on the peripheral side is maintained to higher than or equal to the systolic blood pressure, and the measurement site is avascularized. The inner pressure of the air bag on the central side is maintained to the pressure near the blood pressure value, and the pulse wave is measured from the change in inner pressure thereof. The inner pressure of the air bag positioned therebetween is opened to atmospheric pressure, and the vibration of the air bag on the central side is prevented from propagating to the air bag on the peripheral side.
摘要翻译：测量装置包括外围一侧的气囊，中央侧的气囊和位于其间的气囊。在血压测量期间，气囊整体地起作用，并且根据其内部压力的变化来测量血压。在脉搏波测量期间，外周侧气囊的内压保持在收缩压以上，测量部位为血管。中央侧的气囊的内部压力保持在接近血压值的压力，并且根据其内部压力的变化来测量脉搏波。位于其间的气囊的内部压力打开到大气压力，并且防止中央侧的气囊的振动传播到周边的气囊。

105. 发明授权

US08999329B2 Agonist antibody to human thrombopoietin receptor 有权
标题翻译：抗人血小板生成素受体的激动剂抗体
公开(公告)号：US08999329B2
公开(公告)日：2015-04-07
申请号：US13543183
申请日：2012-07-06
申请人： Masayuki Kai , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
发明人： Masayuki Kai , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
IPC分类号： A61K39/395 , C07K16/28 , C07K14/52 , C07K14/715 , A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/524 , C07K14/715 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/72 , C07K2317/74 , Y10S424/801 , Y10S424/809
摘要： This invention provides an agonist antibody to a human thrombopoietin receptor (human c-Mpl), and pharmaceutical compositions comprising the same for use in treatment of thrombocytopenia. The disclosed agonist antibody comprises (1) antibody constant regions comprising heavy and light chain constant regions, each of which may optionally contain domain substitutions, or may contain deletions, substitutions, additions, or insertions of amino acid residues, and (2) antibody variable regions capable of binding to and activating a human thrombopoietin receptor. The-agonist antibody further induces colony formation at a concentration of 10,000 ng/ml or lower, and has a maximal activity at least 50% higher than that of PEG-rHuMGDF and an 50% effective concentration (EC50) of 100 nM or less.
摘要翻译：本发明提供了对人类血小板生成素受体（人c-Mpl）的激动剂抗体，以及包含其用于治疗血小板减少症的药物组合物。所公开的激动剂抗体包含（1）包含重链和轻链恒定区的抗体恒定区，每个区可任选地含有结构域取代，或可含有氨基酸残基的缺失，替换，添加或插入，和（2）抗体可变能够结合并激活人血小板生成素受体的区域。激动剂抗体进一步诱导浓度为10,000ng / ml或更低的集落形成，并且具有比PEG-rHuMGDF高至少50％的最大活性和100nM或更低的50％有效浓度（EC 50）。

106. 发明授权

US08911726B2 Stabilized human Igg4 antibodies 有权
标题翻译：稳定的人Igg4抗体
公开(公告)号：US08911726B2
公开(公告)日：2014-12-16
申请号：US11663340
申请日：2005-09-22
申请人： Nobuaki Takahashi , Hideaki Yoshida
发明人： Nobuaki Takahashi , Hideaki Yoshida
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13 , C07K16/00
CPC分类号： C07K16/2878 , A61K39/39591 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/76 , C07K2317/94
摘要： A highly stable mutant of human IgG4 antibody is provided. Such antibody is an antibody in which the CH3 domain of human IgG4 is substituted with the CH3 domain of human IgG1 and which exhibits inhibited aggregate formation, an antibody in which the CH3 and CH2 domains of human IgG4 are substituted with the CH3 and CH2 domains of human IgG1, respectively, or an antibody in which arginine at position 409 indicated in the EU index proposed by Kabat et al. of human IgG4 is substituted with lysine and which exhibits inhibited aggregate formation.
摘要翻译：提供了高度稳定的人IgG4抗体突变体。这样的抗体是其中人IgG4的CH3结构域被人IgG1的CH3结构域取代并且表现出抑制聚集体形成的抗体，其中人IgG4的CH 3和CH 2结构域被CH 3和CH 2结构域所取代的抗体或者其中在Kabat等人提出的欧盟指标中指出的409位精氨酸的抗体。的人IgG4被赖氨酸取代，并且其表现出抑制的聚集体形成。

107. 发明授权

US08236314B2 Agonist antibody to human thrombopoietin receptor 失效
标题翻译：抗人血小板生成素受体的激动剂抗体
公开(公告)号：US08236314B2
公开(公告)日：2012-08-07
申请号：US13232277
申请日：2011-09-14
申请人： Masayuki Kai , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
发明人： Masayuki Kai , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/524 , C07K14/715 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/72 , C07K2317/74 , Y10S424/801 , Y10S424/809
摘要： This invention provides an agonist antibody to a human thrombopoietin receptor (human c-Mpl), and pharmaceutical compositions comprising the same for use in treatment of thrombocytopenia. The disclosed agonist antibody comprises (1) antibody constant regions comprising heavy and light chain constant regions, each of which may optionally contain domain substitutions, or may contain deletions, substitutions, additions, or insertions of amino acid residues, and (2) antibody variable regions capable of binding to and activating a human thrombopoietin receptor. The-agonist antibody further induces colony formation at a concentration of 10,000 ng/ml or lower, and has a maximal activity at least 50% higher than that of PEG-rHuMGDF and an 50% effective concentration (EC50) of 100 nM or less.
摘要翻译：本发明提供了对人类血小板生成素受体（人c-Mpl）的激动剂抗体，以及包含其用于治疗血小板减少症的药物组合物。所公开的激动剂抗体包含（1）包含重链和轻链恒定区的抗体恒定区，每个区可任选地含有结构域取代，或可含有氨基酸残基的缺失，替换，添加或插入，和（2）抗体可变能够结合并激活人血小板生成素受体的区域。激动剂抗体进一步诱导浓度为10,000ng / ml或更低的集落形成，并且具有比PEG-rHuMGDF高至少50％的最大活性和100nM或更低的50％有效浓度（EC 50）。

108. 发明申请

US20120053326A1 AGONIST ANTIBODY TO HUMAN THROMBOPOIETIN RECEPTOR 失效
标题翻译：人类抗抑郁药受体的激素抗体
公开(公告)号：US20120053326A1
公开(公告)日：2012-03-01
申请号：US13232277
申请日：2011-09-14
申请人： Masayuki KAI , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
发明人： Masayuki KAI , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/524 , C07K14/715 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/72 , C07K2317/74 , Y10S424/801 , Y10S424/809
摘要： This invention provides an agonist antibody to a human thrombopoietin receptor (human c-Mpl), and pharmaceutical compositions comprising the same for use in treatment of thrombocytopenia. The disclosed agonist antibody comprises (1) antibody constant regions comprising heavy and light chain constant regions, each of which may optionally contain domain substitutions, or may contain deletions, substitutions, additions, or insertions of amino acid residues, and (2) antibody variable regions capable of binding to and activating a human thrombopoietin receptor. The-agonist antibody further induces colony formation at a concentration of 10,000 ng/ml or lower, and has a maximal activity at least 50% higher than that of PEG-rHuMGDF and an 50% effective concentration (EC50) of 100 nM or less.
摘要翻译：本发明提供了对人类血小板生成素受体（人c-Mpl）的激动剂抗体，以及包含其用于治疗血小板减少症的药物组合物。所公开的激动剂抗体包含（1）包含重链和轻链恒定区的抗体恒定区，每个区可任选地含有结构域取代，或可含有氨基酸残基的缺失，替换，添加或插入，和（2）抗体可变能够结合并激活人血小板生成素受体的区域。激动剂抗体进一步诱导浓度为10,000ng / ml或更低的集落形成，并且具有比PEG-rHuMGDF高至少50％的最大活性和100nM或更低的50％有效浓度（EC 50）。

109. 发明申请

US20110230774A1 DEVICE FOR MEASURING INFORMATION REGARDING BLOOD PRESSURE 审中-公开
标题翻译：用于测量血压信息的装置
公开(公告)号：US20110230774A1
公开(公告)日：2011-09-22
申请号：US13073393
申请日：2011-03-28
申请人： Tatsuya Kobayashi , Yoshihiko Sano , Hideaki Yoshida
发明人： Tatsuya Kobayashi , Yoshihiko Sano , Hideaki Yoshida
IPC分类号： A61B5/0225
CPC分类号： A61B5/022 , A61B5/02125
摘要： With a measurement device attached to the upper arm as a master, a measurement device, which is a slave, attached to the ankle is controlled to measure a pulse wave in synchronization. The measurement device on the master side obtains a measurement result from the measurement device on the slave side, and detects the appearance time difference of the pulse wave waveforms by synchronizing the pulse waves measured in both measurement devices, thereby calculating a Pulse Wave Velocity as the index of arterial sclerosis.
摘要翻译：将测量装置附接到上臂作为主机，控制附接到脚踝的作为从动装置的测量装置同步测量脉搏波。主机侧的测定装置从从动侧的测定装置得到测定结果，通过使在两个测定装置中测定的脉搏波同步来检测出脉搏波形的出现时间差，算出脉搏波速度为动脉硬化指数。

110. 发明申请

US20110160599A1 DEVICE FOR MEASURING INFORMATION REGARDING BLOOD PRESSURE 有权
标题翻译：用于测量血压信息的装置
公开(公告)号：US20110160599A1
公开(公告)日：2011-06-30
申请号：US13044231
申请日：2011-03-09
申请人： Tatsuya Kobayashi , Hideaki Yoshida
发明人： Tatsuya Kobayashi , Hideaki Yoshida
IPC分类号： A61B5/0225
CPC分类号： A61B5/0225 , A61B5/02 , A61B5/021 , A61B5/02141 , A61B8/04
摘要： A measurement device includes an air bag on a peripheral side, an air bag on a central side, and an air bag positioned therebetween. During blood pressure measurement, the air bags integrally behave, and the blood pressure is measured from the change in inner pressure thereof. During pulse wave measurement, the inner pressure of the air bag on the peripheral side is maintained to higher than or equal to the systolic blood pressure, and the measurement site is avascularized. The inner pressure of the air bag on the central side is maintained to the pressure near the blood pressure value, and the pulse wave is measured from the change in inner pressure thereof. The inner pressure of the air bag positioned therebetween is opened to atmospheric pressure, and the vibration of the air bag on the central side is prevented from propagating to the air bag on the peripheral side.
摘要翻译：测量装置包括外围一侧的气囊，中央侧的气囊和位于其间的气囊。在血压测量期间，气囊整体地起作用，并且根据其内部压力的变化来测量血压。在脉搏波测量期间，外周侧气囊的内压保持在收缩压以上，测量部位为血管。中央侧的气囊的内部压力保持在接近血压值的压力，并且根据其内部压力的变化来测量脉搏波。位于其间的气囊的内部压力打开到大气压力，并且防止中央侧的气囊的振动传播到周边的气囊。

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