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101. 发明申请

US20110059488A1 Anti-MPL Antibodies 失效
标题翻译：抗MPL抗体
公开(公告)号：US20110059488A1
公开(公告)日：2011-03-10
申请号：US12874872
申请日：2010-09-02
申请人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
发明人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
IPC分类号： C12P21/06 , C07H21/00 , C12N15/63 , C12N5/00
CPC分类号： C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75
摘要： Anti-human Mpl antibodies were isolated and purified, and then anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were purified using genetic engineering techniques. Furthermore, the present inventors succeeded in humanizing anti-human Mpl sc(Fv)2.The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
摘要翻译：分离和纯化抗人Mpl抗体，然后使用遗传工程技术纯化抗人Mpl双抗体和抗人Mpl sc（Fv）2。此外，本发明人成功地将抗人Mpl sc（Fv）2人源化。测定双抗体和sc（Fv）2的TPO样激动活性，发现其活性高于抗人Mpl抗体的活性，或与天然存在的人TPO配体相当或更高的活性。

102. 发明申请

US20110033452A1 Anti-Glypican 3 Antibody Having Modified Sugar Chain 审中-公开
标题翻译：具有改性糖链的抗磷脂酰肌醇蛋白3抗体
公开(公告)号：US20110033452A1
公开(公告)日：2011-02-10
申请号：US12852950
申请日：2010-08-09
申请人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
发明人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08 , C12N5/071 , A61P35/00
CPC分类号： C07K16/303 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/732
摘要： An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.
摘要翻译：提供了具有修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体，更具体地，提供了缺乏岩藻糖的磷脂酰肌醇蛋白聚糖3抗体。具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体可以通过包括将编码抗磷脂酰肌醇蛋白聚糖3抗体的核酸引入具有降低的岩藻糖加成能力的宿主细胞中的方法来生产，例如YB2 / 0细胞和缺乏细胞的细胞岩藻糖转运蛋白具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体具有高水平的细胞毒活性，因此可用作细胞生长抑制剂如抗癌剂。

103. 发明申请

US20100251566A1 SHOCK ABSORBING FOOTWEAR CONSTRUCTION 有权
标题翻译：震动吸收鞋结构
公开(公告)号：US20100251566A1
公开(公告)日：2010-10-07
申请号：US12819630
申请日：2010-06-21
申请人： Kiyotaka Nakano
发明人： Kiyotaka Nakano
IPC分类号： A43B13/18 , A43B13/12
CPC分类号： A43B13/181 , A43B21/26
摘要： A footwear sole includes shock absorbing elements that extend from upper and lower plates. In one embodiment, the shock absorbing elements include a bridge defining a plurality of receptacles extending from the lower plate and a plurality of protrusions extending from the upper plate. Each protrusion is associated with one receptacle, and a portion of each protrusion extends into the receptacle.
摘要翻译：鞋底包括从上板和下板延伸的减震元件。在一个实施例中，冲击吸收元件包括限定从下板延伸的多个容器的桥，以及从上板延伸的多个突起。每个突起与一个容器相关联，并且每个突起的一部分延伸到容器中。

104. 发明申请

US20100183595A1 Antibody against secreted N-terminal peptide of GPC3 present in blood or C-terminal peptide of GPC3 审中-公开
标题翻译： GPC3血液或C末端肽中存在的GPC3分泌型N-末端肽的抗体
公开(公告)号：US20100183595A1
公开(公告)日：2010-07-22
申请号：US12584728
申请日：2009-09-11
申请人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
发明人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/18 , C07K16/30 , C07K16/303 , C07K17/00 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/732 , C07K2317/734 , G01N33/57488
摘要： Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to determine whether a subject suffers from cancer, in particular hepatoma. Also disclosed is an antibody against GPC as well as a cell disrupting agent and an anti-cancer agent comprising the same, which can disrupt cells, in particular cancer cells.
摘要翻译：公开了一种能够检测测试样品中磷脂酰肌醇蛋白聚糖3（GPC3）分泌形式的分泌形式的GPC3的抗体。可以确定受试者是否患有癌症，特别是肝癌。还公开了针对GPC的抗体以及细胞破碎剂和包含该抗体的抗癌剂，其可破坏细胞，特别是癌细胞。

105. 发明申请

US20100026966A1 LIGHT SOURCE DEVICE AND PROJECTOR 有权
标题翻译：光源设备和投影机
公开(公告)号：US20100026966A1
公开(公告)日：2010-02-04
申请号：US12508021
申请日：2009-07-23
申请人： Kiyotaka Nakano
发明人： Kiyotaka Nakano
IPC分类号： G03B21/16 , F21V29/02
CPC分类号： G03B21/16 , G03B21/2093
摘要： A light source device includes: a light source lamp; and a housing, wherein the housing includes: a pair of openings formed, along a top and bottom with direction of a luminous flux emission of the light source device; a duct member provided so as to cover the pair of openings, and having an intake which outside air is introduced from the pair of openings to an air flow channel upstream side; a first air flow guide member provided inside the duct member, and causing the air introduced from the intake to circulate to either one of the pair of openings via the duct member by pivots under its own weight; and a second air flow guide members provided in positions in the housing corresponding to the openings, and causing the air introduced from the openings to circulate toward the light source lamp.
摘要翻译：光源装置包括：光源灯; 以及壳体，其中，所述壳体包括：一对开口，沿着顶部和底部形成有所述光源装置的光束发射方向; 设置成覆盖所述一对开口的管道构件，并且具有外部空气从所述一对开口引导到空气流动通道上游侧的入口; 第一气流引导构件，设置在所述管道构件内部，并且使得从所述入口引入的空气经由所述管道构件通过枢轴在其自身重量下循环到所述一对开口中的任一个; 以及第二气流引导构件，其设置在与所述开口对应的壳体中的位置，并且使从所述开口引入的空气朝向所述光源灯循环。

106. 外观设计

USD594195S1 Footwear sole 有权
公开(公告)号：USD594195S1
公开(公告)日：2009-06-16
申请号：US29328931
申请日：2008-12-04
申请人： Kiyotaka Nakano
设计人： Kiyotaka Nakano

107. 发明申请

US20080124330A1 Anti-Glypican 3 Antibody Having Modified Sugar Chain 有权
标题翻译：具有改性糖链的抗磷脂酰肌醇蛋白3抗体
公开(公告)号：US20080124330A1
公开(公告)日：2008-05-29
申请号：US11577944
申请日：2005-10-26
申请人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
发明人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00 , C12P21/04
CPC分类号： C07K16/303 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/732
摘要： An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.
摘要翻译：提供了具有修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体，更具体地，提供了缺乏岩藻糖的磷脂酰肌醇蛋白聚糖3抗体。具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体可以通过包括将编码抗磷脂酰肌醇蛋白聚糖3抗体的核酸引入具有降低的岩藻糖加成能力的宿主细胞中的方法来生产，例如YB2 / 0细胞和缺乏细胞的细胞岩藻糖转运蛋白具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体具有高水平的细胞毒活性，因此可用作细胞生长抑制剂如抗癌剂。

108. 外观设计

USD569604S1 Footwear upper 有权
公开(公告)号：USD569604S1
公开(公告)日：2008-05-27
申请号：US29281228
申请日：2007-06-19
申请人： Kiyotaka Nakano
设计人： Kiyotaka Nakano

109. 外观设计

USD569603S1 Footwear upper 有权
公开(公告)号：USD569603S1
公开(公告)日：2008-05-27
申请号：US29281227
申请日：2007-06-19
申请人： Kiyotaka Nakano
设计人： Kiyotaka Nakano

110. 发明申请

US20070190599A1 Anti-glypican 3 antibody 有权
标题翻译：抗磷脂酰肌醇蛋白聚糖3抗体
公开(公告)号：US20070190599A1
公开(公告)日：2007-08-16
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
IPC分类号： C07K16/28 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译：公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。

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