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1. 发明授权

US08940488B2 Cancer diagnosis and treatment of cancer using anti-robo 1 antibody 有权
标题翻译：癌症诊断和治疗癌症使用抗robo 1抗体
公开(公告)号：US08940488B2
公开(公告)日：2015-01-27
申请号：US11547534
申请日：2005-03-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahshi , Yasuko Kinoshita
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahshi , Yasuko Kinoshita
IPC分类号： G01N33/53 , G01N33/574 , G01N33/576
CPC分类号： G01N33/57438 , C07K2317/732 , C07K2317/734 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57446 , G01N33/576
摘要： A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
摘要翻译：公开了一种诊断癌症的方法，包括检测ROBO1蛋白。另外，用于治疗由异常细胞生长引起的疾病的方法包括施用与ROBO1结合的抗体，以及药物组合物，细胞生长抑制剂和抗癌剂，其包含结合ROBO1作为有效成分的抗体的方法，披露此外，公开了通过使ROBO1表达细胞与与ROBO1结合的抗体接触来抑制ROBO1表达细胞中的细胞损伤的方法和抑制ROBO1表达细胞的生长的方法。此外，公开了通过检测ROBO1蛋白来监测肝炎进展的方法。

2. 发明申请

US20110082284A1 Gene overexpressed in cancer 审中-公开
标题翻译：基因在癌症中过表达
公开(公告)号：US20110082284A1
公开(公告)日：2011-04-07
申请号：US12807314
申请日：2010-08-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译：公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。本发明的基因和蛋白质可用于诊断和治疗癌症。

3. 发明申请

US20090192108A1 Gene overexpressed in cancer 有权
标题翻译：基因在癌症中过表达
公开(公告)号：US20090192108A1
公开(公告)日：2009-07-30
申请号：US12229750
申请日：2008-08-26
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： A61K31/7088 , C07K14/00 , C07K16/00 , C07H21/00 , C12N15/74 , C12N5/10 , G01N33/567 , C12Q1/68 , A61P35/00
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译：公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。本发明的基因和蛋白质可用于诊断和治疗癌症。

4. 发明申请

US20060186190A1 Banknote-processing device 失效
标题翻译：钞票处理装置
公开(公告)号：US20060186190A1
公开(公告)日：2006-08-24
申请号：US10564227
申请日：2004-07-29
申请人： Yukio Ito
发明人： Yukio Ito
IPC分类号： G07F19/00 , G06K13/00
CPC分类号： G07D11/0021
摘要： A banknote processing device where banknotes are stopped at a predetermined position of a stacker guide without being deformed. Braking means (4) is provided at a portion of a stacker guide (3), and the braking means (4) has a rolling body (7) producing a braking force in the advance direction of an inserted banknote without folding the banknote.
摘要翻译：一种纸币处理装置，其中纸币在堆积引导件的预定位置停止而不变形。制动装置（4）设置在堆垛机引导件（3）的一部分处，并且制动装置（4）具有在折叠纸币的同时在插入的纸币的前进方向产生制动力的滚动体（7）。

5. 发明申请

US20060167232A1 Antibody against n-terminal peptide or c-terminal peptide of gpc3 solubilized in blood 审中-公开
标题翻译：针对血液中gpc3的n末端肽或c-末端肽的抗体
公开(公告)号：US20060167232A1
公开(公告)日：2006-07-27
申请号：US10526741
申请日：2003-09-04
申请人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
发明人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/18 , C07K16/30 , C07K16/303 , C07K17/00 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/732 , C07K2317/734 , G01N33/57488
摘要： Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to determine whether a subject suffers from cancer, in particular hepatoma. Also disclosed is an antibody against GPC as well as a cell disrupting agent and an anti-cancer agent comprising the same, which can disrupt cells, in particular cancer cells.
摘要翻译：公开了一种能够检测测试样品中磷脂酰肌醇蛋白聚糖3（GPC3）分泌形式的分泌形式的GPC3的抗体。可以确定受试者是否患有癌症，特别是肝癌。还公开了针对GPC的抗体以及细胞破碎剂和包含该抗体的抗癌剂，其可破坏细胞，特别是癌细胞。

6. 发明申请

US20060113160A1 Bill processing apparatus 审中-公开
标题翻译：票据处理设备
公开(公告)号：US20060113160A1
公开(公告)日：2006-06-01
申请号：US11291035
申请日：2005-11-29
申请人： Noboru Yamagishi , Nobuyuki Iida , Yukio Ito
发明人： Noboru Yamagishi , Nobuyuki Iida , Yukio Ito
IPC分类号： G07F7/04
CPC分类号： G07F7/04
摘要： A bill processing apparatus which has a shutter portion for opening and closing a bill conveyance path and a stack portion for storing a bill guided along the bill conveyance path into a bill storage portion, and which includes a driver portion that causes a single drive portion (stack motor) to drive the shutter portion and the stack portion, in which the drive portion comprises a first driving member (a front end of a stack link) that drives the shutter portion and a second driving member (protruding face of the stack link) that drives the stack portion; and an unoperated region in which the shutter portion or the stack portion does not operate with respect to the operation of at least one of the first driving member and the second driving member.
摘要翻译：一种纸币处理装置，具有用于打开和关闭纸币输送路径的快门部分和用于将沿着纸币输送路径引导的纸币存储到纸币存储部分中的纸币部分，并且包括驱动部分，该驱动部分使单个驱动部分堆叠电动机）驱动快门部分和堆叠部分，其中驱动部分包括驱动快门部分的第一驱动部件（堆叠连杆的前端）和第二驱动部件（堆叠连杆的突出面）驱动堆叠部分; 以及未操作区域，其中所述活门部分或所述堆叠部分相对于所述第一驱动构件和所述第二驱动构件中的至少一个的操作不操作。

7. 发明授权

US06543763B2 Bank-note processing device 失效
公开(公告)号：US06543763B2
公开(公告)日：2003-04-08
申请号：US10006251
申请日：2001-12-04
申请人： Yukio Ito , Yasuyuki Kodama , Noboru Yamagishi , Tadashi Hatamachi
发明人： Yukio Ito , Yasuyuki Kodama , Noboru Yamagishi , Tadashi Hatamachi
IPC分类号： B65H2944
CPC分类号： B65H29/44 , B65H29/16 , B65H29/40 , B65H31/26 , B65H2403/5331 , B65H2404/6581 , B65H2404/6591 , B65H2404/725 , B65H2407/33 , B65H2701/1912 , G07D11/0012 , G07D11/0021 , G07D11/003 , G07F19/202
摘要： A bank-note processing device wherein disposed between a pair of rotary drums (22, 23) is a stacker lever (53) that presses that portion of the bank-note (31) inserted in bank-note guide slits (22b, 23b) which is positioned on the side of a bank-note reverse-flowing-preventive lever (32) toward a stacker (20) in operative association with the movement of a stacker chute (51), whereby even if a large number of wrinkled bank-notes are received in the stacker, jamming of bank-notes is minimized.

8. 发明授权

US06457586B2 Bank-note processing device 失效
标题翻译：银行票据处理装置
公开(公告)号：US06457586B2
公开(公告)日：2002-10-01
申请号：US09788190
申请日：2001-02-16
申请人： Shigeru Yasuda , Yukio Ito , Tadashi Hatamachi , Noboru Yamagishi , Kouji Akiba
发明人： Shigeru Yasuda , Yukio Ito , Tadashi Hatamachi , Noboru Yamagishi , Kouji Akiba
IPC分类号： B07C5344
CPC分类号： G07D7/04 , G07D7/12
摘要： A unit box (11) containing a bank-note conveyor belt unit (4) and a bank-note identifying unit (5) and not containing a bank-note accommodating unit, is provided in an openable and closable fashion with respect to a body (3) of a bank-note processing device (1), so that a conveyor belt (21) facing the side of a bank-note input opening (2) is exposed when the unit box (11) is opened.
摘要翻译：以相对于身体的开放和关闭的方式设置包含纸币传送带单元（4）和钞票识别单元（5）并且不包含纸币容纳单元的单元盒（11）（1）的纸币处理装置（3），使得当单位箱（11）打开时，面向纸币输入开口（2）侧的输送带（21）露出。

9. 发明授权

US6103208A Adsorbent for ethylene, method for adsorbing and removing ethylene and method for purifying an exhaust gas 有权
标题翻译：用于乙烯的吸附剂，用于吸附和除去乙烯的方法和净化废气的方法
公开(公告)号：US6103208A
公开(公告)日：2000-08-15
申请号：US429301
申请日：1999-10-28
申请人： Hiroshi Ogawa , Yukio Ito , Masao Nakano , Keiji Itabashi
发明人： Hiroshi Ogawa , Yukio Ito , Masao Nakano , Keiji Itabashi
IPC分类号： B01D53/94 , B01J20/18 , B01J8/02 , B01J8/00 , B01J21/00 , B01J29/06 , C01B21/00
CPC分类号： B01J20/186 , B01D53/9486 , B01D2253/108 , B01D2255/1023 , B01D2255/104
摘要： A method for purifying an exhaust gas by contacting the exhaust gas with an exhaust gas-purifying catalyst comprising a nitrogen oxide-removing catalyst and an adsorbent for ethylene comprising a zeolite which contains Ag, and also Pd, optionally which has a ferrierite structure.
摘要翻译：通过使排气与包含除氧化氮催化剂和含有Ag的沸石的乙烯吸附剂的废气净化催化剂进行净化排气的方法，以及任选地具有镁碱沸石结构的Pd。

10. 发明授权

US6007012A Fishing reel having a reversal preventative mechanism 失效
标题翻译：钓鱼卷轴具有反转预防机制
公开(公告)号：US6007012A
公开(公告)日：1999-12-28
申请号：US003522
申请日：1998-01-06
申请人： Yukio Ito
发明人： Yukio Ito
IPC分类号： A01K89/01 , A01K89/015 , A01K89/02
CPC分类号： A01K89/015 , A01K89/0117
摘要： The fishing reel comprises: a fishing line take-up drive mechanism (16) which is disposed in a reel main body (12) and drives a spool (10) so that the spool (10) takes up a fishing line therearound; a reversal preventive mechanism (18) which is disposed in the reel main body (12) and can be switched selectively between a reversal preventive state for preventing the reversal of the fishing line take-up drive mechanism in a fishing line play-out direction and a reversal allowable state for allowing the reversal of the fishing line take-up drive mechanism; and, a reversal prevention switching mechanism (22) which is disposed in the reel main body (12) and, by operating an operation part (20), switches the reversal preventive state and reversal allowable state of the reversal preventive mechanism over to each other. And, the reversal prevention switching mechanism holds the reversal preventive mechanism in the reversal preventive state while the operation part thereof is not operated, and can switch the reversal preventive mechanism from the reversal preventive state over to the reversal allowable state only when the operation part is operated.
摘要翻译：钓鱼卷轴包括：钓线吸收驱动机构（16），其设置在卷轴主体（12）中并驱动卷轴（10），使卷线筒（10）卷绕在其上; 反转防止机构（18），其布置在所述卷轴主体（12）中，并且可以在防止钓鱼线播放方向上的钓线卷取驱动机构反转的防止反转状态之间选择性地切换;以及允许反转钓线吸收驱动机构的反转允许状态; 并且，设置在卷轴主体（12）中并通过操作操作部（20）的反转防止切换机构（22）将反转防止机构的反转防止状态和反转允许状态切换到彼此。并且，防反转切换机构将防反转机构保持在反转防止状态，同时其操作部分不被操作，并且只有当操作部分是操作部分时，才将反转防止机构从反转预防状态转换到可反转允许状态操作。

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