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101. 发明授权

US07922663B2 Implantable ultrasound system for maintaining vessel patency and perfusion 有权
标题翻译：用于维持血管通畅和灌注的植入式超声系统
公开(公告)号：US07922663B2
公开(公告)日：2011-04-12
申请号：US11903735
申请日：2007-09-24
申请人： Binh C. Tran , Abhi Chavan , Rodney W. Salo , Jonathan Kwok
发明人： Binh C. Tran , Abhi Chavan , Rodney W. Salo , Jonathan Kwok
IPC分类号： A61B8/00
CPC分类号： A61B17/2202 , A61B2017/22027
摘要： An apparatus comprising an implantable acoustic transducer, an acoustic transducer interface circuit communicatively coupled to the acoustic transducer, and a controller circuit communicatively coupled to the acoustic transducer interface circuit. The controller is configured to, in response to receiving an indication of a patient condition associated with a development of a blood vessel obstruction, initiate delivery of acoustic energy that mitigates the blood vessel obstruction. Other systems and methods are described.
摘要翻译：包括可植入声学换能器，通信地耦合到声换能器的声换能器接口电路以及通信地耦合到声换能器接口电路的控制器电路的装置。控制器被配置为响应于接收到与血管阻塞的发展相关联的患者状况的指示，启动缓解血管阻塞的声能的传递。描述了其他系统和方法。

102. 发明授权

US07869881B2 Baroreflex stimulator with integrated pressure sensor 有权
标题翻译：具有集成压力传感器的Baroreflex刺激器
公开(公告)号：US07869881B2
公开(公告)日：2011-01-11
申请号：US10745921
申请日：2003-12-24
申请人： Imad Libbus , Rodney W. Salo
发明人： Imad Libbus , Rodney W. Salo
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/36057 , A61N1/36564
摘要： An aspect relates to an implantable medical device. An embodiment of the device comprises a pulse generator, sensor circuitry, a lead, and a controller. The pulse generator generates baroreflex stimulation pulses. The lead is adapted to be electrically connected to the pulse generator and to the sensor circuitry. The lead includes an electrode to distribute the baroreflex stimulation pulses to a baroreflex site and a pressure sensor to provide a signal indicative of blood pressure to the sensor circuitry. The controller is connected to the pulse generator and the sensor circuitry. The controller adapted to adjust the baroreflex stimulation pulses based on the blood pressure. Other aspects are provided herein.
摘要翻译：一个方面涉及可植入医疗装置。该装置的实施例包括脉冲发生器，传感器电路，引线和控制器。脉冲发生器产生压力反射刺激脉冲。引线适于电连接到脉冲发生器和传感器电路。引线包括用于将压力反射刺激脉冲分布到压力反射部位的电极和压力传感器，以向传感器电路提供指示血压的信号。控制器连接到脉冲发生器和传感器电路。控制器适于基于血压调节压力反射刺激脉冲。本文提供了其他方面。

103. 发明申请

US20090024047A1 DEVICES AND METHODS FOR RESPIRATION THERAPY 审中-公开
标题翻译：用于呼吸治疗的装置和方法
公开(公告)号：US20090024047A1
公开(公告)日：2009-01-22
申请号：US11780861
申请日：2007-07-20
申请人： Robert D. Shipley , Rodney W. Salo
发明人： Robert D. Shipley , Rodney W. Salo
IPC分类号： A61B5/08 , A61B5/00 , A61F2/02
CPC分类号： A61N1/3601 , A61B5/0031 , A61B5/0816 , A61B5/113 , G06Q50/24
摘要： Embodiments of the invention are related to devices and methods for respiration therapy, amongst other things. In an embodiment, the invention includes a system for providing respiration therapy to a patient, including an implantable device comprising a chronically implanted respiration sensor, the respiration sensor configured to generate a signal indicative of respiration rate of the patient; and an external interface device in communication with the implantable device, the external interface device comprising an output device and configured to deliver respiration therapy to the patient, the respiration therapy comprising one or more breathing prompts generated by the output device. In an embodiment, the invention includes a method for providing respiration therapy to a patient. In an embodiment, the invention includes a method of monitoring a heart failure patient for decompensation events. Other aspects and embodiments are provided herein.
摘要翻译：除了别的以外，本发明的实施例涉及用于呼吸治疗的装置和方法。在一个实施例中，本发明包括用于向患者提供呼吸治疗的系统，包括可植入装置，其包括长期植入的呼吸传感器，所述呼吸传感器被配置为产生指示患者呼吸速率的信号; 以及与所述可植入装置通信的外部接口装置，所述外部接口装置包括输出装置并且被配置为向所述患者递送呼吸治疗，所述呼吸治疗包括由所述输出装置产生的一个或多个呼吸提示。在一个实施例中，本发明包括用于向患者提供呼吸治疗的方法。在一个实施例中，本发明包括监测失败患者的失代偿事件的方法。本文提供了其它方面和实施例。

104. 发明申请

US20080275350A1 SYSTEM FOR ANCHORING AN IMPLANTABLE SENSOR IN A VESSEL 有权
标题翻译：用于在船舶中锚固可移动传感器的系统
公开(公告)号：US20080275350A1
公开(公告)日：2008-11-06
申请号：US12103963
申请日：2008-04-16
申请人： Wangcai Liao , Bin Mi , Rodney W. Salo
发明人： Wangcai Liao , Bin Mi , Rodney W. Salo
IPC分类号： A61B5/0215 , A61M29/00
CPC分类号： A61B5/02152 , A61B5/6862 , A61B5/6876 , A61B5/6882
摘要： A system and a method of disposing a second sensor module overlying a first sensor module system is described. A first assembly including an expandable anchor and a sensor module is at least partially overlapped by a second assembly including an expandable anchor and a sensor module. If necessary or desired, the functions of the second sensor module can replace the functions of the first sensor module. The sensor module may include a blood pressure sensor.
摘要翻译：描述了布置覆盖在第一传感器模块系统上的第二传感器模块的系统和方法。包括可扩张锚和传感器模块的第一组件至少部分地由包括可扩张锚和传感器模块的第二组件重叠。如果需要或需要，第二传感器模块的功能可以替代第一传感器模块的功能。传感器模块可以包括血压传感器。

105. 发明授权

US06973349B2 Method and apparatus for minimizing post-infarct ventricular remodeling 有权
公开(公告)号：US06973349B2
公开(公告)日：2005-12-06
申请号：US10005184
申请日：2001-12-05
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/05 , A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.

106. 发明授权

US4911174A Method for matching the sense length of an impedance measuring catheter to a ventricular chamber 失效
标题翻译：将阻抗测量导管的感测长度与心室的匹配的方法
公开(公告)号：US4911174A
公开(公告)日：1990-03-27
申请号：US309221
申请日：1989-02-13
申请人： Brian D. Pederson , Rodney W. Salo
发明人： Brian D. Pederson , Rodney W. Salo
IPC分类号： A61B10/00 , A61B5/042 , A61B5/05 , A61B5/053 , A61B5/107
CPC分类号： A61B5/0538 , A61B5/042 , A61B5/0422 , A61B5/0535 , A61B2562/0209 , A61B2562/043
摘要： A method for matching the distance spanned by a plurality of surface electrodes on an impedance measuring catheter to the size of a ventricular chamber to be measured is disclosed. The catheter includes a plurality of longitudinally spaced electrodes extending from its distal end and spanning a distance known to be greater than the maximum length of a ventricular chamber. With the distal end of the catheter located at the apex of the ventricle, an AC drive signal is applied between the distal electrode and a proximal electrode known to be outside of the ventricle. By then sensing the resulting voltage between successive adjacent electrode pairs and comparing same, the pair where a different characteristic is exhibited is known to be at the transition between the ventricle and the atrium.

107. 发明授权

US4674518A Method and apparatus for measuring ventricular volume 失效
标题翻译：测量心室容量的方法和装置
公开(公告)号：US4674518A
公开(公告)日：1987-06-23
申请号：US773048
申请日：1985-09-06
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61B5/05 , A61B5/029 , A61B5/103 , A61B5/107 , G01F17/00 , A61B5/04
CPC分类号： A61B5/1073 , A61B5/029 , A61B5/0295 , G01F17/00
摘要： A method and apparatus for the instantaneous measurement of venticular volume using an intracavity electrical impedance catheter having plural pairs of spaced surface electrodes driven by a corresponding plurality of electrical signals, each of the signals exhibiting a different discrete frequency, and having plural pairs of spaced surface electrodes for sensing the potentials at predetermined locations within the ventricle. Switching means are provided for selectively coupling the drive signals to predetermined pairs of surface electrodes and for selecting the sensing electrode pairs to be utilized at any given time for read-back of the sensed potentials. The read-back signals are demodulated and converted from an analog signal to a digital quantity. Then, a digital computer is used to determine from the sensed digital quantities the extrapolated value of impedance corresponding to sources spaced an infinite distance apart. Knowing the extrapolated impedance value, the volume of blood in the ventricle can be computed using the formula V=.rho.L.sup.2 /R.sub.0 wherein R.sub.0 is the extrapolated impedance value, L is the distance between the spaced sensing electrodes spanning the ventricle and .rho. is the resistivity of the blood.
摘要翻译：一种用于使用腔内电阻抗导管瞬时测量通气量的方法和装置，其具有由相应的多个电信号驱动的多对间隔表面电极，每个信号呈现不同的离散频率，并且具有多对间隔表面用于感测心室内预定位置处的电位的电极。提供开关装置，用于选择性地将驱动信号耦合到预定的一对表面电极，并用于选择在任何给定时间用于读出感测电位的感测电极对。回读信号被解调并从模拟信号转换成数字量。然后，使用数字计算机从感测的数字量中确定对应于间隔无限距离的源的阻抗的外推值。知道外插阻抗值，可以使用公式V = rho L2 / R0计算心室内血液的体积，其中R0是外推阻抗值，L是跨越心室的间隔感应电极之间的距离，rho是电阻率的血液

108. 发明授权

US08612001B2 Method and apparatus for minimizing post-infarct ventricular remodeling 失效
标题翻译：用于最小化梗死后心室重塑的方法和装置
公开(公告)号：US08612001B2
公开(公告)日：2013-12-17
申请号：US13034560
申请日：2011-02-24
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.
摘要翻译：心脏节律管理装置，其中预激励起搏应用于心室心肌梗死区域附近的一个或多个部位。这种起搏服务器可以预防或最小化梗死后重塑。

109. 发明授权

US08295928B2 Pre-excitation pacing for treatment of hypertension 有权
标题翻译：预激发起搏治疗高血压
公开(公告)号：US08295928B2
公开(公告)日：2012-10-23
申请号：US13279503
申请日：2011-10-24
申请人： Rodney W. Salo , Robert Shipley
发明人： Rodney W. Salo , Robert Shipley
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564
摘要： Described herein are methods and apparatus for treating hypertension with electrical pre-excitation pacing therapy. Electrical pre-excitation of a hypertrophic region advances the timing of the regional contraction and reduces its contribution to the overall contraction. Such pre-excitation pacing therapy may be beneficial to hypertensive patients with an abnormal distribution of ventricular wall stress/strain.
摘要翻译：本文描述了用电预激发起步疗法治疗高血压的方法和装置。增生区域的电预激发促进了区域收缩的时机，并减少了其对整体收缩的贡献。这种预激励起搏治疗可能有益于心室壁应力/应变异常分布的高血压患者。

110. 发明申请

US20120041505A1 PRE-EXCITATION PACING FOR TREATMENT OF HYPERTENSION 有权
标题翻译：用于治疗高血压的预激活剂
公开(公告)号：US20120041505A1
公开(公告)日：2012-02-16
申请号：US13279503
申请日：2011-10-24
申请人： Rodney W. Salo , Robert Shipley
发明人： Rodney W. Salo , Robert Shipley
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564
摘要： Described herein are methods and apparatus for treating hypertension with electrical pre-excitation pacing therapy. Electrical pre-excitation of a hypertrophic region advances the timing of the regional contraction and reduces its contribution to the overall contraction. Such pre-excitation pacing therapy may be beneficial to hypertensive patients with an abnormal distribution of ventricular wall stress/strain.
摘要翻译：本文描述了用电预激发起步疗法治疗高血压的方法和装置。增生区域的电预激发促进了区域收缩的时机，并减少了其对整体收缩的贡献。这种预激励起搏治疗可能有益于心室壁应力/应变异常分布的高血压患者。

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