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101. 发明授权

US4817013A Multichannel gas analyzer and method of use 失效
标题翻译：多通道气体分析仪及其使用方法
公开(公告)号：US4817013A
公开(公告)日：1989-03-28
申请号：US922043
申请日：1986-10-17
申请人： James E. Corenman , James R. Braig , Daniel S. Goldberger , Emil P. Rojas , James H. Stone
发明人： James E. Corenman , James R. Braig , Daniel S. Goldberger , Emil P. Rojas , James H. Stone
IPC分类号： G01N21/31 , G01N21/35 , G01N21/64
CPC分类号： G01N21/3504 , G01N2021/3129 , G01N2201/121
摘要： An improved gas analyzer system (FIG. 1) and method of use for detecting and displaying the constituent gases of a respiratory gas stream, the system comprising an optical bench (109) through which a respiratory gas flows and in which measurements of the gas are taken; analog input circuits (122) for receiving signals output from the optical bench (109); analog processing circuits (124) for processing signals output from the analog input circuits (122); display processing circuits (128) for processing the signals output from the analog processing circuits (124) and other system circuitry; pixel logic circuits/analog outputs (130) for processing signals output from the display processing circuitry (128) and providing analog output ports; a five button panel (148), an alarm-knob board (144), and a speaker driver (152) for operator interface and activation of audible and visual alarms; a CRT driver for driving the CRT; and a power supply (158) for powering the system.
摘要翻译：一种改进的气体分析器系统（图1）和用于检测和显示呼吸气流的组成气体的方法，该系统包括一个光学平台（109），呼吸气体通过该工作台流动，其中气体的测量是采取模拟输入电路（122），用于接收从光学平台（109）输出的信号; 模拟处理电路（124），用于处理从模拟输入电路（122）输出的信号; 显示处理电路（128），用于处理从模拟处理电路（124）和其它系统电路输出的信号; 用于处理从显示处理电路（128）输出的信号并提供模拟输出端口的像素逻辑电路/模拟输出（130）五按钮面板（148），报警旋钮板（144）和扬声器驱动器（152），用于操作者界面和激活声音和视觉报警器; 用于驱动CRT的CRT驱动器; 以及用于为系统供电的电源（158）。

102. 发明申请

US20130165900A1 FLUID COMPONENT ANALYSIS SYSTEMS AND METHODS FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20130165900A1
公开(公告)日：2013-06-27
申请号：US13619825
申请日：2012-09-14
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/172
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

103. 发明申请

US20110313318A1 SYSTEMS AND METHODS TO REDUCE FLUID CONTAMINATION 有权
标题翻译：减少流体污染的系统和方法
公开(公告)号：US20110313318A1
公开(公告)日：2011-12-22
申请号：US13162315
申请日：2011-06-16
申请人： Peter Rule , James R. Braig , Richard Keenan , David N. Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan , David N. Callicoat
IPC分类号： A61B5/15
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/1459 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/157 , A61B5/6866 , A61M5/1415 , A61M5/1452 , A61M5/1723 , A61M2005/14208 , A61M2205/3331 , A61M2205/50 , A61M2205/52 , A61M2230/201
摘要： Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.
摘要翻译：描述了用于测定来自样品如血液或血浆的一种或多种分析物的浓度的方法和系统。本文描述的系统可以被配置为从体液源抽出一定体积的样品，将抽出的样品的第一部分引导到分析物监测系统，并将样品的第二部分返回给患者。分析物监测系统可以包括自动采血系统，其被配置为以低压和/或撤出速率从患者的脉管系统中提取血液，以便减少或防止从输注流体中排出的流体的污染。

104. 发明申请

US20110190606A1 FLUID HANDLING CASSETTE 有权
标题翻译：流体处理CASSETTE
公开(公告)号：US20110190606A1
公开(公告)日：2011-08-04
申请号：US13046611
申请日：2011-03-11
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/157
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.
摘要翻译：提供了可移除地与体液分析器接合的流体处理模块。模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。流体处理元件可以具有至少一个控制元件接口。

105. 发明申请

US20110011167A1 FLUID HANDLING CASSETTE WITH A FLUID CONTROL INTERFACE AND SAMPLE SEPARATOR 有权
标题翻译：具有流体控制界面和样品分离器的流体处理箱
公开(公告)号：US20110011167A1
公开(公告)日：2011-01-20
申请号：US11316676
申请日：2005-12-21
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： G01N1/10
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.
摘要翻译：提供了可移除地与体液分析器接合的流体处理模块。模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。流体处理元件可以具有至少一个控制元件接口。

106. 发明申请

US20100331754A1 Method and Systems for Controlling Ultrafiltration Using Central Venous Pressure Measurements 审中-公开
标题翻译：使用中央静脉压测量控制超滤的方法和系统
公开(公告)号：US20100331754A1
公开(公告)日：2010-12-30
申请号：US12875888
申请日：2010-09-03
申请人： Barry N. Fulkerson , James R. Braig , Victor Gura
发明人： Barry N. Fulkerson , James R. Braig , Victor Gura
IPC分类号： A61M1/16
CPC分类号： A61M1/3653 , A61B5/02152 , A61B5/412 , A61M1/3659 , A61M1/3661 , A61M2230/30 , B01D61/22 , B01D61/32
摘要： The volume of fluid removed from a patient during ultrafiltration is controlled automatically on the basis of central venous pressure (CVP) measurements. In one embodiment, a central venous catheter (CVC) is used for accessing blood during dialysis. A sensor located at the tip of the catheter or inside the dialysis machine is used to periodically measure CVP. CVP feedback data helps prevent the excessive removal of fluids from the patient.
摘要翻译：基于中心静脉压（CVP）测量自动控制在超滤期间从患者移除的流体体积。在一个实施例中，中心静脉导管（CVC）用于在透析期间接近血液。位于导管尖端或透析机内部的传感器用于定期测量CVP。 CVP反馈数据有助于防止患者过度去除液体。

107. 发明申请

US20090192367A1 ANALYTE DETECTION SYSTEM WITH PERIODIC SAMPLE DRAW AND BODY FLUID ANALYZER 审中-公开
标题翻译：具有周期性抽样和体液分析仪的分析检测系统
公开(公告)号：US20090192367A1
公开(公告)日：2009-07-30
申请号：US12343421
申请日：2008-12-23
申请人： James R. Braig , Peter Rule
发明人： James R. Braig , Peter Rule
IPC分类号： A61B5/15
CPC分类号： A61B5/1486 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B2562/0295 , A61M5/14232 , A61M2005/1726 , A61M2230/201 , G01N27/3271 , G01N33/49
摘要： An embodiment of a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.
摘要翻译：用于分析患者体液的系统的实施例包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。泵系统耦合到流体输送网络。泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体运输网络通过病人端。至少一个电化学测试元件位于流体输送网络的流体输送点附近。电化学测试元件被定位成接收由流体输送网络输送到输送点的体液的一部分。分析物检测系统被配置为接收测试元件并测量体液部分中的至少一种分析物。

108. 发明申请

US20090076434A1 Method and System for Achieving Volumetric Accuracy in Hemodialysis Systems 审中-公开
标题翻译：用于实现血液透析系统体积精度的方法和系统
公开(公告)号：US20090076434A1
公开(公告)日：2009-03-19
申请号：US12210080
申请日：2008-09-12
申请人： David J. Mischelevich , James R. Braig , Thomas P. Robinson , Milan V. Treka , Barry N. Fulkerson , Cherles E. Clemens , Russ T. Joseph , Clark B. Foster
发明人： David J. Mischelevich , James R. Braig , Thomas P. Robinson , Milan V. Treka , Barry N. Fulkerson , Cherles E. Clemens , Russ T. Joseph , Clark B. Foster
IPC分类号： A61M1/34
CPC分类号： A61M1/3441 , A61M1/3486
摘要： Volumetric accuracy in hemodialysis systems is provided by swapping pumps between the replacement fluid side and the output side for a hemofiltration system and between the return fluid side and the sorbent side for a closed-loop, sorbent-based system, such that same quantity of fluid is pumped at each point after the end of an even number of pump swaps. A method for calculating the time interval between swaps is provided based on an allowable difference in amount pumped in the two functions at any given time. A mechanism is provided for compensating for the differences in head pressure presented to the pumps for fluid coming from the replacement-fluid containers or the reservoir and that coming back from the patient through the dialyzer. The pump-swapping system provides an accurate means that can be inexpensively implemented, including using a disposable device.
摘要翻译：在血液透析系统中的体积精度通过在用于血液滤过系统的置换流体侧和输出侧之间以及在返回流体侧和吸附剂侧之间交换泵来提供闭环的基于吸附剂的系统，使得相同量的流体在偶数个泵交换结束后的每个点泵送。基于在任何给定时间在两个功能中泵送的数量的允许差异来提供用于计算互换之间的时间间隔的方法。提供了一种机构，用于补偿来自更换流体容器或储存器的流体的泵头压力差异以及从患者通过透析器返回的头部压力的差异。泵交换系统提供了可以廉价实施的精确装置，包括使用一次性装置。

109. 发明授权

US07061593B2 Device and method for in vitro determination of analyte concentrations within body fluids 失效
公开(公告)号：US07061593B2
公开(公告)日：2006-06-13
申请号：US10219627
申请日：2002-08-14
申请人： James R. Braig , Peter Rule , Philip C. Hartstein
发明人： James R. Braig , Peter Rule , Philip C. Hartstein
IPC分类号： G01N33/48
CPC分类号： A61B5/01 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

110. 发明授权

US06825044B2 Method for adjusting a blood analyte measurement 失效
标题翻译：用于调节血液分析物测量的方法
公开(公告)号：US06825044B2
公开(公告)日：2004-11-30
申请号：US10301927
申请日：2002-11-21
申请人： Peng Zheng , Jennifer H. Gable , W. Dale Hall , Kenneth G. Witte , James R. Braig
发明人： Peng Zheng , Jennifer H. Gable , W. Dale Hall , Kenneth G. Witte , James R. Braig
IPC分类号： G01N2164
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. A transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation is provided. Phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. A method for adjusting an analyte measurement is provided. The method provides a hydration correction process for calibration and correction whereby analyte concentrations within the material sample may be determined. The hydration correction process is particularly suitable for determining blood analyte concentrations within human tissue.
摘要翻译：提供了用于确定材料样品中的分析物浓度的装置和方法。在样品中诱导调制温度梯度，并在所选分析物的吸收峰和参考波长处测量发射的红外辐射。调制温度梯度由表面温度调制控制。提供了将表面温度调制与测量的红外辐射的调制相关联的传递函数。检测传递函数的相位和幅度差异。测量，相关和处理与分析物浓度有关的这些相位和幅度差异，以确定材料样品中的分析物浓度。提供了一种用于调节分析物测量的方法。该方法提供用于校准和校正的水合校正过程，从而可以确定材料样品中的分析物浓度。水合校正过程特别适用于测定人体组织内的血液分析物浓度。

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