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101. 发明授权

US07308307B1 Implantable single-chamber atrial pacing device providing active ventricular far field sensing and rate limit 有权
标题翻译：可植入的单室心房起搏装置，提供主动心室远场感测和速率限制
公开(公告)号：US07308307B1
公开(公告)日：2007-12-11
申请号：US10792207
申请日：2004-03-02
申请人： Xing Pei , Mark W. Kroll
发明人： Xing Pei , Mark W. Kroll
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/365
摘要： A maximum pacing rate is dynamically established during single-chamber atrial pacing of a heart by a rate control system within a single-chamber or dual-chamber cardiac stimulation device which paces the atria of a heart on demand at the end of an escape interval. The system includes a detector that detects an atrial activation of the heart and an R wave of the heart corresponding to the detected atrial activation. The system further includes a rate limit circuit that determines a minimum RA interval and extends the escape interval to an extended escape interval to end with the minimum RA interval.
摘要翻译：在单室或双室心脏刺激装置中的速率控制系统在心脏的单室心房起搏期间动态地建立最大起搏速率，其在逃逸间隔结束时根据需要对心脏的心房进行起搏。该系统包括检测心脏的心房激活和对应于检测到的心房激活的心脏的R波的检测器。所述系统还包括速率限制电路，其确定最小RA间隔并且将逃生间隔延伸到扩展逃逸间隔以最小RA间隔结束。

102. 发明授权

US07305270B1 Cardiac pacing/sensing lead providing far-field signal rejection 失效
标题翻译：心脏起搏/感应引线提供远场信号抑制
公开(公告)号：US07305270B1
公开(公告)日：2007-12-04
申请号：US11112508
申请日：2005-04-21
申请人： Mark W. Kroll , John R. Helland
发明人： Mark W. Kroll , John R. Helland
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573 , A61N1/3702 , A61N1/3704
摘要： A proximal end of a lead body carries a connector assembly. A first electrical conductor within the lead body electrically connects a tip electrode to a first electrical contact on the connector assembly. A collar electrode is carried by a distal end portion of the lead body. A second electrical conductor within the lead body electrically connects the collar electrode to a second electrical contact on the connector assembly. A ring electrode, carried by the distal end portion of the lead body, is disposed proximally of the collar electrode in spaced-apart relationship thereto and is connected through a switching device to a node point along the first conductor. The switching device has a first state permitting an electrical current to be conducted between the ring electrode and the node point and a second state in which the ring electrode is electrically isolated from the node point. Preferably, the switching device comprises a diode.
摘要翻译：引线体的近端承载连接器组件。引线体内的第一电导体将尖端电极与连接器组件上的第一电触点电连接。凸缘电极由引线体的远端部分承载。引线体内的第二电导体将接头电极电连接到连接器组件上的第二电触头。由引线体的远端部分承载的环形电极以与其成间隔开的关系设置在套环电极的近侧，并且通过开关装置连接到沿着第一导体的节点。开关器件具有允许电流在环形电极和节点之间传导的第一状态和环形电极与节点电气隔离的第二状态。优选地，开关装置包括二极管。

103. 发明授权

US07305266B1 Cardiac stimulation devices and methods for measuring impedances associated with the heart 有权
标题翻译：用于测量与心脏相关的阻抗的心脏刺激装置和方法
公开(公告)号：US07305266B1
公开(公告)日：2007-12-04
申请号：US10881676
申请日：2004-06-29
申请人： Mark W. Kroll
发明人： Mark W. Kroll
IPC分类号： A61N1/368
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/7285 , A61N1/0504 , A61N1/056 , A61N1/375 , A61N1/3962
摘要： An exemplary method includes introducing current between a first pair of electrodes configured for placement internally in a patient, triggering a potential measurement between a second pair of electrodes configured for placement internally in a patient wherein communication of a signal through the patient allows for proper triggering, measuring potential between the second pair of electrodes and, based at least in part on the measuring and the introducing, determining a cardiac condition. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括在第一对电极之间引入电流，所述第一对电极被配置为在患者体内放置，触发被配置用于放置在患者内部的第二对电极之间的电位测量，其中通过患者的信号通信允许适当的触发，测量第二对电极之间的电位，并且至少部分地基于测量和引入来确定心脏状况。还公开了其它示例性方法，装置，系统等。

104. 发明授权

US07272438B2 Mode switching heart stimulation apparatus and method 有权
标题翻译：模式切换心脏刺激装置及方法
公开(公告)号：US07272438B2
公开(公告)日：2007-09-18
申请号：US10964226
申请日：2004-10-12
申请人： Mark W. Kroll , Paul A. Levine
发明人： Mark W. Kroll , Paul A. Levine
IPC分类号： A61B5/0464
CPC分类号： A61N1/3622
摘要： In a heart stimulation device a mode of operation is switched in response to detection of atrial tachyarrhythmia such as atrial fibrillation. The stimulation device may initially operate in a normal mode of pacing then, upon detection of atrial tachyarrhythmia, the stimulation device may change how it senses signals and it may switch to another mode of pacing at one or more sites in the ventricle.
摘要翻译：在心脏刺激装置中，响应于房颤如心房颤动的心房快速性心律失常的检测而切换手术模式。刺激装置可以起初以正常的起搏方式进行操作，然后，在检测到心房快速性心律失常时，刺激装置可以改变其如何感测信号，并且可以切换到心室中一个或多个部位的另一种起搏模式。

105. 发明授权

US07254440B1 Implantable ischemia and myocardial infarction monitor and method 有权
标题翻译：植入性缺血和心肌梗死监测和方法
公开(公告)号：US07254440B1
公开(公告)日：2007-08-07
申请号：US10765508
申请日：2004-01-26
申请人： Mark W. Kroll
发明人： Mark W. Kroll
IPC分类号： A61B5/0452 , A61B5/0468
CPC分类号： A61B5/0452 , A61B5/0468 , A61B5/7242
摘要： An implantable ischemia detecting devices generates a plurality of electrograms for analysis. A processor integrates the ST segment and T wave of each electrogram and normalizes the resulting integral by a normalizing factor to provide a ST segment score and T wave score, respectively. The ST segment and T wave scores are then utilized to compute a total ST segment and T wave score for analysis in detecting or monitoring ischemia of a patient's heart.
摘要翻译：可植入缺血检测装置产生多个用于分析的电描记图。处理器整合每个电图的ST段和T波，并通过归一化因子对所得积分进行归一化，分别提供ST段得分和T波得分。然后利用ST段和T波分数计算总ST段和T波分数，用于检测或监测患者心脏缺血。

106. 发明授权

US07225020B1 System and method for providing preventive overdrive pacing and antitachycardia pacing using an implantable cardiac stimulation device 失效
标题翻译：使用可植入心脏刺激装置提供预防性超速起搏和抗心动过速起搏的系统和方法
公开(公告)号：US07225020B1
公开(公告)日：2007-05-29
申请号：US10657963
申请日：2003-09-08
申请人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
发明人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
IPC分类号： A61N1/05
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3682 , A61N1/3714 , A61N1/3956 , A61N2001/0585
摘要： Techniques for enabling both preventive overdrive pacing and antitachycardia pacing (ATP) within an implantable device are provided. The device gains the benefits of overdrive pacing for preventing the onset of a tachycardia and, if one nevertheless occurs, ATP is employed to terminate the tachycardia. In particular, a technique is provided for promptly detecting the onset of atrial tachycardia during preventive overdrive pacing based on loss of capture of atrial pacing pulses. A technique is also provided for using detection of loss of capture of atrial or ventricular pacing pulses to trigger automatic switching from overdrive pacing to ATP. A setup technique determines whether to enable the automatic switching from overdrive pacing to ATP within a particular patient. Also, techniques are provided for verifying loss of capture of atrial or ventricular backup pacing pulses and for detecting low amplitude ventricular fibrillation based on loss of capture of ventricular backup pacing pulses.
摘要翻译：提供了在植入式装置内实现预防性超速起搏和抗心动过速起搏（ATP）的技术。该装置获得超速起搏的好处，以防止心动过速的发作，并且如果仍然发生，则使用ATP来终止心动过速。特别地，提供了一种技术，用于基于心房起搏脉冲的捕获损失，在预防性超速起搏中及时检测心房心动过速的发生。还提供了一种技术，用于检测心房或心室起搏脉冲的捕获损失，以触发从过速起搏到ATP的自动切换。设置技术确定是否启用在特定患者内从过速起搏到ATP的自动切换。此外，提供了用于验证心房或心室起搏脉冲的捕获损失的技术，并且用于基于心室起搏脉冲捕获的丧失来检测低振幅心室颤动。

107. 发明授权

US07212855B1 System and method for providing preventive overdrive pacing and antitachycardia pacing using an implantable cardiac stimulation device 失效
公开(公告)号：US07212855B1
公开(公告)日：2007-05-01
申请号：US10657878
申请日：2003-09-08
申请人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
发明人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
IPC分类号： A61N1/05
CPC分类号： A61N1/3622 , A61N1/3712 , A61N1/3714
摘要： Techniques for enabling both preventive overdrive pacing and antitachycardia pacing (ATP) within an implantable device are provided. The device gains the benefits of overdrive pacing for preventing the onset of a tachycardia and, if one nevertheless occurs, ATP is employed to terminate the tachycardia. In particular, a technique is provided for promptly detecting the onset of atrial tachycardia during preventive overdrive pacing based on loss of capture of atrial pacing pulses. A technique is also provided for using detection of loss of capture of atrial or ventricular pacing pulses to trigger automatic switching from overdrive pacing to ATP. A setup technique determines whether to enable the automatic switching from overdrive pacing to ATP within a particular patient. Also, techniques are provided for verifying loss of capture of atrial or ventricular backup pacing pulses and for detecting low amplitude ventricular fibrillation based on loss of capture of ventricular backup pacing pulses.

108. 发明授权

US07175271B2 Tan-thru glasses 有权
标题翻译：谭眼镜
公开(公告)号：US07175271B2
公开(公告)日：2007-02-13
申请号：US11057949
申请日：2005-02-14
申请人： Mark W. Kroll , Lori C. Kroll
发明人： Mark W. Kroll , Lori C. Kroll
IPC分类号： G02C7/10
CPC分类号： A41D13/0125 , A41D31/0038 , A41D2400/14 , A41D2400/26 , A41D2400/28 , A42B3/12 , A45B25/18 , A45B2025/183 , A61N5/06 , A61N5/0614 , A61N2005/0645 , A61N2005/0648 , B63C9/125 , B63C9/1255 , B63C9/20 , G02B5/208 , G02B5/223 , G02C5/00 , G02C7/10
摘要： Sunglasses with securement bows which are somewhat transmissive to ultraviolet light are taught which allow outdoor exposure without the sharp untanned lines normally seen on the side of the wearer's head. Eyeglasses with securement bows which are somewhat transmissive to ultraviolet light are taught which allow outdoor exposure without the sharp untanned lines normally seen on the side of the wearer's head. Eyeglasses and sunglasses with ultraviolet transmitting nose bridges are also taught.
摘要翻译：教导具有对紫外线有些透射的固定弓的太阳眼镜，这允许户外曝光，而没有通常在佩戴者头部一侧看到的尖锐的未穿线。教导具有对紫外线有些透射的固定弓的眼镜，这允许户外曝光，而没有通常在佩戴者头部一侧看到的尖锐的未穿线。还教授了具有紫外线透射鼻梁的眼镜和太阳眼镜。

109. 发明授权

US07164944B1 Analgesic therapy for ICD patients 有权
标题翻译： ICD患者镇痛治疗
公开(公告)号：US07164944B1
公开(公告)日：2007-01-16
申请号：US10417477
申请日：2003-04-15
申请人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
发明人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61N1/36071
摘要： An exemplary method includes delivering a therapy selected from tiered therapies that include cardioversion and/or defibrillation therapies wherein the delivered therapy aims to treat a cardiac condition, delivering analgesic stimulation, determining whether the delivered therapy successfully treated the cardiac condition, and responsive to the determining, changing one or more analgesic stimulation parameters. Various other exemplary methods and/or devices capable of performing such methods are also disclosed.
摘要翻译：示例性方法包括递送选自包括心脏复律和/或除颤疗法的分层治疗的治疗，其中递送的治疗旨在治疗心脏病症，递送镇痛刺激，确定递送的治疗是否成功治疗了心脏病症，并且响应于确定改变一个或多个镇痛刺激参数。还公开了能够执行这些方法的各种其它示例性方法和/或装置。

110. 发明授权

US07139611B1 System and method for rejecting far-field signals using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置排除远场信号的系统和方法
公开(公告)号：US07139611B1
公开(公告)日：2006-11-21
申请号：US10430039
申请日：2003-05-05
申请人： Mark W. Kroll , Peter Boileau
发明人： Mark W. Kroll , Peter Boileau
IPC分类号： A61N1/05
CPC分类号： A61N1/368 , A61N1/056 , A61N2001/0585
摘要： A technique is provided for filtering far-field electrical cardiac signals from near-field signals. Atrial tip and ring signals are sensed using unipolar electrodes and any timing differences between corresponding events within the signals are detected. Then, far-field signals are filtered from the tip and ring signals based on the detected timing differences, such that substantially only near-field atrial signals remain. The technique exploits the fact that near-field atrial signals are sensed when a conduction wave passes by the atrial electrodes. In contrast, far-field signals from the ventricles propagate to the atrium at near the speed of light. Hence, any significant timing difference between corresponding events appearing in the atrial signals is indicative of a near-field event, whereas the lack of a significant timing difference is indicative of a far-field event. In one example, a sense amplifier is provided with a Boolean logic circuit to aid in time delay-based filtering.
摘要翻译：提供了用于从近场信号过滤远场电心脏信号的技术。使用单极电极感测心尖和环形信号，并检测信号内相应事件之间的任何定时差异。然后，基于检测到的定时差，从尖端和环形信号过滤远场信号，使得基本上只有近场心房信号保留。该技术利用了当导电波通过心房电极时感测近场心房信号的事实。相比之下，来自心室的远场信号在光速附近传播到心房。因此，出现在心房信号中的相应事件之间的任何显着的定时差异表示近场事件，而缺乏有效定时差异是指示远场事件。在一个示例中，读出放大器设置有布尔逻辑电路以辅助基于时间延迟的滤波。

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