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101. 发明申请

US20100081643A1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS 有权
标题翻译：新型循环苄嘧啶衍生物作为抗糖尿病药物有用
公开(公告)号：US20100081643A1
公开(公告)日：2010-04-01
申请号：US12563782
申请日：2009-09-21
申请人： BRETT C. BOOKSER , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
发明人： BRETT C. BOOKSER , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
IPC分类号： A61K31/4184 , C07D235/26 , C07D403/12 , C07D401/12 , C07D413/10 , A61K31/397 , A61K31/44 , A61K31/5025 , A61K31/4439 , A61P3/00 , A61P9/00
CPC分类号： C07D235/26 , C07D235/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译：结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。

102. 发明申请

US20090312695A1 Automatic Heart Rate Triggering of Injection of Radiopharmaceuticals for Nuclear Stress Test 审中-公开
标题翻译：用于核应力测试的放射性药物注射的自动心率触发
公开(公告)号：US20090312695A1
公开(公告)日：2009-12-17
申请号：US12522179
申请日：2008-01-07
申请人： David Wilson , Elaine Borgemenke
发明人： David Wilson , Elaine Borgemenke
IPC分类号： A61M5/172 , A61M5/142 , A61M36/06
CPC分类号： A61M5/1723 , A61B5/0245 , A61B5/4884 , A61M5/14244 , A61M2230/06
摘要： A radiopharmaceutical injection system having a powered injector that includes radiation shielding, a biometric sensor, and a controller communicatively interconnected with both the powered injector and the biometric sensor. The controller may be configured to control the powered injector in response to a signal from the biometric sensor that indicates a biometric parameter is within a target range.
摘要翻译：一种具有动力注射器的放射性药物注射系统，其包括辐射屏蔽，生物测定传感器和与动力注射器和生物测定传感器通信地互连的控制器。控制器可以被配置为响应于来自生物特征传感器的指示生物特征参数在目标范围内的信号来控制动力注射器。

103. 外观设计

USD578360S1 Grips for a two-handed tool 有权
标题翻译：掌握双手工具
公开(公告)号：USD578360S1
公开(公告)日：2008-10-14
申请号：US29292594
申请日：2007-10-18
申请人： Michael Nellenbach , Curtis Bailey , David Wilson
设计人： Michael Nellenbach , Curtis Bailey , David Wilson

104. 发明申请

US20080039715A1 Three-dimensional optical guidance for catheter placement 审中-公开
标题翻译：导管放置三维光导
公开(公告)号：US20080039715A1
公开(公告)日：2008-02-14
申请号：US11811554
申请日：2007-06-11
申请人： David Wilson , Sergei Vinogradov , Sofia Apreleva
发明人： David Wilson , Sergei Vinogradov , Sofia Apreleva
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/061
摘要： A system is provided comprising an optically-guided catheter having a proximal end, a distal end, and at least one lumen. A light-emitting means is coupled to the catheter, the catheter is inserted into place in the patient, and light is emitted as a point or points from a selected location, usually the distal tip, of the catheter to which it is coupled. The system further comprises an external detection device that detects the transdermally projected light, emitted by the light-emitting point from within the patient, thereby indicating precise placement of the catheter within the patient. A system and method for three-dimensional visualization using an internally positioned light emitter and an externally positioned detection array are also provided.
摘要翻译：提供了一种包括具有近端，远端和至少一个内腔的光学引导导管的系统。发光装置耦合到导管，将导管插入患者的适当位置，并且将光从作为其所联接的导管的选定位置（通常为远端）的点或点发射。该系统还包括外部检测装置，其检测由患者内的发光点发射的透皮投射的光，从而指示导管在患者体内的精确放置。还提供了一种使用内部定位的光发射器和外部定位的检测阵列进行三维可视化的系统和方法。

105. 发明申请

US20070250414A1 SYSTEMS AND METHODS FOR MANAGING INFORMATION RELATING TO MEDICAL FLUIDS AND CONTAINERS THEREFOR 失效
公开(公告)号：US20070250414A1
公开(公告)日：2007-10-25
申请号：US11618065
申请日：2006-12-29
申请人： Frank Fago , David Wilson , Chad Gibson , William Bausmith , Vernon Ortenzi , Elaine Haynes , Elaine Borgemenke , John Lewis , Gary Wagner
发明人： Frank Fago , David Wilson , Chad Gibson , William Bausmith , Vernon Ortenzi , Elaine Haynes , Elaine Borgemenke , John Lewis , Gary Wagner
IPC分类号： G06Q10/00
CPC分类号： G06Q50/22 , A61B90/98 , A61M5/002 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/14566 , A61M5/16827 , A61M5/1785 , A61M5/31511 , A61M5/44 , A61M2005/14553 , A61M2205/17 , A61M2205/3569 , A61M2205/60 , A61M2205/6054 , G06F19/00 , G06F19/321 , G06F19/3462 , G06F19/3468 , G06Q10/08 , G06Q10/087 , G06Q50/24 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to management of information relating to medical fluids, containers therefor, and medical fluid administration devices for administering such medical fluids to patients. Data tags (e.g., RFID tags) are generally associated with containers of the invention and may be electromagnetically read from and/or written to using an electromagnetic device, for example, that may be associated with a medical fluid administration device of the invention.

106. 发明申请

US20070241883A1 SYSTEMS AND METHODS FOR MANAGING INFORMATION RELATING TO MEDICAL FLUIDS AND CONTAINERS THEREFOR 有权
公开(公告)号：US20070241883A1
公开(公告)日：2007-10-18
申请号：US11617920
申请日：2006-12-29
申请人： Frank Fago , David Wilson , Chad Gibson , William Bausmith , Vernon Ortenzi , Elaine Haynes , Elaine Borgemenke , John Lewis , Gary Wagner
发明人： Frank Fago , David Wilson , Chad Gibson , William Bausmith , Vernon Ortenzi , Elaine Haynes , Elaine Borgemenke , John Lewis , Gary Wagner
IPC分类号： G08B1/00
CPC分类号： G06Q50/22 , A61B90/98 , A61M5/002 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/14566 , A61M5/16827 , A61M5/1785 , A61M5/31511 , A61M5/44 , A61M2005/14553 , A61M2205/17 , A61M2205/3569 , A61M2205/60 , A61M2205/6054 , G06F19/00 , G06F19/321 , G06F19/3462 , G06F19/3468 , G06Q10/08 , G06Q10/087 , G06Q50/24 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to management of information relating to medical fluids, containers therefore, and medical fluid administration devices for administering such medical fluids to patients. Data tags (e.g., RFID tags) are generally associated with containers of the invention and may be electromagnetically read from and/or written to using an electromagnetic device, for example, that may be associated with a medical fluid administration device of the invention.

107. 发明申请

US20070209446A1 Frozen material detection using electric field sensor 有权
标题翻译：使用电场传感器进行冷冻材料检测
公开(公告)号：US20070209446A1
公开(公告)日：2007-09-13
申请号：US11373071
申请日：2006-03-10
申请人： Bradley Stewart , Sergio de Alba Garcin , Rogelio Garcia , Gabriel Barba , David Wilson
发明人： Bradley Stewart , Sergio de Alba Garcin , Rogelio Garcia , Gabriel Barba , David Wilson
IPC分类号： G01B7/16
CPC分类号： G01N27/22
摘要： An electric field sensor may be used to detect accumulation of frozen material. In one embodiment, an e-field system includes a first electrode, a second electrode located at a distance from the first electrode, the second electrode forming a capacitive element with the first electrode, wherein a gap is present between the first and second electrodes, and an electric field sensor having an electrode terminal coupled to the first electrode and providing an electric field output value representative of an amount of frozen material located in the gap between the first and second electrodes. The system may also include a first insulator adjacent the first electrode and outside the gap, and a conductive layer adjacent the first insulator, where the first insulator is between the first electrode and the conductive layer, and where a shield output of the electric field sensor is coupled to the conductive layer.
摘要翻译：可以使用电场传感器来检测冷冻材料的积聚。在一个实施例中，电场系统包括第一电极，位于距离第一电极一定距离的第二电极，第二电极与第一电极形成电容元件，其中在第一和第二电极之间存在间隙，以及电场传感器，其具有耦合到所述第一电极的电极端子，并且提供表示位于所述第一和第二电极之间的间隙中的冷冻材料的量的电场输出值。该系统还可以包括邻近第一电极并在间隙外部的第一绝缘体和邻近第一绝缘体的导电层，其中第一绝缘体位于第一电极和导电层之间，并且其中电场传感器的屏蔽输出耦合到导电层。

108. 发明申请

US20070208005A1 TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR 审中-公开
标题翻译：作为组胺H3受体的拮抗剂和/或反转激素，四氢叶酸
公开(公告)号：US20070208005A1
公开(公告)日：2007-09-06
申请号：US11573732
申请日：2005-08-12
申请人： Christopher Parr , Paula Pickering , Sanjeet Sehmi , David Wilson
发明人： Christopher Parr , Paula Pickering , Sanjeet Sehmi , David Wilson
IPC分类号： A61K31/55 , C07D413/02 , C07D403/02
CPC分类号： C07D223/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/10
摘要： The present invention relates to novel benzazepine derivatives having pharmaceutical activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译：本发明涉及具有药物活性的新的苯并氮杂衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神障碍中的用途。

109. 发明申请

US20070185089A1 Benzazepine derivatives for the treatment of neurological and psychiatric disorders 审中-公开
标题翻译：苯扎氮平衍生物用于治疗神经和精神疾病
公开(公告)号：US20070185089A1
公开(公告)日：2007-08-09
申请号：US10598759
申请日：2005-03-10
申请人： Mark Bamford , Thomas Heightman , David Wilson , Jason Witherington
发明人： Mark Bamford , Thomas Heightman , David Wilson , Jason Witherington
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to novel benzazepine derivatives of formula (I); wherein: R1 represents —C3-7 cycloalkyl optionally substituted by C1-3 alkyl; R2 represents -aryl, -heterocyclyl, heteroaryl, -aryl-X—C3-8 cycloalkyl, cycloalkyl, -aryl-X-aryl, -aryl-X-heteroaryl, -aryl-X-heterocyclyl, -heteroaryl-X—C3-8 cycloalkyl, -heteroaryl-X-aryl, -heteroaryl-X-heteroaryl, -heteroaryl-X-heterocyclyl, -heterocyclyl-X—C3-8 cyclooalkyl, -heterocyclyl-X-aryl, -heterocyclyl-X-heteroaryl or -heterocyclyl-X-heterocyclyl; X represents a bond, O, CO, —CH2O—, —COCH2—, —COCH2O—, —CONR2b—, —COCH2NR2bCO—, —CSNH—, SO2, —SO2C1-3 alkyl-, —SO2C2-3 alkenyl-, —COC2-3 alkenyl-, —CO—C(R2a)(R2b)— or —CO—C(R2a)(R2b)CH2—; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译：本发明涉及式（I）的新型苯并氮杂衍生物; 其中：R 1表示任选被C 1-3烷基取代的-C 3-7环烷基; R 2表示芳基，杂环基，杂芳基， - 芳基-XC 3-8环烷基，环烷基， - 芳基-X-芳基， - 芳基-X-杂芳基，芳基-X-杂环基， - 杂芳基-XC 3-8环烷基， - 杂芳基-X-芳基， - 杂芳基-X-杂芳基， - 杂芳基-X-杂环基， - 杂环基-XC

110. 发明申请

US20070179596A1 Medical Devices, Drug Coatings And Methods for Maintaining the Drug Coatings Thereon 审中-公开
标题翻译：医疗器械，药物涂料和维护药物涂层的方法
公开(公告)号：US20070179596A1
公开(公告)日：2007-08-02
申请号：US11736137
申请日：2007-04-17
申请人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
发明人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
IPC分类号： A61F2/90
CPC分类号： A61B17/0644 , A61B17/00491 , A61B17/0469 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/608 , B05D1/18 , B05D3/0254 , B05D3/0493 , A61K2300/00 , C08L27/14 , C08L27/12 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。

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