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101. 发明授权

US07973139B2 Antibodies against nogo receptor 有权
标题翻译：针对nogo受体的抗体
公开(公告)号：US07973139B2
公开(公告)日：2011-07-05
申请号：US11090847
申请日：2005-03-25
申请人： Adam Bell , Craig A. Rosen
发明人： Adam Bell , Craig A. Rosen
IPC分类号： C07K16/00 , C07K14/00 , C12N15/85 , C12N5/12 , A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.
摘要翻译：本发明涉及特异性结合Nogo受体（NogoR）的抗体和相关分子。这样的抗体具有例如用于治疗脊髓损伤，脑损伤，麻痹，退行性神经系统疾病和中风的用途。本发明还涉及编码抗NogoR抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。

102. 发明申请

US20110151473A1 Polynucleotides and Polypeptides Encoding Receptors 审中-公开
标题翻译：编码受体的多核苷酸和多肽
公开(公告)号：US20110151473A1
公开(公告)日：2011-06-23
申请号：US12952967
申请日：2010-11-23
申请人： Jian Ni , Craig A. Rosen , Reiner L. Gentz
发明人： Jian Ni , Craig A. Rosen , Reiner L. Gentz
IPC分类号： C12Q1/68 , C07H21/00 , C07K14/705
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
摘要翻译：公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。

103. 发明申请

US20110081360A1 Human G-Protein Chemokine Receptor (CCR5) HDGNR10 审中-公开
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：US20110081360A1
公开(公告)日：2011-04-07
申请号：US12943722
申请日：2010-11-10
申请人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
发明人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K39/395 , C07H21/04 , C07K16/00 , A61P37/04 , A61P9/00 , A61P17/06 , A61P17/00 , A61P11/00
CPC分类号： C07K14/7158 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译：本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

104. 发明授权

US07906634B2 HEMCM42 nucleic acids 有权
标题翻译： HEMCM42核酸
公开(公告)号：US07906634B2
公开(公告)日：2011-03-15
申请号：US12324825
申请日：2008-11-26
申请人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
发明人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

105. 发明申请

US20110002888A1 Albumin Fusion Proteins 有权
公开(公告)号：US20110002888A1
公开(公告)日：2011-01-06
申请号：US12793658
申请日：2010-06-03
申请人： Craig A. Rosen , Adam Bell , Paul A. Moore , Yanggu Shi , David Lafleur , Jason B. Bock , Michael W. Laird , William A. Haseltine , Douglas B. Woods , Mani Subramanian
发明人： Craig A. Rosen , Adam Bell , Paul A. Moore , Yanggu Shi , David Lafleur , Jason B. Bock , Michael W. Laird , William A. Haseltine , Douglas B. Woods , Mani Subramanian
IPC分类号： A61K38/21 , C07K14/76 , A61K38/38 , C07H21/00 , C12N15/63 , C12N5/10 , A61K38/46 , A61K38/18 , A61K38/22 , A61K39/395 , A61K38/43 , C12N9/96 , A61K39/12 , A61K38/30 , A61P35/00 , A61P3/04 , A61P3/10 , A61P3/00 , A61P37/02 , A61P9/08 , A61P9/00 , A61P9/04 , A61P1/16 , A61P25/30 , A61P31/12 , A61P9/12
CPC分类号： C07K14/58 , C07K14/765 , C07K2319/01
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

106. 发明授权

US07838636B1 Antibodies to HWHGU54 polypeptides 有权
标题翻译： HWHGU54多肽的抗体
公开(公告)号：US07838636B1
公开(公告)日：2010-11-23
申请号：US11760578
申请日：2007-06-08
申请人： Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
发明人： Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
IPC分类号： C07K16/40 , C12P21/08 , C12P21/06 , C12N15/09
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

107. 发明申请

US20100144058A1 B-LYMPHOCYTE STIMULATOR BINDING POLYPEPTIDES AND METHODS BASED THEREON 有权
标题翻译： B-LYMPHOCYTE刺激物结合聚合物及其方法
公开(公告)号：US20100144058A1
公开(公告)日：2010-06-10
申请号：US12701301
申请日：2010-02-05
申请人： James P. Beltzer , M. Daniel Potter , Tony J. Fleming , Craig A. Rosen
发明人： James P. Beltzer , M. Daniel Potter , Tony J. Fleming , Craig A. Rosen
IPC分类号： G01N33/53 , C07K7/08 , C07K14/00 , C07K16/00
CPC分类号： C07K7/08 , A61K38/00 , A61K39/00 , C07K14/70578 , C07K14/7151 , C07K2319/00
摘要： Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate function of B lymphocyte stimulator or B lymphocyte stimulator receptor, comprising B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate B lymphocyte stimulator function or B lymphocyte stimulator receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator.
摘要翻译：特异性结合B淋巴细胞刺激物蛋白或B淋巴细胞刺激物样多肽的结合多肽可用于本发明的用于检测，诊断或预测与异常B淋巴细胞刺激物或B淋巴细胞刺激受体表达或不适当功能相关的疾病或病症的方法 B淋巴细胞刺激剂或B淋巴细胞刺激物受体，其包含特异性结合B淋巴细胞刺激物的B淋巴细胞刺激物结合多肽或其片段或变体。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激剂或B淋巴细胞刺激剂受体表达或不适当的B淋巴细胞刺激物功能或B淋巴细胞刺激因子受体功能相关的疾病或病症的方法和组合物，其包括向动物，优选人，有效量的一种或多种B淋巴细胞刺激剂结合多肽或其片段或变体，其特异性结合B淋巴细胞刺激物。

108. 发明申请

US20100093627A1 ALBUMIN FUSION PROTEINS 有权
公开(公告)号：US20100093627A1
公开(公告)日：2010-04-15
申请号：US12534585
申请日：2009-08-03
申请人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
IPC分类号： A61K38/38 , C12N15/63 , C12N5/00 , C12N1/19 , C12N5/07 , C12P21/00 , C07K14/76 , A61P3/00 , A61P37/06
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

109. 发明申请

US20090247482A1 50 Human Secreted Proteins 审中-公开
标题翻译： 50人类分泌蛋白
公开(公告)号：US20090247482A1
公开(公告)日：2009-10-01
申请号：US12275899
申请日：2008-11-21
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： A61K31/7088 , C12N15/11 , C12N15/00 , C12N5/06 , C12N15/87 , C12P21/04
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

110. 发明申请

US20090169565A1 NEUTROKINE-ALPHA ANTIBODIES AND METHODS OF USE THEREOF 有权
标题翻译： NEUTROKINE-ALPHA抗体及其使用方法
公开(公告)号：US20090169565A1
公开(公告)日：2009-07-02
申请号：US12393693
申请日：2009-02-26
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53 , A61P37/00
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.
摘要翻译：本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

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