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101. 发明申请

US20140155420A1 INHIBITORS OF EYA2 审中-公开
标题翻译： EYA2抑制剂
公开(公告)号：US20140155420A1
公开(公告)日：2014-06-05
申请号：US13978820
申请日：2012-01-10
申请人： Rui Zhao , Heide L. Ford , Noel Southall , Erika Englund , Samarjit Patnaik , Marc Ferrer , Wei Zheng , Seameen Dehdashti , Juan Marugan
发明人： Rui Zhao , Heide L. Ford , Noel Southall , Erika Englund , Samarjit Patnaik , Marc Ferrer , Wei Zheng , Seameen Dehdashti , Juan Marugan
IPC分类号： A61K31/443 , A61K31/4174 , A61K31/277 , A61K31/4709 , A61K31/255 , A61K31/155
CPC分类号： A61K31/443 , A61K31/15 , A61K31/155 , A61K31/255 , A61K31/277 , A61K31/4174 , A61K31/4709
摘要： The invention provides small molecule inhibitors of EYA2 phosphatase activity and EYA2 binding to Six1. These inhibitors are proposed for use in methods of treating cancer in a subject, such as those involving Six1 and/or EYA2 disregulation. In some embodiments, the invention further provides for the administration of a second cancer therapy to the subject.
摘要翻译：本发明提供EYA2磷酸酶活性的小分子抑制剂和与Six1结合的EYA2。这些抑制剂被提出用于治疗受试者的癌症的方法，例如涉及Six1和/或EYA2失调的那些。在一些实施方案中，本发明进一步提供对受试者施用第二次癌症治疗。

102. 发明授权

US08692068B2 Promoter molecules for use in plants 有权
标题翻译：用于植物的启动子分子
公开(公告)号：US08692068B2
公开(公告)日：2014-04-08
申请号：US13174745
申请日：2011-06-30
申请人： Diane M. Ruezinsky , Crystal L. Hewitt , Wei Zheng
发明人： Diane M. Ruezinsky , Crystal L. Hewitt , Wei Zheng
IPC分类号： C12N15/82 , C12N15/87 , A01H1/00 , C12N15/00
CPC分类号： A23D9/007 , C12N15/823 , C12N15/8235 , C12N15/8247
摘要： The present invention relates to polynucleotide molecules for regulating gene expression in plants. In particular, the present invention relates to promoters isolated from Brassica napus that are useful for regulating gene expression of heterologous polynucleotide molecules in plants. The present invention also relates to expression constructs and transgenic plants containing the heterologous polynucleotide molecules.
摘要翻译：本发明涉及用于调节植物中基因表达的多核苷酸分子。特别地，本发明涉及从甘蓝型油菜中分离的可用于调节植物中异源多核苷酸分子的基因表达的启动子。本发明还涉及含有异源多核苷酸分子的表达构建体和转基因植物。

103. 发明申请

US20130225811A1 QUINAZOLINE DERIVATIVES AND QUINAZOLINE COMPLEX PROTEIN KINASE INHIBITOR FOR INHIBITING MULTIPLICAITON OF TUMOR CELLS AND PREPARATION METHOD THEREOF 有权
标题翻译：喹诺酮衍生物和喹唑啉复合蛋白激酶抑制剂抑制肿瘤细胞多形性及其制备方法
公开(公告)号：US20130225811A1
公开(公告)日：2013-08-29
申请号：US13882100
申请日：2011-10-27
申请人： Fuyi Wang , Qun Luo , Liyun Ji , Wei Zheng , Shuang Lv , Xianchan Li
发明人： Fuyi Wang , Qun Luo , Liyun Ji , Wei Zheng , Shuang Lv , Xianchan Li
IPC分类号： C07F15/00
CPC分类号： C07F15/0053 , C07D239/94 , C07D403/12 , C07F15/0046 , C07F17/02
摘要： Quinazoline derivatives represented by general formula (1) and quinazoline complexes as protein kinase inhibitors, and their preparation methods are provided. Wherein, in general formula (1), at least one of R and R′ is a group containing an atom capable of coordinating with noble metals, m and n are either the same or different and are integers from 0 to 5. Said quinazoline complex as protein kinase inhibitor is formed by coordination compound containing noble metal and said quinazoline derivative ligand capable of coordinating with noble metal in the coordination compound. Used as tyrosine protein kinase inhibitors, Quinazoline derivatives and quinazoline complexes as protein kinase inhibitors provided by the present invention have exhibited good inhibitory effect on proliferation of various tumor cells including human breast cancer cells line (drug-resistant) MCF-7/A, human breast cancer cell line (sensitive) MCF-7/S, prostate cancer cell PC-3, keratinocytes Colo-16, human non-small cell lung cancer cell line A549, etc.
摘要翻译：提供了由通式（1）表示的喹唑啉衍生物和喹唑啉配合物作为蛋白激酶抑制剂及其制备方法。其中，在通式（1）中，R和R'中的至少一个是含有与贵金属配位的原子的基团，m和n相同或不同，为0〜5的整数。所述喹唑啉络合物因为蛋白激酶抑制剂是由含有贵金属的配位化合物和能与配位化合物中的贵金属配位的喹唑啉衍生物配体形成的。作为酪氨酸蛋白激酶抑制剂，本发明提供的蛋白激酶抑制剂喹唑啉衍生物和喹唑啉配合物对包括人乳腺癌细胞系（耐药性）MCF-7 / A，人类在内的各种肿瘤细胞的增殖具有良好的抑制作用乳腺癌细胞株（敏感）MCF-7 / S，前列腺癌细胞PC-3，角质形成细胞Colo-16，人非小细胞肺癌细胞株A549等

104. 发明申请

US20130200396A1 PREVENTION OF LIGHT LEAKAGE IN BACKSIDE ILLUMINATED IMAGING SENSORS 审中-公开
标题翻译：防止背光照明成像传感器中的光泄漏
公开(公告)号：US20130200396A1
公开(公告)日：2013-08-08
申请号：US13367162
申请日：2012-02-06
申请人： Wei Zheng , Vincent Venezia , Hsin-Chih Tai
发明人： Wei Zheng , Vincent Venezia , Hsin-Chih Tai
IPC分类号： H01L31/0232
CPC分类号： H01L27/14623 , H01L27/1464
摘要： An apparatus includes a semiconductor layer, a dielectric layer, and a light prevention structure. The semiconductor layer has a front surface and a backside surface. The semiconductor layer includes a light sensing element and a periphery circuit region containing a light emitting element and not containing the light sensing element. The dielectric layer contacts at least a portion of the backside surface of the semiconductor layer. At least a portion of the light prevention structure is disposed between the light sensing element and the light emitting element. The light prevention structure is positioned to prevent light emitted by the light emitting element from reaching the light sensing element.
摘要翻译：一种装置包括半导体层，电介质层和防光结构。半导体层具有前表面和背面。半导体层包括光检测元件和包含发光元件并且不包含光感测元件的外围电路区域。电介质层与半导体层的背面的至少一部分接触。防光结构的至少一部分设置在感光元件和发光元件之间。防光结构被定位成防止由发光元件发射的光到达感光元件。

105. 发明授权

US08502026B2 Transgenic plants with enhanced agronomic traits 有权
标题翻译：具有增强农学性状的转基因植物
公开(公告)号：US08502026B2
公开(公告)日：2013-08-06
申请号：US12860188
申请日：2010-08-20
申请人： Maureen Daley , Jason Fenner , Beth Savidge , Dale Val , Wei Zheng
发明人： Maureen Daley , Jason Fenner , Beth Savidge , Dale Val , Wei Zheng
IPC分类号： C12N15/52 , C12N15/54 , C12N15/82 , C12N5/10 , C12N1/13 , A01H5/00 , A01H5/10 , A01H13/00
CPC分类号： C12N15/8261 , C11B1/00 , C12N15/8218 , C12N15/8243 , Y02A40/146
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein, enhanced seed oil and modified oil composition. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
摘要翻译：本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐寒性，增加的产量，增强的氮利用效率，增强的氮利用效率，种子蛋白，增强种子油和改性油组成。还公开了用于制备具有增强特征的转基因种子和植物的方法。

106. 发明授权

US08404541B2 Strapping contact for charge protection 有权
标题翻译：带式触点用于充电保护
公开(公告)号：US08404541B2
公开(公告)日：2013-03-26
申请号：US12790578
申请日：2010-05-28
申请人： Wei Zheng , Jean Yang , Mark Randolph , Ming Kwan , Yi He , Zhizheng Liu , Meng Ding
发明人： Wei Zheng , Jean Yang , Mark Randolph , Ming Kwan , Yi He , Zhizheng Liu , Meng Ding
IPC分类号： H01L21/8247
CPC分类号： H01L27/105 , H01L27/11526 , H01L27/11531
摘要： A semiconductor device includes a substrate and a memory cell formed on the substrate. The memory cell includes a word line. The semiconductor device also includes a protection area formed in the substrate, a conductive structure configured to extend the word line to the protection area, and a contact configured to short the word line and the protection area.
摘要翻译：半导体器件包括衬底和形成在衬底上的存储单元。存储单元包括字线。半导体器件还包括形成在衬底中的保护区域，被配置为将字线延伸到保护区域的导电结构以及被配置为使字线和保护区域短路的触点。

107. 发明授权

US08392701B2 Method and apparatus for ensuring packet transmission security 失效
标题翻译：确保分组传输安全性的方法和装置
公开(公告)号：US08392701B2
公开(公告)日：2013-03-05
申请号：US12672178
申请日：2008-07-22
申请人： Xiangqing Chang , Wei Zheng
发明人： Xiangqing Chang , Wei Zheng
IPC分类号： H04L9/00
CPC分类号： H04L63/101 , H04L9/0844 , H04L63/164 , H04L2209/125
摘要： An apparatus and method for ensuring distributed packet transmission security are provided. In an embodiment of the present invention, a main control board allocates SA information to multiple processing boards according to a pre-defined criterion, so that each processing board which receives and stores the SA information may implement IPSec processing. As such, the IPSec processing is shared by the multiple processing boards. Accordingly, when there are a large number of IPSec tunnels on one interface, the IPSec processing to the packets passing the IPSec tunnels will not completely rely on only the processing board where the interface is located. Instead, the IPSec processing is allocated to different processing boards. Therefore, the multiple processing boards effectively share the IPSec processing corresponding to multiple SAs. The efficiency of the IPSec processing is increased.
摘要翻译：提供了一种用于确保分布式分组传输安全性的装置和方法。在本发明的一个实施例中，主控板根据预先定义的标准将SA信息分配给多个处理板，从而接收和存储SA信息的每个处理板可以实现IPSec处理。因此，IPSec处理由多个处理板共享。因此，当一个接口上存在大量IPSec隧道时，对IPSec隧道传输的报文进行IPSec处理不能完全依赖接口所在的处理板。而是将IPSec处理分配给不同的处理板。因此，多个处理板有效共享与多个SA相对应的IPSec处理。 IPSec处理效率提高。

108. 发明授权

US08364682B1 Identifier mapping from joined data 有权
标题翻译：从连接数据的标识符映射
公开(公告)号：US08364682B1
公开(公告)日：2013-01-29
申请号：US13101213
申请日：2011-05-05
申请人： Ori Gershony , Wei Zheng , Andrei Pascovici , Tim Hesterberg
发明人： Ori Gershony , Wei Zheng , Andrei Pascovici , Tim Hesterberg
IPC分类号： G06F7/00
CPC分类号： G06F17/30867 , G06Q30/02
摘要： Methods, systems, and apparatus, for refining log file join data. In one aspect, a method includes receiving first join data defining first joins of records in a first log file to records in a second log file. Each first join of a record in the first log file to a record in the second log file is based on an association of the first identifier of the record in the first log file to the second identifier of the record in the second log file. Associations of the first identifiers to the second identifiers in the first join data that meet a confidence threshold are stored in a mapping of first identifiers to second identifiers as a mapped association. For each mapped association, records that include the first identifier from the first log file are associated with records that include the second identifier from the second log file.
摘要翻译：方法，系统和设备，用于优化日志文件连接数据。在一个方面，一种方法包括接收定义第一日志文件中记录的第一连接的第一连接数据以在第二日志文件中记录。将第一日志文件中的记录的第一次连接记录到第二日志文件中的记录是基于第一日志文件中的记录的第一标识符与第二日志文件中记录的第二标识符的关联。第一标识符与满足置信阈值的第一连接数据中的第二标识符的关联被存储在作为映射关联的第一标识符到第二标识符的映射中。对于每个映射的关联，包括来自第一日志文件的第一标识符的记录与包括来自第二日志文件的第二标识符的记录相关联。

109. 发明申请

US20130004490A1 DELIVERY OF TRANSTHYRETIN ACROSS THE BLOOD-BRAIN BARRIER AS A TREATMENT FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译：作为治疗阿尔茨海默病的血脑屏障的血液透析递送
公开(公告)号：US20130004490A1
公开(公告)日：2013-01-03
申请号：US13515050
申请日：2010-12-14
申请人： Juan Jose Marugan , Wei Zheng , Silvia Muro-Galindo
发明人： Juan Jose Marugan , Wei Zheng , Silvia Muro-Galindo
IPC分类号： A61K39/395 , C07K16/18 , A61K39/44 , C12N15/62 , A61P25/28 , C12N1/21 , C08G63/91 , C12P21/02 , C12N15/63 , C12N1/19 , C12N5/10 , A61K38/17 , C07K19/00
CPC分类号： C07K14/70525 , A61K38/00 , A61K47/6811 , A61K47/6849 , C07K14/4717 , C07K2319/33
摘要： The invention provides a composition comprising transthyretin and an ICAM-1 targeting agent, wherein the transthyretin and ICAM-1 targeting agent are coupled together, as well as methods of preparing such compositions. The invention further provides a diabody capable of binding specifically to ICAM-1 and transthyretin. The invention also provides a method of use of such composition in the manufacture of a medicament for treating an amyloid-β related neurodegenerative disease, comprising administering to a subject a composition comprising transthyretin coupled to an ICAM-1 targeting agent in an amount effective to treat the neurodegenerative disease, wherein the composition is administered to the subject outside of the blood-brain barrier.
摘要翻译：本发明提供了包含转甲状腺素蛋白和ICAM-1靶向剂的组合物，其中转甲状腺素蛋白和ICAM-1靶向剂偶联在一起，以及制备这种组合物的方法。本发明还提供能够特异性结合ICAM-1和转甲状腺素蛋白的双抗体。本发明还提供了一种使用这种组合物在制备用于治疗淀粉样蛋白的药物中的方法。包括向受试者施用包含与有效治疗神经变性疾病的量的ICAM-1靶向剂偶联的转甲状腺素蛋白的组合物，其中所述组合物在所述血脑屏障外给予受试者。

110. 发明申请

US20120257632A1 METHOD, COMBINER AND SYSTEM FOR TRANSMITTING SIGNALS 有权
标题翻译：方法，发送信号的组合器和系统
公开(公告)号：US20120257632A1
公开(公告)日：2012-10-11
申请号：US13529956
申请日：2012-06-21
申请人： Pingjing WANG , Wei ZHENG , Jian SHEN , Jianjun CHEN
发明人： Pingjing WANG , Wei ZHENG , Jian SHEN , Jianjun CHEN
IPC分类号： H04L12/56
CPC分类号： H04L41/0213 , H04L41/06 , H04L69/324 , H04W88/085
摘要： Methods and apparatus are provided for receiving AISG protocol signals sent by one or more local devices and adding corresponding labels to the AISG protocol signals, where the labels are used to identify mapping relationships between the local devices that send the AISG protocol signals and peer devices. The AISG protocol signals to which the labels have been added are packed into data packet and sent to a peer combiner through a shared feeder. The peer combiner unpacks the data packet and sends the AISG protocol signals to corresponding peer devices according to the labels added to the AISG protocol signals.
摘要翻译：提供了用于接收由一个或多个本地设备发送的AISG协议信号的方法和装置，并向AISG协议信号添加相应的标签，其中标签用于标识发送AISG协议信号的本地设备和对等设备之间的映射关系。已经添加了标签的AISG协议信号被打包到数据分组中，并通过共享馈线发送到对等体组合器。对等组合器根据添加到AISG协议信号的标签，对数据包进行解包，并将AISG协议信号发送给相应的对等设备。

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