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101. 发明申请

US20110098219A1 System for Curing Hepatic Cancer with Leptin 审中-公开
标题翻译：瘦素治疗肝癌的系统
公开(公告)号：US20110098219A1
公开(公告)日：2011-04-28
申请号：US12689718
申请日：2010-01-19
申请人： Shen-Nien Wang , Yao-Tsung Yeh , King-Teh Lee , Hsiang-Jen Yang , Sheau-Fang Yang
发明人： Shen-Nien Wang , Yao-Tsung Yeh , King-Teh Lee , Hsiang-Jen Yang , Sheau-Fang Yang
IPC分类号： A61K31/57 , A61K38/22 , A61P35/00 , A61P1/16
CPC分类号： A61K31/57 , A61K38/2264 , A61K2300/00
摘要： The present invention cures hepatic cancer by MPA with the help of leptin. A therapeutic drug of MPA combined with leptin is applied to a liver cancer patient. Or, MPA can be directly applied to a patient having a high leptin expression. Or, if a patient has a low leptin expression, MPA is applied to the patient after leptin expression is increased. Hence, expression of leptin can be taken as a predictive factor and a prognostic factor of treatment effect on curing the patient with MPA.
摘要翻译：借助于瘦素，本发明通过MPA治疗肝癌。将MPA与瘦素结合的治疗药物应用于肝癌患者。或者，MPA可以直接应用于具有高瘦素表达的患者。或者，如果患者瘦素低表达，则在瘦素表达增加后，将MPA施用于患者。因此，瘦素的表达可以作为治疗MPA患者治疗效果的预测因素和预后因素。

102. 发明授权

US07906289B2 Using genetic polymorphisms of the BICD1 gene as a method for diagnosing and treating myopia 有权
标题翻译：使用BICD1基因的遗传多态性作为诊断和治疗近视的方法
公开(公告)号：US07906289B2
公开(公告)日：2011-03-15
申请号：US12180820
申请日：2008-07-28
申请人： Suh-Hang Hank Juo
发明人： Suh-Hang Hank Juo
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： Using the BICD1 gene as a method for diagnosing myopia and/or myopia related complications is provided. The method includes obtaining a biological sample from a subject, and determining at least one SNP genotype in the BICD1 gene in the biological sample, wherein the presence of the SNP genotype indicates that the subject is susceptible to myopia. The SNP genotype is selected from the group consisting of SNPs rs7966276, rs1151029, rs2650122, and rs10771923. In addition, the present invention also provides a method of screening a material for preventing, treating myopia, and a method of assessing a subject for probability of response to a myopia therapeutic agent.
摘要翻译：提供使用BICD1基因作为诊断近视和/或近视相关并发症的方法。该方法包括从受试者获得生物样品，并确定生物样品中BICD1基因中的至少一种SNP基因型，其中SNP基因型的存在表明受试者易患近视。 SNP基因型选自SNPs rs7966276，rs1151029，rs2650122和rs10771923。此外，本发明还提供了筛选用于预防，治疗近视的材料的方法，以及评估受试者对近视治疗剂的响应概率的方法。

103. 发明授权

US07875432B2 Method for diagnosing spinal muscular atrophy 有权
标题翻译：脊柱肌肉萎缩诊断方法
公开(公告)号：US07875432B2
公开(公告)日：2011-01-25
申请号：US12497900
申请日：2009-07-06
申请人： Shou-Mei Wu , Chun-Chiu Wang , Jan-Gowth Chang , Yuh-Jyh Jong
发明人： Shou-Mei Wu , Chun-Chiu Wang , Jan-Gowth Chang , Yuh-Jyh Jong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10S435/975
摘要： A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and the primers to obtain fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8, labeling the fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a fluorescent primer to obtain fluorescence-labeled exon fragments, and analyzing the fluorescence-labeled exon fragments by a capillary electrophoresis. If the SMN1/SMN2 ratios in exon 7 and 8 are different, it indicates that the subject is susceptible to spinal muscular atrophy. Additionally, if the peak of certain exon fragment appears crossed, it indicates an intragenic mutation in the exon.
摘要翻译：提供了一种诊断脊髓性肌萎缩的方法。该方法包括提供含有SMN基因核苷酸的受试者的生物样品，通过使用该核苷酸作为模板的通用多重PCR扩增SMN外显子1,2a，2b,3,4,5,6,7和8，以及引物以获得SMN外显子1,2a，2b，3,4,5,6,7和8的片段，标记SMN外显子1,2a，2b，3,4,5,6,7的片段通过荧光引物获得荧光标记的外显子片段，并通过毛细管电泳分析荧光标记的外显子片段。如果外显子7和8中的SMN1 / SMN2比例不同，则表明受试者易受脊髓性肌肉萎缩。另外，如果某些外显子片段的峰出现杂交，则表示外显子中具有基因内突变。

104. 发明申请

US20100021889A1 USING GENETIC POLYMORPHISMS OF THE BICD1 GENE AS A METHOD FOR DIAGNOSING AND TREATING MYOPIA 有权
标题翻译：使用BICD1基因的遗传多态性作为诊断和治疗MYOPIA的方法
公开(公告)号：US20100021889A1
公开(公告)日：2010-01-28
申请号：US12180820
申请日：2008-07-28
申请人： Suh-Hang Hank Juo
发明人： Suh-Hang Hank Juo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： Using the BICD 1 gene as a method for diagnosing myopia and/or myopia related complications is provided. The method includes obtaining a biological sample from a subject, and determining at least one SNP genotype in the BICD1 gene in the biological sample, wherein the presence of the SNP genotype indicates that the subject is susceptible to myopia. The SNP genotype is selected from the group consisting of SNPs rs7966276, rs1151029, rs2650122, and rs10771923. In addition, the present invention also provides a method of screening a material for preventing, treating myopia, and a method of assessing a subject for probability of response to a myopia therapeutic agent.
摘要翻译：提供使用BICD 1基因作为诊断近视和/或近视相关并发症的方法。该方法包括从受试者获得生物样品，并确定生物样品中BICD1基因中的至少一种SNP基因型，其中SNP基因型的存在表明受试者易患近视。 SNP基因型选自SNPs rs7966276，rs1151029，rs2650122和rs10771923。此外，本发明还提供了筛选用于预防，治疗近视的材料的方法，以及评估受试者对近视治疗剂的响应概率的方法。

105. 发明申请

US20080075783A1 Gliclazide nanosphere and manufacturing method therefor and application thereof 有权
标题翻译：格列齐特纳米球及其制备方法及其应用
公开(公告)号：US20080075783A1
公开(公告)日：2008-03-27
申请号：US11595250
申请日：2006-11-10
申请人： Yung-Kuang Lo , Thau-Ming Cham
发明人： Yung-Kuang Lo , Thau-Ming Cham
IPC分类号： A61K9/50 , A61K9/16
CPC分类号： A61K9/5138 , A61K9/5192 , Y10S977/906
摘要： An novel gliclazide nanosphere, the manufacturing method therefor and the application thereof are provided in the present application is provided. The gliclazide nanosphere is prepared by reacting the solid gliclazide with a polymeric matrix for improving the dissolution property and safety of gliclazide, and is benefit for immediately releasing dosage application in clinical therapy.
摘要翻译：本申请中提供了一种新颖的格列齐特纳米球，其制备方法及其应用。格列齐特纳米球通过使固体格列齐特与聚合物基质反应来制备，以改善格列齐特的溶出性质和安全性，有利于立即释放临床治疗中的剂量应用。

106. 发明申请

US20080064705A1 Theophylline-based nitophenylpiperazine derivatives for enhancing aortic smooth muscle relaxation 审中-公开
标题翻译：基于茶碱的硝基苯基哌嗪衍生物，用于增强主动脉平滑肌松弛
公开(公告)号：US20080064705A1
公开(公告)日：2008-03-13
申请号：US11520174
申请日：2006-09-12
申请人： Ing-Jun Chen
发明人： Ing-Jun Chen
IPC分类号： A61K31/522 , C07D473/02
CPC分类号： A61K31/522 , C07D473/08
摘要： A substance for enhancing an aortic smooth muscle relaxation is provided. The substance is one selected from the group consisting of a compound of formula (I), a pharmaceutical acceptable therefrom and a solvate therefrom, wherein either of R1 and R2 is one of a hydrogen and a nitro group.
摘要翻译：提供了用于增强主动脉平滑肌松弛的物质。该物质是选自式（I）化合物，其可接受药物和其溶剂化物的化合物，其中R1和R2中的任一个是氢和硝基之一。

107. 发明授权

US07229652B2 Extract from the leaves of Toona sinensis Roem., and the preparation process and uses thereof 有权
标题翻译：从香椿叶提取物及其制备方法及用途
公开(公告)号：US07229652B2
公开(公告)日：2007-06-12
申请号：US10785444
申请日：2004-02-23
申请人： Shyng-Shiou Yuan , Hseng-Kuang Hsu , Yi-Chen Chia
发明人： Shyng-Shiou Yuan , Hseng-Kuang Hsu , Yi-Chen Chia
IPC分类号： A61K36/00
CPC分类号： A61K36/58
摘要： Disclosed are extracts from the leaves of Toona sinensis Roem. prepared by extracting the leaves of Toona sinensis Roem. using water and an alcohol in sequence. Also disclosed are processes for preparing extracts from the leaves of Toona sinensis Roem., and uses of such extracts in the manufacture of medicaments for use in the treatment of ovarian cancer and/or bladder cancer.
摘要翻译：披露了香椿叶的提取物。通过提取香椿的叶子制备。依次使用水和酒精。还公开了从Toona sinensis Roem的叶子制备提取物的方法，以及这些提取物在制备用于治疗卵巢癌和/或膀胱癌的药物中的用途。

108. 发明申请

US20060068396A1 Method for biochip detecting limited cells 审中-公开
标题翻译：生物芯片检测有限细胞的方法
公开(公告)号：US20060068396A1
公开(公告)日：2006-03-30
申请号：US10948224
申请日：2004-09-24
申请人： Shiu-Ru Lin , Tian-Lu Cheng , Yi-Fang Chen , Chan-Han Wu
发明人： Shiu-Ru Lin , Tian-Lu Cheng , Yi-Fang Chen , Chan-Han Wu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/507
摘要： The present invention is a method for a biochip detecting limited cells. The present invention comprises steps of: obtaining a nylon membrane chip having required nucleotide fragments arranged in a dot matrix way by using a manual spotter; naturally drying by heat and fixing the nucleotide fragments on the nylon membrane chip by a rapid nucleic acid cross-linker when preparing a chip; collecting some normal whole blood to be linearly amplified; synthesizing required amount of cDNA by a reverse transcription to obtain a marker as a probe; processing labeling, hybridization and post-hybridization to the chip and the marker; processing chemical color reaction; and automatically analyzing the result image after the chemical color reaction. Accordingly, a gene biochip operation technology platform with low cost, easy operation and high efficiency is obtained. And so the functions and the applications of the gene biochip can be effectively worked out and the practical applications of the gene biochip on related fields can be conclusively popularized.
摘要翻译：本发明是一种检测有限细胞的生物芯片的方法。本发明包括以下步骤：通过使用手动打斑机获得具有以点阵方式布置的所需核苷酸片段的尼龙膜芯片; 通过加热自然干燥，并在制备芯片时通过快速核酸交联剂固定尼龙膜芯片上的核苷酸片段; 收集一些正常全血要线性扩增; 通过逆转录合成所需量的cDNA以获得作为探针的标记; 加工标记，杂交和后期杂交到芯片和标记物; 加工化学色素反应; 并在化学反应后自动分析结果图像。因此，获得了低成本，易于操作和高效率的基因生物芯片操作技术平台。因此可以有效地制定基因生物芯片的功能和应用，基因生物芯片在相关领域的实际应用可以得到最终推广。

109. 发明申请

US20060034774A1 Galactopyrannosyltriaminetetracarboxylate as ligands for bioactivated paramagnetic metal complexes 审中-公开
标题翻译：作为生物活化的顺磁金属配合物的配体的半乳糖吡喃葡糖基三胺四羧酸盐
公开(公告)号：US20060034774A1
公开(公告)日：2006-02-16
申请号：US11200801
申请日：2005-08-10
申请人： Yun-Ming Wang , Ya-Wen Hsu , Gin-Chung Liu
发明人： Yun-Ming Wang , Ya-Wen Hsu , Gin-Chung Liu
IPC分类号： A61K49/10 , C07H17/00
CPC分类号： A61K49/085 , A61K49/10 , A61K49/103 , C07H17/00
摘要： The present invention provides a triaminetetraacetatesaccharide coordinating to metal ion to form bioactive metal complexes. The bioactive metal complexes of the present invention can be used as contrast agents for magnetic resonance imaging (MRI).
摘要翻译：本发明提供一种与金属离子配位以形成生物活性金属络合物的三胺四乙酸糖。本发明的生物活性金属配合物可用作磁共振成像（MRI）的造影剂。

110. 发明授权

US06939869B2 Pyrrolo[2,1-c][1,4] benzodiazepine-indole derivatives, their preparation process, and uses of the same 有权
标题翻译：吡咯并[2,1-c] [1,4]苯并二氮杂 - 吲哚衍生物，其制备方法及其用途
公开(公告)号：US06939869B2
公开(公告)日：2005-09-06
申请号：US10242802
申请日：2002-09-12
申请人： Jeh-Jeng Wang
发明人： Jeh-Jeng Wang
IPC分类号： C07D209/42 , C07D403/04 , A61K31/55 , A61P35/00 , C07D487/00
CPC分类号： C07D403/04 , C07D209/42
摘要： Disclosed herein are novel pyrrolo[2,1-c][1,4]benzodiazepine-indole derivatives of formula (I): wherein each of the substituents is given the definition as set forth in the Specification and claims. Also disclosed are the preparation process of these derivatives and their uses in the manufacture of pharmaceutical compositions.
摘要翻译：本文公开的是式（I）的新颖的吡咯并[2,1-c] [1,4]苯并二氮杂 - 吲哚衍生物：其中每个取代基被给出如说明书和权利要求书中所阐述的定义。还公开了这些衍生物的制备方法及其在制备药物组合物中的用途。

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