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101. 发明申请

US20130175290A1 SYNCHRONISED DISPENSING DEVICE, METHOD FOR SYNCHRONISING FLOWS, AND METHOD FOR MIXING A MIXABLE MATERIAL 有权
标题翻译：同步分配装置，用于同步流动的方法和混合混合材料的方法
公开(公告)号：US20130175290A1
公开(公告)日：2013-07-11
申请号：US13823340
申请日：2011-08-10
申请人： Sebastian Vogt , Hubert Buechner
发明人： Sebastian Vogt , Hubert Buechner
IPC分类号： B01F3/08
CPC分类号： B01F3/08 , B01F5/0602 , B01F15/0087 , B01F15/0226 , B01F15/0243 , B01F15/0416 , B01F2215/0029 , B05C17/00556 , B05C17/00566 , B05C17/015 , G05D11/005
摘要： A cartridge system for mixing and applying a mixable material has a discharge opening and at least two cartridges which have interiors delimited in some areas by a cartridge head. A device regulates streams from the cartridges, is arranged on the cartridge head and has an outflow opening and conveying mechanisms for conveying the starting components to the outflow opening. Each conveying mechanism has a connection to an interior of a cartridge, which has a cartridge opening, and is arranged rotatably in the device. Volumetric flows of the components are defined by the angular velocities of the conveying mechanisms, and the conveying mechanisms are coupled to each other in such a way that the ratio of the angular velocities relative to each other is fixed, such that a defined mixing ratio can be generated at the outflow opening.
摘要翻译：用于混合和施加可混合材料的盒系统具有排出开口和至少两个盒，其具有通过盒头在一些区域内部限定的内部。设备调节来自墨盒的流，布置在墨盒头部上，并具有用于将起始部件输送到流出开口的流出开口和输送机构。每个传送机构具有与盒的内部的连接，其具有盒开口，并且可旋转地布置在装置中。部件的体积流量由传送机构的角速度限定，并且输送机构以相对于彼此的角速度比固定的方式彼此连接，使得限定的混合比可以在流出口产生。

102. 发明申请

US20130172896A1 DISPENSING DEVICE FOR BONE CEMENT 有权
标题翻译：骨水泥分配装置
公开(公告)号：US20130172896A1
公开(公告)日：2013-07-04
申请号：US13822685
申请日：2011-09-21
申请人： Sebastian Vogt , Hubert Buechner
发明人： Sebastian Vogt , Hubert Buechner
IPC分类号： A61B17/88
CPC分类号： A61B17/8802 , A61B17/8822 , A61B17/8825 , B05C17/0052 , B05C17/00553 , B05C17/00596 , B05C17/015
摘要： A discharge device discharges the content of a container by applying a compressed gas. The device has a housing, at least one compressed gas container, an operating device for setting a gas flow from the compressed gas container and an opening means for opening the compressed gas container. The opening means is movable in relation to the compressed gas container, and the device has a holder for securing the container on the device. The holder is in operative connection with the opening means in such a way that securing the container on the holder brings about a movement of the opening means in relation to the compressed gas container that opens the compressed gas container.
摘要翻译：排出装置通过施加压缩气体来排出容器的内容物。该装置具有壳体，至少一个压缩气体容器，用于设定来自压缩气体容器的气体流动的操作装置和用于打开压缩气体容器的打开装置。打开装置相对于压缩气体容器是可移动的，并且该装置具有用于将容器固定在装置上的保持器。保持器与打开装置操作连接，使得将容器固定在保持器上使打开装置相对于打开压缩气体容器的压缩气体容器移动。

103. 发明申请

US20130158158A1 Paste-Like Bone Cement 有权
标题翻译：糊状骨水泥
公开(公告)号：US20130158158A1
公开(公告)日：2013-06-20
申请号：US13715314
申请日：2012-12-14
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt
IPC分类号： A61L24/04
CPC分类号： A61L24/043 , A61K6/005 , A61K6/0073 , A61K6/083 , A61L24/001 , A61L24/0089 , A61L24/06 , A61L27/16 , A61L27/26 , A61L27/50 , A61L2430/02 , C08L33/08 , C08L33/10 , C08L33/14
摘要： The present invention relates to a kit comprising at least two pastes, A and B. Paste A contains at least one monomer for radical polymerisation; and at least one barbituric acid derivative as polymerisation initiator. Paste B contains at least one monomer for radical polymerisation; and at least one heavy metal compound as polymerisation accelerator that is selected from heavy metal salts and heavy metal complexes. Paste B contains less than 0.01% by weight, relative to the total weight of paste B, of a peroxide; at least one of the pastes A and B contains-at least one filling agent that is poorly soluble or insoluble in the monomer for radical polymerization in either paste A or B respectively; and at least one of the pastes A and B contains at least one inorganic halide salt.
摘要翻译：本发明涉及包含至少两种糊剂A和B的试剂盒。糊剂A含有至少一种用于自由基聚合的单体; 和至少一种巴比妥酸衍生物作为聚合引发剂。糊剂B含有至少一种用于自由基聚合的单体; 和至少一种重金属化合物作为选自重金属盐和重金属络合物的聚合促进剂。糊剂B相对于糊料B的总重量小于0.01重量％的过氧化物; 糊剂A和B中的至少一种含有至少一种难溶于或不溶于单体中的糊剂A或B中的自由基聚合的填充剂; 并且糊料A和B中的至少一种含有至少一种无机卤化物盐。

104. 发明申请

US20130122184A1 COATING METHOD AND COATING DEVICE FOR MEDICAL IMPLANTS 有权
标题翻译：医用植绒涂层方法和涂层装置
公开(公告)号：US20130122184A1
公开(公告)日：2013-05-16
申请号：US13666553
申请日：2012-11-01
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt , Ekaterini Copanaki , Sebastian Gaiser
IPC分类号： B05D1/28
CPC分类号： B05D1/28 , B05C1/06 , B05D1/24
摘要： Methods and devices coat, at least regions of, a medical implant, preferably of an artificial joint or a fixation for a joint. The method provides a medical implant, fills a device with a liquid having at least one pharmaceutically active substance, wherein the device has a compressed, at least over regions thereof, elastic, porous transfer means increases a volume of the transfer means, whereby the liquid is taken up at least partly into the pores of the transfer means, and transfers the liquid from the transfer means to a medical implant surface to be coated. The device coats, at least regions of, a medical implant, by means of the method, whereby the device has a compressed, at least over regions thereof, elastic, porous transfer means.
摘要翻译：方法和装置至少覆盖医疗植入物的区域，优选为人造关节或关节的固定。所述方法提供医用植入物，用具有至少一种药物活性物质的液体填充装置，其中所述装置具有压缩的至少其上部区域的弹性多孔转移装置增加所述转移装置的体积，由此液体至少部分地被吸收到转移装置的孔中，并将液体从转移装置转移到待涂覆的医用植入物表面。该装置通过该方法涂覆医疗植入物的至少区域，由此该装置具有压缩的至少其上部的弹性多孔转移装置。

105. 发明授权

US07989519B2 Initiator system for self-curing plastic materials, its use, and bone cement compositions containing it 有权
标题翻译：用于自固化塑料材料的引发剂体系，其用途和含有它的骨水泥组合物
公开(公告)号：US07989519B2
公开(公告)日：2011-08-02
申请号：US12254541
申请日：2008-10-20
申请人： Sebastian Vogt , Hubert Buchner
发明人： Sebastian Vogt , Hubert Buchner
IPC分类号： A61K6/083 , C09K3/00
CPC分类号： A61L24/043 , A61L24/001 , A61L27/26 , A61L27/50 , A61L2430/02 , C08L33/12
摘要： An initiator system for self-curing plastic material comprises a) at least one salt of a dialklylbarbituric acid and/or an alkylcycloalkylbarbituric acid and/or alkylarylbarbituric acid and/or a cycloalkylarylbarbituric acid that is insoluble in methacrylate monomers; b) at least one heavy metal salt that is insoluble in methacrylate monomers; c) at least one halogenide ion donor that is insoluble in methacrylate monomers; and d) at least one acid that is soluble in methacrylate monomers. The initiator system can be used for the preparation of paste/paste, paste/powder, paste/liquid, powder/liquid, and liquid/liquid combinations for the production of medical plastic material and dental materials. Additionally, a bone cement composition containing the initiator system is described.
摘要翻译：用于自固化塑料材料的引发剂体系包括：a）不溶于甲基丙烯酸酯单体的至少一种二烷基巴比妥酸和/或烷基环烷基巴比妥酸和/或烷基芳基巴比妥酸和/或环烷基芳基巴比妥酸的盐; b）至少一种不溶于甲基丙烯酸酯单体的重金属盐; c）至少一种不溶于甲基丙烯酸酯单体的卤化物离子供体; 和d）至少一种可溶于甲基丙烯酸酯单体的酸。引发剂系统可用于制备糊剂/糊剂，糊剂/粉末，糊剂/液体，粉末/液体和液体/液体组合，用于生产医用塑料材料和牙科材料。此外，描述了含有引发剂体系的骨水泥组合物。

106. 发明申请

US20110183932A1 THREE-COMPONENT BONE CEMENT 有权
标题翻译：三组分骨水泥
公开(公告)号：US20110183932A1
公开(公告)日：2011-07-28
申请号：US13012909
申请日：2011-01-25
申请人： Sebastian VOGT , Hubert BÜCHNER
发明人： Sebastian VOGT , Hubert BÜCHNER
IPC分类号： A61L24/06 , A61K31/7036 , A61P31/00
CPC分类号： A61L24/0073 , A61L24/0015 , A61L24/06 , A61L27/44 , A61L2300/00 , A61L2430/02 , A61L2430/24 , C08L33/10
摘要： A paste is provided from which bone cement can be formed, which is to the largest extent possible bubble-free and has a high impact strength. The paste includes (i) 15-50 weight percent of at least one mono-functional, hydrophobic methacrylic acid ester, (ii) 40-85 weight percent of at least one filler, (iii) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having at least one peroxide group, (iv) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having no peroxide groups, (v) 0.000001-3 weight percent of at least one accelerator soluble in the methacrylic acid ester (i) and capable of forming radicals from the radical initiators according to (iii) and (iv), (vi) 0.001-5 weight percent of at least one halide salt, and (vii) 0.2-3 weight percent of at least one cross-linking agent.
摘要翻译：提供了可以形成骨粘固剂的浆料，其最大程度上可能是无气泡的并且具有高冲击强度。该糊状物包括（i）15-50重量％的至少一种单官能疏水性甲基丙烯酸酯，（ii）40-85重量％的至少一种填料，（iii）0.01-4重量％的至少一种可溶于甲基丙烯酸酯（i）中并且具有至少一个过氧化物基团的自由基引发剂，（iv）0.01-4重量％的可溶于甲基丙烯酸酯（i）中并且不含过氧化物基团的至少一种自由基引发剂（v ）0.000001-3重量％的可溶于甲基丙烯酸酯（i）中的至少一种促进剂，并能够根据（ⅲ）和（ⅳ），（vi）的自由基引发剂形成自由基，至少0.001-5重量％一种卤化物盐，和（vii）0.2-3％重量的至少一种交联剂。

107. 发明申请

US20100160483A1 POLYMETHYLMETHACRYLATE BONE CEMENT COMPOSITION FOR CONTROLLED HYPERTHERMIA TREATMENT 审中-公开
标题翻译：用于控制高血压治疗的聚甲基丙烯酸甲酯骨水泥组合物
公开(公告)号：US20100160483A1
公开(公告)日：2010-06-24
申请号：US12641895
申请日：2009-12-18
申请人： Sebastian VOGT , Hubert Büchner
发明人： Sebastian VOGT , Hubert Büchner
IPC分类号： C08L33/12
CPC分类号： A61L27/50 , A61L27/16 , A61L27/446 , A61L2430/02 , C08L33/12
摘要： The invention relates to a polymethylmethacrylate bone cement composition that contains polymethylmethacrylate, radio-opaquer, methylmethacrylate and/or alkylmethacrylates, and an initiator system and comprises, in addition, ferromagnetic and/or superparamagnetic particles of a particle size of up to maximally 500 μm—which allows it to be heated by alternating magnetic fields—and further contains at least one biodegradable or biocompatible crystalline substance having a melting point in the range of 43-46° C. The cured cement can be used for local over-heating (hyperthermia) therapy in the absence of undesired temperature peaks.
摘要翻译：本发明涉及一种聚甲基丙烯酸甲酯骨水泥组合物，其包含聚甲基丙烯酸甲酯，无光乳剂，甲基丙烯酸甲酯和/或甲基丙烯酸烷基酯，以及引发剂体系，此外还包含粒径达最大为500μm- 其允许其通过交变磁场加热 - 并且还包含至少一种具有在43-46℃范围内的熔点的可生物降解或生物相容的结晶物质。固化的水泥可用于局部过热（热疗）在没有不希望的温度峰值的情况下进行治疗。

108. 发明申请

US20090105366A1 PASTE-LIKE POLYMETHYLMETHACRYLATE BONE CEMENT 审中-公开
标题翻译： PASTE-LIKE聚甲基丙烯酸甲酯骨水泥
公开(公告)号：US20090105366A1
公开(公告)日：2009-04-23
申请号：US12254516
申请日：2008-10-20
申请人： SEBASTIAN VOGT , HUBERT BUCHNER
发明人： SEBASTIAN VOGT , HUBERT BUCHNER
IPC分类号： A61L24/00
CPC分类号： A61L24/001 , A61L24/043 , A61L24/06 , A61L2430/02 , C08L33/12
摘要： What is described is a paste-like PMMA bone cement that is characterised in that a paste-like component A, which is made up of one or more methacrylate monomers that can be distilled and polymerised by radical polymerisation, at least one polymer that is soluble in the methacrylate monomer/methacrylate monomers, at least one particulate polymer that is insoluble in the methacrylate monomer/methacrylate monomers and has a particle size of less than 500 μm, and at least one radical initiator, and a paste-like component B, which is made up of one or more methacrylate monomers that can be distilled and polymerised by radical polymerisation, at least one polymer that is soluble in the methacrylate monomer/methacrylate monomers, at least one particulate polymer that is insoluble in the methacrylate monomer/methacrylate monomers and has a particle size of less than 500 μm, and at least one accelerator, is present and in that a tack-free paste that cures by itself is generated upon mixing the paste-like components A and B.
摘要翻译：描述的是一种糊状PMMA骨粘固剂，其特征在于，由一种或多种可通过自由基聚合蒸馏和聚合的甲基丙烯酸酯单体组成的糊状组分A至少一种可溶解的聚合物在甲基丙烯酸酯单体/甲基丙烯酸酯单体中，至少一种不溶于甲基丙烯酸酯单体/甲基丙烯酸酯单体并且具有小于500μm的颗粒，和至少一种自由基引发剂和糊状组分B的颗粒状聚合物，其中由可以通过自由基聚合蒸馏和聚合的一种或多种甲基丙烯酸酯单体组成，至少一种可溶于甲基丙烯酸酯单体/甲基丙烯酸酯单体的聚合物，至少一种不溶于甲基丙烯酸酯单体/甲基丙烯酸酯单体的颗粒聚合物和具有小于500μm的粒度，并且存在至少一种促进剂，并且在混合后产生其自身固化的无粘性糊状物 e糊状组分A和B.

109. 发明申请

US20090105144A1 ONE-COMPONENT BONE CEMENT PASTES AND METHODS FOR CURING THEM 有权
标题翻译：单组分骨水泥浆及其固化方法
公开(公告)号：US20090105144A1
公开(公告)日：2009-04-23
申请号：US12255224
申请日：2008-10-21
申请人： SEBASTIAN VOGT , HUBERT BUCHNER
发明人： SEBASTIAN VOGT , HUBERT BUCHNER
IPC分类号： A61L24/06 , A61K38/18
CPC分类号： A61L24/0094 , A61L24/0089 , A61L2430/02 , C08L33/10
摘要： One-component bone cement pastes, containing: AI at least one methacrylate monomer that is suited for radical polymerisation; AII at least one polymer that is soluble in AI; AIII at least one particulate polymer that is insoluble in AI and has a particle size of less than 500 μm; optionally AIV at least one initiator that can be activated, in particular at least one radical-forming initiator or at least one radical initiator that is soluble in AI and subject to thermal decomposition; optionally AV at least one electrically conductive radio-opaquer, in particular in the form of ferromagnetic particles; are well-suited, e.g., for producing paste-like two-component bone cements, for producing means for the fixation of total endoprostheses and revision endoprostheses, for producing selfcuring filling materials for vertebroplasty, kyphoplasty or femoral neck augmentation, or for producing local agent release systems, and, in the presence of component AV, can be heated through alternating magnetic fields of 500 Hz to 50 kHz or through induction until the decomposition of an initiator AIV commences. From this also results a method for the curing of pastes containing at least one initiator that can be activated, in particular at least one radical-forming initiator or at least one radical initiator that is subject to thermal decomposition; and at least electrically conductive particles, in particular ferromagnetic particles; whereby the paste is exposed to an alternating magnetic field with a frequency in the range of 500 Hz to 50 kHz, or whereby the paste is heated by induction until the decomposition of the initiator commences.
摘要翻译：单组分骨水泥膏，含有：至少一种适合自由基聚合的甲基丙烯酸单体; AII至少一种可溶于AI的聚合物; AIII至少一种不溶于AI且粒径小于500μm的颗粒状聚合物; 任选地AIV至少一个可以被活化的引发剂，特别是至少一种自由基形成引发剂或至少一种可溶于AI并经受热分解的自由基引发剂; 可选地AV至少一种导电性无光透明物，特别是铁磁性颗粒的形式; 适用于生产糊状双组分骨水泥，用于生产用于固定总内假体和修复内用假体的装置，用于生产用于椎体成形术，脊椎后凸成形术或股骨颈增大的自固化填充材料，或用于生产局部剂释放系统，并且在组分AV的存在下，可以通过500Hz至50kHz的交变磁场或通过感应加热直到引发剂AIV的分解开始。由此还可以得到含有至少一种可被活化的引发剂，特别是至少一种自由基形成引发剂或至少一种经受热分解的自由基引发剂的糊剂固化的方法。和至少导电颗粒，特别是铁磁颗粒; 由此将糊状物暴露于频率在500Hz至50kHz范围内的交变磁场，或者通过感应加热糊状物直到引发剂开始分解。

110. 发明申请

US20230081855A1 AUGMENTATION DEVICE, AUGMENTATION SYSTEM, AND IMPLANTATION METHOD 有权
公开(公告)号：US20230081855A1
公开(公告)日：2023-03-16
申请号：US17929473
申请日：2022-09-02
申请人： Heraeus Medical GmbH
发明人： Sebastian VOGT , Thomas KLUGE
IPC分类号： A61F2/30 , A61F2/46
摘要： The invention relates to an augmentation device comprising an annular cone surrounding a channel extending through the cone from a proximal cone end to a distal cone end of the cone. The invention further relates to an augmentation system comprising such an augmentation device and an applicator, as well as an implantation method of an augmentation device using such an augmentation system.

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