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91. 发明授权

US07265232B2 Process for producing glycidyl ether 有权
标题翻译：缩水甘油醚的制备方法
公开(公告)号：US07265232B2
公开(公告)日：2007-09-04
申请号：US10515384
申请日：2003-05-29
申请人： Yoshiro Furukawa , Yasushi Miki , Keisuke Yaegashi
发明人： Yoshiro Furukawa , Yasushi Miki , Keisuke Yaegashi
IPC分类号： C07D301/28
CPC分类号： C07D303/22
摘要： A process for producing a glycidyl ether and an optically active compound thereof with high yield and an optically high purity comprising reacting an alcohol with epihalohydrin in a base to thereby produce a glycidyl ether, the reaction performed in a two-layer system of a nonaqueous organic solvent and an aqueous solvent.
摘要翻译：一种以高产率和光学高纯度制备缩水甘油醚和其光学活性化合物的方法，包括使醇与表卤代醇在碱中反应，从而产生缩水甘油醚，该反应在非水有机物的双层体系中进行溶剂和水溶剂。

92. 发明申请

US20050130936A1 Processes and intermediates for preparing benzyl epoxides 失效
标题翻译：制备苄基环氧化物的方法和中间体
公开(公告)号：US20050130936A1
公开(公告)日：2005-06-16
申请号：US11048389
申请日：2005-02-01
申请人： Michael Reeder
发明人： Michael Reeder
IPC分类号： C07D301/28 , C07B61/00 , C07C213/02 , C07C215/28 , C07C217/82 , C07C229/36 , C07C233/78 , C07C269/06 , C07C271/16 , C07C271/18 , C07C271/20 , C07C271/22 , C07D301/26 , C07D301/27 , C07D303/36 , A61K31/695 , A61K31/138 , A61K31/277
CPC分类号： C07D303/36 , C07D301/26
摘要： Disclosed are intermediates and processes for preparing epoxides of the formula: where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the production of pharmaceutical agents.
摘要翻译：公开了用于制备下式的环氧化物的中间体和方法：其中R和PROT在本文中定义。这些环氧化物可用作生物活性化合物的生产中的中间体，即在制药中。

93. 发明授权

US5359097A Process for preparation of glycidyl ether 失效
标题翻译：缩水甘油醚的制备方法
公开(公告)号：US5359097A
公开(公告)日：1994-10-25
申请号：US571543
申请日：1990-08-22
申请人： Kiyoshi Kawamura , Tomio Ota
发明人： Kiyoshi Kawamura , Tomio Ota
IPC分类号： C07D301/28 , C07D303/22 , C07D405/12 , C07D407/12 , C07D417/12 , C07D311/04
CPC分类号： C07D303/22 , C07D407/12
摘要： A process is provided for preparation of a glycidyl ether represented by the general formula ##STR1## wherein A represents an aryl group optionally having a substituent or a heteroaryl group optionally having a substituent, and the carbon atom marked with * is an asymmetric carbon,which comprises reacting an aryl alcohol represented by the general formulaA--OH (I)wherein A is as defined above,with an epihalohydrin in the presence of a quaternary ammonium salt; and, if necessary, further treating the reaction product with a base. According to the present process, it is possible to prepare by simple procedures and in a high optical purity glycidyl ethers of the above formula (II) useful as an intermediate for preparation of medicines, particularly medicines having .beta.-adrenoreceptor blocking action or the like.
摘要翻译： PCT No.PCT / JP89 / 01293 Sec。 371 1990年7月18日第 102（e）日期1990年7月18日PCT提交1989年12月25日PCT公布。出版物WO90 / 07506 日本1990年7月12日提供了一种制备由任选具有取代基的通式或由任选具有取代基的杂芳基表示的缩水甘油醚的方法，标有*的碳原子是不对称碳，其包括使由季铵盐存在下的表卤代醇，由通式A-OH（I）表示的芳基醇，其中A如上所定义; 并且如果需要，用碱进一步处理反应产物。根据本方法，可以通过简单的方法和上述式（II）的高光学纯度的缩水甘油醚制备，其可用作制备药物的中间体，特别是具有β-肾上腺素受体阻断作用的药物等。

94. 发明授权

US5304662A Polyglycidyl compounds 失效
标题翻译：聚缩水甘油基化合物
公开(公告)号：US5304662A
公开(公告)日：1994-04-19
申请号：US900
申请日：1993-01-06
申请人： Michael R. Thoseby , Bryan Dobinson
发明人： Michael R. Thoseby , Bryan Dobinson
IPC分类号： C07B61/00 , C07D301/28 , C07D303/24 , C08G59/20 , C08G59/22 , C08G59/24 , C08G59/32 , C07D303/12 , C07D303/34 , C08G59/00
CPC分类号： C07D303/24 , C08G59/22 , C08G59/24 , C08G59/3218
摘要： A compound having the formula (I): ##STR1## in which n is an integer ranging from 2 to 6; X is the residue of an optionally substituted primary or secondary aliphatic or cycloaliphatic polyol of formula II:X(OH).sub.n IIin which X and n have their previous significance; and Z is a group of formula:--CH.sub.2 --CH(CH.sub.2 OY)--in which Y is the residue of an optionally substituted primary or secondary aliphatic or cycloaliphatic monohydric alcohol, or Z is a group of formula: ##STR2## in which W is an optionally substituted aliphatic carbon chain, which may contain one or more heteroatoms, or Z is a group of formula--CH.sub.2 --CH(T)--in which T is an aliphatic or cycloaliphatic alkyl group.
摘要翻译：具有式（I）的化合物：（*化学结构*）I，其中n为2-6的整数; X是式II的任选取代的伯或仲脂族或脂环族多元醇的残基：X（OH）nII，其中X和n具有其先前的含义; 和Z是式-CH 2 -CH（CH 2 OY） - 的基团，其中Y是任选取代的伯或仲脂族或脂环族一元醇的残基，或Z是下列基团：（*化学结构*）其中W是可以含有一个或多个杂原子的任选取代的脂族碳链，或Z是式-CH 2 -CH（T） - 的基团，其中T是脂族或脂环族烷基。

95. 发明授权

US5290958A Phase transfer catalytic process for preparing intermediates of atenolol, propranolol, and their derivatives 失效
标题翻译：用于制备阿替洛尔，普萘洛尔及其衍生物的中间体的相转移催化方法
公开(公告)号：US5290958A
公开(公告)日：1994-03-01
申请号：US33047
申请日：1993-08-18
申请人： Shyue-Ming Jang , Tian-Shy Shieh
发明人： Shyue-Ming Jang , Tian-Shy Shieh
IPC分类号： C07C41/16 , C07D301/28 , C07D303/22 , C07C41/03 , C07C43/205 , C07D303/23
CPC分类号： C07D303/22 , C07C41/16
摘要： A phase transfer catalytic process for the preparation of epoxide and halohydrin intermediates, which can be subsequently and directly reacted with isopropylamine to produce beta-adrenergic antagonists such as atenolol, propanolol and their derivatives. In the process disclosed in the present invention, quaternary ammonium salts of high alkyl groups or tertiary ammonium salts of lower alkyl groups are used as catalyst in the phase transfer catalytic oxygenated-alkylation reaction between an aromatic alcohol such as p-hydroxyphenyl acetamide (for the production of atenolol) or .alpha.-naphthol (for the production of propranolol) and epichlorohydrin to yield epoxide and halohydrin intermediates. The quaternary ammonium salts of high alkyl groups are represented by the following formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are C.sub.1 to C.sub.20 alkyl groups and at least one of the R.sub.1, R.sub.2, R.sub.3, or R.sub.4 is a C.sub.9 to C.sub.20 alkyl group, and X is a halide group. And the tertiary ammonium salts of lower alkyl groups are presented by the following formula: ##STR2## wherein R.sub.5 is a C.sub.1 to C.sub.20 alkyl group, H is hydrogen, and X is a halide group.
摘要翻译：用于制备环氧化物和卤代醇中间体的相转移催化方法，其可以随后和异丙胺直接反应以产生β-肾上腺素能拮抗剂，例如阿替洛尔，丙酰洛伦及其衍生物。在本发明公开的方法中，在芳基醇如对羟基苯基乙酰胺之间的相转移催化氧化 - 烷基化反应中使用高级烷基的季铵盐或低级烷基的叔铵盐作为催化剂（对于产生阿替洛尔）或（α） - 萘酚（用于生产普萘洛尔）和表氯醇以产生环氧化物和卤代醇中间体。高烷基的季铵盐由下式表示：（*化学结构*）其中R 1，R 2，R 3和R 4是C 1至C 20烷基和R 1，R 2，R 3或R 4中的至少一个是C 9〜20烷基，X是卤化物基团。低级烷基的叔铵盐由下式表示：（*化学结构*）其中R 5为C 1至C 20烷基，H为氢，X为卤化物基团。

96. 发明授权

US5117010A Process for the preparation of addition products of epoxides and alcohols 失效
标题翻译：制备环氧化物和醇类加成产物的方法
公开(公告)号：US5117010A
公开(公告)日：1992-05-26
申请号：US745569
申请日：1991-08-15
申请人： Chi-Wen F. Cheng
发明人： Chi-Wen F. Cheng
IPC分类号： B01J27/122 , B01J27/128 , B01J27/135 , B01J27/138 , B01J27/18 , B01J27/24 , C07B61/00 , C07C41/03 , C07C43/23 , C07D301/27 , C07D301/28 , C07D303/18 , C07D303/24 , C08G59/00
CPC分类号： C07C41/03 , C07D303/24
摘要： The present invention relates to the preparation of di-secondary alcohols comprising the reaction of an alcohol and a diglycidyl ether of a dihydric phenol in the presence of a catalyst of the formula (IV):MX (IV)wherein M is a metal from Groups IB to VIIIB or a metal or metalloid from Groups IIA to VA of the Periodic Chart of Elements or an ammonium ion and X is an anion selected from the group consisting of BF.sub.4.sup.-, PF.sub.6.sup.-, AsF.sub.6.sup.-, SbF.sub.6.sup.-, AlF.sub.4.sup.-, TiF.sub.6.sup.2-, SiF.sub.6.sup.2-, and ZrF.sub.6.sup.2- to produce the di-secondary alcohol, which can then be subjected to glycidylation to produce a glycidyl ether, orthe reaction of an alcohol, glycol or polyol and epichlorohydrin in the presence of the foregoing catalyst, followed by ring closure employing an alkali to produce a mono- or polyglycidyl ether. The monoglycidyl ether can be further reacted with a dihydric phenol to produce a di-secondary alcohol which is then glycidylized to produce a glycidyl ether.

97. 发明授权

US5068293A Naphthol-based epoxy resins, intermediates for the same, process for preparing the same, and epoxy resin compositions containing the same 失效
标题翻译：基于萘基的环氧树脂，其中间体，其制备方法和含有其的环氧树脂组合物
公开(公告)号：US5068293A
公开(公告)日：1991-11-26
申请号：US575022
申请日：1990-08-30
申请人： Masashi Kaji , Takanori Aramaki , Norito Nakahara , Yasuharu Yamada
发明人： Masashi Kaji , Takanori Aramaki , Norito Nakahara , Yasuharu Yamada
IPC分类号： C07D303/27 , C07C39/14 , C07D301/28 , C08G59/06 , C08G59/20 , C08G59/32 , C08G59/62 , C08G61/00 , C08G61/02
CPC分类号： C08G61/02 , C08G59/063 , C08G59/3218
摘要： The invention relates to naphthol-based epoxy resins of the general formula (I) ##STR1## in which A is a naphthalene nucleus, R is hydrogen or methyl, and n is an integer from 0 to 15, naphthol aralkyl resins which are intermediates for said epoxy resins, a process for the preparation of said naphthol aralkyl resins, and epoxy resin compositions containing said naphthol-based epoxy resins which are highly heat- and moisture-resistant, possess excellent impact strength and other mechanical properties, and are useful for such applications as lamination, molding, casting, and adhesion.

98. 发明授权

US4764581A Liquid-crystalline diglycidyl compounds, the preparation of these, and the use of these in curable epoxide mixtures 失效
标题翻译：液晶二缩水甘油基化合物，它们的制备以及它们在可固化环氧化物混合物中的用途
公开(公告)号：US4764581A
公开(公告)日：1988-08-16
申请号：US64745
申请日：1987-06-22
申请人： Hanns P. Muller , Roland Gipp , Heinrich Heine
发明人： Hanns P. Muller , Roland Gipp , Heinrich Heine
IPC分类号： C07D303/22 , C07D301/28 , C07D303/24 , C08G59/20 , C08G59/22 , C08G59/24 , C08G59/38 , C09K19/34 , C07D303/16
CPC分类号： C07D303/24 , C08G59/226 , C08G59/245 , C08G59/38 , C09K19/2007 , C09K19/3411
摘要： The invention relates to new, liquid-crystalline diglycidyle compounds of optionally ring-substituted 4-hydroxyphenyl 4-hydroxybenzoates, a synthesis of p-epoxypropoxy-phenyl p-epoxy-propoxybenzoate, furthermore epoxy resin mixtures containing the new diglycidyle compounds, and the use of the new diglycidyl compounds and the epoxy resin mixtures thereof in curable mixtures.
摘要翻译：本发明涉及任选环取代的4-羟基苯基-4-羟基苯甲酸酯的新型液晶二缩水甘油酯化合物，对环氧丙氧基 - 对苯氧基苯甲酸苯酯的合成，以及含有新的二缩水甘油醚化合物的环氧树脂混合物，以及使用的新二缩水甘油基化合物及其环氧树脂混合物在可固化混合物中的应用。

99. 发明授权

US4649181A Glycidyloxy diketones 失效
标题翻译：糖基氧基二酮
公开(公告)号：US4649181A
公开(公告)日：1987-03-10
申请号：US718575
申请日：1985-04-01
申请人： Roland Darms , Charles E. Monnier
发明人： Roland Darms , Charles E. Monnier
IPC分类号： C07D303/32 , C07B61/00 , C07D301/28 , C07D303/24 , C07D303/27 , C08G59/00 , C08G59/20 , C08G59/24 , C08G59/30 , C08G59/32 , C08F283/00
CPC分类号： C08G59/3218 , C07D303/24 , C08G59/245
摘要： Novel glycidyloxy diketones of the formula I ##STR1## (in which, for example, X is glycidyloxy, Y is H and R is 1,3-phenylene) are described.The compounds of the formula can be used together with customary curing agents and/or curing catalysts for the preparation of crosslinked (cured) products which have good thermal and mechanical properties.
摘要翻译：描述了式I的新型缩水甘油氧基二酮（I）（其中，例如，X是缩水甘油氧基，Y是H，R是1,3-亚苯基）。式的化合物可以与常规固化剂和/或固化催化剂一起使用，用于制备具有良好热和机械性能的交联（固化）产物。

100. 发明授权

US4383118A Preparation of glycidyl polyethers of polyphenols 失效
标题翻译：多酚的缩水甘油聚醚的制备
公开(公告)号：US4383118A
公开(公告)日：1983-05-10
申请号：US296213
申请日：1981-08-25
申请人： Jean-Louis Locatelli , Gerard Soula
发明人： Jean-Louis Locatelli , Gerard Soula
IPC分类号： C08G59/68 , B01J31/00 , B01J31/06 , C07B61/00 , C07C37/66 , C07C41/03 , C07D301/28 , C07D303/27 , C08G59/00 , C08G59/06 , C07D301/00
CPC分类号： B01J31/165 , B01J31/068 , C07C37/66 , C07C41/03 , C08G59/063
摘要： Glycidyl polyethers of polyphenols are prepared by reacting at least one alkali metal salt of a polyphenol with at least one 1-halogeno-2,3-epoxyalkane, in an anhydrous and essentially aprotic reaction medium, and in the presence of a catalytically effective amount of a catalyst which comprises a cross-linked organic polymeric support, said support having a plurality of catalytically active functional groups covalently coupled thereto, the free valence of said functional groups having the structural formula: ##STR1## The subject process is admirably suited, for example, for the preparation of epoxy resins from the disodium salt of bisphenol A and epichlorohydrin.
摘要翻译：通过使多酚的至少一种碱金属盐与至少一种1-卤代-2,3-环氧烷烃在无水和基本上非质子传递的反应介质中，并且在催化有效量的包含交联的有机聚合物载体的催化剂，所述载体具有与其共价偶联的多个催化活性官能团，所述官能团的游离价态具有以下结构式：本方法适合于例如，用于由双酚A和表氯醇的二钠盐制备环氧树脂。

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