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91. 发明申请

US20050196818A1 Antibodies to alpha-synuclein 有权
标题翻译： α-突触核蛋白的抗体
公开(公告)号：US20050196818A1
公开(公告)日：2005-09-08
申请号：US10984192
申请日：2004-11-08
申请人： Tamie Chilcote , Robin Barbour
发明人： Tamie Chilcote , Robin Barbour
IPC分类号： C07K16/18 , G01N20060101 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： C07K16/18 , G01N33/6896 , Y10S530/809
摘要： The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically binding to such epitopes.
摘要翻译：本发明提供了检测α-突触核蛋白的方法。本发明还鉴定用于这种检测的α突触核蛋白的优选表位，并提供与这些表位特异性结合的抗体。

92. 发明申请

US20050196816A1 Immunoglobulin E detection in mammalian species 失效
标题翻译：哺乳动物物种中的免疫球蛋白E检测
公开(公告)号：US20050196816A1
公开(公告)日：2005-09-08
申请号：US10758165
申请日：2004-01-15
申请人： Bruce Hammerberg
发明人： Bruce Hammerberg
IPC分类号： C07K16/42 , C12N1/00 , G01N20060101 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： C07K16/4291 , G01N33/6854 , G01N2800/24
摘要： The present invention provides antibodies (e.g., monoclonal antibodies) that specifically binds to mammalian IgE (e.g., dog IgE). In some embodiments the antibodies bind to an epitope between amino acids 145-166 of mammalian IgE; in other embodiments the antibodies bind to an epitope between amino acids 356-374 of mammalian IgE. The antibodies may be used for allergen reactivity testing in human subjects or animal subjects for veterinary purposes.
摘要翻译：本发明提供了特异性结合哺乳动物IgE（例如狗IgE）的抗体（例如单克隆抗体）。在一些实施方案中，抗体结合哺乳动物IgE的氨基酸145-166之间的表位; 在其它实施方案中，抗体结合哺乳动物IgE的第356-374位氨基酸之间的表位。抗体可用于人类受试者或动物受试者用于兽医目的的变应原反应性测试。

93. 发明申请

US20050186682A1 Apparatus and method for process monitoring 失效
标题翻译：用于过程监控的装置和方法
公开(公告)号：US20050186682A1
公开(公告)日：2005-08-25
申请号：US11099707
申请日：2005-04-05
申请人： Thomas Witty , Robert Case
发明人： Thomas Witty , Robert Case
IPC分类号： G01N20060101 , G01N21/00 , G01N21/05 , G01N33/00 , G01N33/53 , G01N33/543
CPC分类号： G01N33/5302 , G01N21/05 , G16H10/40 , Y10T436/11 , Y10T436/115831 , Y10T436/117497 , Y10T436/118339
摘要： An apparatus is provided for testing fluid samples includes a sensor, which can be light source, directed to a flow cell and a photo sensor for detecting a light beam reflected from the flow cell. The photo sensor monitors the fluid in the flow cell by sensing the reflected light beam from the flow cell, thereby monitoring the test process. The apparatus may have additional light source so that the photo sensor may monitor the test process by detecting the absorption light beam or fluorescent light beam from the flow cell at different phases of the test process.
摘要翻译：提供了一种用于测试流体样品的装置，其包括可以是光源的传感器，其被引导到流动池和用于检测从流动池反射的光束的光传感器。光传感器通过感测来自流动池的反射光束来监测流动池中的流体，从而监测测试过程。该装置可以具有额外的光源，使得光传感器可以通过在测试过程的不同阶段检测来自流动池的吸收光束或荧光光束来监视测试过程。

94. 发明申请

US20050180882A1 Rapid sample analysis and storage devices and methods of use 有权
标题翻译：快速样品分析和储存装置及使用方法
公开(公告)号：US20050180882A1
公开(公告)日：2005-08-18
申请号：US10990324
申请日：2004-11-15
申请人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
发明人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
IPC分类号： A61B5/00 , A61B10/00 , A61M1/00 , B01L3/00 , B65D81/00 , G01N20060101 , G01N31/22 , G01N33/48 , G01N33/487
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/0074 , A61B2010/0077 , B01L3/5023 , B01L3/5027 , B01L3/5029 , B01L2200/027 , B01L2200/0605 , B01L2300/0825 , B01L2400/0406 , B01L2400/0644 , G01N33/48714
摘要： The present invention provides test devices for detecting an analyte suspected of being present in a liquid sample. The devices contain a reservoir compartment, a test compartment, and a port for a sample collection well. The devices also have a rotatable sample collection well located in the port. The device has an upper chamber for insertion of a sample applicator, an expression plate for wringing out the sample applicator and applying sample to the device, a lower chamber, and an aliquot outlet and a reservoir outlet for the movement of sample through the device. The device also contains test elements for detecting the analyte of interest. By rotating the sample collection well, the operator is able to direct distribution of collected sample in the device. Methods of using the devices and kits containing the devices are also provided.
摘要翻译：本发明提供了用于检测疑似存在于液体样品中的分析物的测试装置。设备包含储存室，测试隔间和样品收集井的端口。这些设备还具有位于端口中的可旋转样品收集。该装置具有用于插入样品施加器的上室，用于拧紧样品施加器并将样品施加到装置的下表面板，下室和用于样品运动通过装置的等分出口和储存器出口。该装置还包含用于检测感兴趣的分析物的测试元件。通过旋转样品收集井，操作者能够将收集的样品直接分布在装置中。还提供了使用包含装置的装置和试剂盒的方法。

95. 发明申请

US20050176136A1 AFINITY DOMAIN FOR ANALYTE SENSOR 审中-公开
标题翻译：用于分析传感器的AFINITY域
公开(公告)号：US20050176136A1
公开(公告)日：2005-08-11
申请号：US10991353
申请日：2004-11-16
申请人： John Burd , Mark Tapsak , Rathbun Rhodes
发明人： John Burd , Mark Tapsak , Rathbun Rhodes
IPC分类号： A61B5/00 , C12M1/34 , C12Q1/00 , G01N20060101
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14865
摘要： Abstract of the DisclosureThe preferred embodiments provide a membrane system, particularly for use on an electrochemical sensor, wherein the membrane system includes an affinity domain that dampens the effects of target interferant(s) on the sensor. The affinity domain can be layer, surface, region, and/or portion of the membrane system formed using sorbents that have an affinity for the target interferant. The sorbents can be adapted to adsorb the interferants, for example using adsorbents such as chromatography packing materials. The sorbents can also be adapted to absorb the interferants by imprinting a molecular structure on the material that forms the affinity domain such that target interferants bind to the imprinted surfaces at the molecular level.
摘要翻译：摘要公开优选的实施方案提供了一种特别用于电化学传感器的膜系统，其中膜系统包括抵消目标干扰物对传感器的影响的亲和结构域。亲和结构域可以是使用对目标干扰物具有亲和力的吸附剂形成的膜系统的层，表面，区域和/或部分。吸附剂可以适于吸附干扰剂，例如使用吸附剂如色谱填充材料。吸附剂也可适用于通过在形成亲和结构域的材料上印记分子结构来吸收干扰物，使得靶分子在分子水平上与印迹表面结合。

96. 发明申请

US20050176029A1 Nanoscale transduction systems for detecting molecular interactions 审中-公开
标题翻译：用于检测分子相互作用的纳米尺度转导系统
公开(公告)号：US20050176029A1
公开(公告)日：2005-08-11
申请号：US10970756
申请日：2004-10-20
申请人： Michael Heller , Benjamin Sullivan , Sanja Zlatanovic , Sadik Esener , Dietrich Dehlinger
发明人： Michael Heller , Benjamin Sullivan , Sanja Zlatanovic , Sadik Esener , Dietrich Dehlinger
IPC分类号： C12Q1/68 , G01N20060101 , G01N33/00 , G01N33/53 , G01N33/543 , H01L21/00
CPC分类号： G01N33/54346 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00
摘要： The present invention relates to nanoscale transduction systems that produce reversible signals to facilitate detection. In one respect, the invention relates to the analysis of molecular binding events using higher order signaling nanoscale constructs, or “nanomachines”, that allow nanostructures to be individually detectable, even in the midst of high background noise. Such systems are particularly useful for improving the performance of rare target detection methods, as well as being generally useful in any field in which sensitivity, discrimination and confidence in detection are important.
摘要翻译：本发明涉及产生可逆信号以促进检测的纳米尺度转导系统。在一个方面，本发明涉及使用更高级信号的纳米尺度构建体或“纳米机器”的分子结合事件的分析，即使在高背景噪声中也允许纳米结构单独检测。这种系统对于改善稀有目标检测方法的性能特别有用，并且在敏感性，鉴别和检测置信度重要的任何领域中通常是有用的。

97. 发明申请

US20050174571A1 System and method for associating container defect information to a specific path of manufacturing 有权
标题翻译：将容器缺陷信息与特定制造路径相关联的系统和方法
公开(公告)号：US20050174571A1
公开(公告)日：2005-08-11
申请号：US10970780
申请日：2004-10-21
申请人： Don Cochran , Dennis Bradley , Steven Cech , Fredrick Awig , Terry Graves , Thomas Palombo , Michael Yoder
发明人： Don Cochran , Dennis Bradley , Steven Cech , Fredrick Awig , Terry Graves , Thomas Palombo , Michael Yoder
IPC分类号： G01N20060101 , G01N21/86 , G01N21/88 , G01N21/90 , G01V8/00
CPC分类号： G01N21/909 , G01N21/8806 , G01N21/9036 , G01N2201/0634
摘要： This application relates to an apparatus and method for automated inspection of formed metal containers. More specifically, it pertains to the use of machine vision systems to identify and correlate manufacturing defects occurring in formed food and beverage containers to specific manufacturing paths or sources of origin (e.g., body makers) used in the container forming process. The disclosed invention is enabled by the placement of a machine-readable code on specific portions of the can body during the forming process and the use of machine vision reading techniques.
摘要翻译：本申请涉及用于形成的金属容器的自动检查的装置和方法。更具体地说，它涉及使用机器视觉系统来识别并将形成的食品和饮料容器中出现的制造缺陷与在容器成型过程中使用的具体制造路径或原始来源（例如身体制造者）相关联。所公开的发明是通过在机器视觉阅读技术的成形过程和机器视觉阅读技术的使用期间将机器可读代码放置在罐体的特定部分上而实现的。

98. 发明申请

US20050170440A1 Treatment and diagnosis of insulin-resistant states 审中-公开
标题翻译：治疗和诊断胰岛素抵抗状态
公开(公告)号：US20050170440A1
公开(公告)日：2005-08-04
申请号：US11056562
申请日：2005-02-11
申请人： Venita DeAlmeida , Timothy Stewart
发明人： Venita DeAlmeida , Timothy Stewart
IPC分类号： G01N33/53 , A61B20060101 , A61K20060101 , A61K31/175 , A61K31/64 , A61K38/00 , A61K38/17 , A61K38/18 , A61K38/22 , A61K38/28 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/10 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/46 , C12N20060101 , C12N5/10 , C12N5/12 , C12N15/09 , C12P21/08 , C12Q1/25 , G01N20060101 , G01N33/537 , G01N33/543 , G01N33/567 , G01N33/577 , G01N33/68
CPC分类号： A61K31/175 , A61K31/64 , A61K38/1709 , C07K14/4703 , G01N33/6893 , G01N2800/042 , G01N2800/044
摘要： Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity. Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing antibodies to Dkk-5 and preparations comprising Dkk-5.
摘要翻译：以有效量施用Dickkopf-5（Dkk-5）蛋白，以治疗涉及胰岛素抵抗的疾病，例如非胰岛素依赖型糖尿病（NIDDM）或肥胖症。还提供了使用Dkk-5作为测量来诊断胰岛素抵抗和相关疾病的方法，以及用于诊断和治疗的试剂盒，以及产生Dkk-5抗体的杂交瘤和包含Dkk-5的制剂。

99. 发明申请

US20050161346A1 Systems and methods for improving electrochemical analyte sensors 有权
标题翻译：改进电化学分析物传感器的系统和方法
公开(公告)号：US20050161346A1
公开(公告)日：2005-07-28
申请号：US11007635
申请日：2004-12-07
申请人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
发明人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
IPC分类号： A61B5/00 , G01N20060101 , G01N27/26
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译：提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本上无干扰的分析物浓度测量。当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。

100. 发明授权

US06921667B2 Methods for direct detection of individual methotrexate metabolites 有权
标题翻译：直接检测甲氨蝶呤代谢物的方法
公开(公告)号：US06921667B2
公开(公告)日：2005-07-26
申请号：US10384066
申请日：2003-03-07
申请人： Thierry Dervieux , Russell B. Richerson
发明人： Thierry Dervieux , Russell B. Richerson
IPC分类号： A01N1/02 , C12Q1/00 , C12Q1/02 , G01N20060101 , G01N21/62 , G01N21/75 , G01N30/02 , G01N33/00 , G01N33/48 , G01N33/94
CPC分类号： G01N33/94 , G01N2800/52 , Y10T436/17 , Y10T436/24
摘要： The present invention provides a method for determining a level of a methotrexate polyglutamate (MTXPG) in a cellular extract by resolving at least one MTXPG in a cellular extract obtained from a human undergoing methotrexate therapy; and detecting at least one resolved MTXPG, thereby determining a level of the resolved MTXPG. A method of the invention can be useful, for example, for determining a level of MTXPG3, MTXPG4 or MTXPG5 or for determining a level of each methotrexate polyglutamate species (MTXPG1 to MTXPG7) present in the cellular extract.
摘要翻译：本发明提供了一种通过从经历氨甲蝶呤治疗的人获得的细胞提取物中拆分至少一种MTXPG来确定细胞提取物中甲氨蝶呤聚谷氨酸（MTXPG）水平的方法; 并检测至少一个解析的MTXPG，从而确定所分辨的MTXPG的水平。本发明的方法可用于例如用于确定MTXPG 3 3，MTXPG 4或MTXPG 5 5的水平，或用于确定水平的细胞提取物中存在的每个甲氨蝶呤聚谷氨酸酯物质（MTXPG 1至MTXPG 7）。

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