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91. 发明授权

US09434684B2 Oxime-substituted amide compound and pest control agent 有权
标题翻译：肟取代酰胺化合物和害虫防治剂
公开(公告)号：US09434684B2
公开(公告)日：2016-09-06
申请号：US14414173
申请日：2013-07-12
申请人： Nissan Chemical Industries, Ltd.
发明人： Motoyoshi Iwasa , Keisuke Tsuji , Mitsutaka Tomizawa , Takeshi Mita , Hidehito Kuwahara , Miho Asahi , Hotaka Imanaka
IPC分类号： C07C251/48 , A01N37/18 , A01N37/34 , A01N41/10 , A01N41/12 , A01N43/10 , C07C255/64 , C07C317/32 , C07C321/28 , C07D213/53 , C07D213/65 , C07D213/82 , C07D241/24 , A01N43/40 , C07D333/38 , C07D407/12 , C07D409/12 , C07C251/52 , C07D213/42 , C07D213/61 , A01N37/20 , A01N43/56 , A01N43/60 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/84 , A01N47/12 , A01N55/00 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07F7/08
CPC分类号： C07D417/12 , A01N37/18 , A01N37/20 , A01N37/34 , A01N41/10 , A01N41/12 , A01N43/10 , A01N43/40 , A01N43/56 , A01N43/60 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/84 , A01N47/12 , A01N55/00 , C07C251/48 , C07C251/52 , C07C255/64 , C07C317/32 , C07C321/28 , C07D213/42 , C07D213/53 , C07D213/61 , C07D213/65 , C07D213/82 , C07D241/24 , C07D333/38 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07F7/0814
摘要： To provide a novel pesticide, especially a fungicide and a nematocide.An oxime-substituted amide compound represented by the formula (I) or its salt, and a pesticide containing it: wherein G1 is a structure represented by G1-1 or the like, G2 is a structure represented by G2-2 or the like: W is an oxygen atom or the like, X1 is a halogen atom, methyl, trifluoromethyl or the like, each of X2, X3, X4 and X5 is independently a hydrogen atom, a halogen atom or the like, each of Y1 and Y3 is independently a halogen atom, cyano, methyl, trifluoromethyl, C2-C6 alkynyl or the like, each of Y2 and Y4 is independently a hydrogen atom, a halogen atom or the like, R1 is C1-C6 alkyl, C1-C4 haloalkyl, (C1-C4)alkyl substituted with R18, C3-C6 cycloalkyl, C3-C6 alkenyl or the like, each of R2 and R3 is independently a hydrogen atom, methyl or the like, R4 is a hydrogen atom or the like, R18 is C3-C6 cycloalkyl, phenyl, phenyl substituted with (Z)m or the like, Z is a halogen atom or the like, and m is an integer of 1, 2 or 3.

92. 发明授权

US09394240B2 Method for producing amide derivative 有权
标题翻译：酰胺衍生物的制备方法
公开(公告)号：US09394240B2
公开(公告)日：2016-07-19
申请号：US14306885
申请日：2014-06-17
申请人： Mitsui Chemicals Agro, Inc.
发明人： Youji Aoki , Yumi Kobayashi , Hidenori Daido , Hiroyuki Katsuta , Hidetaka Tsukada , Atsushi Hirabayashi , Yusuke Takahashi , Michikazu Nomura , Atsuko Kawahara
IPC分类号： C07C237/28 , C07C235/68 , A01N37/46 , A01N43/40 , C07C205/58 , C07C231/02 , C07C233/81 , C07C255/57 , C07D213/82 , C07C255/58
CPC分类号： C07C233/76 , A01N37/46 , A01N43/40 , C07C205/58 , C07C231/02 , C07C233/81 , C07C235/68 , C07C255/57 , C07C255/58 , C07D213/82 , C07C237/42
摘要： An amide derivative represented by Formula (3), which exhibits excellent efficacy in pest control effect, is produced by allowing a compound represented by the following Formula (1) and a compound represented by Formula (2) to react with each other. In Formula (1) to Formula (3), Y1 and Y2 each represent a halogen atom or a haloalkyl group; Rf represents a C3-C4 perfluoroalkyl group; and R1 and R2 each represent a hydrogen atom or an alkyl group; LG represents a leaving group; T represents a hydrogen atom or a fluorine atom; X1, X3, X4, and X5 each represent a hydrogen atom, a halogen atom, or the like; and A represents a nitrogen atom, a methine group, or the like.
摘要翻译：通过使由下式（1）表示的化合物和由式（2）表示的化合物彼此反应来制备在害虫防治效果上显示出优异效果的由式（3）表示的酰胺衍生物。在式（1）至式（3）中，Y 1和Y 2各自表示卤原子或卤代烷基; Rf表示C3-C4全氟烷基; 并且R 1和R 2各自表示氢原子或烷基; LG代表离职团体; T表示氢原子或氟原子; X1，X3，X4和X5各自表示氢原子，卤素原子等; A表示氮原子，次甲基等。

93. 发明申请

US20160185723A1 C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE 有权
标题翻译： C-H氟化物（II）氟化物的杂环化合物
公开(公告)号：US20160185723A1
公开(公告)日：2016-06-30
申请号：US14907694
申请日：2014-07-28
申请人： THR REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： John HARTWIG , Patrick FIER
IPC分类号： C07D213/61 , C07D405/04 , C07D213/75 , C07D213/81 , C07D239/42 , C07D213/79 , C07D213/82 , C07D213/80 , C07D213/65 , C07D215/18 , C07D401/04 , C07D213/803
CPC分类号： C07D213/61 , C07D213/63 , C07D213/65 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/803 , C07D213/81 , C07D213/82 , C07D215/18 , C07D239/42 , C07D239/46 , C07D401/04 , C07D405/04
摘要： The present invention provides compositions and methods for the selective C—H fluorination of nitrogen-containing heteroarenes with AgF2, which has previously been considered too reactive for practical, selective C—H fluorination. Fluorinated heteroarenes are prevalent in numerous pharmaceuticals, agrochemicals and materials. However, the reactions used to introduce fluorine into these molecules require pre-functionalized substrates or the use of F2 gas. The present invention provides a mild and general method for the C—H fluorination of nitrogen-containing heteroarene compounds to 2-fluoro-heteroarenes with commercially available AgF2. In various embodiments, these reactions occur at ambient temperature within one hour and occur with exclusive selectivity for fluorination at the 2-position. Exemplary reaction conditions are effective for fluorinating diazine heteroarenes to form a single fluorinated isomer.
摘要翻译：本发明提供了含有AgF 2的含氮杂芳烃选择性C-H氟化的组合物和方法，其先前被认为对于实际的选择性C-H氟化反应过大。氟化杂芳烃在许多药物，农药和材料中是普遍存在的。然而，用于将氟引入这些分子的反应需要预功能化的底物或使用F2气体。本发明提供了一种使用市售的AgF2将含氮杂芳烃化合物C-H氟化为2-氟 - 杂芳烃的温和的一般方法。在各种实施方案中，这些反应在环境温度下在1小时内发生，并且以2-位氟化的排他选择性发生。示例性的反应条件对于使二嗪杂芳族化合物氟化以形成单一氟化异构体是有效的。

94. 发明申请

US20160168132A1 DI(HETERO)ARYLAMIDES AND SULFONAMIDES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： DI（HETERO）ARYLAMIDES和SULFONAMIDES，其制备方法及其治疗方法
公开(公告)号：US20160168132A1
公开(公告)日：2016-06-16
申请号：US14908944
申请日：2014-07-30
申请人： MINORYX THERAPEUTICS S.L.
发明人： Xavier BARRIL ALONSO , Ana Maria GARCÍA COLLAZO , Juan AYMAMI BOFARULL , Marc REVÉS VILAPLANA , Rodolfo LAVILLA GRIFOLS , Marc MARTINELL PEDEMONTE
IPC分类号： C07D405/12 , C07D239/48 , C07C235/56 , C07D213/74 , C07C255/60 , C07D213/81 , C07D213/82 , C07D401/12 , C07D215/20 , C07C233/80 , C07C311/21
CPC分类号： C07D405/12 , A61K31/167 , A61K31/18 , A61K31/44 , A61K31/505 , C07C233/80 , C07C235/56 , C07C235/64 , C07C255/54 , C07C255/60 , C07C311/21 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D215/20 , C07D239/48 , C07D401/12
摘要： The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of conditions associated with the alteration of the activity of β-galactosidase, specially galactosidase beta-1 or GLB1, including GM1 gangliosidoses and Morquio syndrome, type B.
摘要翻译：本发明涉及式（I）的化合物：以及其制备方法，包含其的药物组合物及其用于治疗和/或预防与改变活动相关的病症的用途。 β-半乳糖苷酶，特别是半乳糖苷酶β-1或GLB1，包括GM1神经节苷脂和Morquio综合征B型。

95. 发明授权

US09359328B2 2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-N-[4-(trifluoromethoxy)phenyl]-3-pyridinecarboxamide benzenesulfonate, crystal of same, crystal polymorph thereof, and methods for production thereof 有权
标题翻译： 2 - [[[2 - [（羟基乙酰基）氨基] -4-吡啶基]甲基]硫基] -N- [4-（三氟甲氧基）苯基] -3-吡啶甲酰胺苯磺酸盐，其结晶，晶体多晶型物，生产
公开(公告)号：US09359328B2
公开(公告)日：2016-06-07
申请号：US14686577
申请日：2015-04-14
申请人： Santen Pharmaceutical Co., Ltd.
发明人： Masashi Niwa , Hiroshi Deguchi
IPC分类号： C07D213/82 , C07D401/12 , A61K31/455
CPC分类号： C07D213/82 , A61K31/455 , C07B2200/13 , C07C303/32 , C07C309/29 , C07D401/12
摘要： In the course of developing 2-[[[2-[(hydroxyacetyl) amino]-4-pyridinyl]methyl]thio]-N-[4-(trifluoromethoxy) phenyl]-3-pyridinecarboxamide(compound A), there are the multiple problems: 1) compound A or its salt is difficult to be recrystallized, the storage stability largely differs depending on the kind of the salt, and it is very difficult to obtain a salt of compound A having excellent storage stability; 2) in a crystallization process of compound A, it is very difficult to control a crystal polymorph, and 3) compound A (free body) causes mineral deposition in the stomach when it is orally administered repeatedly. For solving these problems, we made examination focusing on the kind of the salt and, as a result, found that 1) benzenesulfonate of compound A does not decompose by light, humidity and other factors in a 1-week preliminary stability test (severe test), and has no problem in its storage stability, 2) a method of selectively producing two kinds of crystal forms of benzenesulfonate of compound A, and that 3) no mineral deposition in the stomach is observed even after a 4-week repeated oral administration.
摘要翻译：在开发2 - [[[2 - [（羟基乙酰基）氨基] -4-吡啶基]甲基]硫基] -N- [4-（三氟甲氧基）苯基] -3-吡啶甲酰胺（化合物A）的过程中，多个问题：1）化合物A或其盐难以重结晶，储存稳定性根据盐的种类而有很大差异，难以获得具有优异储存稳定性的化合物A的盐; 2）在化合物A的结晶过程中，控制晶体多晶型是非常困难的，3）化合物A（游离体）在重复口服给药时会引起胃中的矿物质沉积。为了解决这些问题，我们考察了盐的种类，结果发现化合物A的1）苯磺酸盐在1周的初步稳定性试验（严重试验）中不会被光，湿度等因素分解），并且其储存稳定性没有问题; 2）选择性地生成化合物A的苯磺酸盐的两种晶体形式的方法，以及3）即使在4周的重复口服给药后也没有观察到在胃中的矿物质沉积。

96. 发明申请

US20160114060A1 PSMA-BINDING AGENTS AND USES THEREOF 有权
标题翻译： PSMA结合剂及其用途
公开(公告)号：US20160114060A1
公开(公告)日：2016-04-28
申请号：US14987032
申请日：2016-01-04
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： Martin G. POMPER , Ronnie Charles MEASE , Ying CHEN
IPC分类号： A61K51/04 , C07D213/82
CPC分类号： A61K51/0455 , A61K9/127 , A61K51/0402 , C07B2200/05 , C07C275/16 , C07C275/18 , C07D213/61 , C07D213/74 , C07D213/82 , C07F7/2208 , Y02P20/55
摘要： Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
摘要翻译：描述了具有放射性同位素取代基的前列腺特异性膜抗原（PSMA）结合化合物及其化学前体。化合物包括含吡啶化合物，具有苯肼结构的化合物和酰化赖氨酸化合物。化合物允许放射性核素用于单光子发射计算机断层摄影（SPECT）和正电子发射断层摄影（PET），用于成像，例如前列腺癌细胞和血管生成。

97. 发明申请

US20160097078A1 ASSAYS, METHODS AND MEANS 审中-公开
公开(公告)号：US20160097078A1
公开(公告)日：2016-04-07
申请号：US14944796
申请日：2015-11-18
申请人： ISIS INNOVATION LIMITED
发明人： Patrick Henry Maxwell , Christopher William Pugh , Peter John Ratcliffe , Christopher Joseph Schofield
IPC分类号： C12Q1/26 , C07C323/60 , C07D213/80 , C07D213/81 , C07D213/82 , C07C235/80 , C07C327/32
CPC分类号： A61K31/455 , A01K2217/05 , A61K31/137 , A61K31/14 , A61K31/165 , A61K31/166 , A61K31/185 , A61K31/192 , A61K31/194 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/21 , A61K31/221 , A61K31/223 , A61K31/225 , A61K31/235 , A61K31/24 , A61K31/265 , A61K31/327 , A61K31/44 , A61K31/4412 , A61K38/00 , A61K39/3955 , C07C235/80 , C07C323/60 , C07C327/32 , C07D213/80 , C07D213/81 , C07D213/82 , C07K14/4702 , C07K16/40 , C07K2317/30 , C12N9/0071 , C12Q1/26 , C12Q1/34 , G01N33/573 , G01N2333/90245 , G01N2500/04 , G01N2500/20
摘要： A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

98. 发明授权

US09301951B2 Compounds and methods for inhibiting phosphate transport 有权
标题翻译：用于抑制磷酸盐转运的化合物和方法
公开(公告)号：US09301951B2
公开(公告)日：2016-04-05
申请号：US14536509
申请日：2014-11-07
申请人： Ardelyx, Inc.
发明人： Jason G. Lewis , Jeffrey W. Jacobs , Nicholas Reich , Michael R. Leadbetter , Noah Bell , Han-Ting Chang , Tao Chen , Marc Navre , Dominique Charmot , Christopher Carreras , Eric Labonte
IPC分类号： A61K31/4418 , A61K31/444 , A61K31/505 , A61K31/506 , C07D213/36 , C07D239/26 , C07D401/10 , C07D403/10 , C07D401/12 , C07D213/81 , C07D213/82 , C07D239/34 , C07D239/42 , C07D403/12 , C07D405/12 , C07D417/12 , A61K31/44 , A61K31/4545 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/59 , A61K31/785 , A61K45/06 , C07D401/14 , C07D405/14 , C07D417/14 , A61K31/496 , A61K31/593
CPC分类号： C07D213/81 , A61K31/44 , A61K31/4418 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/59 , A61K31/593 , A61K31/785 , A61K45/06 , C07D213/30 , C07D213/38 , C07D213/50 , C07D213/82 , C07D239/34 , C07D239/42 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14
摘要： Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, A, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：具有作为磷酸盐转运抑制剂的活性的化合物，更具体地，公开了肠顶膜Na /磷酸盐共转运的抑制剂。所述化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中X，Y，A，R 1和R 2如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

99. 发明授权

US09278910B2 GLP-1 receptor stabilizers and modulators 有权
标题翻译： GLP-1受体稳定剂和调节剂
公开(公告)号：US09278910B2
公开(公告)日：2016-03-08
申请号：US14122176
申请日：2012-05-31
申请人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Junko Tamiya , Liming Huang , Thomas Fowler , Andrew Novak , Premji Meghani , Enugurthi Brahmachary , Adam Richard Yeager
发明人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Junko Tamiya , Liming Huang , Thomas Fowler , Andrew Novak , Premji Meghani , Enugurthi Brahmachary , Adam Richard Yeager
IPC分类号： C07D271/06 , C07C235/38 , A61K9/00 , A61K47/20 , A61K47/26 , A61K47/40 , A61K47/48 , A61K45/06 , A61K31/155 , A61K38/26 , C07C255/57 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D309/06 , C07D309/08 , C07D311/16 , C07C271/28 , C07D215/48 , C07D217/02 , C07C275/42 , C07D317/68 , C07D231/12 , C07D333/38 , C07D233/60 , C07C311/08 , C07C311/13 , C07C311/21 , C07D235/06 , C07C311/29 , C07D235/12 , C07D235/18 , C07C311/48 , C07D239/26 , C07D239/28 , C07C317/28 , C07C317/44 , C07D239/74 , C07D413/04 , C07D239/91 , C07D413/12 , C07D241/42 , C07D241/44 , C07D417/12 , C07C323/62 , C07C229/14 , C07D249/08 , C07D257/04 , C07C233/47 , C07C233/51 , C07D261/18 , C07C233/81 , C07C233/83 , C07C235/12 , C07D263/32 , C07D263/34 , C07C235/48 , C07D263/48 , C07D263/57 , C07C237/22 , C07C237/36 , C07C237/42 , C07D271/07 , C07D271/107 , C07D207/267 , C07D277/30 , C07D209/08 , C07D277/56 , C07D277/66 , C07D279/12 , C07D211/14 , C07D211/34 , C07D211/62 , C07D295/15 , C07D295/155 , C07D295/205 , C07D213/55 , C07D213/65 , C07D307/24 , C07D307/54 , C07D307/68 , C07D307/79 , C08B37/16 , C08L5/16 , B82Y5/00 , A61K31/235 , A61K31/341 , A61K31/4406 , A61K31/4465 , A61K31/495 , A61K31/505 , A61K31/5375 , A61K31/54 , C07D295/24
CPC分类号： A61K31/4245 , A61K9/0019 , A61K9/0095 , A61K31/155 , A61K31/235 , A61K31/341 , A61K31/4406 , A61K31/4439 , A61K31/4465 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/5375 , A61K31/54 , A61K38/22 , A61K38/26 , A61K45/06 , A61K47/20 , A61K47/26 , A61K47/40 , A61K47/6951 , B82Y5/00 , C07C229/14 , C07C233/47 , C07C233/51 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/38 , C07C235/48 , C07C237/22 , C07C237/36 , C07C237/42 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/48 , C07C317/28 , C07C317/44 , C07C323/62 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/267 , C07D209/08 , C07D211/14 , C07D211/34 , C07D211/62 , C07D213/55 , C07D213/65 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/02 , C07D231/12 , C07D233/60 , C07D235/06 , C07D235/12 , C07D235/18 , C07D239/26 , C07D239/28 , C07D239/74 , C07D239/91 , C07D241/42 , C07D241/44 , C07D249/08 , C07D257/04 , C07D261/18 , C07D263/32 , C07D263/34 , C07D263/48 , C07D263/57 , C07D271/06 , C07D271/07 , C07D271/107 , C07D277/30 , C07D277/56 , C07D277/66 , C07D279/12 , C07D295/15 , C07D295/155 , C07D295/205 , C07D295/24 , C07D307/24 , C07D307/54 , C07D307/68 , C07D307/79 , C07D309/06 , C07D309/08 , C07D311/16 , C07D317/68 , C07D333/38 , C07D413/04 , C07D413/12 , C07D417/12 , C08B37/0015 , C08L5/16 , A61K2300/00
摘要： Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1 (7-36), GLP-1 (9-36), oxyntomodulin and exendin variants.
摘要翻译：结合胰高血糖素样肽1（GLP-1）受体的化合物，其合成方法，其治疗和/或预防用途的方法及其在体外稳定GLP-1受体中用于GLP- 1受体。某些化合物自身或存在受体配体如GIP（1-42），PTH可能具有作为胰高血糖素受体，GIP受体，GLP-1和GLP-2受体以及PTH受体的调节剂或增效剂的活性（1-34），胰高血糖素（1-29），GLP-2（1-33），GLP-1（7-36），GLP-1（9-36），胃泌酸调节蛋白和毒蜥外泌肽变体。

100. 发明授权

US09266869B2 Substituted dialkyl(oxido)-lambda4-sulfanylidene nicotinamide derivatives as kinase inhibitors 有权
标题翻译：取代的二烷基（氧化）-λ4-亚硫酸基烟酰胺衍生物作为激酶抑制剂
公开(公告)号：US09266869B2
公开(公告)日：2016-02-23
申请号：US14565660
申请日：2014-12-10
申请人： Allergan, Inc.
发明人： Sougato Boral , Shimiao Wang , Thomas Malone , Julie Wurster , Jie Shen , Michael Robinson
IPC分类号： C07D413/12 , C07D405/12 , C07D409/14 , C07D213/82 , C07D401/12 , C07D405/14
CPC分类号： C07D413/12 , C07D213/82 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译：本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。

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