专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明授权

US4341797A Bis-(amidine phenyl)cyclohexanecarboxylic acid ketones, compositions containing same and method of use 失效
标题翻译：双（脒基苯基）环己烷羧酸酮，含有它们的组合物和使用方法
公开(公告)号：US4341797A
公开(公告)日：1982-07-27
申请号：US270720
申请日：1981-06-05
申请人： George C. Rovnyak
发明人： George C. Rovnyak
IPC分类号： C07C257/18 , C07C123/00 , A61K31/195
CPC分类号： C07C257/18 , C07C2101/14
摘要： Bis-(amidine phenyl)cyclohexanecarboxylic acid ketones are provided having the structure ##STR1## wherein R is hydrogen, lower alkyl or aryl and n is 0, 1 or 2, and acid-addition salts thereof. In addition, pharmaceutical compositions containing the above compounds and a method of using same to treat inflammatory conditions in mammalian species are also provided.
摘要翻译：提供了具有结构的双 - （脒基苯基）环己烷羧酸酮，其中R是氢，低级烷基或芳基，n是0,1或2，及其酸加成盐。此外，还提供了含有上述化合物的药物组合物及其用于治疗哺乳动物物种中的炎性病症的方法。

92. 发明授权

US4066696A Aromatic amidines as antiviral agents in animals 失效
标题翻译：芳香胺作为动物中的抗病毒剂
公开(公告)号：US4066696A
公开(公告)日：1978-01-03
申请号：US769854
申请日：1977-02-18
申请人： Allen R. Kraska , Rodney C. Schnur
发明人： Allen R. Kraska , Rodney C. Schnur
IPC分类号： A61K31/155 , A61K31/135 , A61K31/18 , A61K31/19 , A61K31/245 , A61K31/255 , A61K31/415 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/505 , A61P31/12 , A61P43/00 , C07C67/00 , C07C239/00 , C07C257/18 , C07C301/00 , C07C309/14 , C07C311/46 , C07C311/49 , C07C313/00 , C07C317/40 , C07D213/75 , C07D233/54 , C07D233/64 , C07D239/42 , C07D277/18 , C07D277/44 , C07D277/46 , C07D277/48 , C07D277/56 , C07C123/00
CPC分类号： C07D213/75 , C07D233/64 , C07D239/42 , C07D277/44 , C07D277/46
摘要： Novel [N,N-di(higher alkyl)aminomethyl]benzamidine and substituted compounds such as [N,N-di(higher alkyl)aminomethyl]-N-(2-propyl)-benzamidine and [N,N-di(higher alkyl)aminomethyl]-N-(p-hydroxyphenyphenyl)-benzamidine and their non-toxic acid addition salts are useful for combating viral infections in vertebrate animals.

93. 发明授权

US3903163A N,N-Disubstituted naphthaleneacetamidines 失效
标题翻译： N，N-二取代萘乙酰胺
公开(公告)号：US3903163A
公开(公告)日：1975-09-02
申请号：US51095674
申请日：1974-10-02
申请人： DOW CHEMICAL CO
发明人： MCCARTHY JR JAMES R
IPC分类号： A61K31/155 , A61K20060101 , A61P25/00 , C07C20060101 , C07C67/00 , C07C239/00 , C07C257/14 , C07C257/18 , C07C129/08
摘要： N,N''-Disubstituted naphthaleneacetamidine compounds such as N, N''-dimethyl-2-naphthaleneacetamidine, and their pharmaceuticallyacceptable salts are prepared by the reaction of a substituted 2naphthylacetonitrile with an alkylamine and an alkylammonium salt, or alternatively, by reaction of a 2-naphthyl-Nalkylacetamide with a trialkyloxonium fluoroborate followed by reaction with a primary alkylamine. The compounds have pharmacological activity as antidepressants and antianxiety or calming agents.
摘要翻译： N，N'-二取代的萘乙酰脒化合物如N，N'-二甲基-2-萘乙脒及其药学上可接受的盐通过取代的2-萘基乙腈与烷基胺和烷基铵盐的反应制备，或者通过 2-萘基-N-烷基乙酰胺与三烷氧基氟硼酸盐反应，然后与伯烷基胺反应。这些化合物具有作为抗抑郁药和抗焦虑或镇定剂的药理活性。

94. 发明申请

US20210130383A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE 有权
公开(公告)号：US20210130383A1
公开(公告)日：2021-05-06
申请号：US16675195
申请日：2019-11-05
申请人： Feng-Wen Yen , Tsun-Yuan Huang
发明人： Feng-Wen Yen , Tsun-Yuan Huang
IPC分类号： C07F15/00 , C07C257/18 , C07D209/88 , C07D217/26 , C07D213/78 , H01L51/00
摘要： A compound having a first ligand of the following is described. Ring A represents a monocyclic aromatic group or a polycyclic aromatic group. Ring B represents a polycyclic aromatic group. Z is a carbon. Z and the right N are coordinated to a metal to form a five-membered chelate ring. R1 and R2 independently represent mono to a maximum possible number of substitutions, or no substitution.

95. 发明授权

US10179124B2 Benzamides and related inhibitors of factor Xa 有权
公开(公告)号：US10179124B2
公开(公告)日：2019-01-15
申请号：US15466530
申请日：2017-03-22
申请人： Millennium Pharmaceuticals, Inc.
发明人： Bing-Yan Zhu , Wenrong Huang
IPC分类号： C07D213/81 , A61K31/44 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , A61K31/616 , A61K45/06 , A61K9/20 , A61K9/48
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

96. 发明授权

US10040750B2 Process for the manufacture of 4-aminobenzoamidine dihydrochloride 有权
公开(公告)号：US10040750B2
公开(公告)日：2018-08-07
申请号：US15190756
申请日：2016-06-23
申请人： Boehringer Ingelheim International GmbH
发明人： Weitong Dong , Christian Wolfgang Hemp , Xiangle Jin , Jun Lu , Ulrich Scholz , Shengmin Su , Wei Xu , Jinsong Yang
IPC分类号： C07C213/00 , C07C249/02 , C07C257/08 , C07C257/18 , C07C217/76
摘要： The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.

97. 发明授权

US09751831B2 Blood brain barrier-penetrating oximes for cholistenerases reactivation 有权
公开(公告)号：US09751831B2
公开(公告)日：2017-09-05
申请号：US13994682
申请日：2011-12-16
申请人： John R. Cashman , Jarosiaw Kalisiak
发明人： John R. Cashman , Jarosiaw Kalisiak
IPC分类号： C07D249/04 , C07D239/06 , C07D233/24 , C07C251/40 , C07C279/12 , C07C257/12 , C07C257/18 , C07C257/14
CPC分类号： C07C251/40 , C07C257/12 , C07C257/14 , C07C257/18 , C07C279/12 , C07D233/24 , C07D239/06 , C07D249/04
摘要： The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.

98. 发明授权

US09629831B2 Benzamides and related inhibitors of factor XA 有权
公开(公告)号：US09629831B2
公开(公告)日：2017-04-25
申请号：US14742465
申请日：2015-06-17
申请人： Millennium Pharmaceuticals, Inc.
发明人： Bing-Yan Zhu , Wenrong Huang
IPC分类号： C07D213/75 , A61K31/44 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , A61K31/616 , A61K45/06 , A61K9/20 , A61K9/48
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

99. 发明授权

US09399616B2 Process for the manufacture of 4-aminobenzoamidine dihydrochloride 有权
标题翻译：制备4-氨基苯甲脒二盐酸盐的方法
公开(公告)号：US09399616B2
公开(公告)日：2016-07-26
申请号：US14055054
申请日：2013-10-16
申请人： Weitong Dong , Christian Wolfgang Hemp , Xiangle Jin , Jun Lu , Ulrich Scholz , Shengmin Su , Wei Xu , Jinsong Yang
发明人： Weitong Dong , Christian Wolfgang Hemp , Xiangle Jin , Jun Lu , Ulrich Scholz , Shengmin Su , Wei Xu , Jinsong Yang
IPC分类号： C07C257/08 , C07C257/18 , C07C249/02
CPC分类号： C07C213/00 , C07C217/76 , C07C249/02 , C07C257/08 , C07C257/18
摘要： The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.
摘要翻译：本发明涉及制备通式（I）的4-氨基苯甲脒（4-AMBA）盐的方法，优选其盐与盐酸或氢溴酸，特别优选二氯化物盐。

100. 发明申请

US20160122370A1 BIMETALLIC COMPLEX COMPRISING CYCLOPENTADIENYL AND AMIDINE LIGANDS 有权
标题翻译：包含环戊二烯基和氨基配体的二元复合物
公开(公告)号：US20160122370A1
公开(公告)日：2016-05-05
申请号：US14898500
申请日：2014-06-18
申请人： LANXESS ELASTOMERS B.V.
发明人： Alexandra BERTHOUD , Victor QUIROGA NORAMBUENA , Gerard VAN DOREMAELE , Martin Alexander ZUIDEVELD , Henricus Johannes ARTS , Richard Thomas William SCOTT
IPC分类号： C07F7/28 , C08F210/02 , C07C257/18
CPC分类号： C07F7/28 , C07C257/18 , C07F17/00 , C08F4/65908 , C08F4/65912 , C08F4/6592 , C08F210/02 , C08F210/16 , C08F210/18 , C08F2410/03 , C08F210/06 , C08F236/20 , C08F2500/25 , C08F2500/17 , C08F2500/03
摘要： The present invention relates to a new bimetallic complex of the formula (1) wherein: M is a group 4-6 metal R1 means is a substituent comprising a heteroatom of group 15, through which R1 is bonded to the imine carbon atom; R2-R6 are the same or different and each represents a hydrogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R2-R6 may be linked to each other to form a ring; R7-R10 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R7-R10 may be linked to each other to form a ring; L is an optional neutral Lewis basic ligand, and j is an integer denoting the number of neutral ligands L; and X is an anionic ligand, and r is an integer denoting the number of anionic ligands X and wherein the two cyclopentadienyl-amidinato-metal-containing moieties as in the brackets are the same or different.
摘要翻译：本发明涉及式（1）的新的双金属络合物，其中：M是4-6族金属，R1表示包含第15族杂原子的取代基，R1与亚胺碳原子键合; R 2 -R 6相同或不同，各自表示氢原子，任选取代的C 1-10烷基，任选取代的C 1-10烷氧基，任选取代的C 6-20芳基，任选取代的C 6-20芳氧基，任选取代的C 7-20芳烷基，任选取代的C 7-20芳烷氧基，被任选取代的C 1-20烃基取代的甲硅烷基，C 1-20烃取代的氨基或相邻的R 2 -R 6 可以相互链接形成环; R7-R10相同或不同，各自表示氢原子，卤素原子，任选取代的C 1-10烷基，任选取代的C 1-10烷氧基，任选取代的C 6-20芳基，任选取代的C 6 -20芳氧基，任选取代的C7-20芳烷基，任选取代的C7-20芳烷氧基，被任选取代的C 1-20烃基取代的甲硅烷基，C 1-20烃取代的氨基或相邻的R7-R10可以彼此连接形成环; L是任选的中性路易斯碱性配体，j是表示中性配体L的数量的整数; X是阴离子配体，r是表示阴离子配位体X的数的整数，其中括号中的两个环戊二烯基 - 脒基金属的部分相同或不同。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式