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91. 发明授权

US09927445B2 Biomarkers for prediction, diagnosis, and monitoring of parkinson's disease 有权
公开(公告)号：US09927445B2
公开(公告)日：2018-03-27
申请号：US14325125
申请日：2014-07-07
申请人： Balwant Rai , Jasdeep Kaur
发明人： Balwant Rai , Jasdeep Kaur
IPC分类号： G01N33/53 , G01N33/543 , G01N33/68 , G01N21/64 , G01N21/93 , G01N21/84 , G01N21/77
CPC分类号： G01N33/6896 , G01N2021/7786 , G01N2333/525 , G01N2333/545 , G01N2333/65 , G01N2333/926 , G01N2800/2821 , G01N2800/2835 , G01N2800/52
摘要： A method for the risk detection, early diagnosis, prognosis, and monitoring of Parkinson's disease in an individual by measuring the amount of specific biomarkers present in a bodily fluid and comparing them to a reference level of biomarkers in a sample from a healthy person, a person previously diagnosed with Parkinson's disease, or an earlier sample from the individual of interest.

92. 发明授权

US09892229B2 Diagnosis and risk stratification of bladder cancer 有权
公开(公告)号：US09892229B2
公开(公告)日：2018-02-13
申请号：US14435991
申请日：2013-10-16
申请人： RANDOX LABORATORIES LTD.
发明人： Mark William Ruddock , Cherith N. Reid , Kate E. Williamson , Frank Emmert-Streib , John V. Lamont , Peter Fitzgerald
IPC分类号： G01N33/48 , G06F19/18 , G01N33/574 , G06F19/24 , G06F19/00 , G06G7/58
CPC分类号： G06F19/18 , G01N33/57407 , G01N33/57484 , G01N2333/4737 , G01N2333/4742 , G01N2333/475 , G01N2333/485 , G01N2333/523 , G01N2333/525 , G01N2333/5406 , G01N2333/5412 , G01N2333/5421 , G01N2333/545 , G01N2333/55 , G01N2333/70578 , G01N2333/70596 , G01N2333/7151 , G01N2333/7452 , G01N2333/928 , G01N2333/96433 , G01N2333/96494 , G01N2333/988 , G01N2400/00 , G06F19/00 , G06F19/24 , G16H50/30
摘要： The invention provides a method of defining the likelihood of a subject having bladder cancer, comprising the steps of: (A) assessing the subject's likelihood of having bladder cancer by: i. identifying at least one sub-population group appropriate to the subject; ii. determining the level of one or more biomarkers selected according to the sub-population group in a sample obtained from the subject; iii. inputting each of the biomarker values into an algorithm to produce an output value; and iv. correlating the output value with the likelihood of the subject having bladder cancer, wherein the sub-population group is selected according to smoking habits, gender, presence/absence of stone disease, history of benign prostate enlargement (BPE) or prescription of anti-hypertensive, anti-platelet and/or anti-ulcer medication, and (B) determining the subject's stratified risk level of serious disease by: v. determining the level of one or more biomarkers specific for one or more risk classifiers defined using Random Forest Classifiers (RFC), logistic regression or another appropriate systems biology or statistical approach in a sample obtained from the subject, vi. inputting each of the biomarker values into an algorithm or algorithms to produce an output value; and vii. correlating the output value with a stratified risk level of underlying serious disease, wherein the likelihood of having bladder cancer is combined with the stratified risk level of having serious disease, wherein the risk of having bladder cancer and/or serious disease is categorized as: high-risk bladder cancer requiring immediate cystoscopy; low-risk bladder cancer requiring urgent cystoscopy; high-risk control requiring close evaluation and further investigation; or low-risk control requiring primary care monitoring.

93. 发明授权

US09808408B2 Biomarker-based methods for formulating compositions that improve skin quality and reduce the visible signs of aging in skin for individuals in a selected population 有权
公开(公告)号：US09808408B2
公开(公告)日：2017-11-07
申请号：US13007632
申请日：2011-01-16
申请人： Qing Stella , Karl Shiqing Wei , Cynthia Ann Garza , Kenneth Robert Wehmeyer , Rohan Lalith Wimalasena
发明人： Qing Stella , Karl Shiqing Wei , Cynthia Ann Garza , Kenneth Robert Wehmeyer , Rohan Lalith Wimalasena
IPC分类号： A61Q19/10 , A61K8/31 , A61K8/03 , G01N33/50 , G01N33/68 , G01N33/92 , G06Q30/02
CPC分类号： A61K8/31 , A61K8/03 , A61K8/96 , A61K49/0006 , A61K2800/87 , A61Q19/10 , G01N33/5088 , G01N33/62 , G01N33/6812 , G01N33/6827 , G01N33/6869 , G01N33/6881 , G01N33/92 , G01N2333/4742 , G01N2333/545 , G01N2500/04 , G01N2800/20 , G06Q30/0201
摘要： In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin in a select population, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality in the population as evidenced by one or more biomarker changes that correlate with improvement as evidenced by one or more objective measurements of skin health in the population.

94. 发明授权

US09804175B2 Methods and kits for diagnosing osteoarthritis and predicting progression 有权
公开(公告)号：US09804175B2
公开(公告)日：2017-10-31
申请号：US14542757
申请日：2014-11-17
申请人： New York University
发明人： Mukundan Attur , Steven B. Abramson
IPC分类号： G01N33/00 , C12Q1/00 , G01N33/74 , C12Q1/68
CPC分类号： G01N33/74 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N2333/475 , G01N2333/52 , G01N2333/545 , G01N2333/964 , G01N2333/96494 , G01N2800/105 , G01N2800/56
摘要： This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject.

95. 发明授权

US09632076B2 Microfluidic device for generating neural cells to simulate post-stroke conditions 有权
公开(公告)号：US09632076B2
公开(公告)日：2017-04-25
申请号：US14539544
申请日：2014-11-12
申请人： The Charles Stark Draper Laboratory, Inc. , The University of South Florida
发明人： Anilkumar Harapanahalli Achyuta , Javier Cuevas , Shivshankar Sundaram , Chris Katnik
IPC分类号： G01N33/50 , G01N21/64 , C12M3/06 , C12M1/34 , C12M1/42
CPC分类号： G01N33/5058 , C12M23/16 , C12M35/02 , C12M35/08 , C12M41/34 , G01N21/6486 , G01N33/5005 , G01N33/5023 , G01N33/5026 , G01N2333/525 , G01N2333/5428 , G01N2333/545 , G01N2500/10 , G01N2510/00
摘要： This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.

96. 发明申请

US20170023590A1 ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS) BIOMARKER PROTEINS 有权
标题翻译：原发性肝炎综合征（AHUS）生物标记蛋白
公开(公告)号：US20170023590A1
公开(公告)日：2017-01-26
申请号：US15287162
申请日：2016-10-06
申请人： Alexion Pharmaceuticals, Inc.
发明人： Susan Faas MCKNIGHT , Roxanne COFIELL , Anjli KUKREJA , Krystin A. BEDARD , Yan YAN
IPC分类号： G01N33/68 , C07K16/18
CPC分类号： G01N33/6893 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/626 , C07K2317/76 , G01N33/6863 , G01N2333/4716 , G01N2333/485 , G01N2333/522 , G01N2333/5412 , G01N2333/5421 , G01N2333/5434 , G01N2333/545 , G01N2333/57 , G01N2333/70503 , G01N2333/70525 , G01N2333/70539 , G01N2333/7151 , G01N2333/7452 , G01N2333/75 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/974 , G01N2800/226 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides biomarker proteins, a change in the concentration or activity level of which are associated with atypical hemolytic uremic syndrome (aHUS) or clinically meaningful treatment of aHUS with a complement inhibitor. Also provided are compositions and methods for interrogating the concentration and/or activity of one or more of the biomarker proteins in a biological fluid. The compositions and methods are useful for, among other things, evaluating risk for developing aHUS, diagnosing aHUS, determining whether a subject is experiencing the first acute presentation of aHUS, monitoring progression or abatement of aHUS, and/or monitoring response to treatment with a complement inhibitor or optimizing such treatment.
摘要翻译：本公开提供了生物标志物蛋白质，其浓度或活性水平的变化与非典型溶血性尿毒症综合征（aHUS）相关，或临床意义上用补体抑制剂治疗HUS。还提供了用于询问生物流体中一种或多种生物标记蛋白的浓度和/或活性的组合物和方法。组合物和方法可用于评估发展为高血压的风险，诊断高血压，确定受试者是否正在经历第一次急性呈现的HUS，监测进展或减轻HUS，和/或监测对治疗的反应补体抑制剂或优化这种治疗。

97. 发明授权

US09493560B2 Dual variable domain immunoglobulins and uses thereof 有权
公开(公告)号：US09493560B2
公开(公告)日：2016-11-15
申请号：US14135107
申请日：2013-12-19
申请人： AbbVie, Inc.
发明人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
IPC分类号： A61K39/395 , A61K39/40 , C07K16/24 , C07K16/46 , G01N33/53 , G01N33/68 , A61K45/06 , A61K47/48 , A61K49/00 , A61K51/10 , G01N33/569 , C07K16/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K49/00 , A61K51/1021 , C07K16/241 , C07K16/245 , C07K16/468 , C07K2317/35 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/53 , G01N33/56966 , G01N33/6857 , G01N33/6869 , G01N2333/54 , G01N2333/545 , G01N2800/24 , G01N2800/7028
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

98. 发明申请

US20160245799A1 METHODS AND APPARATUS FOR CONDUCTING MULTIPLE MEASUREMENTS ON A SAMPLE 审中-公开
标题翻译：用于在样品上进行多重测量的方法和装置
公开(公告)号：US20160245799A1
公开(公告)日：2016-08-25
申请号：US15146293
申请日：2016-05-04
申请人： Meso Scale Technologies, LLC.
发明人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
IPC分类号： G01N33/53 , G01N33/573 , G01N33/68 , G01N33/569
CPC分类号： G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
摘要翻译：使用具有多个测定域的测定模块进行多重测试测量。在优选实施方案中，这些测量在具有集成电极的测定模块中进行，所述测量模块具有适于接收测定模块的读取器装置，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。

99. 发明申请

US20160238616A1 METHOD FOR DIAGNOSING AN INFLAMMATORY CONDITION IN THE FEMALE GENITAL TRACT 审中-公开
标题翻译：用于诊断女性生殖器官炎症反应条件的方法
公开(公告)号：US20160238616A1
公开(公告)日：2016-08-18
申请号：US15033225
申请日：2014-10-31
申请人： University of Cape Town
发明人： Lindi Masson , Jo-Ann Shelley Passmore
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/571 , G01N33/6866 , G01N33/6869 , G01N2333/522 , G01N2333/545 , G01N2800/7095
摘要： A method of diagnosing an inflammatory condition of the genital tract caused by bacterial vaginosis (BV) or a sexually transmitted infection (STI) in a female subject is described. The method measures the concentration of IP-10 and either of IL-β or IL-α in a sample of cervicovaginal fluid from the subject and compares these to predetermined levels of IP-10 and either of IL-1β or IL-1α, respectively. A down-regulated IP-10 level in the sample or an up-regulated IL-1β or IL-1α level in the sample will be regarded as a positive result, i.e. indicating that there is a high probability that the subject has an STI or BV. The subject could then either be directly treated, e.g. with broad spectrum antibiotics, or referred for appropriate STI screening. The sample can be obtained from a vaginal secretion from the subject. A test kit for performing the method is also described.
摘要翻译：描述了一种诊断由女性受试者的细菌性阴道炎（BV）或性传播感染（STI）引起的生殖道炎症状况的方法。该方法测量来自受试者的子宫颈阴道液样品中的IP-10和IL-β或IL-α的浓度，并分别与IP-10和IL-1β或IL-1α的预定水平进行比较。样本中的下调的IP-10水平或样本中上调的IL-1β或IL-1α水平将被认为是阳性结果，即表明该受试者具有STI或 BV。然后可以直接对待受试者，例如，使用广谱抗生素，或提及适当的STI筛选。样品可以从受试者的阴道分泌物中获得。还描述了用于执行该方法的测试套件。

100. 发明申请

US20160231330A1 BIOMARKERS RELATED TO ORGAN FUNCTION 审中-公开
标题翻译：与机关功能相关的生物标志
公开(公告)号：US20160231330A1
公开(公告)日：2016-08-11
申请号：US15024297
申请日：2014-09-23
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人： Paulo Artur Chaves Fontes , John A. Kellum
IPC分类号： G01N33/68
CPC分类号： G01N33/6863 , C12Q1/6883 , C12Q2600/158 , G01N33/6866 , G01N33/6869 , G01N2333/525 , G01N2333/5406 , G01N2333/5412 , G01N2333/5421 , G01N2333/5428 , G01N2333/5434 , G01N2333/545 , G01N2333/56 , G01N2333/57 , G01N2570/00 , G01N2800/085 , G01N2800/50 , G01N2800/60
摘要： Disclosed herein are methods of identifying biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) that can be used to predict organ or tissue function or dysfunction. In some embodiments, the methods include ex vivo perfusion of the organ or tissue, collection of samples from the organ or tissue (for example, perfusate, fluids produced by the organ (such as bile or urine), or tissue biopsies) and measuring the level of one or more biomarkers in the sample. It is also disclosed herein that an analysis of biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) present in a biological sample from an organ, tissue, or subject can be used to identify whether the organ, tissue, or subject is at risk for (or has) organ dysfunction or organ failure.
摘要翻译：本文公开了可用于预测器官或组织功能或功能障碍的生物标志物（例如基因（例如RNA或mRNA），蛋白质和/或小分子）的方法。在一些实施方案中，所述方法包括器官或组织的离体灌注，来自器官或组织（例如，灌注液，由器官（例如胆汁或尿液）产生的流体）或组织活组织检查的样品的收集）样品中一种或多种生物标志物的水平。本文还公开了可以使用存在于来自器官，组织或受试者的生物样品中的生物标志物（例如RNA或mRNA），蛋白质和/或小分子的分析来鉴定是否器官，组织或受试者处于（或具有）器官功能障碍或器官衰竭的风险中。

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