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91. 发明申请

US20060142484A1 SULFOALKYLATED CELLULOSE POLYMER NETWORK 审中-公开
标题翻译： SULFOALKYLATED纤维素聚合物网络
公开(公告)号：US20060142484A1
公开(公告)日：2006-06-29
申请号：US11027050
申请日：2004-12-29
申请人： Wolfgang Glasser , Alena Michalek , S. Weerawarna , Carole Herriott , Richard Jewell
发明人： Wolfgang Glasser , Alena Michalek , S. Weerawarna , Carole Herriott , Richard Jewell
IPC分类号： C08B37/00
CPC分类号： C08J3/246 , C08B15/005
摘要： Sulfoalkylated cellulose polymer network having superabsorbent properties.
摘要翻译：具有超吸收性能的磺烷基化纤维素聚合物网络。

92. 发明授权

US06958393B2 Cellulose derivatives having gel-like rheological properties and process for the preparation thereof 有权
标题翻译：具有凝胶状流变性的纤维素衍生物及其制备方法
公开(公告)号：US06958393B2
公开(公告)日：2005-10-25
申请号：US10626338
申请日：2003-07-23
申请人： Hartwig Schlesiger , Arne Henning Kull , Erik-Andreas Klohr
发明人： Hartwig Schlesiger , Arne Henning Kull , Erik-Andreas Klohr
IPC分类号： C08B11/08 , C08B1/02 , C08B11/00 , C08B11/02 , C08B11/193 , C08B11/20 , C08B15/00 , C08B15/10
CPC分类号： C08B11/193 , C08B11/00 , C08B11/02 , C08B15/00 , C08B15/005
摘要： A description is given of cellulose derivatives having gel-like rheological properties in aqueous solution characterized in that: a) cellulose is alkalized with aqueous alkali metal hydroxide solution in the presence of a suspension medium, b) the alkalized cellulose is reacted with one or more alkylene oxides, c) then reacted with an alkyl halide present in the suspension medium d) subsequently or simultaneously the alkalized cellulose is reacted with a crosslinking agent in an amount of 0.0001 to 0.05 eq, where the unit “eq” represents the molar ratio of crosslinking agent relative to the anhydroglucose unit (AGU) of the cellulose used, and e) after, if appropriate, further addition of alkali metal hydroxide and/or alkylating agent, the resultant irreversibly crosslinked cellulose derivative is separated off from the reaction mixture, if appropriate purified and dried.
摘要翻译：给出了在水溶液中具有凝胶状流变性的纤维素衍生物的描述，其特征在于：a）在悬浮介质存在下，纤维素用碱金属氢氧化物水溶液碱化，b）碱化的纤维素与一种或多种环氧烷，c）然后与存在于悬浮介质中的烷基卤反应d）随后或同时使碱化的纤维素与0.0001至0.05当量的交联剂反应，其中单位“eq”表示交联剂相对于所使用的纤维素的脱水葡萄糖单元（AGU），以及e）如果适当，进一步加入碱金属氢氧化物和/或烷基化剂后，得到的不可逆交联的纤维素衍生物与反应混合物分离，如果适当纯化并干燥。

93. 发明授权

US06923961B2 Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis 有权
标题翻译：化学活化的羧多糖和用于抑制粘附形成和促进止血的方法
公开(公告)号：US06923961B2
公开(公告)日：2005-08-02
申请号：US10135133
申请日：2002-04-30
申请人： Lin-Shu Liu , Richard Berg
发明人： Lin-Shu Liu , Richard Berg
IPC分类号： A61K31/715 , A61K38/22 , A61K38/48 , A61K48/00 , C08B15/00 , C08L1/28
CPC分类号： C08B15/005 , A61K31/715 , A61K38/4833 , A61K48/00 , C08L1/286 , C08L2666/14
摘要： Carboxypolysaccharides (CPS) including carboxymethyl cellulose and their derivatives are provided that can be made into sponges, gels, membranes, particulates and other forms, for a variety of antiadhesion, antithrombogenic, drug delivery and/or hemostatic applications during surgery and pharmacological therapeutics. CPSs derivatized with primary amines can be used alone or in combination with poly(ethylene glycol) and poly(ethylene oxides) and other poly(alkylene oxides) to form materials having improved drug delivery, antiadhesion, and hemostatic uses. Applications include other types of chemical modifications of CPS to provide hydrogen, ionic, Van der Walls interactions and/or covalent bonding with drugs, biologicals and other therapeutic or diagnostic purposes.
摘要翻译：提供包括羧甲基纤维素及其衍生物的多糖（CPS），其可以制成海绵，凝胶，膜，颗粒和其它形式，用于手术和药理学治疗期间的各种抗粘连，抗血栓形成，药物递送和/或止血应用。用伯胺衍生的CPS可以单独使用或与聚（乙二醇）和聚（环氧乙烷）和其他聚（环氧烷）组合使用以形成具有改善的药物递送，抗粘附和止血用途的材料。应用包括其他类型的CPS的化学修饰，以提供氢，离子，范德壁相互作用和/或与药物，生物学和其他治疗或诊断目的的共价键合。

94. 发明申请

US20050148767A1 Self-cross-linked alkyl cellulose 失效
标题翻译：自交联烷基纤维素
公开(公告)号：US20050148767A1
公开(公告)日：2005-07-07
申请号：US11062565
申请日：2005-02-23
申请人： Fumio Yoshii , Tamikazu Kume , Tadashi Murakami
发明人： Fumio Yoshii , Tamikazu Kume , Tadashi Murakami
IPC分类号： A61K8/73 , A61K31/717 , A61K47/38 , A61Q19/00 , C08B11/20 , C08B15/00 , C08B37/00
CPC分类号： A61K31/717 , A61K8/731 , A61K9/0014 , A61K47/38 , A61Q19/00 , C08B11/20 , C08B15/005
摘要： A process for producing a self-cross-linking alkyl cellulose derivative, which includes irradiating, with radioactive rays, a mixture of a starting alkyl cellulose derivative (the number of carbon atoms of the alkyl group is 1 through 3, the alkyl group may be substituted by a hydroxyl group or a carboxyl group, and the carboxyl group may form a salt) (100 parts by weight) and water (5-2,000 parts by weight), and thus obtained self-cross-linking alkyl cellulose derivative has an improved biodegradability and excellent water-absorbability.
摘要翻译：一种自交联烷基纤维素衍生物的制造方法，其包括用放射线照射原料烷基纤维素衍生物的混合物（烷基的碳原子数为1〜3，烷基可以为被羟基或羧基取代，羧基可以形成盐）（100重量份）和水（5-2,000重量份），因此得到的自交联烷基纤维素衍生物具有改进的生物降解性和吸水性优异。

95. 发明授权

US06875862B2 Self-cross-linked alkyl cellulose and processes for producing the same 失效
标题翻译：自交联烷基纤维素及其制备方法
公开(公告)号：US06875862B2
公开(公告)日：2005-04-05
申请号：US09770634
申请日：2001-01-29
申请人： Fumio Yoshii , Tamikazu Kume , Tadashi Murakami
发明人： Fumio Yoshii , Tamikazu Kume , Tadashi Murakami
IPC分类号： A61K8/73 , A61K31/717 , A61K47/38 , A61Q19/00 , C08B11/20 , C08B15/00 , C08B11/187 , A61K31/715
CPC分类号： A61K31/717 , A61K8/731 , A61K9/0014 , A61K47/38 , A61Q19/00 , C08B11/20 , C08B15/005
摘要： A process for producing a self-cross-linking alkyl cellulose derivative, which includes irradiating, with radioactive rays, a mixture of a starting alkyl cellulose derivative (the number of carbon atoms of the alkyl group is 1 through 3, the alkyl group may be substituted by a hydroxyl group or a carboxyl group, and the carboxyl group may form a salt) (100 parts by weight) and water (5-2,000 parts by weight), and thus obtained self-cross-linking alkyl cellulose derivative has an improved biodegradability and excellent water-absorbability.
摘要翻译：一种自交联烷基纤维素衍生物的制造方法，其包括用放射线照射原料烷基纤维素衍生物的混合物（烷基的碳原子数为1〜3，烷基可以为被羟基或羧基取代，羧基可以形成盐）（100重量份）和水（5-2,000重量份），因此得到的自交联烷基纤维素衍生物具有改进的生物降解性和吸水性优异。

96. 发明申请

US20040167326A1 Water-dispersible polysaccharide derivatives of reduced glyoxal content, and a process for decreasing the glyoxal content in glyoxal-crosslinked polysaccharide derivatives 审中-公开
标题翻译：降低乙二醛含量的水分散性多糖衍生物和降低乙二醛交联多糖衍生物中乙二醛含量的方法
公开(公告)号：US20040167326A1
公开(公告)日：2004-08-26
申请号：US10781230
申请日：2004-02-19
发明人： Meinolf Brackhagen , Hartwig Schlesiger
IPC分类号： C08B011/00
CPC分类号： C08B11/20 , C08B15/005
摘要： A description is given of glyoxal-treated polysaccharide derivatives which, to decrease the unbound glyoxal, are treated with an aqueous solution of one or more water-soluble aluminium salts, or one or more water-soluble borates, or a combination of one or more water-soluble aluminium salts and one or more water-soluble borates, and, if appropriate, with suitable buffer substances to set the pH, and then dried. A description is likewise given of a process for decreasing the content of unbound glyoxal in glyoxal-treated polysaccharide derivatives.
摘要翻译：对乙二醛处理的多糖衍生物进行了描述，为了减少未结合的乙二醛，用一种或多种水溶性铝盐或一种或多种水溶性硼酸盐的水溶液或一种或多种水溶性铝盐和一种或多种水溶性硼酸盐，并且如果合适，用合适的缓冲物质来调节pH值，然后干燥。同样给出了降低乙二醛处理的多糖衍生物中未结合乙二醛的含量的方法。

97. 发明授权

US06765042B1 Acidic superabsorbent polysaccharides 失效
标题翻译：酸性超吸收多糖
公开(公告)号：US06765042B1
公开(公告)日：2004-07-20
申请号：US09868139
申请日：2001-09-19
申请人： Jeffrey Wilson Thornton , Bas Schraven , Harm Jan Thiewes , Dorine Lisa Van Brussel-Verreast , Luca Bemporad , Anne-Mieke Yvonne Wilhelmina Verwiiligen , Arie Cornelis Besemer , Pia Kalentuin
发明人： Jeffrey Wilson Thornton , Bas Schraven , Harm Jan Thiewes , Dorine Lisa Van Brussel-Verreast , Luca Bemporad , Anne-Mieke Yvonne Wilhelmina Verwiiligen , Arie Cornelis Besemer , Pia Kalentuin
IPC分类号： C08J324
CPC分类号： C08B15/005 , A61L15/28 , A61L15/60 , Y10S526/903 , C08L1/26 , C08L3/04
摘要： A process is disclosed for producing an acidic superabsorbent polysaccharide derivative, comprising the steps of: (a) crosslinking at least one polysaccharide containing acidic groups, such as carboxymethyl cellulose and/or 6-carboxy starch, with a crosslinking agent to produce a gel; (b) if necessary, adjusting the pH of the polysaccharide to a value between 3.5 and 5.5; (c) comminuting the acidified polysaccharide gel; and (d) drying the comminuted polysaccharide at elevated temperature. The superabsorbent polysaccharide obtainable by this process has a pH below 5 and provides odour control when contacted with malodorous fluids.
摘要翻译：公开了一种制备酸性超吸收性多糖衍生物的方法，其包括以下步骤：（a）将至少一种含酸性基团的多糖例如羧甲基纤维素和/或6-羧基淀粉与交联剂交联以产生凝胶; （b）如果需要，将多糖的pH调节至3.5至5.5之间的值; （c）粉碎酸化多糖凝胶; 和（d）在升高的温度下干燥经粉碎的多糖。通过该方法可获得的超吸收性多糖具有低于5的pH，并且当与恶臭液体接触时提供气味控制。

98. 发明申请

US20040117033A1 Method for composite cell-based implants 审中-公开
标题翻译：基于复合细胞的植入物的方法
公开(公告)号：US20040117033A1
公开(公告)日：2004-06-17
申请号：US10731366
申请日：2003-12-09
发明人： Carmelita G. Frondoza , David S. Hungerford , Alan H. Shikani , Abraham J. Domb , David J. Fink , Leonard Bloom
IPC分类号： A61F002/02
CPC分类号： A61L27/3817 , A61F2/08 , A61K9/0024 , A61K9/1652 , A61K9/5036 , A61K35/12 , A61K47/36 , A61L27/3633 , A61L27/3641 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/3852 , C08B15/005 , C08B33/00 , C08B37/00 , C08B37/0021 , C08B37/006 , C08H1/00 , C08J3/12 , C08J2305/08 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N2500/02 , C12N2531/00 , C12N2533/70 , C12N2533/72
摘要： This invention is a method for the implantation of a combination of cells or cell-microcarrier aggregates wherein one component comprises a solid implantable construct and a second component comprises an injectable formulation. For example, in one embodiment, the solid implant may be first implanted to fill the majority of the cavity receiving the implant, and then cells or cell-microcarrier aggregates in an injectable format, with or without the addition of gelling materials to promote rapid gelling in situ, may be injected into spaces surrounding the solid implant in order to secure the solid implant in the site and/or to promote rapid adherence and/or integration of the solid implant to surrounding tissues. Also contemplated in this embodiment is that the cellular composition of the injectable component may differ from that of the solid component. For example, the solid implant may result from the culturing of chondrocytes on microcarriers or scaffolds, thereby resulting in an implant having cartilage-like properties, whereas the injectable cells or aggregates may result from the culturing of stem cells, resulting thereby in cells capable of producing cells of a chondrogenic, fibroblastic, myoblastic or osteoblastic phenotype. In this example, cells in the injectable aggregates may promote the fixation to or rapid integration of the solid cartilage implant into surrounding cartilage, connective tissue, muscle or bone, respectively.
摘要翻译：本发明是用于植入细胞或细胞 - 微载体聚集体的组合的方法，其中一个组分包含固体可植入构建体，第二组分包含可注射制剂。例如，在一个实施例中，可以首先植入固体植入物以填充接收植入物的空腔的大部分，然后填充可注射形式的细胞或细胞 - 微载体聚集体，伴随或不添加胶凝材料以促进快速凝胶化原位可以注入到固体植入物周围的空间中，以将固体植入物固定在部位中和/或促进固体植入物与周围组织的快速粘附和/或整合。在该实施方案中也考虑到可注射组分的细胞组成可能不同于固体组分。例如，固体植入物可以由微载体或支架上的软骨细胞的培养产生，从而导致具有软骨样特性的植入物，而可注射细胞或聚集体可能是由培养干细胞导致的，从而导致能够产生软骨形成，成纤维细胞，成肌细胞或成骨细胞表型的细胞。在该实施例中，可注射聚集体中的细胞可以促进将固体软骨植入物固定或者快速整合到周围软骨，结缔组织，肌肉或骨骼中。

99. 发明授权

US5770711A Polysaccharides substituted with polycarboxylated moieties 失效
标题翻译：被多羧基部分取代的多糖
公开(公告)号：US5770711A
公开(公告)日：1998-06-23
申请号：US723799
申请日：1996-09-30
申请人： Sharon Linda Greene , Rosann Marie Kaylor , Kenneth Raymond Smith
发明人： Sharon Linda Greene , Rosann Marie Kaylor , Kenneth Raymond Smith
IPC分类号： A61L15/28 , A61L15/62 , C08B11/12 , C08B15/00 , D06M13/11 , D06M13/192 , D21C9/00 , D21H11/20 , C08B15/10 , C08B37/00 , D21H13/04
CPC分类号： D21H11/20 , A61L15/28 , A61L15/62 , C08B11/12 , C08B15/005 , D06M13/11 , D06M13/192 , D21C9/005
摘要： A derivatized polysaccharide in which at least a portion of the active hydrogens originally present in the polysaccharide are substituted by monovalent aliphatic groups containing at least two carboxylic acid groups to an extent sufficient to provide a degree of substitution of at least about 0.1. The monovalent aliphatic groups contain from 4 to about 10 carbon atoms. The polysaccharide may be cellulose. At least a portion of the carboxylic acid groups present in the derivatized polysaccharide may be crosslinked permanently or reversibly. The monovalent aliphatic groups containing at least two carboxylic acid groups may be derived from 2,3-epoxysuccinic acid; 1,2-epoxypropane-1,2,3-tricarboxylic acid; 2-(epoxyethyl)-succinic acid; or mixtures thereof. Also provided is a method of preparing a derivatized polysaccharide. The method involves providing a polysaccharide; dispersing the polysaccharide in a strongly alkaline aqueous alcohol solution; adding to the dispersion an excess of an aliphatic polycarboxylic acid having an epoxy group, wherein the aliphatic polycarboxylic acid contains from 4 to about 10 carbon atoms; and heating the dispersion at a temperature and for a time sufficient to permit the reaction of epoxy groups of the aliphatic polycarboxylic acid with active hydrogens present in the polysaccharide to an extent sufficient to result in a degree of substitution of at least about 0.1. The present invention further provides a paper containing an amount of the derivatized cellulose described above sufficient to provide improved strength characteristics to the paper, compared with an otherwise identical paper which lacks the derivatized cellulose.
摘要翻译：最初存在于多糖中的活性氢的至少一部分被含有至少两个羧酸基团的一价脂族基团取代至足以提供至少约0.1的取代度的衍生多糖。一价脂族基团含有4至约10个碳原子。多糖可以是纤维素。存在于衍生化多糖中的羧酸基团的至少一部分可以永久地或可逆地交联。含有至少两个羧酸基团的一价脂族基团可以衍生自2,3-环氧琥珀酸; 1,2-环氧丙烷-1,2,3-三羧酸; 2-（环氧乙基） - 琥珀酸; 或其混合物。还提供了制备衍生化多糖的方法。该方法包括提供多糖; 将多糖分散在强碱性醇水溶液中; 向所述分散体中加入过量的具有环氧基的脂族多元羧酸，其中所述脂肪族多元羧酸含有4至约10个碳原子; 并在足以允许脂族多元羧酸的环氧基与多糖中存在的活性氢反应的温度和时间下加热分散体至足以导致至少约0.1的取代度的程度。本发明还提供了一种含有上述衍生纤维素量的纸，足以与纸张相比提供改善的强度特性，与缺乏衍生纤维素的其它相同的纸相比。

100. 发明授权

US5767196A Method of carrying out electrophoresis with a submerged gel 失效
标题翻译：用浸没凝胶进行电泳的方法
公开(公告)号：US5767196A
公开(公告)日：1998-06-16
申请号：US579272
申请日：1995-12-27
申请人： Branko Kozulic
发明人： Branko Kozulic
IPC分类号： B01D57/02 , C07K1/26 , C08B15/00 , C08B31/00 , C08B37/00 , C08B37/12 , C08J3/24 , G01N27/447 , G01N27/26
CPC分类号： C08J3/24 , B01D57/02 , C08B15/005 , C08B31/003 , C08B37/00 , G01N27/44747 , C08J2301/00 , C08J2305/00
摘要： A method of gel electrophoresis carried out in a submerged gel mode in which the gel is a bed of water insoluble, transparent, cross linked gel, which has been formed by: dissolving a polysaccharide, including at least one linear polysaccharide such as agarose or hydroxyethyl cellulose, in a suitable solvent, such as water; adding a cross linking agent, which is not charged nor becomes charged upon contact with water in a pH in the range of about 2 to 11, to the solution; and incubating this mixture in a quiescent state to substantially simultaneously react the polysaccharide and the cross linking agent and to gel the reaction product into a bed. The polysaccharide is at least one linear polysaccharides, but that linear polysaccharide may also be admixed with other linear polysaccharides and/or at least one non-linear polysaccharide. Synthetic organic polymers may also be admixed in the cross linking reaction mixture. The polysaccharide, and/or other polymers in the cross linking reaction mixture may be charged but are preferably uncharged, but if charged, the charge must be low enough so that the charge of the resulting gel, if any, will not interfere with the use of the gel to support an electrophoresis process carried out in a submerged gel mode. When the linear polysaccharide is agarose, the gel has improved elasticity and transparency.
摘要翻译：一种以浸没凝胶模式进行的凝胶电泳方法，其中凝胶是水不溶性，透明的交联凝胶床，其通过以下形成：将多糖包括至少一种线性多糖如琼脂糖或羟乙基纤维素，在合适的溶剂如水中; 加入交联剂，其在约2至11的pH范围内与水接触时不带电，也不会与溶液充电; 并将该混合物在静止状态下孵育以基本上同时使多糖和交联剂反应并将反应产物凝胶化成床。多糖是至少一种线性多糖，但也可以将线性多糖与其它线性多糖和/或至少一种非线性多糖混合。合成的有机聚合物也可以在交联反应混合物中混合。可以将交联反应混合物中的多糖和/或其它聚合物加入，但优选不带电荷，但如果加入，则电荷必须足够低，使得所得凝胶的电荷（如果有的话）将不会干扰使用的凝胶以支持以浸没凝胶模式进行的电泳过程。当线性多糖是琼脂糖时，凝胶具有改善的弹性和透明度。

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