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    • 94. 发明授权
    • Blood serum-isolation device
    • 血清分离装置
    • US4083788A
    • 1978-04-11
    • US633399
    • 1975-11-19
    • Louis T. Ferrara
    • Louis T. Ferrara
    • B01L3/14G01N33/49B01D21/26
    • B01L3/50215G01N33/491
    • A blood serum separation unit which includes a tubular structure having openings at each of opposite ends and having a slidable disk element mounted within a base end thereof, having an outside diameter substantially less than an inside diameter of the tubular element such that upon centrifugal action the slidable disk will be slidable therewithin by torque of centrifugal action, and the tubular element being mounted substantially flushly within but removable from an outer tube having an upper open end and having a stopper-plug which when inserted plugs both the outer tubular container and the tubular element located therewithin, the plug being of a composition penetrable by a tubular needle for introducing blood from a subject to space within the tubular container and tubular element, the disk being of a specific gravity intermediate between those specific gravities of blood serum and blood coagulant precipitate whereby upon inversion of the blood-containing tube and the thereafter subjection of the same to centrifugal action forces, the coagulant precipitate is separated and compacted at an upper end of the tubular element by the disk and upon removal of the stopper-plug serum is left isolated in the remaining outer tube base, the coagulant precipitate having been removed with the inner tubular element.
    • 一种血清分离单元,其包括管状结构,其在每个相对端处具有开口,并且具有安装在其基端内的可滑动盘元件,其外径基本上小于管状元件的内径,使得在离心作用时, 滑动盘可以通过离心作用的扭矩而在其中滑动,并且管状元件基本上平齐地安装在具有上开口端的外管内并且具有止动塞的外管中,该止塞塞插入时插入外管状容器和管 元件位于其中,插塞具有可由管状针穿透的组合物,用于将血液从受试者引导到管状容器和管状元件内的空间,所述盘的比重介于血清和血液凝固剂沉淀物的比重之间 由此在含血管及其后的su反转时 将其与离心作用力相同,凝结剂沉淀物通过盘在管状元件的上端分离和压实,并且在除去塞子塞后将血清留在剩余的外管基底中,凝结剂沉淀物具有 用内部管状元件去除。
    • 95. 发明授权
    • Fluid collection device with phase partitioning means
    • 具有相分离装置的流体收集装置
    • US4055501A
    • 1977-10-25
    • US649881
    • 1976-01-16
    • William D. Cornell
    • William D. Cornell
    • G01N33/48B01L3/14B04B5/02G01N33/49B01D21/26
    • G01N33/491B01L3/50215
    • A blood collection device includes a tube for receiving a sample of whole blood for centrifugal separation into the lighter phase, plasma or serum, and the heavier cellular phase. The tube has a needle-pierceable stopper at one end for maintaining a negative pressure in the tube. A blood phase partitioning device is disposed within the tube and includes an upper cylinder member and a lower piston member slidable in the upper member. The cylindrical member has a plurality of peripheral holes therein and a specific gravity greater than that of the piston member, with the members together having a specific gravity between that of the lighter phase and that of the heavier phase. A sealant is disposed within and in direct contact with the cylindrical member and has a specific gravity substantially equal to that of the two members together. During centrifugation of the blood, the partitioning device automatically moves to the interface of the two phases, and the members move relative to each other forcing the sealant radially outwardly through the peripheral holes in the cylindrical member and against the inner wall of the tube to provide a permanent partition between the two separated phases.
    • 采血装置包括用于接收全血样品以便离心分离成更轻相,血浆或血清和较重细胞相的管。 该管在一端具有可刺穿的塞子,用于维持管中的负压。 血液分配装置设置在管内并且包括可在上部构件中滑动的上部气缸构件和下部活塞构件。 圆柱形构件在其中具有多个周边孔,比重大于活塞构件的周长孔,其中构件的比重在较轻相位和较重相位之间。 密封剂设置在圆柱形构件内并与圆筒构件直接接触,并且具有与两个构件的比重基本相等的比重。 在血液离心期间,分隔装置自动移动到两相界面,并且构件相对于彼此移动,迫使密封剂径向向外穿过圆柱形构件中的周边孔并抵靠管的内壁,以提供 两个分离阶段之间的永久分隔。
    • 98. 发明授权
    • Method and apparatus for multiphase fluid collection and separation
    • 多相流体收集和分离的方法和装置
    • US3920549A
    • 1975-11-18
    • US45205974
    • 1974-03-18
    • CORNING GLASS WORKS
    • GIGLIELLO JOSEPH FKRAGLE HARRY A
    • G01N33/48B01D21/26B01L3/14B04B5/02G01N33/49
    • B01L3/50215B01D21/262B01D21/34B01D2221/10G01N33/491
    • A multiphase fluid collection and separation assembly including a container, means for closuring the open end of the container, a gel-like material having a specific gravity greater than at least one phase of the multiphase fluid to be separated, and an energizer member having a specific gravity greater than that of the gel-like material. The energizer member may be shaped to mate with a portion of the bottom end of the container and is dimensioned to permit the flow of the gel-like material between its outer surface and the inner surface of the container wall. The energizer member may be hollowed and may be provided with a plurality of longitudinally-oriented equally-spaced-apart ridges. A method of automatically separating and partitioning two differing-density phases of a multiphase fluid, is also disclosed; the method includes the steps of partially submerging the energizer member in the gel-like material, thereby maintaining the gel-like material in its initial position, and thereafter, initiating and controlling the flow of the gel-like material by moving the energizer against the gel-like material in response to the application of a centrifugal force.
    • 一种多相流体收集和分离组件,包括容器,用于封闭容器的开口端的装置,比重大于要分离的多相流体的至少一相的凝胶状材料,以及具有 比重大于凝胶状材料的比重。 加力构件可以成形为与容器的底端的一部分配合,并且其尺寸被设计成允许凝胶状材料在其外表面和容器壁的内表面之间流动。 增力构件可以是中空的并且可以设置有多个纵向定向的等间隔开的脊。 还公开了一种自动分离和分配多相流体的两个不同密度相的方法; 该方法包括以下步骤:将激发器部件浸没在凝胶状材料中,从而将凝胶状材料保持在其初始位置,然后通过使激发剂抵抗着色剂来启动和控制凝胶状材料的流动 凝胶状材料响应于离心力的应用。