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91. 发明授权

US09393407B2 Minimally invasive epicardial pacemaker 有权
标题翻译：微创心外膜起搏器
公开(公告)号：US09393407B2
公开(公告)日：2016-07-19
申请号：US14390943
申请日：2013-04-05
申请人： Children's Hospital Los Angeles , University of Southern California
发明人： Yaniv Bar-Cohen , Gerald Loeb , Michael Silka , Ramen Chmait
IPC分类号： A61N1/05 , A61N1/375 , A61N1/372 , A61N1/362 , A61N1/378
CPC分类号： A61N1/0587 , A61N1/059 , A61N1/362 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3787 , Y10T29/49002
摘要： A fully implantable cardiac pacemaker system is provided. The pacemaker system includes a pacemaker having an electrode sub-assembly containing an electrode and a base into which the electrode is embedded. It also includes an implantable package that has electronic components for providing electrical pulses to a patient's heart. The pacemaker also has a power supply and a flexible electrically conductive lead that connects the electronic components to the electrode. In addition to the pacemaker, the pacemaker system includes a removable insertion casing that is physically attached to the base portion of the electrode sub-assembly. Upon insertion of the pacemaker into a patient's heart, the pacemaker is detached from the removable insertion casing and deployed fully in the patient's chest. The pacemaker system has particular use in fetal applications.
摘要翻译：提供完全可植入的心脏起搏器系统。起搏器系统包括具有电极子组件的起搏器，该电极子组件包含电极和嵌入电极的基座。它还包括具有用于向患者心脏提供电脉冲的电子部件的可植入包装。起搏器还具有将电子部件连接到电极的电源和柔性导电引线。除了起搏器之外，起搏器系统包括物理地附接到电极子组件的基部的可移除插入壳体。将心脏起搏器插入患者心脏后，起搏器与可拆卸的插入套管分离，并充分部署在病人的胸部。起搏器系统在胎儿应用中特别有用。

92. 发明授权

US09381351B2 Devices and methods for stimulating nerves 有权
标题翻译：用于刺激神经的装置和方法
公开(公告)号：US09381351B2
公开(公告)日：2016-07-05
申请号：US14056937
申请日：2013-10-17
申请人： FemPulse, LLC
发明人： Alexandra Haessler
IPC分类号： A61N1/36 , A61M5/142 , A61N1/375 , A61N1/05 , A61B5/053 , A61N1/372
CPC分类号： A61N1/36007 , A61B5/0538 , A61M5/14276 , A61M31/002 , A61M2210/1017 , A61M2230/005 , A61M2230/06 , A61M2230/30 , A61N1/0514 , A61N1/0524 , A61N1/0551 , A61N1/0556 , A61N1/36017 , A61N1/36107 , A61N1/37205 , A61N1/3756
摘要： A device for stimulating nerves adjacent the vagina includes a nerve stimulating element coupled to a main body. The nerve stimulating element is positioned and designed to stimulate the vesical, Frankenhauser's and/or inferior hypogastric plexuses. The device may reside in the vaginal fornices. An implant is also provided which has a nerve stimulating element in contact with a uterosacral ligament.
摘要翻译：用于刺激与阴道相邻的神经的装置包括联接到主体的神经刺激元件。神经刺激元件被定位和设计以刺激Vesical，Frankenhauser和/或下腹部下腹丛。该装置可能驻留在阴道穹窿中。还提供了具有与子宫骶韧带接触的神经刺激元件的植入物。

93. 发明申请

US20160175599A1 LEADLESS CARDIAC STIMULATION SYSTEMS 审中-公开
标题翻译：无铅心脏刺激系统
公开(公告)号：US20160175599A1
公开(公告)日：2016-06-23
申请号：US15058920
申请日：2016-03-02
申请人： CARDIAC PACEMAKERS, INC.
发明人： Roger Hastings , William J. Drasler , Daniel M. Lafontaine , Anupama Sadasiva , Scott R. Smith
IPC分类号： A61N1/375 , A61N1/372 , A61N1/365 , A61N1/05
CPC分类号： A61N1/3756 , A61N1/0587 , A61N1/059 , A61N1/08 , A61N1/3627 , A61N1/365 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37241 , A61N1/37288 , A61N1/375 , A61N1/3787
摘要： Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrodes that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Each of the electrodes contains a source of electrical energy for pacing the myocardium and is adapted to receive electromagnetic energy from a source outside the myocardium. The system also includes a source adapted for placement outside the myocardium and that uses locally measured electrocardiograms to synchronize pacing of the heart by sending electromagnetic commands to the electrodes to pace the myocardium surrounding the electrodes. Also disclosed is various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.
摘要翻译：提供了使用无引线电极来提供起搏治疗的各种构造的系统。在一个示例中，提供用于心脏心肌的多个部位的系统包括使用经皮，经腔，导管递送系统可植入位于心肌附近的位置的无线起搏电极。每个电极包含用于起搏心肌的电能源，并且适于从心肌外部的源接收电磁能。该系统还包括适于放置在心肌外部的源，并且使用局部测量的心电图来通过向电极发送电磁命令来同步心脏的起搏，以对电极周围的心肌进行加速。还公开了用于递送和植入电极组件的这种系统，无线电极组件和输送导管的各种配置。

94. 发明申请

US20160158561A1 SYSTEMS AND METHODS FOR FIXATING TRANSVENOUSLY IMPLANTED MEDICAL DEVICES 审中-公开
标题翻译：用于固定移植医疗器械的系统和方法
公开(公告)号：US20160158561A1
公开(公告)日：2016-06-09
申请号：US15015721
申请日：2016-02-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： G. Shantanu Reddy
IPC分类号： A61N1/372 , A61N1/37 , A61N1/05
CPC分类号： A61N1/37217 , A61N1/056 , A61N1/057 , A61N1/0573 , A61N1/362 , A61N1/3702 , A61N1/37205 , A61N1/375 , A61N1/37516 , A61N1/3756 , A61N2001/0585
摘要： A transvenously implantable medical device (TIMD) includes an electrical lead and a control module. The electrical lead includes one or more electrodes and is adapted for transvenous implantation. The electrical lead is also pre-biased to expand from a collapsed state to an expanded state to mechanically engage an internal wall of a blood vessel. The control module is secured to and in electrical communication with the electrical lead. The control module includes a signal management component and a power component disposed in a housing adapted for implantation into the blood vessel. The control module is adapted for at least one of stimulating and sensing a physiologic response using the one or more electrodes of the electrical lead.
摘要翻译：可转移植入式医疗装置（TIMD）包括电引线和控制模块。电引线包括一个或多个电极并且适于经静脉植入。电引线也被预偏压以从折叠状态膨胀到膨胀状态以机械地接合血管的内壁。控制模块固定在电气导线上并与电线电连通。控制模块包括信号管理部件和设置在适于植入血管的壳体中的功率部件。控制模块适用于使用电引线的一个或多个电极来刺激和感测生理反应中的至少一个。

95. 发明授权

US09352145B2 Methods and systems for treating a psychotic disorder 有权
标题翻译：治疗精神病的方法和系统
公开(公告)号：US09352145B2
公开(公告)日：2016-05-31
申请号：US12497386
申请日：2009-07-02
申请人： Todd K. Whitehurst , Kristen N. Jaax
发明人： Todd K. Whitehurst , Kristen N. Jaax
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372 , A61N1/375
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/37205 , A61N1/3756
摘要： Methods of treating a psychotic disorder include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters configured to treat the psychotic disorder. Systems for treating a psychotic disorder include a stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters configured to treat the psychotic disorder.
摘要翻译：治疗精神病的方法包括根据配置成治疗精神病性障碍的一种或多种刺激参数，用植入的刺激剂将至少一种刺激应用于患者内的刺激部位。用于治疗精神病的系统包括刺激器，其被配置为根据被配置为治疗精神病性障碍的一种或多种刺激参数将至少一种刺激施加到患者内的刺激部位。

96. 发明授权

US09333364B2 Methods and systems for heart failure treatments using ultrasound and leadless implantable devices 有权
标题翻译：使用超声和无引导植入式装置进行心脏衰竭治疗的方法和系统
公开(公告)号：US09333364B2
公开(公告)日：2016-05-10
申请号：US12829183
申请日：2010-07-01
申请人： Debra S. Echt , Richard E. Riley , Mark W. Cowan , Axel F. Brisken
发明人： Debra S. Echt , Richard E. Riley , Mark W. Cowan , Axel F. Brisken
IPC分类号： A61N1/36 , A61N1/362 , A61N1/378 , A61N1/372
CPC分类号： A61N1/362 , A61N1/3627 , A61N1/37205 , A61N1/3787 , A61N7/00 , A61N2007/0004
摘要： The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.
摘要翻译：本发明依赖于控制器 - 发射器装置将超声能量输送到心脏组织中，以便直接改善心脏功能和/或激发一个或多个植入的接收器 - 刺激器装置，其将超声能量转换成电能以进行兴奋和/ 或心脏衰竭的非兴奋性治疗。声能可以作为单个突发或多个突发应用。

97. 发明授权

US09327109B2 Implantable electroacupuncture device for reducing hypertension 有权
标题翻译：用于降低高血压的植入式电针装置
公开(公告)号：US09327109B2
公开(公告)日：2016-05-03
申请号：US14446512
申请日：2014-07-30
申请人： Valencia Technologies Corporation
发明人： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
IPC分类号： A61N1/05 , A61N1/36 , A61N1/372 , A61N1/375 , A61H39/00 , A61N1/378
CPC分类号： A61N1/0504 , A61H39/002 , A61H2201/5005 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/3605 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10S128/907
摘要： Disclosed is an implantable, coin-sized, self-contained, leadless electroacupuncture (EA) device having at least two electrode contacts attached to the surface of its housing. The electrodes include a central cathode electrode on a bottom side of the housing, and a circumferential anode electrode that surrounds the cathode electrode. In one embodiment, the anode annular electrode is a ring electrode placed around the perimeter edge of the coin-shaped housing. The EA device is adapted to be implanted through a very small incision, e.g., less than about 2-3 cm in length, directly adjacent to a selected acupuncture site known to moderate or affect a hypertension condition of a patient. Appropriate power management circuitry within the device allows a primary battery having a relatively high internal impedance to be used without causing unacceptable dips in battery voltage when the instantaneous battery current surges. Stimulation pulses are generated during a stimulation session that has a duration of T3 minutes and which is applied every T4 minutes. The duty cycle, or ratio of T3 to T4, is very low, not greater than 0.05. This low duty cycle, along with careful power management, allows the EA device to perform its intended function for several years.
摘要翻译：公开了一种植入式，硬币大小的独立的无引线电针（EA）装置，其具有附接到其壳体表面的至少两个电极触点。电极包括在壳体的底侧上的中央阴极电极和围绕阴极电极的周向阳极电极。在一个实施例中，阳极环形电极是围绕硬币形壳体的周边边缘放置的环形电极。 EA装置适于通过非常小的切口植入，例如长度小于约2-3厘米，直接与已知中度或影响患者高血压状况的所选择的针灸部位相邻。器件内的合适的电源管理电路允许使用具有相对较高的内部阻抗的一次电池，而不会在瞬间电池电流骤升时导致电池电压的不可接受的下降。在刺激会话期间产生刺激脉冲，持续时间为T3分钟，每T4分钟应用一次。 T3到T4的占空比或比例很低，不大于0.05。这个低占空比，以及仔细的电源管理，允许EA设备执行其预期功能几年。

98. 发明授权

US09327069B2 Methods and systems for treating a medical condition by promoting neural remodeling within the brain 有权
公开(公告)号：US09327069B2
公开(公告)日：2016-05-03
申请号：US11393565
申请日：2006-03-29
申请人： Allison M. Foster , Rafael Carbunaru , Kristen N. Jaax , Todd K. Whitehurst
发明人： Allison M. Foster , Rafael Carbunaru , Kristen N. Jaax , Todd K. Whitehurst
IPC分类号： A61N1/05 , A61M5/142 , A61N1/36 , A61N1/372
CPC分类号： A61M5/14276 , A61M2210/0693 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/3605 , A61N1/36082 , A61N1/37205
摘要： Methods of treating a medical condition include applying at least one stimulus to a stimulation site within the brain of a patient with an implanted stimulator in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient. Systems for treating a medical condition include an implantable stimulator configured to apply at least one stimulus to a stimulation site within the brain of a patient in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient.

99. 发明申请

US20160114176A1 LOCAL LEAD TO IMPROVE ENERGY EFFICIENCY IN IMPLANTABLE WIRELESS ACOUSTIC STIMULATORS 有权
标题翻译：本地领先提高可伸缩无线呼吸刺激仪的能量效率
公开(公告)号：US20160114176A1
公开(公告)日：2016-04-28
申请号：US14979359
申请日：2015-12-22
申请人： EBR Systems, Inc.
发明人： Nathanial P. Willis , Richard E. Riley , Mark W. Cowan
IPC分类号： A61N1/372 , A61N1/05 , A61N1/362
CPC分类号： A61N1/37217 , A61N1/056 , A61N1/0587 , A61N1/362 , A61N1/3684 , A61N1/37205 , A61N1/3756 , A61N1/3787
摘要： A wireless cardiac stimulation device is disclosed comprising a controller-transmitter, a receiver, and a stimulating electrode, wherein the stimulating electrode and the receiver are separately implantable at cardiac tissue locations of the heart and are connected by a local lead. Having separately implantable receiver and stimulating electrodes improves the efficiency of ultrasound mediated wireless stimulation by allowing the receiver to be placed optimally for reception efficiency, thereby resulting in longer battery life, and by allowing the stimulating electrode to be placed optimally for stimulus delivery. Another advantage is a reduced risk of embolization, since the receiver and stimulating electrode ensemble is attached at two locations of the heart wall, with the connecting local leads serving as a safety tether should either the receiver or the stimulating electrode become dislodged.
摘要翻译：公开了一种无线心脏刺激装置，其包括控制器发射器，接收器和刺激电极，其中刺激电极和接收器可分别植入心脏的心脏组织位置并且通过局部引线连接。具有单独可植入的接收器和刺激电极通过允许接收器最佳地放置接收效率来提高超声介导的无线刺激的效率，从而导致更长的电池寿命，并且通过允许刺激电极被最优地放置用于刺激递送。另一个优点是降低了栓塞的风险，因为接收器和刺激电极组合附接在心脏壁的两个位置处，连接的局部引线作为安全系绳应该被接收器或刺激电极移开。

100. 发明申请

US20160114157A1 DELIVERY DEVICES AND METHODS FOR LEADLESS CARDIAC DEVICES 有权
标题翻译：用于无铅心脏装置的递送装置和方法
公开(公告)号：US20160114157A1
公开(公告)日：2016-04-28
申请号：US14919310
申请日：2015-10-21
申请人： CARDIAC PACEMAKERS, INC.
发明人： Benjamin J. Haasl , Brian L. Schmidt
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N1/37205 , A61N1/3756 , A61N2001/058
摘要： Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may an outer tubular member and an inner tubular member slidably disposed within the lumen of the outer tubular member. A distal holding section may extend distally of a distal end of the inner tubular member and define a cavity therein for receiving an implantable leadless pacing device. The device may further include a hub portion including at least a first hub portion affixed adjacent to the proximal end of the outer tubular member and a second hub portion affixed adjacent to the proximal end of the inner tubular member. A first locking mechanism configured to releasably couple the outer tubular member and the inner tubular member may be disposed within the hub portion.
摘要翻译：公开了用于递送植入式无引脚起搏装置的输送装置，系统和方法。示例性递送装置可以是外管状构件和可滑动地设置在外管状构件的内腔内的内管状构件。远端保持部分可以延伸到内部管状构件的远端的远端并且在其中限定空腔，用于接收可植入无引线起搏装置。该装置还可以包括毂部分，该毂部分至少包括邻近外部管状构件的近端固定的第一轮毂部分和邻近内部管状部件的近端固定的第二轮毂部分。构造成可释放地联接外部管状构件和内部管状构件的第一锁定机构可以设置在轮毂部分内。

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