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91. 发明授权

US07749253B2 Spine distraction implant and method 有权
公开(公告)号：US07749253B2
公开(公告)日：2010-07-06
申请号：US11790909
申请日：2007-04-27
申请人： James F. Zucherman , Ken Y. Hsu , T. Wade Fallin , Henry A. Klyce
发明人： James F. Zucherman , Ken Y. Hsu , T. Wade Fallin , Henry A. Klyce
IPC分类号： A61B17/70
CPC分类号： A61B17/7065 , A61B17/025 , A61B17/66 , A61B17/7062 , A61B17/7064 , A61B17/7068 , A61B17/7071 , A61B2017/00867 , A61B2017/0256 , A61K31/37 , Y10S606/91
摘要： A spine distraction implant alleviates pain associated with spinal stenosis and facet arthropathy by expanding the volume in the spine canal and/or neural foramen. The implant provides a spinal extension stop while allowing freedom of spinal flexion.

92. 发明申请

US20100105764A1 USE 审中-公开
标题翻译：使用
公开(公告)号：US20100105764A1
公开(公告)日：2010-04-29
申请号：US12475910
申请日：2009-06-01
申请人： Michael John Reed , Atul Purohit , Paul Alexander Foster , Simon Paul Newman , Lok Wai Lawrence Woo , Barry Victor Lloyd Potter , Gillian Reed
发明人： Michael John Reed , Atul Purohit , Paul Alexander Foster , Simon Paul Newman , Lok Wai Lawrence Woo , Barry Victor Lloyd Potter , Gillian Reed
IPC分类号： A61K31/366 , A61P35/00
CPC分类号： A61K31/37
摘要： There is provided a method for the manufacture of a medicament for the treatment of cancer comprising a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2), wherein the cancer is of a type, in which the cancer cells overexpress aromatase enzyme.
摘要翻译：提供了一种制备用于治疗癌症的药物的方法，其包括能够抑制类固醇硫酸酯酶的化合物（E.C.3.1.6.2），其中所述癌症是癌细胞过度表达芳香酶的类型。

93. 发明申请

US20100069480A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症的方法和组合
公开(公告)号：US20100069480A1
公开(公告)日：2010-03-18
申请号：US12553878
申请日：2009-09-03
申请人： Isaac Cohen
发明人： Isaac Cohen
IPC分类号： A61K31/352 , A61P35/00 , C07D311/30
CPC分类号： A61K31/352 , A61K31/37
摘要： Isolated compounds and combinations of isolated compounds isolated from Scutellaria barbata D. Don are effective in the generation of reactive oxygen species, induction of DNA damage and induction of apoptosis in cancer cells. The compounds and combinations may be prepared as pharmaceutical compositions for administration to mammals, such as humans, for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers.
摘要翻译：从黄芩分离的分离化合物和分离的化合物的组合可以有效地产生活性氧，诱导DNA损伤和诱导癌细胞凋亡。化合物和组合可以制备为用于给予哺乳动物（例如人）用作治疗固体癌症如上皮癌的药物组合物。这样的上皮癌包括乳腺癌和卵巢癌。

94. 发明申请

US20100034878A1 COMBINATION OF VITAMIN K AND VITAMIN K ANTAGONIST SUCH AS R-ISOMER OF WARFARIN, PHENPROCOUMON OR R-ISOMER OF PHENPROCOUMON AS ANTICOAGULANT THERAPY 审中-公开
标题翻译：维生素K和维生素K拮抗剂的组合如作为抗惊厥治疗的芬太尼，苯丙胺或异丙酚的R-ISOMER
公开(公告)号：US20100034878A1
公开(公告)日：2010-02-11
申请号：US12519505
申请日：2007-12-18
申请人： Henry I. Bussey , Marie B. Walker
发明人： Henry I. Bussey , Marie B. Walker
IPC分类号： A61K9/28 , A61K31/122 , A61K31/35
CPC分类号： A61K31/122 , A61K31/352 , A61K31/37 , A61K2300/00
摘要： Medications which are derived by combining one or more doses of the agonist, vitamin K, with doses of one or more selected vitamin K antagonists such as the R-isomer of warfarin, the R-isomer of phenprocoumon, or the racemic phenprocoumon are useful in anticoagulant therapy. These products are designed to minimize or circumvent the detrimental impact of newly identified genetic-based variables that currently significantly complicate the therapeutic response of individual patients to anticoagulation therapy.
摘要翻译：通过将一种或多种剂量的激动剂维生素K与一种或多种选择的维生素K拮抗剂的剂量（例如华法林的R-异构体，苯丙孕酮的R-异构体或外消旋苯磺素）合并而得到的药物可用于抗凝治疗。这些产品旨在最大限度地减少或规避新确定的基因型变量的有害影响，目前这些变量使个体患者抗凝治疗的治疗反应显着复杂化。

95. 发明申请

US20100015134A1 Therapy With CD4 Binding Peptides and Radiation 有权
标题翻译：用CD4结合肽和辐射治疗
公开(公告)号：US20100015134A1
公开(公告)日：2010-01-21
申请号：US11990581
申请日：2006-08-18
申请人： Paul Parren , Ole Baadsgaard , Denis Alexander
发明人： Paul Parren , Ole Baadsgaard , Denis Alexander
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , A61P35/02
CPC分类号： C07K16/2812 , A61K31/37 , A61K39/395 , A61K41/0066 , A61K2039/505 , A61K2300/00
摘要： The present invention relates to a peptide, such as an antibody, capable of binding to CD4 and use thereof for the mediation of radiation treatment of a clinical condition. The radiation treatment may for instance by treatment with PUVA.
摘要翻译：本发明涉及能够结合CD4的肽，例如抗体，以及其用于临床病症的放射治疗的介导。放射治疗可以例如通过用PUVA处理。

96. 发明授权

US07635378B2 Spine distraction implant and method 失效
公开(公告)号：US07635378B2
公开(公告)日：2009-12-22
申请号：US11924878
申请日：2007-10-26
申请人： James F. Zucherman , Ken Y. Hsu , T. Wade Fallin , Henry A. Klyce
发明人： James F. Zucherman , Ken Y. Hsu , T. Wade Fallin , Henry A. Klyce
IPC分类号： A61B17/70 , A61F2/44
CPC分类号： A61B17/7065 , A61B17/025 , A61B17/66 , A61B17/7062 , A61B17/7064 , A61B17/7068 , A61B17/7071 , A61B2017/00867 , A61B2017/0256 , A61K31/37 , Y10S606/91
摘要： A spine distraction implant alleviates pain associated with spinal stenosis and facet arthropathy by expanding the volume in the spine canal and/or neural foramen. The implant provides a spinal extension stop while allowing freedom of spinal flexion.

97. 发明申请

US20090285797A1 USE OF INHIBITORS OF CYP2A6 FOR REGULATING NICOTINE METABOLISM 审中-公开
标题翻译： CYP2A6抑制剂用于调节NICOTINE代谢的用途
公开(公告)号：US20090285797A1
公开(公告)日：2009-11-19
申请号：US12237713
申请日：2008-09-25
申请人： Edward M. Sellers , Rachel F. Tyndale
发明人： Edward M. Sellers , Rachel F. Tyndale
IPC分类号： A61K31/366 , A61K39/395 , A61K31/7048 , A61K31/4174 , A61K31/4164
CPC分类号： A61K31/7032 , A61K31/122 , A61K31/131 , A61K31/27 , A61K31/351 , A61K31/37 , A61K31/4178 , A61K31/4439
摘要： The invention relates to methods and compositions for regulating nicotine metabolism. Also provided are methods for screening and assessing substances for regulating nicotine metabolism. Methods are provided for assessing nicotine metabolism.
摘要翻译：本发明涉及用于调节尼古丁代谢的方法和组合物。还提供了用于筛选和评估用于调节尼古丁代谢的物质的方法。提供了评估尼古丁代谢的方法。

98. 发明申请

US20090170930A1 METHODS FOR DIRECTING DIFFERENTIATION OF CLONOGENIC NEURAL STEM CELLS WITH COUMARINS 审中-公开
标题翻译：用COUMARIN指导克隆性神经干细胞分化的方法
公开(公告)号：US20090170930A1
公开(公告)日：2009-07-02
申请号：US12400756
申请日：2009-03-09
申请人： Cheng HE , Weidong ZHANG , Xiaohui XU , Wei ZHANG , Juan SU , Chuan ZHANG
发明人： Cheng HE , Weidong ZHANG , Xiaohui XU , Wei ZHANG , Juan SU , Chuan ZHANG
IPC分类号： A61K31/35
CPC分类号： A61K31/37
摘要： A method for promoting differentiation of clonogenic neural stem cells (NSCs), comprising administering to a patient in the need of such promoting a coumarin compound represented by formula I or by formula II. The representative coumarin compounds include 7-hydroxycoumarin, daphnoretin, scopoletin, edgeworin, aesculetin and esculetin-6-β-D-glucopyranoside. The coumarin compounds showed significant activity of directing the differentiation of NSCs in pharmacological test and thereof could be used to prepare drugs to direct NSCs differentiated to oligodendrocyte progenitor cells (OPCs) for the treatment of demyelinating diseases or spinal cord injury. The drug could be a pure coumarin compound or a pharmaceutical composition comprising a therapeutical dose of a coumarin compound as active ingredients and a pharmaceutically-acceptable carrier. The content of the active ingredients in the pharmaceutical composition is between 0.1% and 99.5% by weight.
摘要翻译：一种促进克隆型神经干细胞（NSCs）分化的方法，包括对需要这样促进由式I或式II表示的香豆素化合物的患者施用。代表性的香豆素化合物包括7-羟基香豆素，芫花tin tin，scopoletin，edgeworin，七叶苷和七叶苷-6-β-D-吡喃葡萄糖苷。香豆素化合物在药理学试验中显示出指导NSCs分化的显着活性，并且其可用于制备药物以指导分化为少突胶质细胞祖细胞（OPCs）的NSCs用于治疗脱髓鞘疾病或脊髓损伤。药物可以是纯香豆素化合物或包含治疗剂量的香豆素化合物作为活性成分和药学上可接受的载体的药物组合物。药物组合物中活性成分的含量为0.1〜99.5重量％。

99. 发明申请

US20090149417A1 Methods and compositions for the treatment of cancer using benzopyrone-type PARP inhibitors 审中-公开
标题翻译：使用苯并吡喃酮型PARP抑制剂治疗癌症的方法和组合物
公开(公告)号：US20090149417A1
公开(公告)日：2009-06-11
申请号：US12288329
申请日：2008-10-17
申请人： Valeria Ossovskaya , Barry M. Sherman
发明人： Valeria Ossovskaya , Barry M. Sherman
IPC分类号： A61K31/37 , A61P35/00 , A61K31/4025 , A61K31/4433 , A61K31/496 , A61K31/4178 , A61K31/7068
CPC分类号： A61K31/37 , A61K31/282 , A61K31/4025 , A61K31/4178 , A61K31/4433 , A61K31/453 , A61K31/496 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K38/21 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
摘要翻译：本发明提供了用于治疗癌症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制聚-ADP-核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供施用这种组合物的制剂和模式。

100. 发明申请

US20090099256A1 Drug for Treating Circulatory Insufficiency 审中-公开
标题翻译：药物治疗循环不足
公开(公告)号：US20090099256A1
公开(公告)日：2009-04-16
申请号：US12084052
申请日：2006-10-23
申请人： Hidetsugu Takagaki , Yasuo Aoki , Mitsuteru Ishiwara
发明人： Hidetsugu Takagaki , Yasuo Aoki , Mitsuteru Ishiwara
IPC分类号： A61K31/353 , C07D311/56 , A61P9/00
CPC分类号： C07D311/56 , A61K31/37
摘要： The present invention relate to a drug for treating circulatory insufficiency containing a benzopyran derivative represented by the following general formula (I): and/or a physiologically acceptable salt thereof as an active ingredient, wherein R1 is an alkyl group having 1 to 10 carbon atoms, or an alkenyl group having 2 to 10 carbon atoms; and any one of R2, R3, R4 and R5 is a hydroxyl group, an alkoxy group, an alkenyloxy group, an alkoxy group substituted with a hydroxyl group, or an alkoxy group substituted with a carboxy group, and the others are hydrogen atoms.
摘要翻译：本发明涉及含有下列通式（I）表示的苯并吡喃衍生物的循环功能不全药物：和/或其生理学上可接受的盐作为有效成分，其中R1为碳原子数1〜10的烷基，或具有2〜10个碳原子的烯基; R 2，R 3，R 4和R 5中的任一个是羟基，烷氧基，烯氧基，被羟基取代的烷氧基或被羧基取代的烷氧基，其它是氢原子。

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