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91. 发明授权

US4463593A Apparatus for monitoring the partial pressure of gases 失效
标题翻译：用于监测气体分压的装置
公开(公告)号：US4463593A
公开(公告)日：1984-08-07
申请号：US319003
申请日：1981-11-06
申请人： Dawood Parker
发明人： Dawood Parker
IPC分类号： G01N7/10 , A61B5/00 , G01N27/40 , G01N27/404 , G01N27/54
CPC分类号： A61B5/1477 , A61B5/14539 , A61B5/14542 , G01N27/40
摘要： An apparatus is disclosed for monitoring the partial pressure of a gas in the liquid flowing in a line, for example the PO.sub.2 or PCO.sub.2 tension in blood. The apparatus comprises a connector adapted for insertion in the line, the connector having a wall which includes a membrane permeable to the gas but impermeable to the liquid. The membrane has a first face in contact with the liquid in the connector and a second face oppositely disposed to the first face. A sensor, for example, an electrochemical sensor, is located adjacent the second face and is responsive to gas passing through the membrane from the liquid.
摘要翻译：公开了一种用于监测在一行中流动的液体中的气体的分压的装置，例如血液中的PO 2或PCO 2张力。该装置包括适于插入管线的连接器，该连接器具有一壁，该壁包括可渗透气体但不透液体的膜。膜具有与连接器中的液体接触的第一面和与第一面相对设置的第二面。传感器，例如电化学传感器位于第二面附近，并响应于从液体通过膜的气体。

92. 发明授权

US4425918A Membrane retainer arrangement for physiological sensing units 失效
标题翻译：用于生理感测单元的膜保持器布置
公开(公告)号：US4425918A
公开(公告)日：1984-01-17
申请号：US307722
申请日：1981-10-02
申请人： Hermann Moll , Helmut J. Leist , Karl-Heinz Pomorin , Georg J. Ullrich
发明人： Hermann Moll , Helmut J. Leist , Karl-Heinz Pomorin , Georg J. Ullrich
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1477 , G01N27/28 , G01N27/404
CPC分类号： A61B5/14542 , A61B5/1477
摘要： Disclosed herein is a retainer arrangement for applying a membrane to a physiological sensing unit for the transcutaneous determination of the magnitude of physiological quantitites, particularly for measuring the partial pressure of gases in blood or the like. The arrangement constitutes a preassembly of a membrane, with a clamping ring accommodating the membrane and having an annular recess receiving the rim of the membrane. The clamping ring has a lip in the form of an inwardly protruding annular edge for removably securing the clamping ring together with the membrane to the sensing unit by virtue of the lip resiliently snapping into a peripheral groove of the sensing unit, the lip defining the periphery of the annular recess. In accordance with the invention, an auxiliary retainer element, is provided for temporarily and removably assembling the membrane with the clamping ring prior to assembly with the sensing unit. The auxiliary retainer element includes a retainer ring fitted loosely into the annular recess of the clamping ring, to maintain the outer rim of the membrane within the annular recess.
摘要翻译：本文公开了一种保持器装置，用于将膜施加到生理感测单元，用于经皮确定生理数量的大小，特别是用于测量血液中的气体等的分压。该装置构成膜的预组装，其中夹紧环容纳膜并且具有容纳膜的边缘的环形凹部。夹紧环具有向内突出的环形边缘的形式的唇缘，用于通过弹性地咬合到感测单元的周边槽中将夹紧环可拆卸地固定到膜片到感测单元，唇缘限定外围的环形凹部。根据本发明，提供辅助保持器元件，用于在与感测单元组装之前临时和可拆卸地将膜与夹紧环组装。辅助保持器元件包括松紧地装配到夹紧环的环形凹部中的保持环，以将膜的外缘保持在环形凹部内。

93. 发明授权

US4401122A Cutaneous methods of measuring body substances 失效
标题翻译：皮肤测量身体物质的方法
公开(公告)号：US4401122A
公开(公告)日：1983-08-30
申请号：US63159
申请日：1979-08-02
申请人： Leland C. Clark, Jr.
发明人： Leland C. Clark, Jr.
IPC分类号： A61B5/00 , C12M1/34 , C12M1/40 , C12Q1/00 , C12Q1/26
CPC分类号： A61B5/145 , A61B5/14532 , A61B5/1477 , A61B5/1486 , C12Q1/005
摘要： Cutaneous methods for measurement of substrates in mammalian subjects are disclosed. A condition of the skin is used to measure a number of important substances which diffuse through the skin or are present underneath the skin in the blood or tissue. According to the technique, an enzyme whose activity is specific for a particular substance or substrate is placed on, in or under the skin for reaction. The condition of the skin is then detected by suitable means as a measure of the amount of the substrate in the body. For instance, the enzymatic reaction product or by-product of the reaction is detected directly through the skin as a measure of the amount of substrate. Polarographic electrodes or enzyme electrodes are employed as skin-contact analyzers in the transcutaneous measurement of oxygen or hydrogen peroxide to quantitatively determine blood substances such as glucose and alcohol. In a preferred quantitative technique, the skin is arterialized, i.e., heated or otherwise treated to arterialize the skin capillaries when the measurements are made. Colorimetric detection methods are also employed.
摘要翻译：公开了用于测量哺乳动物受试者中底物的皮肤方法。皮肤的状况用于测量通过皮肤扩散或存在于血液或组织中皮肤下方的许多重要物质。根据该技术，将活性对特定物质或底物特异的酶置于皮肤内或皮下进行反应。然后通过合适的手段检测皮肤的状况，作为体内基质量的量度。例如，通过皮肤直接检测酶反应产物或反应的副产物作为底物量的量度。在氧气或过氧化氢的经皮测量中使用极谱电极或酶电极作为皮肤接触分析仪，以定量测定血液物质如葡萄糖和酒精。在优选的定量技术中，当进行测量时，皮肤被动脉化，即加热或以其它方式治疗以动脉化皮肤毛细血管。还使用比色检测方法。

94. 再颁专利

USRE30317E Method and apparatus for determining the perfusion efficiency factor of animal tissue 失效
标题翻译：用于确定动物组织的灌注效率因子的方法和装置
公开(公告)号：USRE30317E
公开(公告)日：1980-07-01
申请号：US850770
申请日：1977-11-11
申请人： Dietrich W. Lubbers , Albert Huch
发明人： Dietrich W. Lubbers , Albert Huch
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/1477 , A61B5/1491 , A61B5/1495
摘要： The perfusion rate in animal tissue is measured percutaneously at a specific locus, and at the same time the indicator concentration is percutaneously measured at the same locus so that the perfusion efficiency factor can be determined. Apparatus for carrying out the above method is also disclosed comprising, in combination, a first and a second wall means defining a first and a second surface, each placed in contact with animal tissue to be measured and respectively cooperating with first and second sensor means so that the temperatures of said surfaces can be compared and simultaneously processed with the measurement of the indicator concentration performed by a separate measuring means also in contact with the tissue, so that the perfusion efficiency factor can be determined.

95. 发明授权

US4207160A Measuring sensor head for determining the contents of gases in liquids 失效
标题翻译：测量液体中气体含量的传感器头
公开(公告)号：US4207160A
公开(公告)日：1980-06-10
申请号：US805704
申请日：1977-06-13
申请人： Horst Frankenberger , Dieter Heller , Georg Ullrich
发明人： Horst Frankenberger , Dieter Heller , Georg Ullrich
IPC分类号： A61B5/00 , G01N27/49 , G01N33/487 , G01N33/49 , G01N27/46
CPC分类号： A61B5/14542 , A61B5/1477 , G01N33/4925
摘要： A measuring sensor head for determining the contents of gases in liquids, particularly for transcutaneous determination of oxygen in blood, as well as a method of manufacturing such sensor head are disclosed. In accordance with the invention, the gas-permeable membrane which covers the front face of the sensor head and which, during use, is applied to the human skin, is preshaped to assume a cap-shaped configuration. This eliminates previously occurring measuring errors due to uncontrollable stresses causing thickness variations generated in conventional membranes and, moreover, provides for an improved sealing effect between the housing of the measuring head and the membrane.
摘要翻译：公开了一种用于确定液体中气体的含量的测量传感器头，特别是用于经皮测定血液中的氧气，以及制造这种传感器头的方法。根据本发明，覆盖传感器头部的前表面并且在使用期间被施加到人体皮肤上的透气膜被预先成形为呈帽状的构造。这消除了由于不可控应力引起的常规膜中产生的厚度变化的先前发生的测量误差，并且还提供了测量头的外壳与膜之间的改进的密封效果。

96. 发明授权

US3985633A Device for the polarographic measurement of oxygen pressure 失效
标题翻译：氧气压力的极化测量装置
公开(公告)号：US3985633A
公开(公告)日：1976-10-12
申请号：US568111
申请日：1975-04-14
申请人： Dietrich W. Lubbers , Albert Huch
发明人： Dietrich W. Lubbers , Albert Huch
IPC分类号： A61B5/00 , G01N27/48 , G01N27/46
CPC分类号： A61B5/14542 , A61B5/1477 , A61B5/1495 , G01N27/48
摘要： A platinum oxygen-pressure measuring electrode is connected with a reference electrode. An indicating device for indicating the oxygen pressure is connected with both of the electrodes, and an arrangement is interposed between the electrodes and an object to be measured and has a surface which is to be placed against the object. The arrangement offers to the diffusion of oxygen from the surface to the measuring electrode a resistance which is greater than the resistance which is offered to such diffusion of the oxygen through the object to be measured.

97. 发明授权

US12150758B2 Waterproof electronic decals for wireless monitoring of biofluids 有权
公开(公告)号：US12150758B2
公开(公告)日：2024-11-26
申请号：US17228615
申请日：2021-04-12
申请人： Purdue Research Foundation
发明人： Ramses Valentin Martinez , Aniket Pal
IPC分类号： H04Q9/00 , A61B5/00 , A61B5/145 , A61B5/1491 , A61B5/1477
CPC分类号： A61B5/14539 , A61B5/0002 , A61B5/1491 , A61B5/6833 , H04Q9/00 , A61B5/14517 , A61B5/1477 , A61B5/6801 , A61B2562/04 , A61B2562/164 , H04Q2209/40 , H04Q2209/43
摘要： A wearable sensor decal may include a flexible wrapper layer, an intermediate layer, and a porous film layer. A first plurality of electrodes may be deposited on the wrapper layer. A heating element may be conductivity coupled to the first plurality of electrodes. A second plurality of electrodes may be deposited on the intermediate layer. A biosensor may be conductively coupled to the second plurality of electrodes. The flexible film may be hydrophilic to allow biofluids pass to the biosensor and the wrapper layer may be hydrophobic to provide waterproofing to the biosensor and heating element. The heating element may be powered to reduce thermal variance in biosensor measurements.

98. 发明授权

US12138053B2 Methods, systems, and devices relating to open microfluidic channels 有权
公开(公告)号：US12138053B2
公开(公告)日：2024-11-12
申请号：US17859878
申请日：2022-07-07
申请人： Tasso, Inc.
发明人： Erwin Berthier , Ben Casavant , Ben Moga
IPC分类号： A61B5/151 , A61B5/1477 , A61B5/15 , A61B5/157
CPC分类号： A61B5/15146 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150412 , A61B5/15087 , A61B5/150984 , A61B5/15105 , A61B5/15117 , A61B5/157 , A61B5/1477
摘要： Various collection devices, systems and methods relating to the use of devices with open microfluidic channels disposed within a housing defining a lumen. These devices make use of microneedles passed through apertures to induce fluid flow into microfluidic channel networks for collection and analysis. The device can be actuated via button when placed on the skin of a patient to collect a fluid sample, such as a blood draw.

99. 发明授权

US12053281B2 Transdermal sampling strip and method for analyzing transdermally emitted gases 有权
公开(公告)号：US12053281B2
公开(公告)日：2024-08-06
申请号：US16952300
申请日：2020-11-19
申请人： Exhalix LLC
发明人： Alireza Shekarriz , Debra May Friedrichsen
IPC分类号： A61B5/1477 , A61B5/145 , A61B10/00 , G01N33/49
CPC分类号： A61B5/1477 , A61B5/14507 , A61B5/14542 , A61B5/14546 , A61B10/00 , A61B10/0064 , A61B2010/0083 , A61B2560/0412 , G01N33/4925
摘要： Transdermally emitted gasses are detected by applying a dermal sampling strip to the skin of a biological subject, capturing the gasses in a vapor space in the dermal sampling strip, and analyzing for at least one such gas captured in the vapor space of the dermal sampling strip. Analysis is preferably performed using an electrocatalytic cell, which can be mounted on the dermal sampling strip and form a wall of the vapor space.

100. 发明公开

US20240225618A1 DEVICE FOR COLLECTING A FRACTION OF THE PERSPIRATION EXCRETED BY A SUBJECT 审中-公开
公开(公告)号：US20240225618A1
公开(公告)日：2024-07-11
申请号：US18559183
申请日：2022-04-14
申请人： UNIVERSITE DE LILLE , CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE , BE-LAB
发明人： Jean-Philippe GARNIER , Régis LOGIER , Jean-Claude DARCHEVILLE
IPC分类号： A61B10/00 , A61B5/00 , A61B5/145 , A61B5/1477 , A61F13/534 , A61F13/537 , A61F13/84
CPC分类号： A61B10/0064 , A61B5/002 , A61B5/14517 , A61B5/14539 , A61B5/1477 , A61B5/4266 , A61B5/6833 , A61F13/53713 , A61B2010/0006 , A61B2562/08 , A61F2013/53445 , A61F2013/53721 , A61F2013/8473
摘要： A device for collecting a fraction of the perspiration excreted by a subject, the device being of the type including a multi-layer patch including: —a first layer including at least one perspiration-collecting aperture and a transfer opening; —a hydrophilic absorbent layer, positioned above the first layer and communicating with the external environment, and communicating with the first layer via the transfer opening; —a film, possibly transparent, that constitutes a barrier against water and against vapour, and that covers at least the upper face of the absorbent layer; the device notably including means for regulating the rate at which perspiration in the liquid and/or vapour state penetrates into the absorbent layer.

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