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91. 发明授权

US07311757B2 Analyte pre-concentrator for gas chromatography 有权
标题翻译：用于气相色谱的分析物预浓缩器
公开(公告)号：US07311757B2
公开(公告)日：2007-12-25
申请号：US11233162
申请日：2005-09-22
申请人： Andrew Tipler , Gary Campbell , Mark Collins
发明人： Andrew Tipler , Gary Campbell , Mark Collins
IPC分类号： B01D53/02
CPC分类号： B01D53/025 , B01D2253/102 , G01N30/12 , G01N2001/2229 , G01N2030/085 , G01N2030/121 , G01N2030/127 , G01N2030/128
摘要： An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube having a restricted outlet and packed with an adsorbent, wherein the tube serves as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.
摘要翻译：公开了用于气相色谱的分析物预浓缩器，其通常包括具有限制出口并装有吸附剂的管，其中管用作色谱注射器的衬垫，作为与色谱柱耦合的吸附阱，和/或耦合到顶空采样器的吸附阱。优选地，加热装置允许管被加热。在优选实施方案中，分析物预浓缩器还包括柱分离附件，使得色谱柱可以暂时与流过管的物质隔离。

92. 发明授权

US07300564B2 Interdigitated electrochemical gas generator 失效
标题翻译：交叉电化学气体发生器
公开(公告)号：US07300564B2
公开(公告)日：2007-11-27
申请号：US10951347
申请日：2004-09-28
申请人： Avinash Dalmia , Otto J. Prohaska
发明人： Avinash Dalmia , Otto J. Prohaska
IPC分类号： C25B9/00
CPC分类号： C25B9/06 , C25B9/08 , G01N27/44 , G01N33/0006
摘要： The invention relates to an electrochemical gas generator including a substrate for providing a surface for electrode deposition, a first electrode deposited on the surface for providing an electrical connection with a conducting medium, a second electrode deposited on the substrate for generating a gas, and a plurality of members extending from at least one side of the first electrode placed alternately with a plurality of extensions protruding from at least one side of the second electrode for improving generator efficiency.
摘要翻译：本发明涉及一种电化学气体发生器，其包括用于提供用于电极沉积的表面的基板，沉积在表面上用于提供与导电介质的电连接的第一电极，沉积在基板上用于产生气体的第二电极，以及从第一电极的至少一侧延伸的多个构件交替布置有从第二电极的至少一侧突出的多个延伸部，用于提高发电机效率。

93. 发明申请

US20070251824A1 Multiplexed analyte quantitation by two-dimensional planar electrochromatography 审中-公开
标题翻译：通过二维平面电色谱法复用分析物定量
公开(公告)号：US20070251824A1
公开(公告)日：2007-11-01
申请号：US11657922
申请日：2007-01-24
申请人： Wayne Patton , Linan Song , Nancy Wilker
发明人： Wayne Patton , Linan Song , Nancy Wilker
IPC分类号： B01D57/02
CPC分类号： G01N33/6803 , G01N27/44782
摘要： The invention relates to methods for isolating an analyte of interest in a sample suspected of containing the analyte of interest using two-dimensional planar electrochromatography. The methods comprise treating at least a portion of the sample with a mobility modifier capable of modifying the mobility of the analyte of interest after the second dimension of planar electrochromatography. Kits and compositions are also disclosed.
摘要翻译：本发明涉及使用二维平面电色谱法分离怀疑含有感兴趣分析物的样品的感兴趣分析物的方法。所述方法包括使用能够在平面电色谱的第二维度之后改变目的分析物的迁移率的迁移率调节剂处理至少一部分样品。还公开了试剂盒和组合物。

94. 发明授权

US07284410B2 Chromatographic interface for thermal desorption systems 失效
标题翻译：用于热解吸系统的色谱界面
公开(公告)号：US07284410B2
公开(公告)日：2007-10-23
申请号：US11169935
申请日：2005-06-29
申请人： Andrew Tipler , Heidi Grecsek , Frank DeLorenzo , Giuseppe Coppola
发明人： Andrew Tipler , Heidi Grecsek , Frank DeLorenzo , Giuseppe Coppola
IPC分类号： G01N30/04
CPC分类号： G01N30/12 , G01N30/16 , G01N30/32 , G01N2030/0015 , G01N2030/128 , G01N2030/324
摘要： Disclosed are systems and methods that include a thermal desorption unit, a chromatographic column, and an interface device between the unit and the column. The interface device controls the fluid flowing into the column, such as by providing additional carrier gas to maintain a substantially constant gas flow or velocity, by proving a controlled temperature increase, or by venting a portion of the gas received from the thermal desorption unit, thereby removing the dependence on the thermal desorption unit for such control. In some embodiments, the interface is a chromatographic injector. In certain embodiments, a transfer line from the desorption unit is coupled to the same port of the interface device as the chromatographic column. In some of these embodiments, this is accomplished by employing a special adaptor.
摘要翻译：公开了包括热解吸单元，色谱柱和单元和柱之间的界面装置的系统和方法。接口装置控制流入柱的流体，例如通过提供额外的载气来维持基本恒定的气流或速度，通过证明控制的温度升高，或通过排出从热解吸单元接收的气体的一部分，从而消除了对这种控制的热解吸单元的依赖性。在一些实施方案中，界面是色谱注射器。在某些实施方案中，来自解吸单元的传输线连接到与色谱柱相同的接口装置的端口。在这些实施例中的一些实施例中，这通过采用特殊适配器来实现。

95. 发明申请

US20070166835A1 MULTIPLEX ASSAYS USING MAGNETIC AND NON-MAGNETIC PARTICLES 审中-公开
标题翻译：使用磁性和非磁性颗粒的多重测定
公开(公告)号：US20070166835A1
公开(公告)日：2007-07-19
申请号：US11615731
申请日：2006-12-22
申请人： Mark Bobrow , Karl Adler , Mack Schermer
发明人： Mark Bobrow , Karl Adler , Mack Schermer
IPC分类号： G01N1/00
CPC分类号： C12Q1/6834 , G01N33/54313 , G01N33/54326 , G01N35/0098 , G01N35/028 , G01N2035/00564 , Y10T436/25 , C12Q2563/149 , C12Q2563/143 , C12Q2537/143
摘要： Disclosed herein are methods and compositions for multiplexed assays using magnetic and non-magnetic particles. Also disclosed are methods and compositions for performing multi-step assays within a single assay vessel.
摘要翻译：本文公开了使用磁性和非磁性颗粒的多重测定法的方法和组合物。还公开了用于在单个测定容器内进行多步测定的方法和组合物。

96. 发明申请

US20070161030A1 Micelle-and microemulsion-assisted planar separations platform for proteomics 审中-公开
标题翻译：用于蛋白质组学的胶束和微乳液辅助平面分离平台
公开(公告)号：US20070161030A1
公开(公告)日：2007-07-12
申请号：US11636327
申请日：2006-12-08
申请人： Wayne Patton
发明人： Wayne Patton
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N27/44747 , G01N27/447 , G01N30/463 , G01N30/58 , G01N30/90 , G01N2030/582
摘要： A method of separating biomolecules includes providing a sample comprising one or more biomolecules, at least one of which is hydrophilic; wetting an amphiphilic planar stationary phase with a microemulsion or micelluar mobile phase; and creating an electrical field between first and second electrodes in electrical contact with opposing edges of the amphiphilic stationary phase, wherein the mobile phase advances across the length of the separation medium and one or more biomolecules are separated.
摘要翻译：分离生物分子的方法包括提供包含一种或多种生物分子的样品，其中至少一种是亲水的; 用微乳液或微胶囊流动相润湿两亲平面固定相; 以及在所述两亲性固定相的相对边缘电接触的第一和第二电极之间产生电场，其中所述流动相跨越所述分离介质的长度并且分离一个或多个生物分子。

97. 发明授权

US07209836B1 Method and system for automatically creating crosstalk-corrected data of a microarray 失效
标题翻译：用于自动创建微阵列串扰校正数据的方法和系统
公开(公告)号：US07209836B1
公开(公告)日：2007-04-24
申请号：US09354500
申请日：1999-07-16
申请人： Mack J. Schermer , Roger D. Dowd , Jun Yang
发明人： Mack J. Schermer , Roger D. Dowd , Jun Yang
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G02B21/004 , C12Q1/6837 , G01N21/253 , C12Q2545/114 , C12Q2563/107
摘要： A method and system are disclosed for automatically creating crosstalk-corrected data of a microarray utilizing calibration dye spots each of which comprises a single pure dye. A microarray scanner, such as a confocal laser microarray scanner, generates dye images, each of which contains at least one of the calibration dye spots for each of the output channels of the scanner. For each of the calibration dye spots, an output of each of the output channels is measured to obtain output measurements. A set of correction factors is computed from the output measurements to correct the data subsequently gathered from the microarray scanner. In other words, the correction factors are applied to quantitation or measurement data obtained from microarray images which contain spots having dyes of known or unknown excitation or emission spectra to obtain crosstalk-corrected data.
摘要翻译：公开了一种方法和系统，用于利用校准染料斑点自动创建微阵列的串扰校正数据，每个染色斑点包含单个纯染料。诸如共焦激光微阵列扫描仪的微阵列扫描器产生染色图像，每个染色图像包含扫描仪的每个输出通道的校准染色斑点中的至少一个。对于每个校准染料斑点，测量每个输出通道的输出以获得输出测量值。从输出测量计算一组校正因子，以校正随后从微阵列扫描仪收集的数据。换句话说，校正因子被应用于从包含具有已知或未知激发或发射光谱的染料的斑点的微阵列图像获得的定量或测量数据，以获得串扰校正的数据。

98. 发明申请

US20060192109A1 Zirconia toughened alumina composition and use in ion and electron optical systems 有权
标题翻译：氧化锆增韧氧化铝组成，用于离子和电子光学系统
公开(公告)号：US20060192109A1
公开(公告)日：2006-08-31
申请号：US11348863
申请日：2006-02-07
申请人： Rosario Mannino , Giuseppe Coppola
发明人： Rosario Mannino , Giuseppe Coppola
IPC分类号： H01J49/00
CPC分类号： H01J49/00 , C04B35/119 , C04B35/4885
摘要： An ion optical system including an ionizer for ionizing one or more compounds, the ionizer including a plurality of components, a mass separator for separating ions of the one or more compounds, the mass separator including a plurality of components, and a detector for identifying the one or more compounds, the detector including a plurality of components. At least one of the plurality of components of at least one of the ionizer, mass separator and detector includes a composition of zirconium oxide and aluminum oxide.
摘要翻译：一种离子光学系统，包括用于离子化一种或多种化合物的离子发生器，所述离子发生器包括多个组分，用于分离所述一种或多种化合物的离子的质量分离器，所述质量分离器包括多个组分，以及用于鉴定一种或多种化合物，所述检测器包括多个组分。离子发生器，质量分离器和检测器中的至少一个的多个部件中的至少一个包括氧化锆和氧化铝的组成。

99. 发明申请

US20060096396A1 Methods and systems for determining a position of a probe 有权
标题翻译：用于确定探针位置的方法和系统
公开(公告)号：US20060096396A1
公开(公告)日：2006-05-11
申请号：US11268867
申请日：2005-11-08
申请人： Richard Harazin , Ronald Zweifel
发明人： Richard Harazin , Ronald Zweifel
IPC分类号： G01B7/00 , G01F25/00
CPC分类号： G01F23/26 , G01B7/003 , G01F23/0023 , G01F23/266 , G01N35/1011
摘要： The present methods and systems include aligning at least two sensors with one or more known locations, selecting at least two of the at least two sensors, electrically driving the probe, based on signals received by the selected sensors, determining whether the probe is aligned with the known location(s), and, optionally adjusting the probe position based on the determination. The methods and systems also include repeatedly returning to electrically driving and positioning the probe until the probe is aligned with the selected sensors, and/or repeatedly returning to selecting at least two of the at least two sensors. The relative position of the probe with respect to the selected sensors may also be determined.
摘要翻译：本发明的方法和系统包括将至少两个传感器与一个或多个已知位置对准，基于由所选传感器接收的信号，选择至少两个传感器中的至少两个传感器，电驱动探头，确定探针是否与已知位置，以及可选地基于该确定来调整探测器位置。所述方法和系统还包括重复返回到电驱动和定位探针，直到探针与所选择的传感器对准，和/或重复返回以选择至少两个传感器中的至少两个。也可以确定探针相对于所选择的传感器的相对位置。

100. 发明授权

US07013707B2 Method and apparatus for enhanced detection of a specie using a gas chromatograph 失效
公开(公告)号：US07013707B2
公开(公告)日：2006-03-21
申请号：US10345608
申请日：2003-01-16
申请人： Otto J. Prohaska , Avinash Dalmia , Andrew Tipler
发明人： Otto J. Prohaska , Avinash Dalmia , Andrew Tipler
IPC分类号： G01N27/26 , G01N27/407 , G01N30/62
CPC分类号： G01N30/62 , G01N27/4045 , G01N30/64 , G01N2030/025 , G01N2030/125 , G01N2030/645
摘要： The invention includes a method and apparatus for a chromatography system having a chromatographic column for separating gases in a mixture from one another and an electrochemical gas sensor coupled to the chromatographic column for detecting a gas being emitted from the column. The electrochemical gas sensor further includes a substrate having a surface for depositing electrodes thereon, an ionomer membrane in contact with the surface, an electrode in contact with the surface, and an opening in the ionomer membrane in a location proximate to the electrode for permitting a gas to diffuse through the opening to simultaneously contact the electrode and the ionomer membrane within the opening.

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