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91. 发明授权

US5760178A Human and rat variants of glycoprotein CD44 containing an additional extracellular domain associated with metastatic potential 失效
标题翻译：含有与转移潜能相关的额外细胞外结构域的糖蛋白CD44的人和大鼠变体
公开(公告)号：US5760178A
公开(公告)日：1998-06-02
申请号：US483322
申请日：1995-06-07
申请人： Peter Herrlich , Helmut Ponta , Ursula Guenthert , Siegfried Matzku , Achim Wenzel
发明人： Peter Herrlich , Helmut Ponta , Ursula Guenthert , Siegfried Matzku , Achim Wenzel
IPC分类号： A61K38/00 , A61K38/17 , A61K39/395 , A61P35/00 , A61P35/04 , C07K20060101 , C07K14/00 , C07K14/47 , C07K14/705 , C07K14/73 , C07K14/82 , C07K16/00 , C07K16/28 , C07K16/30 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/13 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/574 , G01N33/68 , C07K1/00 , C07K17/00 , C12P21/06
CPC分类号： C07K16/2884 , C07K14/705 , A61K38/00 , Y10S530/828
摘要： A monoclonal antibody (MAb1.1ASML) directed against a surface glycoprotein of the metastasizing rat pancreatic carcinoma cell line BSp73ASML, was used to identify and isolate a complementary DNA (cDNA) clone capable of encoding for a glycoprotein with partial homology to CD44, a presumed adhesion molecule. This clone, which was subsequently designated pMeta-1, contains an additional extracellular domain of 162 amino acids inserted into the CD44 protein between amino acid positions 223 and 247 (by analogy to human and murine CD44). This new variant was expressed only in the metastasizing cell lines of two rat tumors, the pancreatic carcinoma BSp73 and the mammary adenocarcinoma 13762NF; it was not expressed in non-metastasizing tumor cell lines nor in normal rat tissues. Overexpression of pMeta-1 in the nonmetastasizing BSp73AS cell line suffices to establish full metastatic behavior. The variant-specific rat CD44 sequence was used to isolate a cDNA clone encoding for a human homologue as well.
摘要翻译：使用针对转移性大鼠胰腺癌细胞系BSp73ASML的表面糖蛋白的单克隆抗体（MAb1.1ASML）来鉴定和分离能够编码与CD44具有部分同源性的糖蛋白的互补DNA（cDNA）克隆，假定粘附分子。随后称为pMeta-1的克隆在氨基酸位置223和247（类似于人和鼠CD44）之间含有插入到CD44蛋白中的162个氨基酸的另外的胞外结构域。该新变体仅在两个大鼠肿瘤的转移细胞系，胰腺癌BSp73和乳腺腺癌13762NF中表达; 在非转移性肿瘤细胞系和正常大鼠组织中未表达。非特异性BSP73AS细胞系中pMeta-1的过度表达足以建立完全转移的行为。变体特异性大鼠CD44序列用于分离编码人同源物的cDNA克隆。

92. 发明授权

US5556371A Device for transanal resectate extraction 失效
标题翻译：经肛门切除提取装置
公开(公告)号：US5556371A
公开(公告)日：1996-09-17
申请号：US303751
申请日：1994-08-18
申请人： Heinrich Schulken , Karl Schlipf
发明人： Heinrich Schulken , Karl Schlipf
IPC分类号： A61B17/32 , A61B1/303 , A61B1/307 , A61B1/31 , A61B17/00 , A61B17/28 , A61B17/34 , A61B1/00
CPC分类号： A61B17/29 , A61B17/00234 , A61B17/3403
摘要： In a device for transanal resectate extraction which includes a rectoscope sleeve with a proximal tubular end portion, a connecting piece sealingly mounted onto said tubular proximate end portion for closing the rectoscope sleeve and including a bore axially extending therethrough and a resectate extractor having a tubular portion extending through the bore so as to be axially movable but position-lockable therein. The tubular portion of the extractor has a protector portion at its distal end with an axial passage in alignment with the tubular extractor portion for receiving grasping pincers inserted through the tubular extractor portion. The protector portion has an outer diameter smaller than the inner diameter of the rectoscope sleeve so that it can be retracted into the sleeve.
摘要翻译：在一种用于经肛门切除术提取的装置中，该装置包括具有近端管状端部部分的立体镜套筒，连接件密封地安装在所述管状近端部分上，用于封闭所述直立管套并且包括轴向延伸穿过其中的孔，以及具有管状部分的切除提取器延伸穿过孔，以便可轴向移动但位于其中。提取器的管状部分在其远端具有保护部分，其轴向通道与管状提取器部分对准，用于接收通过管状提取器部分插入的抓持钳。保护部分的外径小于直肠镜套筒的内径，使其能够缩回到套筒中。

93. 发明授权

US5512161A Process for galvanically forming structured plate-shaped bodies 失效
标题翻译：用于电镀形成结构化板状体的方法
公开(公告)号：US5512161A
公开(公告)日：1996-04-30
申请号：US404173
申请日：1995-03-06
申请人： Heinz Dinglreiter , Helmut Kalb , Richard Rapp
发明人： Heinz Dinglreiter , Helmut Kalb , Richard Rapp
IPC分类号： B29C59/02 , B81B1/00 , C25D1/10
CPC分类号： B81B1/00 , B29C59/026 , C25D1/10 , B29C2059/023
摘要： In a process for galvanically forming structured plate-like bodies, wherein a layer of a plastic material is structured at one side and structure bodies with plane front surfaces are formed thereon so as to rise from a contiguous electrically conductive base, the front surfaces of the structure bodies are provided with isolated spangles of electrically conductive material which are electrically insulated from each other and sized and spaced such that a line across a front surface intersects at least one of the spangles and the structure base--used as a cathode--and the structured bodies are then galvanically covered with a metal to form the structured plate on the layer of plastic material.
摘要翻译：在电镀形成结构化的板状体的方法中，其中塑料材料层被构造在一侧，并且在其上形成具有平面前表面的结构体，以便从连续的导电基底上升，结构体设置有导电材料的隔离的矩形，它们彼此电绝缘并且尺寸和间隔使得穿过前表面的线与至少一个矩形和用作阴极的结构基底相交，并且结构化然后用金属电镀覆盖体，以在塑料材料层上形成结构化板。

94. 发明授权

US5266962A Method of converting transverse electrical modes and a helically outlined aperture antenna for implementing the method 失效
标题翻译：转换横向电气模式的方法和用于实施该方法的螺旋轮廓孔径天线
公开(公告)号：US5266962A
公开(公告)日：1993-11-30
申请号：US803079
申请日：1991-12-06
申请人： Arnold Mobius , Manfred Thumm
发明人： Arnold Mobius , Manfred Thumm
IPC分类号： H01P1/16 , G21K1/16 , H01Q13/06 , H01Q19/15 , H05H1/46 , H05H7/02 , H01Q13/00
CPC分类号： H05H7/02 , G21K1/16 , H01Q19/15
摘要： A mode converter for converting transverse electric modes into hybrid modes of type EH.sub.mn and including a circular waveguide provided with corrugations extending in a circumferential (azimuth) direction that become deeper toward its end and are continued in a subsequent helically outlined aperture antenna with constant depth. The emitted radiation is circularly polarized and, by the use of suitable reflectors for the emitted radiation, may be cause to be linearly polarized. The emitted radiation no longer has any sidelobes in the far field and its characteristic has a Gaussian profile over the azimuth angle.
摘要翻译：用于将横向电模式转换成EHmn型混合模式的模式转换器，并且包括圆形波导，该圆形波导具有在周向（方位角）方向上延伸的波纹，其朝向其端部变得更深，并且在随后的具有恒定深度的螺旋轮廓孔径天线中继续。发射的辐射是圆偏振的，并且通过使用用于发射的辐射的合适的反射器可能被引起线性偏振。发射的辐射在远场不再具有旁瓣，其特征在方位角上具有高斯分布。

95. 发明授权

US5251007A Dual-beam spectrometer 失效
标题翻译：双光束光谱仪
公开(公告)号：US5251007A
公开(公告)日：1993-10-05
申请号：US720757
申请日：1991-07-01
申请人： Gunter Rinke
发明人： Gunter Rinke
IPC分类号： G01J3/28 , G01J3/36 , G01J3/42
CPC分类号： G01J3/36 , G01J3/2803 , G01J3/42 , G01J2003/2866 , G01J3/0294
摘要： The invention relates to a dual-beam spectrometer in which a measuring beam, after passage through a measuring cell, and a reference beam each travel through an entrance slit into a spectrometer. Both beams are spectrally separated by means of an optical grating. The spectrometer is intended to operate with a single photodiode array. According to the invention, the two entrance slits, the center of the grating and the measuring and reference spectra lie in one plane; both spectra are recorded on a single detector array, with the spectrum of the measuring beam of the +1 order directly following the spectrum of the reference beam of the -1 order.
摘要翻译： PCT No.PCT / DE90 / 00887 Sec。 371日期1991年7月1日 102（e）日期1991年7月1日PCT 1990年11月19日PCT PCT。公开号WO91 / 08454 日期：1991年6月13日。本发明涉及一种双光束光谱仪，其中在通过测量池之后的测量光束和参考光束各自穿过入口狭缝进入光谱仪。两个光束通过光栅光谱分离。光谱仪旨在使用单个光电二极管阵列进行操作。根据本发明，两个入口狭缝，光栅的中心和测量和参考光谱位于一个平面中; 两个光谱都记录在单个检测器阵列上，+1阶的测量光谱的光谱直接跟随-1阶的参考光束的光谱。

96. 发明授权

US5249359A Process for manufacturing finely structured bodies such as heat exchangers 失效
标题翻译：用于制造诸如热交换器的精细结构体的方法
公开(公告)号：US5249359A
公开(公告)日：1993-10-05
申请号：US854065
申请日：1992-03-19
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Peter Schmid , Peter Bichler , Winfried Brunner , Wolfgang Simon
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Peter Schmid , Peter Bichler , Winfried Brunner , Wolfgang Simon
IPC分类号： B01D25/00 , B01J19/00 , B01J35/04 , B23B1/00 , B23C3/00 , B23P15/26 , C02F3/10 , F28D9/00 , G02B5/18 , B23D15/00
CPC分类号： G02B5/1852 , B01D25/001 , B01J19/0093 , B01J35/04 , B23B1/00 , B23C3/00 , B23P15/26 , F28D9/00 , F28D9/0037 , F28F13/185 , B01D2201/46 , C02F3/101 , F28F2260/00 , Y02W10/15 , Y10T29/301 , Y10T29/307 , Y10T29/4935 , Y10T29/49366 , Y10T29/49826
摘要： A method of producing a finely structured body which includes a plurality of stacked, cut sections of foil at least one of which is provided with grooves in a selected groove direction on at least one surface thereof, and which has a plurality of closely juxtaposed, channel-like perforations with high shape accuracy, true dimensions and high surface quality. The method includes: a. providing a vacuum clamping means comprised of a ground, sintered metal plate which is connected to a vacuum source and which is positioned on a work table which is movable in two mutually perpendicular directions X and Y; b. positioning a machinable foil on the ground, sintered metal plate and clamping the machinable foil thereto by applying an effective amount of vacuum; c. cutting a plurality of parallel grooves into the surface of the machinable foil by means of at least one shaping diamond positioned on a cutting spindle and adjustable in a direction Z, each groove of the plurality of grooves having a groove length, a groove width, and a cross-sectional shape that is constant over the groove length and freely selectable; d. cutting the grooved machinable foil into cut sections having selected lengths and widths; and e. stacking the cut sections, wherein the plurality of grooves have a form precision such that, for groove lengths of more than 1000 .mu.m, the groove width has an accuracy of about +1 .mu.m for land widths which equal or exceed about 15 .mu.m.
摘要翻译：一种制造精细结构体的方法，其包括多个层叠的切割部分的箔，其至少一个在其至少一个表面上沿选定的凹槽方向设置有凹槽，并且具有多个紧密并置的通道类似的穿孔具有高的形状精度，真实的尺寸和高的表面质量。该方法包括：a。提供真空夹紧装置，其包括接地的烧结金属板，该金属板连接到真空源并且位于可在两个相互垂直的方向X和Y上移动的工作台上; b。将可机加工的箔定位在地面上，烧结金属板，并通过施加有效量的真空将可机加工的箔夹紧在其上; C。通过位于切割轴上的至少一个成形金刚石将多个平行凹槽切割成可加工箔的表面，并且可沿方向Z调节，多个凹槽中的每个凹槽具有凹槽长度，凹槽宽度和在槽长度上恒定的横截面形状并且可自由选择; d。将切槽的可加工箔切割成具有选定长度和宽度的切割部分; 和e。堆叠切割部分，其中多个凹槽具有形状精度，使得对于大于1000μm的凹槽长度，对于等于或超过约15μm的凹槽宽度，凹槽宽度具有约+1μm的精度。

97. 发明授权

US5182238A Protective layer of hard material with homogeneous distribution of elements 失效
标题翻译：具有均质分布元素的硬质材料保护层
公开(公告)号：US5182238A
公开(公告)日：1993-01-26
申请号：US335601
申请日：1989-04-10
申请人： Helmut Holleck
发明人： Helmut Holleck
IPC分类号： C23C14/06 , C23C14/35
CPC分类号： C23C14/0641 , C23C14/0635 , Y10T428/31678 , Y10T428/31815
摘要： A primarily crystalline, titanium-containing protective layer of hard material with homogeneous distribution of elements on the surfaces of a substrate material. The protective layer comprises a stabilized mixed phase having a crystal structure made of a metallic hard material which is at least one material selected from TiN and TiC and a covalent hard material which is at least one material selected from SiC and Si.sub.3 N.sub.4.
摘要翻译：一种主要结晶的含钛保护层的硬质材料，在基材表面上均匀分布元素。保护层包括具有由金属硬质材料制成的晶体结构的稳定混合相，其为选自TiN和TiC中的至少一种材料，以及选自SiC和Si 3 N 4中的至少一种材料的共价硬质材料。

98. 发明授权

US5054522A Microvalve 失效
标题翻译： MICROVALVE
公开(公告)号：US5054522A
公开(公告)日：1991-10-08
申请号：US527194
申请日：1990-05-23
申请人： Bernd Kowanz , Dirk Schmidt , Wolfgang Ehrfeld
发明人： Bernd Kowanz , Dirk Schmidt , Wolfgang Ehrfeld
IPC分类号： B65D90/58 , B65D90/60 , B65D90/64 , F16K3/02 , F16K31/02
CPC分类号： F16K31/02 , B65D90/587 , B65D90/60 , F16K3/02 , F16K3/0254 , F16K99/0001 , F16K99/0011 , F16K99/0051 , Y10T137/86718 , Y10T137/86759
摘要： A valve plate (14) provided with slot-like valve ports (16) is able to slide between two stationary valve plates (10 and 12) which are joined with each other and are provided with corresponding slot-like valve ports (16). A electrostatic drive is integrated in the valve plates (10, 12 and 14). It consists of strip-like electrodes (20 and 22) which are arranged opposite to corresponding electrodes of another valve plate. By the application of suitable actuating potentials with the same or opposite polarity to the electrodes of different valve plates the actuating forces may be produced, which are needed for moving the movable valve plate (14).
摘要翻译：设置有槽状阀口（16）的阀板（14）能够在彼此接合的两个固定阀板（10和12）之间滑动并且设置有相应的槽状阀口（16）。静电驱动器集成在阀板（10,12和14）中。它由与另一个阀板的相应电极相对设置的带状电极（20和22）组成。通过向不同阀板的电极施加具有相同或相反极性的合适的致动电位，可以产生用于移动可移动阀板（14）所需的致动力。

99. 发明授权

US4981558A Process for the reproduction of a microstructured, plate-shaped body 失效
标题翻译：微结构化板状体的再生方法
公开(公告)号：US4981558A
公开(公告)日：1991-01-01
申请号：US452030
申请日：1989-12-18
申请人： Asim Maner
发明人： Asim Maner
IPC分类号： C25D1/02 , C25D1/10
CPC分类号： C25D1/10
摘要： A process for reproducing a structured, plate-shaped body, comprising the steps of: (a) providing a composite body containing an electrically insulating molding compound layer and an electrically conducting molding compound layer, (b) pressing a first microstructured body, having an outer face, into the electrically insulating molding compound layer while applying ultrasound so that the outer face of the first microstructured body projects into the electrically conducting layer, (c) removing the first microstructured body from the composite body while applying ultrasound to form an impression in the composite body, (d) electroplating a metal into the impression in the composite body to fill the impression with metal and form a second microstructured body, and (e) removing the composite body from the second microstructured body.
摘要翻译：一种用于再现结构化的板状体的方法，包括以下步骤：（a）提供包含电绝缘模塑料层和导电模塑料层的复合体，（b）压制第一微结构体，具有外表面，同时施加超声波，使得第一微结构体的外表面突出到导电层中，（c）从复合体中移除第一微结构体同时施加超声波以形成印象复合体，（d）将金属电镀到复合体中的印模中以用金属填充印模并形成第二微结构体，以及（e）从第二微结构体去除复合体。

100. 发明授权

US4912978A Apparatus for determining the oscillation parameters of a band 失效
标题翻译：用于确定频带的振荡参数的装置
公开(公告)号：US4912978A
公开(公告)日：1990-04-03
申请号：US252536
申请日：1988-10-03
申请人： Alexander Solmos
发明人： Alexander Solmos
IPC分类号： G01H1/14 , G01H13/00 , G01N29/00
CPC分类号： G01H13/00 , G01H1/14 , Y10S73/01
摘要： An apparatus is provided for determining the natural frequencies of a longitudinally oscillating band excited by a transmitting oscillator, and whose oscillations are received by a receiving oscillator and evaluated. At least one of the exciting oscillator and the receiving oscillator is a sandwich oscillator having metal end masses. The oscillations are transmitted longitudinally along the pre-tensioned length of the band disposed between the transmitting oscillator and the receiving oscillator. An attachment device for attaching the band to the respective oscillators includes a roller which is spring-biased to rest in a groove formed in one face of each of the respective oscillators.
摘要翻译：提供一种装置，用于确定由发射振荡器激励的纵向振动频带的固有频率，并且其振荡由接收振荡器接收并进行评估。励磁振荡器和接收振荡器中的至少一个是具有金属端块的夹层振荡器。振荡沿着布置在发射振荡器和接收振荡器之间的频带的预张紧长度纵向传输。用于将带附接到各个振荡器的附接装置包括一个辊，该辊被弹簧偏置以保持在形成在每个相应振荡器的一个面中的凹槽中。

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